Instalación y carga de packages

``{r installing} if (!requireNamespace(“BiocManager”, quietly = TRUE)) install.packages(“BiocManager”)

BiocManager::install(“limma”) BiocManager::install(“topGO”) BiocManager::install(“GO.db”) BiocManager::install(“org.Hs.eg.db”) BiocManager::install(“rtracklayer”) BiocManager::install(“GenomicRanges”) BiocManager::install(“ChIPQC”) BiocManager::install(“ChIPseeker”) BiocManager::install(“TxDb.Hsapiens.UCSC.hg19.knownGene”) install_github(“ColeWunderlich/soGGi”) BiocManager::install(“Rsubread”) BiocManager::install(“venn”)

library(devtools)
## Loading required package: usethis
library(rtracklayer)
## Loading required package: GenomicRanges
## Loading required package: stats4
## Loading required package: BiocGenerics
## Loading required package: parallel
## 
## Attaching package: 'BiocGenerics'
## The following objects are masked from 'package:parallel':
## 
##     clusterApply, clusterApplyLB, clusterCall, clusterEvalQ,
##     clusterExport, clusterMap, parApply, parCapply, parLapply,
##     parLapplyLB, parRapply, parSapply, parSapplyLB
## The following objects are masked from 'package:stats':
## 
##     IQR, mad, sd, var, xtabs
## The following objects are masked from 'package:base':
## 
##     anyDuplicated, append, as.data.frame, basename, cbind, colnames,
##     dirname, do.call, duplicated, eval, evalq, Filter, Find, get, grep,
##     grepl, intersect, is.unsorted, lapply, Map, mapply, match, mget,
##     order, paste, pmax, pmax.int, pmin, pmin.int, Position, rank,
##     rbind, Reduce, rownames, sapply, setdiff, sort, table, tapply,
##     union, unique, unsplit, which, which.max, which.min
## Loading required package: S4Vectors
## 
## Attaching package: 'S4Vectors'
## The following object is masked from 'package:base':
## 
##     expand.grid
## Loading required package: IRanges
## Loading required package: GenomeInfoDb
library(GenomicRanges)
library(ChIPQC)
## Loading required package: ggplot2
## Loading required package: DiffBind
## Loading required package: SummarizedExperiment
## Loading required package: Biobase
## Welcome to Bioconductor
## 
##     Vignettes contain introductory material; view with
##     'browseVignettes()'. To cite Bioconductor, see
##     'citation("Biobase")', and for packages 'citation("pkgname")'.
## Loading required package: DelayedArray
## Loading required package: matrixStats
## 
## Attaching package: 'matrixStats'
## The following objects are masked from 'package:Biobase':
## 
##     anyMissing, rowMedians
## 
## Attaching package: 'DelayedArray'
## The following objects are masked from 'package:matrixStats':
## 
##     colMaxs, colMins, colRanges, rowMaxs, rowMins, rowRanges
## The following objects are masked from 'package:base':
## 
##     aperm, apply, rowsum
## 
library(DT)
library(dplyr)
## 
## Attaching package: 'dplyr'
## The following object is masked from 'package:matrixStats':
## 
##     count
## The following object is masked from 'package:Biobase':
## 
##     combine
## The following objects are masked from 'package:GenomicRanges':
## 
##     intersect, setdiff, union
## The following object is masked from 'package:GenomeInfoDb':
## 
##     intersect
## The following objects are masked from 'package:IRanges':
## 
##     collapse, desc, intersect, setdiff, slice, union
## The following objects are masked from 'package:S4Vectors':
## 
##     first, intersect, rename, setdiff, setequal, union
## The following objects are masked from 'package:BiocGenerics':
## 
##     combine, intersect, setdiff, union
## The following objects are masked from 'package:stats':
## 
##     filter, lag
## The following objects are masked from 'package:base':
## 
##     intersect, setdiff, setequal, union
library(tidyr)
## 
## Attaching package: 'tidyr'
## The following object is masked from 'package:S4Vectors':
## 
##     expand
library(ChIPseeker)
## ChIPseeker v1.24.0  For help: https://guangchuangyu.github.io/software/ChIPseeker
## 
## If you use ChIPseeker in published research, please cite:
## Guangchuang Yu, Li-Gen Wang, Qing-Yu He. ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization. Bioinformatics 2015, 31(14):2382-2383
library(TxDb.Hsapiens.UCSC.hg19.knownGene)
## Loading required package: GenomicFeatures
## Loading required package: AnnotationDbi
## 
## Attaching package: 'AnnotationDbi'
## The following object is masked from 'package:dplyr':
## 
##     select
library(soGGi)
## Warning: replacing previous import 'ggplot2::Position' by
## 'BiocGenerics::Position' when loading 'soGGi'
library(limma)
## 
## Attaching package: 'limma'
## The following object is masked from 'package:BiocGenerics':
## 
##     plotMA
library(venn)
library(tidyr)
library(Rsubread)
library(csaw)
library(edgeR)
library(UpSetR)
library(enrichR)
## Welcome to enrichR
## Checking connection ...
## Connection is Live!

Lectura y carga de los datos de muestras ATAC-seq

setwd("/Users/javi/Documents/Master Bioinformática UOC/Proyecto fin de máster/Datos originales/ATAC-seq/GSE111013_RAW")
list.filenames<-list.files(pattern ="CD8.peaks.narrowPeak.gz$")
list.filenames
##  [1] "GSM3020245_ATAC-seq_CLL1_0d_CD8.peaks.narrowPeak.gz"  
##  [2] "GSM3020246_ATAC-seq_CLL1_3d_CD8.peaks.narrowPeak.gz"  
##  [3] "GSM3020247_ATAC-seq_CLL1_030d_CD8.peaks.narrowPeak.gz"
##  [4] "GSM3020248_ATAC-seq_CLL1_120d_CD8.peaks.narrowPeak.gz"
##  [5] "GSM3020266_ATAC-seq_CLL2_0d_CD8.peaks.narrowPeak.gz"  
##  [6] "GSM3020267_ATAC-seq_CLL2_3d_CD8.peaks.narrowPeak.gz"  
##  [7] "GSM3020268_ATAC-seq_CLL2_8d_CD8.peaks.narrowPeak.gz"  
##  [8] "GSM3020269_ATAC-seq_CLL2_30d_CD8.peaks.narrowPeak.gz" 
##  [9] "GSM3020270_ATAC-seq_CLL2_120d_CD8.peaks.narrowPeak.gz"
## [10] "GSM3020286_ATAC-seq_CLL4_0d_CD8.peaks.narrowPeak.gz"  
## [11] "GSM3020287_ATAC-seq_CLL4_3d_CD8.peaks.narrowPeak.gz"  
## [12] "GSM3020311_ATAC-seq_CLL5_0d_CD8.peaks.narrowPeak.gz"  
## [13] "GSM3020312_ATAC-seq_CLL5_1d_CD8.peaks.narrowPeak.gz"  
## [14] "GSM3020313_ATAC-seq_CLL5_2d_CD8.peaks.narrowPeak.gz"  
## [15] "GSM3020314_ATAC-seq_CLL5_3d_CD8.peaks.narrowPeak.gz"  
## [16] "GSM3020315_ATAC-seq_CLL5_8d_CD8.peaks.narrowPeak.gz"  
## [17] "GSM3020316_ATAC-seq_CLL5_30d_CD8.peaks.narrowPeak.gz" 
## [18] "GSM3020317_ATAC-seq_CLL5_150d_CD8.peaks.narrowPeak.gz"
## [19] "GSM3020318_ATAC-seq_CLL5_240d_CD8.peaks.narrowPeak.gz"
## [20] "GSM3020343_ATAC-seq_CLL6_0d_CD8.peaks.narrowPeak.gz"  
## [21] "GSM3020344_ATAC-seq_CLL6_030d_CD8.peaks.narrowPeak.gz"
## [22] "GSM3020345_ATAC-seq_CLL6_120d_CD8.peaks.narrowPeak.gz"
## [23] "GSM3020346_ATAC-seq_CLL6_280d_CD8.peaks.narrowPeak.gz"
## [24] "GSM3020366_ATAC-seq_CLL7_0d_CD8.peaks.narrowPeak.gz"  
## [25] "GSM3020367_ATAC-seq_CLL7_1d_CD8.peaks.narrowPeak.gz"  
## [26] "GSM3020368_ATAC-seq_CLL7_3d_CD8.peaks.narrowPeak.gz"  
## [27] "GSM3020369_ATAC-seq_CLL7_8d_CD8.peaks.narrowPeak.gz"  
## [28] "GSM3020370_ATAC-seq_CLL7_30d_CD8.peaks.narrowPeak.gz" 
## [29] "GSM3020371_ATAC-seq_CLL7_150d_CD8.peaks.narrowPeak.gz"
## [30] "GSM3020383_ATAC-seq_CLL8_0d_CD8.peaks.narrowPeak.gz"  
## [31] "GSM3020384_ATAC-seq_CLL8_3d_CD8.peaks.narrowPeak.gz"  
## [32] "GSM3020385_ATAC-seq_CLL8_030d_CD8.peaks.narrowPeak.gz"
list.data<-list()
for (i in 1:length(list.filenames)){
list.data[[i]]<-import(list.filenames[i], "narrowPeak")

}
names(list.data)<-list.filenames
CD8.data<-list.data

a<-CD8.data$`GSM3020245_ATAC-seq_CLL1_0d_CD8.peaks.narrowPeak.gz`

hist(a$score)

as.matrix(summary(as.factor(a@seqnames)))
##                       [,1]
## chr1                  5041
## chr10                 2444
## chr11                 2644
## chr12                 2763
## chr13                 1382
## chr14                 1822
## chr15                 1483
## chr16                 1653
## chr17                 2233
## chr17_gl000205_random    4
## chr18                 1064
## chr19                 2042
## chr19_gl000208_random    1
## chr1_gl000191_random     2
## chr1_gl000192_random     3
## chr2                  4354
## chr20                 1213
## chr21                  539
## chr22                  852
## chr3                  3481
## chr4                  2377
## chr5                  2827
## chr6                  3444
## chr7                  2698
## chr7_gl000195_random     7
## chr8                  2167
## chr9                  1980
## chr9_gl000199_random     1
## chrM                    10
## chrUn_gl000214           1
## chrUn_gl000219          10
## chrUn_gl000220          19
## chrUn_gl000224           3
## chrUn_gl000226           2
## chrX                  1711
short.names<-sapply(strsplit(list.filenames, "-seq_"), "[", 2)
short.names<-sapply(strsplit(short.names, ".peaks"), "[", 1)
short.names
##  [1] "CLL1_0d_CD8"   "CLL1_3d_CD8"   "CLL1_030d_CD8" "CLL1_120d_CD8"
##  [5] "CLL2_0d_CD8"   "CLL2_3d_CD8"   "CLL2_8d_CD8"   "CLL2_30d_CD8" 
##  [9] "CLL2_120d_CD8" "CLL4_0d_CD8"   "CLL4_3d_CD8"   "CLL5_0d_CD8"  
## [13] "CLL5_1d_CD8"   "CLL5_2d_CD8"   "CLL5_3d_CD8"   "CLL5_8d_CD8"  
## [17] "CLL5_30d_CD8"  "CLL5_150d_CD8" "CLL5_240d_CD8" "CLL6_0d_CD8"  
## [21] "CLL6_030d_CD8" "CLL6_120d_CD8" "CLL6_280d_CD8" "CLL7_0d_CD8"  
## [25] "CLL7_1d_CD8"   "CLL7_3d_CD8"   "CLL7_8d_CD8"   "CLL7_30d_CD8" 
## [29] "CLL7_150d_CD8" "CLL8_0d_CD8"   "CLL8_3d_CD8"   "CLL8_030d_CD8"
short.names[3]<-"CLL1_30d_CD8"
short.names[21]<-"CLL6_30d_CD8"
short.names[32]<-"CLL8_30d_CD8"

Filtrado de picos detectados

Filtramos los datos para mantener sólo aquellos pertenecientes a los cromosomas canónicos y no sexuales. Eliminamos también los picos artefactales asociados a “blacklists”

setwd("/Users/javi/Documents/Master Bioinformática UOC/Proyecto fin de máster/PEC3 ATAC-seq")
blkList <- import.bed("hg19-blacklist.v2.bed.gz")
Canonical_chrom<-c("chr1", "chr2", "chr3", "chr4","chr5", "chr6","chr7", "chr8","chr9", "chr10","chr11", "chr12","chr13", "chr14","chr15", "chr16","chr17", "chr18","chr19", "chr20", "chr21", "chr22")
CD8.filtered<-list()
CD8.data[[1]]
## GRanges object with 52277 ranges and 6 metadata columns:
##           seqnames              ranges strand |                          name
##              <Rle>           <IRanges>  <Rle> |                   <character>
##       [1]     chr1         10069-10311      * |     ATAC-seq_FE_0d_CD8_peak_1
##       [2]     chr1       569790-570064      * |     ATAC-seq_FE_0d_CD8_peak_2
##       [3]     chr1       713839-714391      * |     ATAC-seq_FE_0d_CD8_peak_3
##       [4]     chr1       839840-840211      * |     ATAC-seq_FE_0d_CD8_peak_4
##       [5]     chr1       894618-894764      * |     ATAC-seq_FE_0d_CD8_peak_5
##       ...      ...                 ...    ... .                           ...
##   [52273]     chrX 154807285-154807739      * | ATAC-seq_FE_0d_CD8_peak_52273
##   [52274]     chrX 154822263-154822422      * | ATAC-seq_FE_0d_CD8_peak_52274
##   [52275]     chrX 154841871-154842108      * | ATAC-seq_FE_0d_CD8_peak_52275
##   [52276]     chrX 154842537-154842743      * | ATAC-seq_FE_0d_CD8_peak_52276
##   [52277]     chrX 154862080-154862534      * | ATAC-seq_FE_0d_CD8_peak_52277
##               score signalValue    pValue    qValue      peak
##           <numeric>   <numeric> <numeric> <numeric> <integer>
##       [1]       111     8.11456  13.91620  11.12580       124
##       [2]       918    32.40973  97.05756  91.87830       136
##       [3]       254    12.97655  28.80828  25.49533       179
##       [4]       160    10.14320  19.03641  16.04733       232
##       [5]        36     4.56444   6.04979   3.66083        32
##       ...       ...         ...       ...       ...       ...
##   [52273]       342    14.33876  37.85284  34.27439       288
##   [52274]        56     5.57876   8.12360   5.60904        36
##   [52275]        40     4.56204   6.51479   4.09957        94
##   [52276]        88     6.67640  11.56942   8.88189        79
##   [52277]       439    17.00429  47.80342  43.95039       285
##   -------
##   seqinfo: 35 sequences from an unspecified genome; no seqlengths
length(list.filenames)
## [1] 32
for (i in 1:length(list.filenames)){
MacsCalls <- CD8.data[[i]]

data.frame(Blacklisted = sum(MacsCalls %over% blkList), Not_Blacklisted = sum(!MacsCalls %over% blkList))

MacsCalls.filtered <- MacsCalls[!MacsCalls %over% blkList]

Filtered.peaks<-MacsCalls.filtered[seqnames(MacsCalls.filtered) %in% Canonical_chrom]
summary(as.factor(seqnames(Filtered.peaks)))

CD8.filtered[[i]]<-Filtered.peaks
}
## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).
## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).
## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).
## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).
## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr17_gl000206_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000212, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226, chrUn_gl000232, chrUn_gl000234, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr17_gl000206_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000212, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226, chrUn_gl000232, chrUn_gl000234, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr17_gl000206_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000212, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226, chrUn_gl000232, chrUn_gl000234, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).
## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000211, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000237
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000211, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000237
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000211, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000237
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).
## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr11_gl000202_random, chr17_gl000204_random, chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000198_random, chr9_gl000199_random, chrM, chrUn_gl000211, chrUn_gl000214, chrUn_gl000216, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr11_gl000202_random, chr17_gl000204_random, chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000198_random, chr9_gl000199_random, chrM, chrUn_gl000211, chrUn_gl000214, chrUn_gl000216, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr11_gl000202_random, chr17_gl000204_random, chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000198_random, chr9_gl000199_random, chrM, chrUn_gl000211, chrUn_gl000214, chrUn_gl000216, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).
summary(CD8.filtered)
##       Length Class   Mode
##  [1,] 49893  GRanges S4  
##  [2,] 21235  GRanges S4  
##  [3,]  8795  GRanges S4  
##  [4,] 37144  GRanges S4  
##  [5,]  4740  GRanges S4  
##  [6,] 45573  GRanges S4  
##  [7,] 17829  GRanges S4  
##  [8,] 24319  GRanges S4  
##  [9,] 43650  GRanges S4  
## [10,] 16994  GRanges S4  
## [11,] 30766  GRanges S4  
## [12,] 42540  GRanges S4  
## [13,] 41899  GRanges S4  
## [14,] 30640  GRanges S4  
## [15,] 47335  GRanges S4  
## [16,] 51973  GRanges S4  
## [17,] 50762  GRanges S4  
## [18,] 47344  GRanges S4  
## [19,] 23617  GRanges S4  
## [20,] 40023  GRanges S4  
## [21,] 40491  GRanges S4  
## [22,] 51247  GRanges S4  
## [23,] 42475  GRanges S4  
## [24,] 36669  GRanges S4  
## [25,] 38848  GRanges S4  
## [26,] 37340  GRanges S4  
## [27,] 44437  GRanges S4  
## [28,] 42586  GRanges S4  
## [29,] 37605  GRanges S4  
## [30,] 43580  GRanges S4  
## [31,] 48230  GRanges S4  
## [32,]  8183  GRanges S4
names(CD8.filtered)<-short.names 
names(CD8.filtered)
##  [1] "CLL1_0d_CD8"   "CLL1_3d_CD8"   "CLL1_30d_CD8"  "CLL1_120d_CD8"
##  [5] "CLL2_0d_CD8"   "CLL2_3d_CD8"   "CLL2_8d_CD8"   "CLL2_30d_CD8" 
##  [9] "CLL2_120d_CD8" "CLL4_0d_CD8"   "CLL4_3d_CD8"   "CLL5_0d_CD8"  
## [13] "CLL5_1d_CD8"   "CLL5_2d_CD8"   "CLL5_3d_CD8"   "CLL5_8d_CD8"  
## [17] "CLL5_30d_CD8"  "CLL5_150d_CD8" "CLL5_240d_CD8" "CLL6_0d_CD8"  
## [21] "CLL6_30d_CD8"  "CLL6_120d_CD8" "CLL6_280d_CD8" "CLL7_0d_CD8"  
## [25] "CLL7_1d_CD8"   "CLL7_3d_CD8"   "CLL7_8d_CD8"   "CLL7_30d_CD8" 
## [29] "CLL7_150d_CD8" "CLL8_0d_CD8"   "CLL8_3d_CD8"   "CLL8_30d_CD8"

Anotación de picos

A continuación pasamos a identificar, en cada muestra, la asociación de los picos detectados a los diferentes genes del genoma humano, así como su rol más probable.

CD8.anno<-list()
txdb <- TxDb.Hsapiens.UCSC.hg19.knownGene

for (i in 1:length(list.filenames)){
CD8.anno[[i]] <- annotatePeak(CD8.filtered[[i]], tssRegion=c(-3000, 3000),
 TxDb=txdb, annoDb="org.Hs.eg.db")
plotAnnoPie(CD8.anno[[i]], main = short.names[i]) #Opcional, sólo para comprobar la calidad de picos
}
## >> preparing features information...      2020-06-01 18:02:45 
## >> identifying nearest features...        2020-06-01 18:02:45 
## >> calculating distance from peak to TSS...   2020-06-01 18:02:47 
## >> assigning genomic annotation...        2020-06-01 18:02:47 
## >> adding gene annotation...          2020-06-01 19:50:36
## Loading required package: org.Hs.eg.db
## 
## 'select()' returned 1:many mapping between keys and columns
## >> assigning chromosome lengths           2020-06-01 19:50:36 
## >> done...                    2020-06-01 19:50:36
## >> preparing features information...      2020-06-01 19:50:37 
## >> identifying nearest features...        2020-06-01 19:50:37 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:37 
## >> assigning genomic annotation...        2020-06-01 19:50:37 
## >> adding gene annotation...          2020-06-01 19:50:39
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:50:39 
## >> done...                    2020-06-01 19:50:39
## >> preparing features information...      2020-06-01 19:50:40 
## >> identifying nearest features...        2020-06-01 19:50:40 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:40 
## >> assigning genomic annotation...        2020-06-01 19:50:40 
## >> adding gene annotation...          2020-06-01 19:50:42
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:50:42 
## >> done...                    2020-06-01 19:50:42
## >> preparing features information...      2020-06-01 19:50:42 
## >> identifying nearest features...        2020-06-01 19:50:42 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:43 
## >> assigning genomic annotation...        2020-06-01 19:50:43 
## >> adding gene annotation...          2020-06-01 19:50:47
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:50:47 
## >> done...                    2020-06-01 19:50:47
## >> preparing features information...      2020-06-01 19:50:47 
## >> identifying nearest features...        2020-06-01 19:50:47 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:48 
## >> assigning genomic annotation...        2020-06-01 19:50:48 
## >> adding gene annotation...          2020-06-01 19:50:50
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:50:50 
## >> done...                    2020-06-01 19:50:50
## >> preparing features information...      2020-06-01 19:50:50 
## >> identifying nearest features...        2020-06-01 19:50:50 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:51 
## >> assigning genomic annotation...        2020-06-01 19:50:51 
## >> adding gene annotation...          2020-06-01 19:50:54
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:50:54 
## >> done...                    2020-06-01 19:50:54
## >> preparing features information...      2020-06-01 19:50:55 
## >> identifying nearest features...        2020-06-01 19:50:55 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:55 
## >> assigning genomic annotation...        2020-06-01 19:50:55 
## >> adding gene annotation...          2020-06-01 19:50:57
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:50:57 
## >> done...                    2020-06-01 19:50:57
## >> preparing features information...      2020-06-01 19:50:57 
## >> identifying nearest features...        2020-06-01 19:50:57 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:58 
## >> assigning genomic annotation...        2020-06-01 19:50:58 
## >> adding gene annotation...          2020-06-01 19:51:00
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:00 
## >> done...                    2020-06-01 19:51:00
## >> preparing features information...      2020-06-01 19:51:00 
## >> identifying nearest features...        2020-06-01 19:51:00 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:01 
## >> assigning genomic annotation...        2020-06-01 19:51:01 
## >> adding gene annotation...          2020-06-01 19:51:03
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:03 
## >> done...                    2020-06-01 19:51:04
## >> preparing features information...      2020-06-01 19:51:04 
## >> identifying nearest features...        2020-06-01 19:51:04 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:04 
## >> assigning genomic annotation...        2020-06-01 19:51:04 
## >> adding gene annotation...          2020-06-01 19:51:07
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:07 
## >> done...                    2020-06-01 19:51:07
## >> preparing features information...      2020-06-01 19:51:07 
## >> identifying nearest features...        2020-06-01 19:51:07 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:08 
## >> assigning genomic annotation...        2020-06-01 19:51:08 
## >> adding gene annotation...          2020-06-01 19:51:10
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:10 
## >> done...                    2020-06-01 19:51:10
## >> preparing features information...      2020-06-01 19:51:10 
## >> identifying nearest features...        2020-06-01 19:51:10 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:11 
## >> assigning genomic annotation...        2020-06-01 19:51:11 
## >> adding gene annotation...          2020-06-01 19:51:13
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:13 
## >> done...                    2020-06-01 19:51:13
## >> preparing features information...      2020-06-01 19:51:13 
## >> identifying nearest features...        2020-06-01 19:51:13 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:14 
## >> assigning genomic annotation...        2020-06-01 19:51:14 
## >> adding gene annotation...          2020-06-01 19:51:17
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:17 
## >> done...                    2020-06-01 19:51:17
## >> preparing features information...      2020-06-01 19:51:18 
## >> identifying nearest features...        2020-06-01 19:51:18 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:18 
## >> assigning genomic annotation...        2020-06-01 19:51:18 
## >> adding gene annotation...          2020-06-01 19:51:20
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:20 
## >> done...                    2020-06-01 19:51:20
## >> preparing features information...      2020-06-01 19:51:20 
## >> identifying nearest features...        2020-06-01 19:51:20 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:21 
## >> assigning genomic annotation...        2020-06-01 19:51:21 
## >> adding gene annotation...          2020-06-01 19:51:23
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:24 
## >> done...                    2020-06-01 19:51:24
## >> preparing features information...      2020-06-01 19:51:24 
## >> identifying nearest features...        2020-06-01 19:51:24 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:25 
## >> assigning genomic annotation...        2020-06-01 19:51:25 
## >> adding gene annotation...          2020-06-01 19:51:27
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:27 
## >> done...                    2020-06-01 19:51:27
## >> preparing features information...      2020-06-01 19:51:27 
## >> identifying nearest features...        2020-06-01 19:51:27 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:29 
## >> assigning genomic annotation...        2020-06-01 19:51:29 
## >> adding gene annotation...          2020-06-01 19:51:31
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:31 
## >> done...                    2020-06-01 19:51:31
## >> preparing features information...      2020-06-01 19:51:31 
## >> identifying nearest features...        2020-06-01 19:51:31 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:32 
## >> assigning genomic annotation...        2020-06-01 19:51:32 
## >> adding gene annotation...          2020-06-01 19:51:34
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:35 
## >> done...                    2020-06-01 19:51:35
## >> preparing features information...      2020-06-01 19:51:35 
## >> identifying nearest features...        2020-06-01 19:51:35 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:35 
## >> assigning genomic annotation...        2020-06-01 19:51:35 
## >> adding gene annotation...          2020-06-01 19:51:38
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:38 
## >> done...                    2020-06-01 19:51:38
## >> preparing features information...      2020-06-01 19:51:38 
## >> identifying nearest features...        2020-06-01 19:51:38 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:39 
## >> assigning genomic annotation...        2020-06-01 19:51:39 
## >> adding gene annotation...          2020-06-01 19:51:41
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:41 
## >> done...                    2020-06-01 19:51:41
## >> preparing features information...      2020-06-01 19:51:41 
## >> identifying nearest features...        2020-06-01 19:51:41 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:44 
## >> assigning genomic annotation...        2020-06-01 19:51:44 
## >> adding gene annotation...          2020-06-01 19:51:45
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:46 
## >> done...                    2020-06-01 19:51:46
## >> preparing features information...      2020-06-01 19:51:46 
## >> identifying nearest features...        2020-06-01 19:51:46 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:47 
## >> assigning genomic annotation...        2020-06-01 19:51:47 
## >> adding gene annotation...          2020-06-01 19:51:49
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:49 
## >> done...                    2020-06-01 19:51:49
## >> preparing features information...      2020-06-01 19:51:49 
## >> identifying nearest features...        2020-06-01 19:51:49 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:50 
## >> assigning genomic annotation...        2020-06-01 19:51:50 
## >> adding gene annotation...          2020-06-01 19:51:52
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:53 
## >> done...                    2020-06-01 19:51:53
## >> preparing features information...      2020-06-01 19:51:53 
## >> identifying nearest features...        2020-06-01 19:51:53 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:54 
## >> assigning genomic annotation...        2020-06-01 19:51:54 
## >> adding gene annotation...          2020-06-01 19:51:56
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:56 
## >> done...                    2020-06-01 19:51:56
## >> preparing features information...      2020-06-01 19:51:56 
## >> identifying nearest features...        2020-06-01 19:51:56 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:57 
## >> assigning genomic annotation...        2020-06-01 19:51:57 
## >> adding gene annotation...          2020-06-01 19:51:59
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:59 
## >> done...                    2020-06-01 19:51:59
## >> preparing features information...      2020-06-01 19:51:59 
## >> identifying nearest features...        2020-06-01 19:51:59 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:00 
## >> assigning genomic annotation...        2020-06-01 19:52:00 
## >> adding gene annotation...          2020-06-01 19:52:03
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:03 
## >> done...                    2020-06-01 19:52:03
## >> preparing features information...      2020-06-01 19:52:03 
## >> identifying nearest features...        2020-06-01 19:52:03 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:04 
## >> assigning genomic annotation...        2020-06-01 19:52:04 
## >> adding gene annotation...          2020-06-01 19:52:06
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:06 
## >> done...                    2020-06-01 19:52:06
## >> preparing features information...      2020-06-01 19:52:07 
## >> identifying nearest features...        2020-06-01 19:52:07 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:07 
## >> assigning genomic annotation...        2020-06-01 19:52:07 
## >> adding gene annotation...          2020-06-01 19:52:09
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:10 
## >> done...                    2020-06-01 19:52:10
## >> preparing features information...      2020-06-01 19:52:10 
## >> identifying nearest features...        2020-06-01 19:52:10 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:11 
## >> assigning genomic annotation...        2020-06-01 19:52:11 
## >> adding gene annotation...          2020-06-01 19:52:13
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:13 
## >> done...                    2020-06-01 19:52:13
## >> preparing features information...      2020-06-01 19:52:13 
## >> identifying nearest features...        2020-06-01 19:52:13 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:14 
## >> assigning genomic annotation...        2020-06-01 19:52:14 
## >> adding gene annotation...          2020-06-01 19:52:16
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:17 
## >> done...                    2020-06-01 19:52:17
## >> preparing features information...      2020-06-01 19:52:17 
## >> identifying nearest features...        2020-06-01 19:52:17 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:18 
## >> assigning genomic annotation...        2020-06-01 19:52:18 
## >> adding gene annotation...          2020-06-01 19:52:20
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:20 
## >> done...                    2020-06-01 19:52:20
## >> preparing features information...      2020-06-01 19:52:20 
## >> identifying nearest features...        2020-06-01 19:52:20 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:21 
## >> assigning genomic annotation...        2020-06-01 19:52:21 
## >> adding gene annotation...          2020-06-01 19:52:23
## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:23 
## >> done...                    2020-06-01 19:52:23

names(CD8.anno)<-list.filenames
CD8.anno$`GSM3020245_ATAC-seq_CLL1_0d_CD8.peaks.narrowPeak.gz`
## Annotated peaks generated by ChIPseeker
## 49893/49893  peaks were annotated
## Genomic Annotation Summary:
##               Feature  Frequency
## 9    Promoter (<=1kb) 29.3688493
## 10   Promoter (1-2kb)  4.3473032
## 11   Promoter (2-3kb)  2.7278376
## 4              5' UTR  0.4128836
## 3              3' UTR  1.4571182
## 1            1st Exon  0.3928407
## 7          Other Exon  2.1465937
## 2          1st Intron 10.0094202
## 8        Other Intron 21.4198385
## 6  Downstream (<=300)  1.0662818
## 5   Distal Intergenic 26.6510332
#With this information we can then subset our peaks/nuc free regions to those only landing in TSS regions (+/- 500)
CD8.anno.TSS<-list()
for (i in 1:length(list.filenames)){
MacsGranges_Anno <- as.GRanges(CD8.anno[[i]])
CD8.anno.TSS[[i]] <- MacsGranges_Anno[abs(MacsGranges_Anno$distanceToTSS) < 
    1000]
}
summary(CD8.anno[[1]]@anno)
## [1] "GRanges object with 49893 ranges and 18 metadata columns"
summary(CD8.anno.TSS[[1]])
## [1] "GRanges object with 14650 ranges and 18 metadata columns"
names(CD8.anno.TSS)<-short.names

Observamos que el piechart de las muestras CLL1_30d_CLL y CLL8_30d_CLL son distintas al resto, lo que nos hace sospechar que los datos de las muestras pueden ser erróneos.

#Estudio diferencial del efecto del ibrutinib.

Búsqueda de piscos comunes.

Analizamos cuál es el grado de solapamiento de los picos entre muestras, y realizamos una primera observación del agrupamiento de picos en muestras del mismo tipo.

GRangesList(CD8.anno.TSS)
## GRangesList object of length 32:
## $CLL1_0d_CD8
## GRanges object with 14650 ranges and 18 metadata columns:
##           seqnames              ranges strand |                          name
##              <Rle>           <IRanges>  <Rle> |                   <character>
##       [1]     chr1       894618-894764      * |     ATAC-seq_FE_0d_CD8_peak_5
##       [2]     chr1       948355-949030      * |     ATAC-seq_FE_0d_CD8_peak_6
##       [3]     chr1       955086-955232      * |     ATAC-seq_FE_0d_CD8_peak_7
##       [4]     chr1     1051386-1051828      * |    ATAC-seq_FE_0d_CD8_peak_11
##       [5]     chr1     1167282-1167606      * |    ATAC-seq_FE_0d_CD8_peak_14
##       ...      ...                 ...    ... .                           ...
##   [14646]     chr9 140445958-140446104      * | ATAC-seq_FE_0d_CD8_peak_50511
##   [14647]     chr9 140473308-140473674      * | ATAC-seq_FE_0d_CD8_peak_50512
##   [14648]     chr9 140484923-140485144      * | ATAC-seq_FE_0d_CD8_peak_50513
##   [14649]     chr9 140499515-140500184      * | ATAC-seq_FE_0d_CD8_peak_50514
##   [14650]     chr9 140513053-140513298      * | ATAC-seq_FE_0d_CD8_peak_50515
##               score signalValue    pValue    qValue      peak       annotation
##           <numeric>   <numeric> <numeric> <numeric> <integer>      <character>
##       [1]        36     4.56444   6.04979   3.66083        32 Promoter (<=1kb)
##       [2]       281    11.00731  31.57639  28.17926       450 Promoter (<=1kb)
##       [3]        56     5.57876   8.12360   5.60904        40 Promoter (<=1kb)
##       [4]       476    17.82272  51.62801  47.66959       289 Promoter (<=1kb)
##       [5]       262    13.79990  29.56773  26.23165       143 Promoter (<=1kb)
##       ...       ...         ...       ...       ...       ...              ...
##   [14646]        36     4.56444   6.04979   3.66083        21 Promoter (<=1kb)
##   [14647]        56     5.57876   8.12360   5.60904       307 Promoter (<=1kb)
##   [14648]        77     6.59308  10.34694   7.71742        99 Promoter (<=1kb)
##   [14649]       287    11.98419  32.19537  28.78043       233 Promoter (<=1kb)
##   [14650]        94     6.54712  12.15277   9.44037        58 Promoter (<=1kb)
##             geneChr geneStart   geneEnd geneLength geneStrand      geneId
##           <integer> <integer> <integer>  <integer>  <integer> <character>
##       [1]         1    879583    894679      15097          2       26155
##       [2]         1    948847    949919       1073          1        9636
##       [3]         1    955503    991499      35997          1      375790
##       [4]         1   1017198   1051736      34539          2       54991
##       [5]         1   1152288   1167447      15160          2       51150
##       ...       ...       ...       ...        ...        ...         ...
##   [14646]         9 140446309 140447007        699          1       64975
##   [14647]         9 140449361 140473387      24027          2       92715
##   [14648]         9 140476531 140484937       8407          2      116225
##   [14649]         9 140500096 140509812       9717          1       92714
##   [14650]         9 140509784 140513308       3525          2       85026
##           transcriptId distanceToTSS         ENSEMBL      SYMBOL
##            <character>     <numeric>     <character> <character>
##       [1]   uc001abz.4             0 ENSG00000188976       NOC2L
##       [2]   uc001acj.4             0 ENSG00000187608       ISG15
##       [3]   uc001ack.2          -271 ENSG00000188157        AGRN
##       [4]   uc001acr.2             0 ENSG00000131591    C1orf159
##       [5]   uc001adh.4             0 ENSG00000078808        SDF4
##       ...          ...           ...             ...         ...
##   [14646]   uc004cnh.4          -205 ENSG00000182154      MRPL41
##   [14647]   uc004cnk.1             0 ENSG00000148399        DPH7
##   [14648]   uc004cno.1             0 ENSG00000165724     ZMYND19
##   [14649]   uc004cns.3             0 ENSG00000197070      ARRDC1
##   [14650]   uc004cnz.3            10 ENSG00000203993  ARRDC1-AS1
##                                                           GENENAME
##                                                        <character>
##       [1] NOC2 like nucleolar associated transcriptional repressor
##       [2]                            ISG15 ubiquitin like modifier
##       [3]                                                    agrin
##       [4]                      chromosome 1 open reading frame 159
##       [5]                            stromal cell derived factor 4
##       ...                                                      ...
##   [14646]                      mitochondrial ribosomal protein L41
##   [14647]                               diphthamide biosynthesis 7
##   [14648]                      zinc finger MYND-type containing 19
##   [14649]                             arrestin domain containing 1
##   [14650]                                   ARRDC1 antisense RNA 1
##   -------
##   seqinfo: 57 sequences (1 circular) from hg19 genome
## 
## ...
## <31 more elements>
consensusToCount <- soGGi:::runConsensusRegions(GRangesList(CD8.anno.TSS), "none")


as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains("_0d_")) %>% venn(main = "Overlap for untreated")

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains("3d_")) %>% venn(main = "Overlap for 3 days samples")

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains("30d_")) %>% venn(main = "Overlap for 30 days samples")

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains(c("120d_", "150d")) ) %>% venn(main = "Overlap for 120 and 150 days samples")

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains("_0d_")) %>% upset()

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains("3d_")) %>% upset()

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains("30d_")) %>% upset()

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains(c("120d_", "150d")) ) %>% upset()

Observamos que, en el caso de células CD8, las muestras parecen solapar de manera coherente. En todos los casos existe un alto número de picos comunes a todas las muestras con respecto a los picos divergentes. En los casos en que existe un gran número de picos comunes a todas las muestras menos a una, es ésta la que tiene menor tamaño y el número de picos comunes faltantes se relaciona con el bajo número de picos totales de la muestra. Por ello, decidimos no eliminar, a priori, ninguna muestra del análisis.

short.names
##  [1] "CLL1_0d_CD8"   "CLL1_3d_CD8"   "CLL1_30d_CD8"  "CLL1_120d_CD8"
##  [5] "CLL2_0d_CD8"   "CLL2_3d_CD8"   "CLL2_8d_CD8"   "CLL2_30d_CD8" 
##  [9] "CLL2_120d_CD8" "CLL4_0d_CD8"   "CLL4_3d_CD8"   "CLL5_0d_CD8"  
## [13] "CLL5_1d_CD8"   "CLL5_2d_CD8"   "CLL5_3d_CD8"   "CLL5_8d_CD8"  
## [17] "CLL5_30d_CD8"  "CLL5_150d_CD8" "CLL5_240d_CD8" "CLL6_0d_CD8"  
## [21] "CLL6_30d_CD8"  "CLL6_120d_CD8" "CLL6_280d_CD8" "CLL7_0d_CD8"  
## [25] "CLL7_1d_CD8"   "CLL7_3d_CD8"   "CLL7_8d_CD8"   "CLL7_30d_CD8" 
## [29] "CLL7_150d_CD8" "CLL8_0d_CD8"   "CLL8_3d_CD8"   "CLL8_30d_CD8"
patientID<-sapply(strsplit(short.names, "CLL"), "[", 2)
patientID<-sapply(strsplit(patientID, "_"), "[", 1)
patientID
##  [1] "1" "1" "1" "1" "2" "2" "2" "2" "2" "4" "4" "5" "5" "5" "5" "5" "5" "5" "5"
## [20] "6" "6" "6" "6" "7" "7" "7" "7" "7" "7" "8" "8" "8"
TreatmentDay<-sapply(strsplit(short.names, "_"), "[", 2)
TreatmentDay
##  [1] "0d"   "3d"   "30d"  "120d" "0d"   "3d"   "8d"   "30d"  "120d" "0d"  
## [11] "3d"   "0d"   "1d"   "2d"   "3d"   "8d"   "30d"  "150d" "240d" "0d"  
## [21] "30d"  "120d" "280d" "0d"   "1d"   "3d"   "8d"   "30d"  "150d" "0d"  
## [31] "3d"   "30d"
TreatmentDay<-sapply(strsplit(TreatmentDay, "d"), "[", 1)
TreatmentDay<-as.numeric(TreatmentDay)
Treatmentdaygrouped <- TreatmentDay
for (i in 1:length(TreatmentDay)){
        if( TreatmentDay[i] > 0 & TreatmentDay[i] < 4){
            Treatmentdaygrouped[i] <- 3
        }
    else if( TreatmentDay[i] > 4 & TreatmentDay[i] < 9){
            Treatmentdaygrouped[i] <- 8
    }
    else if( TreatmentDay[i] > 30){
            Treatmentdaygrouped[i] <- 120
    }
}
length(Treatmentdaygrouped)
## [1] 32

PCA

Realizamos una reducción de la dimensionalidad por PCA

PCA_Plot <- as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(-consensusIDs) %>% as.matrix %>% t %>% prcomp %>% .$x %>% data.frame %>% mutate(Samples = rownames(.)) %>% mutate(Group = gsub("_\\d", "", Samples)) %>% ggplot(aes(x = PC1, y = PC2, shape=patientID,colour = TreatmentDay)) + geom_point(size = 5)+ scale_shape_manual(values=c(18:25))

PCA_Plot

A pesar de lo agrupado de un gran número de muestras, no detectamos claramente ningún outlier en el resto, por lo que mantenemos todas las muestras en nuestro análisis.

Opcional Conservamos sólo picos abiertos en más de la mitad de las muestras

``{r Identifying a set of non-redundant peaks. 2}

consensusToCount <- soGGi:::runConsensusRegions(GRangesList(CD8.anno.TSS), “none”) head(consensusToCount)

day0<-subset.Vector(CD8.anno.TSS, Treatmentdaygrouped == 0) day3<-subset.Vector(CD8.anno.TSS, Treatmentdaygrouped == 3) day8<-subset.Vector(CD8.anno.TSS, Treatmentdaygrouped == 8) day30<-subset.Vector(CD8.anno.TSS, Treatmentdaygrouped == 30) day120<-subset.Vector(CD8.anno.TSS, Treatmentdaygrouped == 120)

consensusday0 <- soGGi:::runConsensusRegions(GRangesList(day0), “none”) consensusday3 <- soGGi:::runConsensusRegions(GRangesList(day3), “none”) consensusday8 <- soGGi:::runConsensusRegions(GRangesList(day8), “none”) consensusday30 <- soGGi:::runConsensusRegions(GRangesList(day30), “none”) consensusday120 <- soGGi:::runConsensusRegions(GRangesList(day120), “none”)

``

A continuación probamos a ver cómo se distribuyen las muestras sin incluir la PC1 (el tratamiento de batch effect que realizaron los autores)

PCA_Plot <- as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(-consensusIDs) %>% as.matrix %>% t %>% prcomp %>% .$x %>% data.frame %>% mutate(Samples = rownames(.)) %>% mutate(Group = gsub("_\\d", "", Samples)) %>% ggplot(aes(x = PC2, y = PC3, shape=patientID,colour = TreatmentDay)) + geom_point(size = 5)+ scale_shape_manual(values=c(18:25))
PCA_Plot

library(tidyr)

PCA_plot_grouped <- as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(-consensusIDs) %>% 
    as.matrix %>% t %>% prcomp %>% .$x %>% data.frame %>% mutate(Samples = rownames(.)) %>% 
    mutate(Group = gsub("_\\d", "", Samples)) %>% ggplot(aes(x = PC1, y = PC2, 
    colour = as.character(Treatmentdaygrouped))) + geom_point(size = 3)

PCA_plot_grouped 

PCA2vs3_plot_grouped <- as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(-consensusIDs) %>% 
    as.matrix %>% t %>% prcomp %>% .$x %>% data.frame %>% mutate(Samples = rownames(.)) %>% 
    mutate(Group = gsub("_\\d", "", Samples)) %>% ggplot(aes(x = PC2, y = PC3, 
    colour = as.character(Treatmentdaygrouped))) + geom_point(size = 3)
PCA2vs3_plot_grouped

PCA2vs3_plot_grouped <- as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(-consensusIDs) %>% 
    as.matrix %>% t %>% prcomp %>% .$x %>% data.frame %>% mutate(Samples = rownames(.)) %>% 
    mutate(Group = gsub("_\\d", "", Samples)) %>% ggplot(aes(x = PC2, y = PC3, 
    colour = patientID)) + geom_point(size = 3)
PCA2vs3_plot_grouped

First we will filter our peaks in a manner similar to Diffbind, where we keep only peaks which are present in at least two replicates (debería ser en todos?)

occurrences <- elementMetadata(consensusToCount) %>% as.data.frame %>% dplyr::select(-consensusIDs) %>% rowSums

table(occurrences) %>% rev %>% cumsum
##    32    31    30    29    28    27    26    25    24    23    22    21    20 
##  1755  3046  4428  5766  6989  8000  8843  9495 10157 10621 10927 11154 11332 
##    19    18    17    16    15    14    13    12    11    10     9     8     7 
## 11497 11662 11802 11933 12061 12195 12324 12464 12595 12748 12907 13079 13270 
##     6     5     4     3     2     1 
## 13438 13678 13980 14399 15081 17553
consensusToCount <- consensusToCount[occurrences >= 5, ] ### Podemos elegir otro número, El número de pacientes? etc

head(consensusToCount)
## GRanges object with 6 ranges and 33 metadata columns:
##       seqnames        ranges strand | CLL1_0d_CD8 CLL1_3d_CD8 CLL1_30d_CD8
##          <Rle>     <IRanges>  <Rle> |   <numeric>   <numeric>    <numeric>
##   [1]     chr1 762186-763239      * |           0           1            1
##   [2]     chr1 875592-876186      * |           0           0            0
##   [3]     chr1 894436-895579      * |           1           1            0
##   [4]     chr1 895780-896547      * |           0           0            0
##   [5]     chr1 901630-902639      * |           0           0            0
##   [6]     chr1 911398-912049      * |           0           0            0
##       CLL1_120d_CD8 CLL2_0d_CD8 CLL2_3d_CD8 CLL2_8d_CD8 CLL2_30d_CD8
##           <numeric>   <numeric>   <numeric>   <numeric>    <numeric>
##   [1]             0           0           1           0            0
##   [2]             0           0           1           0            0
##   [3]             1           0           1           0            0
##   [4]             0           0           1           0            0
##   [5]             0           0           1           0            0
##   [6]             0           0           1           0            0
##       CLL2_120d_CD8 CLL4_0d_CD8 CLL4_3d_CD8 CLL5_0d_CD8 CLL5_1d_CD8 CLL5_2d_CD8
##           <numeric>   <numeric>   <numeric>   <numeric>   <numeric>   <numeric>
##   [1]             1           0           1           1           1           1
##   [2]             1           0           0           1           0           0
##   [3]             1           0           1           1           1           1
##   [4]             1           0           0           1           1           1
##   [5]             1           0           1           1           1           1
##   [6]             1           0           1           1           1           1
##       CLL5_3d_CD8 CLL5_8d_CD8 CLL5_30d_CD8 CLL5_150d_CD8 CLL5_240d_CD8
##         <numeric>   <numeric>    <numeric>     <numeric>     <numeric>
##   [1]           1           1            1             1             1
##   [2]           1           1            0             1             0
##   [3]           1           1            1             1             1
##   [4]           1           1            1             1             1
##   [5]           1           1            1             1             1
##   [6]           1           1            1             1             1
##       CLL6_0d_CD8 CLL6_30d_CD8 CLL6_120d_CD8 CLL6_280d_CD8 CLL7_0d_CD8
##         <numeric>    <numeric>     <numeric>     <numeric>   <numeric>
##   [1]           1            1             1             1           1
##   [2]           0            0             0             0           0
##   [3]           1            1             1             1           1
##   [4]           1            1             1             1           1
##   [5]           1            1             1             1           1
##   [6]           1            1             1             1           1
##       CLL7_1d_CD8 CLL7_3d_CD8 CLL7_8d_CD8 CLL7_30d_CD8 CLL7_150d_CD8
##         <numeric>   <numeric>   <numeric>    <numeric>     <numeric>
##   [1]           1           1           1            1             1
##   [2]           0           1           1            1             1
##   [3]           1           1           1            1             1
##   [4]           1           1           1            1             1
##   [5]           1           1           1            1             1
##   [6]           1           1           1            1             1
##       CLL8_0d_CD8 CLL8_3d_CD8 CLL8_30d_CD8 consensusIDs
##         <numeric>   <numeric>    <numeric>  <character>
##   [1]           1           1            0  consensus_1
##   [2]           1           0            0  consensus_3
##   [3]           1           1            1  consensus_4
##   [4]           1           1            0  consensus_5
##   [5]           1           1            0  consensus_7
##   [6]           1           1            0  consensus_8
##   -------
##   seqinfo: 57 sequences (1 circular) from hg19 genome
# Aquí entiendo que el tutorial designa los 13606 picos comunes

#Conservamos sólo picos abiertos en más de la mitad de las muestras consensusday0 # 7 muestras consensusday120 # 7 muestras consensusday3# 10 muestras consensusday30 # 5 muestras consensusday8 # 3 muestras

consensus.anno <- annotatePeak(consensusToCount, tssRegion=c(-1000, 1000), TxDb=txdb, annoDb="org.Hs.eg.db")
## >> preparing features information...      2020-06-01 19:52:44 
## >> identifying nearest features...        2020-06-01 19:52:44 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:44 
## >> assigning genomic annotation...        2020-06-01 19:52:44 
## >> adding gene annotation...          2020-06-01 19:52:46
## 'select()' returned 1:many mapping between keys and columns
## >> assigning chromosome lengths           2020-06-01 19:52:46 
## >> done...                    2020-06-01 19:52:46
consensus.anno.TSS<-as.GRanges(consensus.anno)

Establecimiento de un índice de apertura de la cromatina en promotores con respecto al tiempo de tratamiento.

Para ello seleccionamos los datos agrupados.

consecount<-as.data.frame(consensus.anno.TSS)

consensus.score.0<-integer(length(consensus.anno.TSS))
for (i in 1:length(Treatmentdaygrouped)){
    if (Treatmentdaygrouped[i] == 0){
        consensus.score.0 <-consensus.score.0 + consecount[, i+5]
    }
}
consensus.score.0<-consensus.score.0/max(consensus.score.0)
consensus.score.3<-as.vector(integer(length(consensus.anno.TSS)))
for (i in 1:length(Treatmentdaygrouped)){
    if (Treatmentdaygrouped[i] == 3){
        consensus.score.3 <-consensus.score.3 + consecount[, i+5]
    }
}
consensus.score.3<-consensus.score.3/max(consensus.score.3)
consensus.score.8<-as.vector(integer(length(consensus.anno.TSS)))
for (i in 1:length(Treatmentdaygrouped)){
    if (Treatmentdaygrouped[i] == 8){
        consensus.score.8 <-consensus.score.8 + consecount[, i+5]
    }
}
consensus.score.8<-consensus.score.8/max(consensus.score.8)


consensus.score.30<-as.vector(integer(length(consensus.anno.TSS)))
for (i in 1:length(Treatmentdaygrouped)){
    if (Treatmentdaygrouped[i] == 30){
        consensus.score.30 <-consensus.score.30 + consecount[, i+5]
    }
}
consensus.score.30<-consensus.score.30/max(consensus.score.30)

consensus.score.120<-as.vector(integer(length(consensus.anno.TSS)))
for (i in 1:length(Treatmentdaygrouped)){
    if (Treatmentdaygrouped[i] == 120){
        consensus.score.120 <-consensus.score.120 + consecount[, i+5]
    }
}
consensus.score.120<-consensus.score.120/max(consensus.score.120)



the.scores<-as.data.frame(cbind(consensus.score.0, consensus.score.3,consensus.score.8, consensus.score.30, consensus.score.120))

names(the.scores)<-c(0, 3, 8, 30, 120)
all.scores<-the.scores

consecount.scores<-cbind(consecount, all.scores)

Detección de promotores afectados por el tratamiento con ibrutinib y evolución temporal

openday0<-subset(consecount.scores, consecount.scores$"0">=0.7)

open0closed3<-subset(openday0, openday0$"3"<=0.3)
knitr::kable(open0closed3[, 49:55])
SYMBOL GENENAME 0 3 8 30 120
7972 INSIG2 insulin induced gene 2 0.7142857 0.2222222 0.3333333 0.5000000 0.4285714
10311 LINC01094 long intergenic non-protein coding RNA 1094 0.8571429 0.2222222 0.3333333 0.5000000 0.5714286
10820 FER FER tyrosine kinase 0.7142857 0.2222222 0.6666667 0.5000000 0.4285714
11004 PPP2R2B-IT1 PPP2R2B intronic transcript 1 0.7142857 0.2222222 0.3333333 0.1666667 0.2857143
11169 MAPK9 mitogen-activated protein kinase 9 0.7142857 0.1111111 0.0000000 0.1666667 0.2857143
open0closed8<-subset(openday0, openday0$"8"<=0.3)
knitr::kable(open0closed8[, 49:55])
SYMBOL GENENAME 0 3 8 30 120
2844 CCND2 cyclin D2 0.7142857 0.8888889 0 0.3333333 0.7142857
4516 PKM pyruvate kinase M1/2 0.8571429 0.5555556 0 0.3333333 0.7142857
7068 DLL3 delta like canonical Notch ligand 3 0.8571429 0.4444444 0 0.0000000 0.4285714
11169 MAPK9 mitogen-activated protein kinase 9 0.7142857 0.1111111 0 0.1666667 0.2857143
open0closed30<-subset(openday0, openday0$"30"<=0.3)
knitr::kable(open0closed30[, 49:55])
SYMBOL GENENAME 0 3 8 30 120
1582 NRP1 neuropilin 1 0.7142857 0.3333333 0.3333333 0.1666667 0.4285714
1622 TMEM273 transmembrane protein 273 0.7142857 0.7777778 0.3333333 0.1666667 0.5714286
2925 PRR4 proline rich 4 0.8571429 0.5555556 0.3333333 0.0000000 0.2857143
3208 BAZ2A bromodomain adjacent to zinc finger domain 2A 0.7142857 0.7777778 0.6666667 0.0000000 0.7142857
7068 DLL3 delta like canonical Notch ligand 3 0.8571429 0.4444444 0.0000000 0.0000000 0.4285714
9840 ATP2C1 ATPase secretory pathway Ca2+ transporting 1 0.8571429 0.6666667 1.0000000 0.1666667 0.5714286
11004 PPP2R2B-IT1 PPP2R2B intronic transcript 1 0.7142857 0.2222222 0.3333333 0.1666667 0.2857143
11169 MAPK9 mitogen-activated protein kinase 9 0.7142857 0.1111111 0.0000000 0.1666667 0.2857143
11514 STK38 serine/threonine kinase 38 0.7142857 0.6666667 0.3333333 0.0000000 0.2857143
12957 RIMS2 regulating synaptic membrane exocytosis 2 0.7142857 0.5555556 0.3333333 0.1666667 0.4285714
open0closed120<-subset(openday0, openday0$"120"<=0.3)
knitr::kable(open0closed120[, 49:55])
SYMBOL GENENAME 0 3 8 30 120
779 DENND2D DENN domain containing 2D 0.7142857 0.6666667 0.3333333 0.3333333 0.2857143
2925 PRR4 proline rich 4 0.8571429 0.5555556 0.3333333 0.0000000 0.2857143
5037 FUS FUS RNA binding protein 0.7142857 0.4444444 0.6666667 0.5000000 0.2857143
5042 ITGAM integrin subunit alpha M 0.7142857 0.4444444 0.3333333 0.5000000 0.2857143
5682 SLFN12L schlafen family member 12 like 0.7142857 0.5555556 0.6666667 0.3333333 0.2857143
11004 PPP2R2B-IT1 PPP2R2B intronic transcript 1 0.7142857 0.2222222 0.3333333 0.1666667 0.2857143
11169 MAPK9 mitogen-activated protein kinase 9 0.7142857 0.1111111 0.0000000 0.1666667 0.2857143
11514 STK38 serine/threonine kinase 38 0.7142857 0.6666667 0.3333333 0.0000000 0.2857143
12300 CDK6 cyclin dependent kinase 6 0.7142857 0.4444444 0.3333333 0.6666667 0.2857143
12514 CREB3L2 cAMP responsive element binding protein 3 like 2 0.7142857 0.4444444 0.3333333 0.5000000 0.2857143
write.table(open0closed3, "CD8_open0closed3.txt", sep="\t")
write.table(open0closed8, "CD8_open0closed8.txt", sep="\t")
write.table(open0closed30, "CD8_open0closed30.txt", sep="\t")
write.table(open0closed120, "CD8_open0closed120.txt", sep="\t")

Opcional: agrupar las muestras de más de un mes y hacer una comparación Antes del tratamiento vs tratamiento estabilizado

open0closed_ibru<-subset(openday0, (openday0\("30"<=0.3) & (openday0\)“120”<=0.3)) open0closed_ibru

closedday0<-subset(consecount.scores, consecount.scores$"0"<=0.3)


closed0open3<-subset(closedday0, closedday0$"3">=0.7)
knitr::kable(closed0open3[, 49:55])
SYMBOL GENENAME 0 3 8 30 120
271 ARID1A AT-rich interaction domain 1A 0.1428571 0.7777778 0.6666667 0.5000000 0.7142857
278 KDF1 keratinocyte differentiation factor 1 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
332 SERINC2 serine incorporator 2 0.2857143 0.7777778 0.3333333 0.3333333 0.4285714
616 PTGER3 prostaglandin E receptor 3 0.2857143 1.0000000 0.6666667 0.6666667 0.7142857
621 SLC44A5 solute carrier family 44 member 5 0.1428571 0.7777778 0.0000000 0.1666667 0.5714286
718 PLPPR5 phospholipid phosphatase related 5 0.1428571 0.7777778 0.6666667 0.1666667 0.4285714
1588 FZD8 frizzled class receptor 8 0.2857143 0.7777778 0.3333333 0.5000000 0.5714286
1668 TET1 tet methylcytosine dioxygenase 1 0.0000000 0.7777778 0.3333333 0.3333333 0.5714286
1840 LOXL4 lysyl oxidase like 4 0.2857143 0.7777778 0.6666667 0.3333333 0.5714286
1944 TCF7L2 transcription factor 7 like 2 0.2857143 0.8888889 0.6666667 0.3333333 0.7142857
2005 TCERG1L transcription elongation regulator 1 like 0.2857143 0.7777778 0.6666667 0.5000000 0.2857143
2463 RIN1 Ras and Rab interactor 1 0.2857143 0.7777778 0.6666667 0.1666667 0.7142857
2486 GRK2 G protein-coupled receptor kinase 2 0.2857143 0.8888889 0.6666667 0.5000000 0.8571429
2713 DSCAML1 DS cell adhesion molecule like 1 0.2857143 0.7777778 0.6666667 0.3333333 0.7142857
3086 ASIC1 acid sensing ion channel subunit 1 0.2857143 0.7777778 0.6666667 0.3333333 0.5714286
3502 KDM2B lysine demethylase 2B 0.2857143 0.8888889 0.6666667 0.3333333 0.7142857
4199 DEGS2 delta 4-desaturase, sphingolipid 2 0.2857143 0.7777778 0.6666667 0.1666667 0.7142857
4663 TTLL13P tubulin tyrosine ligase like 13, pseudogene 0.2857143 0.7777778 0.3333333 0.5000000 0.5714286
5020 ZNF629 zinc finger protein 629 0.1428571 0.7777778 0.6666667 0.3333333 0.5714286
5027 HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 0.1428571 0.7777778 0.6666667 0.1666667 0.7142857
5158 KCTD19 potassium channel tetramerization domain containing 19 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
5360 MYO1C myosin IC 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
5586 CCDC144CP coiled-coil domain containing 144C, pseudogene 0.2857143 0.7777778 0.6666667 0.3333333 0.8571429
5596 KSR1 kinase suppressor of ras 1 0.2857143 0.7777778 0.6666667 0.5000000 0.5714286
5943 NOG noggin 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
6211 CCDC57 coiled-coil domain containing 57 0.2857143 0.7777778 0.3333333 0.1666667 0.7142857
6379 ONECUT2 one cut homeobox 2 0.2857143 0.7777778 0.3333333 0.3333333 0.7142857
6497 CSNK1G2 casein kinase 1 gamma 2 0.2857143 0.7777778 0.3333333 0.3333333 0.7142857
6498 BTBD2 BTB domain containing 2 0.2857143 0.7777778 0.6666667 0.5000000 1.0000000
6525 TLE2 TLE family member 2, transcriptional corepressor 0.2857143 0.7777778 0.6666667 0.3333333 0.7142857
6565 FSD1 fibronectin type III and SPRY domain containing 1 0.2857143 0.8888889 0.6666667 0.5000000 0.7142857
6638 ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif 10 0.2857143 0.8888889 0.6666667 0.5000000 0.8571429
6969 LSR lipolysis stimulated lipoprotein receptor 0.2857143 0.7777778 0.6666667 0.5000000 0.5714286
7034 SPINT2 serine peptidase inhibitor, Kunitz type 2 0.1428571 0.7777778 0.6666667 0.1666667 0.2857143
7475 ZSCAN18 zinc finger and SCAN domain containing 18 0.2857143 1.0000000 0.6666667 0.3333333 0.8571429
7881 DUSP2 dual specificity phosphatase 2 0.2857143 0.7777778 0.3333333 0.1666667 0.4285714
8148 CERKL ceramide kinase like 0.1428571 0.8888889 0.6666667 0.1666667 0.4285714
8242 PARD3B par-3 family cell polarity regulator beta 0.2857143 0.7777778 0.6666667 0.5000000 0.5714286
8363 DGKD diacylglycerol kinase delta 0.2857143 0.7777778 0.3333333 0.3333333 0.5714286
8428 SDCBP2 syndecan binding protein 2 0.2857143 0.7777778 0.6666667 0.5000000 0.8571429
8484 JAG1 jagged canonical Notch ligand 1 0.2857143 0.8888889 0.3333333 0.3333333 0.4285714
8486 ISM1 isthmin 1 0.1428571 0.7777778 0.3333333 0.3333333 0.5714286
8518 LOC284798 uncharacterized LOC284798 0.2857143 0.7777778 0.3333333 0.5000000 0.7142857
8539 TSPY26P testis specific protein Y-linked 26, pseudogene 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
8547 C20orf203 chromosome 20 open reading frame 203 0.1428571 0.7777778 0.6666667 0.3333333 0.7142857
8753 SLC17A9 solute carrier family 17 member 9 0.2857143 0.7777778 0.0000000 0.5000000 0.2857143
8928 COL6A2 collagen type VI alpha 2 chain 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
9043 MN1 MN1 proto-oncogene, transcriptional regulator 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
9070 SEC14L2 SEC14 like lipid binding 2 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
9262 LINC00899 long intergenic non-protein coding RNA 899 0.2857143 0.7777778 0.6666667 0.3333333 0.7142857
9596 WDR82 WD repeat domain 82 0.2857143 0.7777778 0.3333333 0.5000000 0.4285714
10588 C5orf49 chromosome 5 open reading frame 49 0.1428571 0.7777778 0.6666667 0.5000000 0.7142857
10742 F2RL1 F2R like trypsin receptor 1 0.2857143 0.8888889 0.3333333 0.5000000 0.5714286
11053 NIPAL4 NIPA like domain containing 4 0.2857143 0.7777778 0.6666667 0.3333333 0.5714286
11056 C5orf52 chromosome 5 open reading frame 52 0.2857143 0.7777778 0.6666667 0.3333333 0.2857143
11161 MGAT4B alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B 0.2857143 0.7777778 0.6666667 0.6666667 0.8571429
11422 VWA7 von Willebrand factor A domain containing 7 0.1428571 0.8888889 0.6666667 0.5000000 0.7142857
11631 DST dystonin 0.2857143 0.8888889 0.3333333 0.3333333 0.4285714
11648 OOEP oocyte expressed protein 0.2857143 0.7777778 0.6666667 0.6666667 0.7142857
11674 ME1 malic enzyme 1 0.2857143 0.7777778 0.6666667 0.5000000 0.5714286
11927 FNDC1 fibronectin type III domain containing 1 0.2857143 0.7777778 0.6666667 0.3333333 0.5714286
12018 ZNF853 zinc finger protein 853 0.2857143 0.7777778 0.3333333 0.5000000 0.4285714
12463 LRRC4 leucine rich repeat containing 4 0.1428571 0.7777778 0.3333333 0.5000000 0.7142857
12642 MIR596 microRNA 596 0.2857143 0.7777778 0.3333333 0.1666667 0.7142857
13034 PTK2 protein tyrosine kinase 2 0.2857143 0.8888889 0.6666667 0.3333333 0.5714286
13116 VLDLR-AS1 VLDLR antisense RNA 1 0.2857143 0.7777778 0.3333333 0.3333333 0.5714286
13377 CORO2A coronin 2A 0.1428571 0.7777778 0.3333333 0.1666667 0.2857143
13391 TMEFF1 transmembrane protein with EGF like and two follistatin like domains 1 0.2857143 0.8888889 0.6666667 0.3333333 0.7142857
closed0open8<-subset(closedday0, closedday0$"8">=0.7)
knitr::kable(closed0open8[, 49:55])
SYMBOL GENENAME 0 3 8 30 120
1719 USP54 ubiquitin specific peptidase 54 0.2857143 0.5555556 1 0.3333333 0.8571429
2310 MS4A6E membrane spanning 4-domains A6E 0.1428571 0.1111111 1 0.1666667 0.2857143
5344 URAHP urate (hydroxyiso-) hydrolase, pseudogene 0.1428571 0.5555556 1 0.1666667 0.4285714
6729 ZNF442 zinc finger protein 442 0.2857143 0.6666667 1 0.5000000 0.7142857
7693 NRXN1 neurexin 1 0.2857143 0.4444444 1 0.6666667 0.4285714
9343 GHRLOS ghrelin opposite strand/antisense RNA 0.1428571 0.3333333 1 0.0000000 0.4285714
9735 SPICE1 spindle and centriole associated protein 1 0.1428571 0.1111111 1 0.1666667 0.4285714
10881 ACSL6 acyl-CoA synthetase long chain family member 6 0.2857143 0.4444444 1 0.5000000 0.2857143
closed0open30<-subset(closedday0, closedday0$"30">=0.7)
knitr::kable(closed0open30[, 49:55])
SYMBOL GENENAME 0 3 8 30 120
closed0open120<-subset(closedday0, closedday0$"120">=0.7)
knitr::kable(closed0open120[, 49:55])
SYMBOL GENENAME 0 3 8 30 120
32 MIB2 mindbomb E3 ubiquitin protein ligase 2 0.0000000 0.3333333 0.6666667 0.5000000 0.7142857
86 CAMTA1 calmodulin binding transcription activator 1 0.2857143 0.5555556 0.6666667 0.0000000 0.7142857
168 MIR4695 microRNA 4695 0.1428571 0.5555556 0.6666667 0.5000000 0.8571429
202 RAP1GAP RAP1 GTPase activating protein 0.2857143 0.4444444 0.3333333 0.5000000 0.7142857
234 STPG1 sperm tail PG-rich repeat containing 1 0.1428571 0.6666667 0.6666667 0.3333333 0.8571429
271 ARID1A AT-rich interaction domain 1A 0.1428571 0.7777778 0.6666667 0.5000000 0.7142857
278 KDF1 keratinocyte differentiation factor 1 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
281 SLC9A1 solute carrier family 9 member A1 0.1428571 0.4444444 0.3333333 0.3333333 0.7142857
355 ZBTB8A zinc finger and BTB domain containing 8A 0.2857143 0.5555556 0.6666667 0.1666667 0.7142857
361 FNDC5 fibronectin type III domain containing 5 0.2857143 0.5555556 0.6666667 0.5000000 0.8571429
399 ZC3H12A zinc finger CCCH-type containing 12A 0.2857143 0.6666667 0.6666667 0.5000000 1.0000000
539 RAB3B RAB3B, member RAS oncogene family 0.2857143 0.6666667 0.6666667 0.5000000 0.7142857
555 PODN podocan 0.1428571 0.4444444 0.6666667 0.5000000 0.7142857
616 PTGER3 prostaglandin E receptor 3 0.2857143 1.0000000 0.6666667 0.6666667 0.7142857
773 KCNA2 potassium voltage-gated channel subfamily A member 2 0.2857143 0.6666667 0.6666667 0.3333333 0.7142857
818 IGSF3 immunoglobulin superfamily member 3 0.1428571 0.5555556 0.3333333 0.5000000 0.7142857
852 H2AC19 H2A clustered histone 19 0.2857143 0.5555556 0.3333333 0.5000000 0.8571429
941 ADAR adenosine deaminase RNA specific 0.2857143 0.4444444 0.6666667 0.3333333 0.7142857
995 PAQR6 progestin and adipoQ receptor family member 6 0.1428571 0.6666667 0.6666667 0.3333333 0.7142857
1043 SLAMF7 SLAM family member 7 0.2857143 0.2222222 0.6666667 0.0000000 0.8571429
1077 PBX1 PBX homeobox 1 0.2857143 0.6666667 0.6666667 0.3333333 0.7142857
1099 XCL1 X-C motif chemokine ligand 1 0.2857143 0.5555556 0.6666667 0.5000000 0.8571429
1262 IL19 interleukin 19 0.1428571 0.4444444 0.6666667 0.0000000 0.7142857
1307 TGFB2-AS1 TGFB2 antisense RNA 1 (head to head) 0.2857143 0.5555556 0.3333333 0.5000000 0.7142857
1337 ENAH ENAH actin regulator 0.2857143 0.6666667 0.6666667 0.3333333 0.7142857
1412 NID1 nidogen 1 0.1428571 0.4444444 0.6666667 0.3333333 0.7142857
1426 MAP1LC3C microtubule associated protein 1 light chain 3 gamma 0.2857143 0.3333333 0.6666667 0.5000000 0.7142857
1558 ARMC4 armadillo repeat containing 4 0.2857143 0.6666667 0.6666667 0.3333333 0.7142857
1564 SVIL supervillin 0.2857143 0.2222222 0.6666667 0.5000000 0.7142857
1719 USP54 ubiquitin specific peptidase 54 0.2857143 0.5555556 1.0000000 0.3333333 0.8571429
1870 KAZALD1 Kazal type serine peptidase inhibitor domain 1 0.2857143 0.4444444 0.6666667 0.3333333 0.7142857
1944 TCF7L2 transcription factor 7 like 2 0.2857143 0.8888889 0.6666667 0.3333333 0.7142857
2290 RTN4RL2 reticulon 4 receptor like 2 0.2857143 0.5555556 0.3333333 0.3333333 0.7142857
2325 LRRC10B leucine rich repeat containing 10B 0.1428571 0.6666667 0.6666667 0.1666667 0.7142857
2426 MALAT1 metastasis associated lung adenocarcinoma transcript 1 0.2857143 0.6666667 0.6666667 0.5000000 0.8571429
2463 RIN1 Ras and Rab interactor 1 0.2857143 0.7777778 0.6666667 0.1666667 0.7142857
2486 GRK2 G protein-coupled receptor kinase 2 0.2857143 0.8888889 0.6666667 0.5000000 0.8571429
2584 LRRC32 leucine rich repeat containing 32 0.0000000 0.2222222 0.6666667 0.1666667 0.7142857
2713 DSCAML1 DS cell adhesion molecule like 1 0.2857143 0.7777778 0.6666667 0.3333333 0.7142857
2761 SORL1 sortilin related receptor 1 0.1428571 0.6666667 0.6666667 0.5000000 0.7142857
2888 PEX5 peroxisomal biogenesis factor 5 0.2857143 0.4444444 0.6666667 0.5000000 0.7142857
2906 LOC642846 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11-like 0.1428571 0.4444444 0.3333333 0.5000000 0.7142857
3384 NUAK1 NUAK family kinase 1 0.1428571 0.2222222 0.3333333 0.3333333 0.7142857
3502 KDM2B lysine demethylase 2B 0.2857143 0.8888889 0.6666667 0.3333333 0.7142857
3791 PCID2 PCI domain containing 2 0.2857143 0.5555556 0.6666667 0.1666667 0.7142857
3947 PYGL glycogen phosphorylase L 0.1428571 0.6666667 0.6666667 0.3333333 0.7142857
4047 ACTN1 actinin alpha 1 0.1428571 0.4444444 0.3333333 0.3333333 0.7142857
4199 DEGS2 delta 4-desaturase, sphingolipid 2 0.2857143 0.7777778 0.6666667 0.1666667 0.7142857
4239 CEP170B centrosomal protein 170B 0.2857143 0.6666667 0.6666667 0.3333333 0.7142857
4277 CHRM5 cholinergic receptor muscarinic 5 0.2857143 0.3333333 0.0000000 0.1666667 0.8571429
4282 SLC12A6 solute carrier family 12 member 6 0.1428571 0.5555556 0.3333333 0.3333333 0.7142857
4561 SIN3A SIN3 transcription regulator family member A 0.2857143 0.5555556 0.6666667 0.5000000 0.7142857
4618 TM6SF1 transmembrane 6 superfamily member 1 0.1428571 0.3333333 0.6666667 0.1666667 0.7142857
4643 HAPLN3 hyaluronan and proteoglycan link protein 3 0.2857143 0.5555556 0.6666667 0.5000000 0.7142857
4711 HBQ1 hemoglobin subunit theta 1 0.2857143 0.6666667 0.6666667 0.5000000 0.7142857
4749 TMEM204 transmembrane protein 204 0.2857143 0.6666667 0.6666667 0.3333333 0.7142857
4795 KREMEN2 kringle containing transmembrane protein 2 0.0000000 0.4444444 0.3333333 0.1666667 0.7142857
4798 TNFRSF12A TNF receptor superfamily member 12A 0.1428571 0.5555556 0.6666667 0.3333333 0.7142857
4995 CORO1A coronin 1A 0.2857143 0.1111111 0.6666667 0.1666667 0.8571429
5027 HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 0.1428571 0.7777778 0.6666667 0.1666667 0.7142857
5158 KCTD19 potassium channel tetramerization domain containing 19 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
5227 ZNF821 zinc finger protein 821 0.2857143 0.5555556 0.6666667 0.1666667 0.7142857
5325 CPNE7 copine 7 0.2857143 0.5555556 0.6666667 0.3333333 0.7142857
5360 MYO1C myosin IC 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
5440 ALOX12-AS1 ALOX12 antisense RNA 1 0.2857143 0.4444444 0.6666667 0.3333333 0.8571429
5466 TMEM102 transmembrane protein 102 0.2857143 0.6666667 0.6666667 0.5000000 0.7142857
5586 CCDC144CP coiled-coil domain containing 144C, pseudogene 0.2857143 0.7777778 0.6666667 0.3333333 0.8571429
5605 SLC46A1 solute carrier family 46 member 1 0.0000000 0.6666667 0.6666667 0.3333333 0.7142857
5627 MYO18A myosin XVIIIA 0.2857143 0.4444444 0.6666667 0.3333333 0.7142857
5717 CWC25 CWC25 spliceosome associated protein homolog 0.2857143 0.6666667 0.3333333 0.1666667 0.8571429
5785 CAVIN1 caveolae associated protein 1 0.1428571 0.5555556 0.6666667 0.5000000 0.7142857
5853 FMNL1 formin like 1 0.1428571 0.4444444 0.6666667 0.3333333 0.7142857
5865 WNT3 Wnt family member 3 0.2857143 0.6666667 0.6666667 0.3333333 0.7142857
5943 NOG noggin 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
6069 RAB37 RAB37, member RAS oncogene family 0.0000000 0.4444444 0.6666667 0.1666667 0.7142857
6076 USH1G USH1 protein network component sans 0.2857143 0.6666667 0.6666667 0.5000000 0.7142857
6080 KCTD2 potassium channel tetramerization domain containing 2 0.2857143 0.3333333 0.0000000 0.3333333 0.7142857
6144 SEPTIN9 septin 9 0.2857143 0.3333333 0.3333333 0.3333333 0.7142857
6161 TIMP2 TIMP metallopeptidase inhibitor 2 0.2857143 0.6666667 0.6666667 0.3333333 0.7142857
6164 C1QTNF1 C1q and TNF related 1 0.2857143 0.5555556 0.6666667 0.3333333 0.7142857
6211 CCDC57 coiled-coil domain containing 57 0.2857143 0.7777778 0.3333333 0.1666667 0.7142857
6213 SLC16A3 solute carrier family 16 member 3 0.2857143 0.4444444 0.3333333 0.3333333 0.8571429
6246 TGIF1 TGFB induced factor homeobox 1 0.2857143 0.5555556 0.6666667 0.1666667 0.7142857
6308 CDH2 cadherin 2 0.2857143 0.3333333 0.0000000 0.1666667 0.7142857
6379 ONECUT2 one cut homeobox 2 0.2857143 0.7777778 0.3333333 0.3333333 0.7142857
6398 BCL2 BCL2 apoptosis regulator 0.2857143 0.5555556 0.3333333 0.5000000 0.7142857
6497 CSNK1G2 casein kinase 1 gamma 2 0.2857143 0.7777778 0.3333333 0.3333333 0.7142857
6498 BTBD2 BTB domain containing 2 0.2857143 0.7777778 0.6666667 0.5000000 1.0000000
6525 TLE2 TLE family member 2, transcriptional corepressor 0.2857143 0.7777778 0.6666667 0.3333333 0.7142857
6529 GNA11 G protein subunit alpha 11 0.2857143 0.3333333 0.6666667 0.5000000 0.7142857
6565 FSD1 fibronectin type III and SPRY domain containing 1 0.2857143 0.8888889 0.6666667 0.5000000 0.7142857
6604 TRIP10 thyroid hormone receptor interactor 10 0.2857143 0.5555556 0.6666667 0.3333333 0.7142857
6612 ZNF358 zinc finger protein 358 0.1428571 0.5555556 0.6666667 0.3333333 0.7142857
6638 ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif 10 0.2857143 0.8888889 0.6666667 0.5000000 0.8571429
6715 ZNF69 zinc finger protein 69 0.1428571 0.5555556 0.6666667 0.3333333 0.7142857
6717 ZNF763 zinc finger protein 763 0.1428571 0.5555556 0.6666667 0.5000000 0.7142857
6729 ZNF442 zinc finger protein 442 0.2857143 0.6666667 1.0000000 0.5000000 0.7142857
6747 RTBDN retbindin 0.2857143 0.4444444 0.6666667 0.5000000 0.7142857
6758 NFIX nuclear factor I X 0.1428571 0.5555556 0.3333333 0.3333333 0.7142857
6772 PALM3 paralemmin 3 0.2857143 0.5555556 0.6666667 0.5000000 0.7142857
6787 TECR trans-2,3-enoyl-CoA reductase 0.2857143 0.5555556 0.6666667 0.1666667 0.7142857
6798 CYP4F12 cytochrome P450 family 4 subfamily F member 12 0.1428571 0.2222222 0.3333333 0.3333333 0.7142857
6909 LINC00664 long intergenic non-protein coding RNA 664 0.2857143 0.5555556 0.6666667 0.3333333 1.0000000
7158 ZNF234 zinc finger protein 234 0.2857143 0.5555556 0.6666667 0.5000000 0.7142857
7165 MIR4531 microRNA 4531 0.2857143 0.5555556 0.6666667 0.5000000 0.7142857
7175 ZNF296 zinc finger protein 296 0.2857143 0.5555556 0.0000000 0.1666667 0.7142857
7247 CCDC114 coiled-coil domain containing 114 0.1428571 0.4444444 0.3333333 0.1666667 0.7142857
7291 CCDC155 coiled-coil domain containing 155 0.0000000 0.5555556 0.6666667 0.3333333 0.7142857
7475 ZSCAN18 zinc finger and SCAN domain containing 18 0.2857143 1.0000000 0.6666667 0.3333333 0.8571429
7557 GDF7 growth differentiation factor 7 0.0000000 0.3333333 0.0000000 0.1666667 0.7142857
7606 FNDC4 fibronectin type III domain containing 4 0.2857143 0.6666667 0.6666667 0.3333333 0.7142857
7936 ECRG4 ECRG4 augurin precursor 0.1428571 0.1111111 0.3333333 0.1666667 0.7142857
7995 AMMECR1L AMMECR1 like 0.0000000 0.1111111 0.0000000 0.0000000 0.7142857
8428 SDCBP2 syndecan binding protein 2 0.2857143 0.7777778 0.6666667 0.5000000 0.8571429
8518 LOC284798 uncharacterized LOC284798 0.2857143 0.7777778 0.3333333 0.5000000 0.7142857
8533 FOXS1 forkhead box S1 0.2857143 0.4444444 0.3333333 0.5000000 0.8571429
8539 TSPY26P testis specific protein Y-linked 26, pseudogene 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
8547 C20orf203 chromosome 20 open reading frame 203 0.1428571 0.7777778 0.6666667 0.3333333 0.7142857
8548 C20orf203 chromosome 20 open reading frame 203 0.2857143 0.3333333 0.6666667 0.0000000 0.7142857
8552 BPIFB1 BPI fold containing family B member 1 0.2857143 0.6666667 0.6666667 0.5000000 0.7142857
8642 KCNK15 potassium two pore domain channel subfamily K member 15 0.2857143 0.6666667 0.6666667 0.1666667 0.7142857
8697 NFATC2 nuclear factor of activated T cells 2 0.2857143 0.6666667 0.6666667 0.0000000 0.7142857
8762 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.2857143 0.6666667 0.6666667 0.5000000 0.7142857
8928 COL6A2 collagen type VI alpha 2 chain 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
8974 RANBP1 RAN binding protein 1 0.2857143 0.4444444 0.6666667 0.5000000 0.8571429
9043 MN1 MN1 proto-oncogene, transcriptional regulator 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
9070 SEC14L2 SEC14 like lipid binding 2 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857
9098 RFPL2 ret finger protein like 2 0.2857143 0.5555556 0.3333333 0.1666667 1.0000000
9262 LINC00899 long intergenic non-protein coding RNA 899 0.2857143 0.7777778 0.6666667 0.3333333 0.7142857
9279 MLC1 modulator of VRAC current 1 0.2857143 0.6666667 0.6666667 0.5000000 0.8571429
9428 DLEC1 DLEC1 cilia and flagella associated protein 0.2857143 0.4444444 0.6666667 0.3333333 0.7142857
9489 LRRC2-AS1 LRRC2 antisense RNA 1 0.2857143 0.6666667 0.6666667 0.6666667 0.8571429
9789 MYLK myosin light chain kinase 0.2857143 0.6666667 0.3333333 0.5000000 0.8571429
9887 PAQR9 progestin and adipoQ receptor family member 9 0.1428571 0.3333333 0.6666667 0.3333333 0.7142857
9911 IGSF10 immunoglobulin superfamily member 10 0.2857143 0.0000000 0.6666667 0.3333333 0.7142857
10165 LINC01096 long intergenic non-protein coding RNA 1096 0.0000000 0.2222222 0.0000000 0.0000000 0.7142857
10296 PPEF2 protein phosphatase with EF-hand domain 2 0.2857143 0.3333333 0.6666667 0.3333333 0.7142857
10515 TRIM61 tripartite motif containing 61 0.2857143 0.5555556 0.6666667 0.5000000 0.7142857
10586 TENT4A terminal nucleotidyltransferase 4A 0.2857143 0.2222222 0.6666667 0.3333333 0.7142857
10588 C5orf49 chromosome 5 open reading frame 49 0.1428571 0.7777778 0.6666667 0.5000000 0.7142857
10947 MATR3 matrin 3 0.0000000 0.4444444 0.3333333 0.1666667 0.7142857
11066 ADRA1B adrenoceptor alpha 1B 0.2857143 0.2222222 0.6666667 0.3333333 0.8571429
11116 ARL10 ADP ribosylation factor like GTPase 10 0.0000000 0.6666667 0.0000000 0.3333333 0.7142857
11161 MGAT4B alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B 0.2857143 0.7777778 0.6666667 0.6666667 0.8571429
11263 SOX4 SRY-box transcription factor 4 0.0000000 0.2222222 0.6666667 0.1666667 0.7142857
11270 C6orf62 chromosome 6 open reading frame 62 0.1428571 0.5555556 0.3333333 0.5000000 0.7142857
11422 VWA7 von Willebrand factor A domain containing 7 0.1428571 0.8888889 0.6666667 0.5000000 0.7142857
11432 ATF6B activating transcription factor 6 beta 0.2857143 0.5555556 0.6666667 0.5000000 0.7142857
11483 GRM4 glutamate metabotropic receptor 4 0.2857143 0.5555556 0.6666667 0.5000000 0.8571429
11528 FGD2 FYVE, RhoGEF and PH domain containing 2 0.2857143 0.2222222 0.3333333 0.1666667 0.7142857
11602 TCTE1 t-complex-associated-testis-expressed 1 0.2857143 0.5555556 0.6666667 0.3333333 0.7142857
11607 CLIC5 chloride intracellular channel 5 0.1428571 0.5555556 0.6666667 0.5000000 0.7142857
11648 OOEP oocyte expressed protein 0.2857143 0.7777778 0.6666667 0.6666667 0.7142857
11791 TPD52L1 TPD52 like 1 0.2857143 0.6666667 0.6666667 0.5000000 0.7142857
12125 TARP TCR gamma alternate reading frame protein 0.2857143 0.5555556 0.3333333 0.3333333 0.8571429
12377 TRIP6 thyroid hormone receptor interactor 6 0.1428571 0.3333333 0.3333333 0.3333333 0.7142857
12431 GPR85 G protein-coupled receptor 85 0.1428571 0.4444444 0.0000000 0.1666667 0.7142857
12463 LRRC4 leucine rich repeat containing 4 0.1428571 0.7777778 0.3333333 0.5000000 0.7142857
12622 INSIG1 insulin induced gene 1 0.2857143 0.3333333 0.0000000 0.1666667 0.7142857
12642 MIR596 microRNA 596 0.2857143 0.7777778 0.3333333 0.1666667 0.7142857
12665 FAM66D family with sequence similarity 66 member D 0.2857143 0.4444444 0.3333333 0.3333333 0.7142857
12715 TNFRSF10C TNF receptor superfamily member 10c 0.0000000 0.6666667 0.6666667 0.3333333 0.7142857
12853 NCOA2 nuclear receptor coactivator 2 0.2857143 0.5555556 0.0000000 0.5000000 0.8571429
12866 LY96 lymphocyte antigen 96 0.2857143 0.6666667 0.6666667 0.5000000 0.7142857
12867 JPH1 junctophilin 1 0.2857143 0.5555556 0.3333333 0.5000000 0.7142857
12961 OXR1 oxidation resistance 1 0.2857143 0.3333333 0.3333333 0.5000000 0.7142857
12969 TRPS1 transcriptional repressor GATA binding 1 0.2857143 0.6666667 0.3333333 0.3333333 0.7142857
13038 DENND3 DENN domain containing 3 0.1428571 0.1111111 0.6666667 0.3333333 0.7142857
13106 CBWD1 COBW domain containing 1 0.2857143 0.4444444 0.3333333 0.5000000 0.7142857
13276 TRPM6 transient receptor potential cation channel subfamily M member 6 0.2857143 0.6666667 0.6666667 0.5000000 0.7142857
13391 TMEFF1 transmembrane protein with EGF like and two follistatin like domains 1 0.2857143 0.8888889 0.6666667 0.3333333 0.7142857
13518 PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase like 1 0.2857143 0.6666667 0.3333333 0.1666667 0.7142857
13562 PRRX2 paired related homeobox 2 0.1428571 0.6666667 0.6666667 0.3333333 0.7142857
13570 NCS1 neuronal calcium sensor 1 0.2857143 0.6666667 0.6666667 0.3333333 0.8571429
13635 NOTCH1 notch receptor 1 0.2857143 0.3333333 0.6666667 0.3333333 0.7142857
write.table(closed0open3, "CD8_closed0open3.txt", sep="\t")
write.table(closed0open8, "CD8_closed0open8.txt", sep="\t")
write.table(closed0open30, "CD8_closed0open30.txt", sep="\t")
write.table(closed0open120, "CD8_closed0open120.txt", sep="\t")

Detección de promotores afectados por el tratamiento con ibrutinib y evolución temporal

Utilizamos la herramienta EnrichR:

dbs <- c( "GO_Molecular_Function_2018", "GO_Biological_Process_2018", "Panther_2016")

dfpeakcomp<-list(open0closed3$SYMBOL, open0closed8$SYMBOL, open0closed30$SYMBOL,open0closed120$SYMBOL, closed0open3$SYMBOL, closed0open8$SYMBOL, closed0open30$SYMBOL, closed0open120$SYMBOL)
enriched <- lapply(dfpeakcomp, enrichr, databases =dbs)
## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.
## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.
## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.
## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.
## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.
## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.
## No genes have been given
## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.
setwd("/Users/javi/Documents/Master Bioinformática UOC/Proyecto fin de máster/PEC3 ATAC-seq/CD8")
summary(enriched[[1]])
##                            Length Class      Mode
## GO_Molecular_Function_2018 9      data.frame list
## GO_Biological_Process_2018 9      data.frame list
## Panther_2016               9      data.frame list
gofilesnames<-c("open0closed3" , "open0closed8", "open0closed30" ,"open0closed120" , "closed0open3" , "closed0open8","closed0open30", "closed0open120" )
names(enriched)<-gofilesnames

for (i in 1:length(names(enriched))){
    filename<-paste("CD8_", gofilesnames[i],"enrichr", sep ="")
    filename.txt<-paste("CD8_", gofilesnames[i],"enrichr.txt", sep ="")
   # printEnrich(enriched[[i]], file = filename.txt ,sep = "\t", columns = c(1:9))
   print("")
   print(filename)
   print(knitr::kable(enriched[[i]]$GO_Molecular_Function_2018[1:10,]))
   print(knitr::kable(enriched[[i]]$GO_Biological_Process_2018[1:10,]))
   print(knitr::kable(enriched[[i]]$Panther_2016[1:10,]))
}
## [1] ""
## [1] "CD8_open0closed3enrichr"
## 
## 
##        Term                                                                  Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## -----  --------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## 1      MAP kinase activity (GO:0004707)                                      1/14       0.0034954                  1             0                      0   285.714286       1616.08794  MAPK9 
## 2      epidermal growth factor receptor binding (GO:0005154)                 1/25       0.0062349                  1             0                      0   160.000000        812.41384  FER   
## 3      non-membrane spanning protein tyrosine kinase activity (GO:0004715)   1/43       0.0107048                  1             0                      0    93.023256        422.05209  FER   
## 4      growth factor receptor binding (GO:0070851)                           1/92       0.0227915                  1             0                      0    43.478261        164.40735  FER   
## 5      protein tyrosine kinase activity (GO:0004713)                         1/147      0.0362171                  1             0                      0    27.210884         90.29181  FER   
## 6      protein kinase activity (GO:0004672)                                  1/513      0.1218486                  1             0                      0     7.797271         16.41307  FER   
## NA     NA                                                                    NA                NA                 NA            NA                     NA           NA               NA  NA    
## NA.1   NA                                                                    NA                NA                 NA            NA                     NA           NA               NA  NA    
## NA.2   NA                                                                    NA                NA                 NA            NA                     NA           NA               NA  NA    
## NA.3   NA                                                                    NA                NA                 NA            NA                     NA           NA               NA  NA    
## 
## 
## Term                                                           Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes     
## -------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ----------
## response to reactive oxygen species (GO:0000302)               2/60       0.0000880          0.4490051             0                      0    133.33333        1245.1073  MAPK9;FER 
## cellular response to reactive oxygen species (GO:0034614)      2/65       0.0001033          0.2636905             0                      0    123.07692        1129.5281  MAPK9;FER 
## cellular response to oxidative stress (GO:0034599)             2/115      0.0003241          0.5512392             0                      0     69.56522         558.9258  MAPK9;FER 
## Fc-epsilon receptor signaling pathway (GO:0038095)             2/182      0.0008088          1.0000000             0                      0     43.95604         312.9628  MAPK9;FER 
## Fc receptor signaling pathway (GO:0038093)                     2/183      0.0008177          0.8345445             0                      0     43.71585         310.7766  MAPK9;FER 
## SREBP signaling pathway (GO:0032933)                           1/6        0.0014992          1.0000000             0                      0    666.66667        4335.2070  INSIG2    
## cellular response to sterol depletion (GO:0071501)             1/7        0.0017489          1.0000000             0                      0    571.42857        3627.8622  INSIG2    
## cellular response to oxygen-containing compound (GO:1901701)   2/274      0.0018198          1.0000000             0                      0     29.19708         184.2060  MAPK9;FER 
## tyrosine phosphorylation of STAT protein (GO:0007260)          1/8        0.0019986          1.0000000             0                      0    500.00000        3107.6633  FER       
## regulation of leukocyte degranulation (GO:0043300)             1/9        0.0022482          1.0000000             0                      0    444.44444        2710.0635  FER       
## 
## 
## Term                                                              Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## ----------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## Oxidative stress response Homo sapiens P00046                     1/24       0.0059861          0.6704476             0                      0    166.66667         853.0514  MAPK9 
## Interferon-gamma signaling pathway Homo sapiens P00035            1/28       0.0069810          0.3909383             0                      0    142.85714         709.2225  MAPK9 
## FAS signaling pathway Homo sapiens P00020                         1/31       0.0077267          0.2884633             0                      0    129.03226         627.4934  MAPK9 
## Toll receptor signaling pathway Homo sapiens P00054               1/49       0.0121912          0.3413542             0                      0     81.63265         359.7583  MAPK9 
## Alzheimer disease-amyloid secretase pathway Homo sapiens P00003   1/56       0.0139231          0.3118770             0                      0     71.42857         305.3005  MAPK9 
## B cell activation Homo sapiens P00010                             1/57       0.0141703          0.2645121             0                      0     70.17544         298.7093  MAPK9 
## Ras Pathway Homo sapiens P04393                                   1/69       0.0171329          0.2741272             0                      0     57.97101         235.7537  MAPK9 
## T cell activation Homo sapiens P00053                             1/73       0.0181189          0.2536648             0                      0     54.79452         219.7698  MAPK9 
## Parkinson disease Homo sapiens P00049                             1/81       0.0200885          0.2499900             0                      0     49.38272         192.9683  MAPK9 
## TGF-beta signaling pathway Homo sapiens P00052                    1/88       0.0218093          0.2442636             0                      0     45.45455         173.8828  MAPK9 
## [1] ""
## [1] "CD8_open0closed8enrichr"
## 
## 
##      Term                                                                  Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## ---  --------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## 1    MAP kinase activity (GO:0004707)                                      1/14       0.0027972                  1             0                      0   357.142857       2099.68841  MAPK9 
## 2    MHC class II protein complex binding (GO:0023026)                     1/16       0.0031964                  1             0                      0   312.500000       1795.54545  PKM   
## 3    Notch binding (GO:0005112)                                            1/17       0.0033959                  1             0                      0   294.117647       1672.11633  DLL3  
## 4    MHC protein complex binding (GO:0023023)                              1/19       0.0037948                  1             0                      0   263.157895       1466.87351  PKM   
## 5    phosphotransferase activity, alcohol group as acceptor (GO:0016773)   1/254      0.0498439                  1             0                      0    19.685039         59.03268  PKM   
## 6    cadherin binding (GO:0045296)                                         1/313      0.0611500                  1             0                      0    15.974441         44.63939  PKM   
## 7    kinase binding (GO:0019900)                                           1/418      0.0810211                  1             0                      0    11.961723         30.06036  CCND2 
## 8    protein kinase binding (GO:0019901)                                   1/495      0.0953915                  1             0                      0    10.101010         23.73501  CCND2 
## 9    RNA binding (GO:0003723)                                              1/1387     0.2498708                  1             0                      0     3.604903          4.99932  PKM   
## NA   NA                                                                    NA                NA                 NA            NA                     NA           NA               NA  NA    
## 
## 
## Term                                                                               Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## ---------------------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## positive regulation of macrophage derived foam cell differentiation (GO:0010744)   1/16       0.0031964                  1             0                      0     312.5000        1795.5455  MAPK9 
## positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)          1/16       0.0031964                  1             0                      0     312.5000        1795.5455  CCND2 
## glycolytic process (GO:0006096)                                                    1/23       0.0045924                  1             0                      0     217.3913        1170.2963  PKM   
## positive regulation of cell cycle G1/S phase transition (GO:1902808)               1/23       0.0045924                  1             0                      0     217.3913        1170.2963  CCND2 
## ATP generation from ADP (GO:0006757)                                               1/24       0.0047917                  1             0                      0     208.3333        1112.6830  PKM   
## glycolytic process through glucose-6-phosphate (GO:0061620)                        1/25       0.0049909                  1             0                      0     200.0000        1060.0262  PKM   
## canonical glycolysis (GO:0061621)                                                  1/25       0.0049909                  1             0                      0     200.0000        1060.0262  PKM   
## glucose catabolic process to pyruvate (GO:0061718)                                 1/25       0.0049909                  1             0                      0     200.0000        1060.0262  PKM   
## positive regulation of cyclin-dependent protein kinase activity (GO:1904031)       1/26       0.0051902                  1             0                      0     192.3077        1011.7279  CCND2 
## regulation of macrophage derived foam cell differentiation (GO:0010743)            1/29       0.0057878                  1             0                      0     172.4138         888.2777  MAPK9 
## 
## 
## Term                                                              Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## ----------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## Pyruvate metabolism Homo sapiens P02772                           1/8        0.0015991          0.1791024             0                      0    625.00000        4023.9353  PKM   
## Cell cycle Homo sapiens P00013                                    1/16       0.0031964          0.1789957             0                      0    312.50000        1795.5455  CCND2 
## Glycolysis Homo sapiens P00024                                    1/17       0.0033959          0.1267791             0                      0    294.11765        1672.1163  PKM   
## Oxidative stress response Homo sapiens P00046                     1/24       0.0047917          0.1341665             0                      0    208.33333        1112.6830  MAPK9 
## Interferon-gamma signaling pathway Homo sapiens P00035            1/28       0.0055886          0.1251846             0                      0    178.57143         926.2548  MAPK9 
## FAS signaling pathway Homo sapiens P00020                         1/31       0.0061860          0.1154717             0                      0    161.29032         820.2369  MAPK9 
## Notch signaling pathway Homo sapiens P00045                       1/38       0.0075788          0.1212616             0                      0    131.57895         642.4203  DLL3  
## PI3 kinase pathway Homo sapiens P00048                            1/42       0.0083741          0.1172375             0                      0    119.04762         569.3584  CCND2 
## Toll receptor signaling pathway Homo sapiens P00054               1/49       0.0097647          0.1215159             0                      0    102.04082         472.3453  MAPK9 
## Alzheimer disease-amyloid secretase pathway Homo sapiens P00003   1/56       0.0111538          0.1249222             0                      0     89.28571         401.4266  MAPK9 
## [1] ""
## [1] "CD8_open0closed30enrichr"
## 
## 
## Term                                                                            Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes  
## ------------------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -------
## manganese ion transmembrane transporter activity (GO:0005384)                   1/6        0.0029966          1.0000000             0                      0     333.3333        1936.7614  ATP2C1 
## vascular endothelial growth factor-activated receptor activity (GO:0005021)     1/7        0.0034952          1.0000000             0                      0     285.7143        1616.1022  NRP1   
## RNA polymerase I regulatory region sequence-specific DNA binding (GO:0001163)   1/8        0.0039936          1.0000000             0                      0     250.0000        1380.7627  BAZ2A  
## RNA polymerase I CORE element sequence-specific DNA binding (GO:0001164)        1/8        0.0039936          1.0000000             0                      0     250.0000        1380.7627  BAZ2A  
## hydrogen-exporting ATPase activity, phosphorylative mechanism (GO:0008553)      1/9        0.0044918          1.0000000             0                      0     222.2222        1201.2204  ATP2C1 
## mitogen-activated protein kinase kinase kinase binding (GO:0031435)             1/10       0.0049898          0.9572134             0                      0     200.0000        1060.0712  STK38  
## semaphorin receptor activity (GO:0017154)                                       1/11       0.0054876          0.9023129             0                      0     181.8182         946.4128  NRP1   
## MAP kinase activity (GO:0004707)                                                1/14       0.0069795          1.0000000             0                      0     142.8571         709.2545  MAPK9  
## calcium-transporting ATPase activity (GO:0005388)                               1/14       0.0069795          0.8925971             0                      0     142.8571         709.2545  ATP2C1 
## ligand-dependent nuclear receptor binding (GO:0016922)                          1/17       0.0084694          0.9748241             0                      0     117.6471         561.3294  BAZ2A  
## 
## 
## Term                                                                Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes       
## ------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------------
## actin cytoskeleton reorganization (GO:0031532)                      2/61       0.0004053                  1             0                      0     65.57377         512.1844  NRP1;ATP2C1 
## regulation of vesicle-mediated transport (GO:0060627)               2/138      0.0020512                  1             0                      0     28.98551         179.4009  RIMS2;NRP1  
## peptidyl-serine phosphorylation (GO:0018105)                        2/145      0.0022611                  1             0                      0     27.58621         168.0521  MAPK9;STK38 
## positive regulation of receptor binding (GO:1900122)                1/6        0.0029966                  1             0                      0    333.33333        1936.7614  NRP1        
## positive regulation of axon guidance (GO:1902669)                   1/6        0.0029966                  1             0                      0    333.33333        1936.7614  NRP1        
## retinal ganglion cell axon guidance (GO:0031290)                    1/6        0.0029966                  1             0                      0    333.33333        1936.7614  NRP1        
## peptidyl-serine modification (GO:0018209)                           2/170      0.0030905                  1             0                      0     23.52941         135.9861  MAPK9;STK38 
## substrate-dependent cell migration, cell extension (GO:0006930)     1/7        0.0034952                  1             0                      0    285.71429        1616.1022  NRP1        
## vascular endothelial growth factor signaling pathway (GO:0038084)   1/7        0.0034952                  1             0                      0    285.71429        1616.1022  NRP1        
## regulation of Cdc42 protein signal transduction (GO:0032489)        1/7        0.0034952                  1             0                      0    285.71429        1616.1022  NRP1        
## 
## 
## Term                                                              Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## ----------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## Axon guidance mediated by semaphorins Homo sapiens P00007         1/17       0.0084694          0.9485690             0                      0    117.64706        561.32936  NRP1  
## Oxidative stress response Homo sapiens P00046                     1/24       0.0119380          0.6685260             0                      0     83.33333        369.00264  MAPK9 
## Interferon-gamma signaling pathway Homo sapiens P00035            1/28       0.0139151          0.5194976             0                      0     71.42857        305.34140  MAPK9 
## FAS signaling pathway Homo sapiens P00020                         1/31       0.0153956          0.4310780             0                      0     64.51613        269.26908  MAPK9 
## Notch signaling pathway Homo sapiens P00045                       1/38       0.0188424          0.4220704             0                      0     52.63158        209.03390  DLL3  
## Toll receptor signaling pathway Homo sapiens P00054               1/49       0.0242369          0.4524216             0                      0     40.81633        151.83185  MAPK9 
## Alzheimer disease-amyloid secretase pathway Homo sapiens P00003   1/56       0.0276558          0.4424926             0                      0     35.71429        128.14001  MAPK9 
## B cell activation Homo sapiens P00010                             1/57       0.0281433          0.3940065             0                      0     35.08772        125.27878  MAPK9 
## Ras Pathway Homo sapiens P04393                                   1/69       0.0339766          0.4228201             0                      0     28.98551         98.03139  MAPK9 
## T cell activation Homo sapiens P00053                             1/73       0.0359140          0.4022371             0                      0     27.39726         91.14047  MAPK9 
## [1] ""
## [1] "CD8_open0closed120enrichr"
## 
## 
## Term                                                                     Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes      
## -----------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -----------
## cAMP response element binding (GO:0035497)                               1/7        0.0034952                  1             0                      0    285.71429       1616.10221  CREB3L2    
## mitogen-activated protein kinase kinase kinase binding (GO:0031435)      1/10       0.0049898                  1             0                      0    200.00000       1060.07117  STK38      
## ATP binding (GO:0005524)                                                 2/255      0.0068112                  1             0                      0     15.68627         78.26183  CDK6;STK38 
## MAP kinase activity (GO:0004707)                                         1/14       0.0069795                  1             0                      0    142.85714        709.25454  MAPK9      
## adenyl ribonucleotide binding (GO:0032559)                               2/279      0.0081043                  1             0                      0     14.33692         69.03747  CDK6;STK38 
## protein serine/threonine kinase activity (GO:0004674)                    2/368      0.0137803                  1             0                      0     10.86957         46.57080  CDK6;STK38 
## purine ribonucleoside triphosphate binding (GO:0035639)                  2/396      0.0158413                  1             0                      0     10.10101         41.87006  CDK6;STK38 
## cyclin-dependent protein serine/threonine kinase activity (GO:0004693)   1/33       0.0163815                  1             0                      0     60.60606        249.18786  CDK6       
## cyclin-dependent protein kinase activity (GO:0097472)                    1/34       0.0168742                  1             0                      0     58.82353        240.11596  CDK6       
## Rab guanyl-nucleotide exchange factor activity (GO:0017112)              1/51       0.0252148                  1             0                      0     39.21569        144.32643  DENND2D    
## 
## 
## Term                                                             Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes            
## ---------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -----------------
## phosphorylation (GO:0016310)                                     3/386      0.0007739                  1             0                      0     15.54404        111.35935  MAPK9;CDK6;STK38 
## protein phosphorylation (GO:0006468)                             3/470      0.0013681                  1             0                      0     12.76596         84.18253  MAPK9;CDK6;STK38 
## regulation of macromolecule metabolic process (GO:0060255)       2/129      0.0017958                  1             0                      0     31.00775        196.04101  MAPK9;CDK6       
## peptidyl-serine phosphorylation (GO:0018105)                     2/145      0.0022611                  1             0                      0     27.58621        168.05205  MAPK9;STK38      
## type B pancreatic cell development (GO:0003323)                  1/6        0.0029966                  1             0                      0    333.33333       1936.76142  CDK6             
## positive regulation of microglial cell activation (GO:1903980)   1/6        0.0029966                  1             0                      0    333.33333       1936.76142  ITGAM            
## astrocyte differentiation (GO:0048708)                           1/6        0.0029966                  1             0                      0    333.33333       1936.76142  CDK6             
## glandular epithelial cell development (GO:0002068)               1/6        0.0029966                  1             0                      0    333.33333       1936.76142  CDK6             
## regulation of dopamine metabolic process (GO:0042053)            1/6        0.0029966                  1             0                      0    333.33333       1936.76142  ITGAM            
## peptidyl-serine modification (GO:0018209)                        2/170      0.0030905                  1             0                      0     23.52941        135.98605  MAPK9;STK38      
## 
## 
## Term                                                                        Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes       
## --------------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------------
## Integrin signalling pathway Homo sapiens P00034                             2/156      0.0026108          0.2924128             0                      0     25.64103        152.51507  MAPK9;ITGAM 
## Oxidative stress response Homo sapiens P00046                               1/24       0.0119380          0.6685260             0                      0     83.33333        369.00264  MAPK9       
## Interferon-gamma signaling pathway Homo sapiens P00035                      1/28       0.0139151          0.5194976             0                      0     71.42857        305.34140  MAPK9       
## FAS signaling pathway Homo sapiens P00020                                   1/31       0.0153956          0.4310780             0                      0     64.51613        269.26908  MAPK9       
## Transcription regulation by bZIP transcription factor Homo sapiens P00055   1/42       0.0208071          0.4660799             0                      0     47.61905        184.40281  CREB3L2     
## Toll receptor signaling pathway Homo sapiens P00054                         1/49       0.0242369          0.4524216             0                      0     40.81633        151.83185  MAPK9       
## Alzheimer disease-amyloid secretase pathway Homo sapiens P00003             1/56       0.0276558          0.4424926             0                      0     35.71429        128.14001  MAPK9       
## B cell activation Homo sapiens P00010                                       1/57       0.0281433          0.3940065             0                      0     35.08772        125.27878  MAPK9       
## Ras Pathway Homo sapiens P04393                                             1/69       0.0339766          0.4228201             0                      0     28.98551         98.03139  MAPK9       
## T cell activation Homo sapiens P00053                                       1/73       0.0359140          0.4022371             0                      0     27.39726         91.14047  MAPK9       
## [1] ""
## [1] "CD8_closed0open3enrichr"
## 
## 
## Term                                                                     Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes               
## -----------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  --------------------
## RNA polymerase II repressing transcription factor binding (GO:0001103)   2/28       0.0040666                  1             0                      0    21.008403        115.65006  TCF7L2;TCERG1L      
## phosphotransferase activity, alcohol group as acceptor (GO:0016773)      4/254      0.0109648                  1             0                      0     4.631774         20.90349  DGKD;GRK2;KSR1;PTK2 
## repressing transcription factor binding (GO:0070491)                     2/53       0.0140378                  1             0                      0    11.098779         47.34743  TCF7L2;TCERG1L      
## kinase activity (GO:0016301)                                             4/280      0.0152016                  1             0                      0     4.201681         17.58973  DGKD;GRK2;KSR1;PTK2 
## JUN kinase binding (GO:0008432)                                          1/6        0.0202297                  1             0                      0    49.019608        191.20596  PTK2                
## prostaglandin E receptor activity (GO:0004957)                           1/6        0.0202297                  1             0                      0    49.019608        191.20596  PTGER3              
## malate dehydrogenase activity (GO:0016615)                               1/6        0.0202297                  1             0                      0    49.019608        191.20596  ME1                 
## protein-lysine 6-oxidase activity (GO:0004720)                           1/6        0.0202297                  1             0                      0    49.019608        191.20596  LOXL4               
## protein-glutamic acid ligase activity (GO:0070739)                       1/7        0.0235619                  1             0                      0    42.016807        157.48413  TTLL13P             
## MAP kinase tyrosine/serine/threonine phosphatase activity (GO:0017017)   1/7        0.0235619                  1             0                      0    42.016807        157.48413  DUSP2               
## 
## 
## Term                                                                                 Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes            
## -----------------------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -----------------
## negative regulation of cell-cell adhesion (GO:0022408)                               3/31       0.0001578          0.8053974             0                      0     28.46300        249.16518  JAG1;SPINT2;PTK2 
## regulation of cell-cell adhesion (GO:0022407)                                        3/32       0.0001737          0.4432780             0                      0     27.57353        238.73147  JAG1;SPINT2;PTK2 
## cell surface receptor signaling pathway involved in heart development (GO:0061311)   2/14       0.0010095          1.0000000             0                      0     42.01681        289.84393  JAG1;NOG         
## myoblast differentiation (GO:0045445)                                                2/16       0.0013254          1.0000000             0                      0     36.76471        243.60455  TCF7L2;JAG1      
## negative regulation of cell adhesion (GO:0007162)                                    3/65       0.0014122          1.0000000             0                      0     13.57466         89.08489  JAG1;SPINT2;PTK2 
## morphogenesis of an epithelium (GO:0002009)                                          2/19       0.0018763          1.0000000             0                      0     30.95975        194.37938  KDM2B;KDF1       
## dorsal/ventral pattern formation (GO:0009953)                                        2/20       0.0020802          1.0000000             0                      0     29.41176        181.62608  NOG;DSCAML1      
## embryonic skeletal system development (GO:0048706)                                   2/21       0.0022941          1.0000000             0                      0     28.01120        170.23517  NOG;DSCAML1      
## embryonic skeletal system morphogenesis (GO:0048704)                                 2/21       0.0022941          1.0000000             0                      0     28.01120        170.23517  NOG;DSCAML1      
## limb development (GO:0060173)                                                        2/24       0.0029954          1.0000000             0                      0     24.50980        142.41856  KDF1;NOG         
## 
## 
## Term                                                       Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes                           
## ---------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  --------------------------------
## Wnt signaling pathway Homo sapiens P00057                  5/278      0.0025556          0.2862237             0                      0     5.289886        31.577870  TCF7L2;TLE2;FZD8;ARID1A;CSNK1G2 
## Angiogenesis Homo sapiens P00005                           3/142      0.0125471          0.7026367             0                      0     6.213753        27.205470  TCF7L2;JAG1;PTK2                
## Pyruvate metabolism Homo sapiens P02772                    1/8        0.0268830          1.0000000             0                      0    36.764706       132.950800  ME1                             
## Alzheimer disease-presenilin pathway Homo sapiens P00004   2/99       0.0447373          1.0000000             0                      0     5.941771        18.460772  TCF7L2;FZD8                     
## Cadherin signaling pathway Homo sapiens P00012             2/150      0.0924229          1.0000000             0                      0     3.921569         9.338747  TCF7L2;FZD8                     
## Integrin signalling pathway Homo sapiens P00034            2/156      0.0987269          1.0000000             0                      0     3.770739         8.730762  COL6A2;PTK2                     
## Notch signaling pathway Homo sapiens P00045                1/38       0.1215004          1.0000000             0                      0     7.739938        16.314534  JAG1                            
## VEGF signaling pathway Homo sapiens P00056                 1/54       0.1681947          1.0000000             0                      0     5.446623         9.709330  PTK2                            
## Parkinson disease Homo sapiens P00049                      1/81       0.2415078          1.0000000             0                      0     3.631082         5.159235  CSNK1G2                         
## CCKR signaling map ST Homo sapiens P06959                  1/165      0.4312279          1.0000000             0                      0     1.782531         1.499320  PTK2                            
## [1] ""
## [1] "CD8_closed0open8enrichr"
## 
## 
##        Term                                                     Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## -----  -------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## 1      acetylcholine receptor binding (GO:0033130)              1/7        0.0027970                  1             0                      0   357.142857      2099.715176  NRXN1 
## 2      long-chain fatty acid-CoA ligase activity (GO:0004467)   1/10       0.0039936                  1             0                      0   250.000000      1380.762654  ACSL6 
## 3      fatty acid ligase activity (GO:0015645)                  1/18       0.0071785                  1             0                      0   138.888889       685.647338  ACSL6 
## 4      calcium channel regulator activity (GO:0005246)          1/26       0.0103545                  1             0                      0    96.153846       439.455183  NRXN1 
## 5      calcium ion binding (GO:0005509)                         1/284      0.1081293                  1             0                      0     8.802817        19.581231  NRXN1 
## 6      metal ion binding (GO:0046872)                           1/442      0.1637387                  1             0                      0     5.656109        10.234636  NRXN1 
## 7      protein homodimerization activity (GO:0042803)           1/664      0.2367400                  1             0                      0     3.765060         5.424672  ACSL6 
## NA     NA                                                       NA                NA                 NA            NA                     NA           NA               NA  NA    
## NA.1   NA                                                       NA                NA                 NA            NA                     NA           NA               NA  NA    
## NA.2   NA                                                       NA                NA                 NA            NA                     NA           NA               NA  NA    
## 
## 
## Term                                                     Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes  
## -------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -------
## vocal learning (GO:0042297)                              1/6        0.0023979                  1             0                      0     416.6667         2513.825  NRXN1  
## imitative learning (GO:0098596)                          1/6        0.0023979                  1             0                      0     416.6667         2513.825  NRXN1  
## postsynaptic density assembly (GO:0097107)               1/7        0.0027970                  1             0                      0     357.1429         2099.715  NRXN1  
## postsynaptic density organization (GO:0097106)           1/9        0.0035949                  1             0                      0     277.7778         1563.399  NRXN1  
## positive regulation of synapse maturation (GO:0090129)   1/9        0.0035949                  1             0                      0     277.7778         1563.399  NRXN1  
## postsynaptic membrane assembly (GO:0097104)              1/9        0.0035949                  1             0                      0     277.7778         1563.399  NRXN1  
## protein localization to synapse (GO:0035418)             1/10       0.0039936                  1             0                      0     250.0000         1380.763  NRXN1  
## regulation of synapse maturation (GO:0090128)            1/10       0.0039936                  1             0                      0     250.0000         1380.763  NRXN1  
## postsynapse assembly (GO:0099068)                        1/11       0.0043922                  1             0                      0     227.2727         1233.617  NRXN1  
## establishment of chromosome localization (GO:0051303)    1/13       0.0051890                  1             0                      0     192.3077         1011.771  SPICE1 
## 
## 
##        Term   Overlap   P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score   Genes 
## -----  -----  --------  --------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## NA     NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.1   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.2   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.3   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.4   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.5   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.6   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.7   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.8   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.9   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## [1] ""
## [1] "CD8_closed0open30enrichr"
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## [1] ""
## [1] "CD8_closed0open120enrichr"
## 
## 
## Term                                                            Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes                                                                    
## --------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -------------------------------------------------------------------------
## small GTPase binding (GO:0031267)                               4/63       0.0022108                  1             0                      0     7.297938        44.622659  PEX5;SORL1;RAP1GAP;FGD2                                                  
## potassium ion transmembrane transporter activity (GO:0015079)   3/38       0.0043661                  1             0                      0     9.074410        49.309335  KCNA2;KCNK15;SLC12A6                                                     
## actin filament binding (GO:0051015)                             5/127      0.0050968                  1             0                      0     4.525296        23.889698  SVIL;FMNL1;ACTN1;MYO18A;CORO1A                                           
## ligand-dependent nuclear receptor binding (GO:0016922)          2/17       0.0093932                  1             0                      0    13.522650        63.120683  NCOA2;ARID1A                                                             
## collagen binding (GO:0005518)                                   3/52       0.0104686                  1             0                      0     6.631300        30.234584  C1QTNF1;NID1;PODN                                                        
## nuclear hormone receptor binding (GO:0035257)                   3/56       0.0128039                  1             0                      0     6.157635        26.834992  NCOA2;TCF7L2;TRIP6                                                       
## protein homodimerization activity (GO:0042803)                  12/664     0.0135321                  1             0                      0     2.077275         8.937877  CDH2;ACTN1;NOG;BCL2;XCL1;PYGL;FSD1;TPD52L1;SDCBP2;CORO1A;DSCAML1;RAP1GAP 
## kinase inhibitor activity (GO:0019210)                          3/59       0.0147352                  1             0                      0     5.844535        24.649410  LRRC4;RTN4RL2;PODN                                                       
## miRNA binding (GO:0035198)                                      2/24       0.0183197                  1             0                      0     9.578544        38.312034  ZC3H12A;MATR3                                                            
## protein kinase inhibitor activity (GO:0004860)                  3/67       0.0206504                  1             0                      0     5.146680        19.969223  LRRC4;RTN4RL2;PODN                                                       
## 
## 
## Term                                                                                                     Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes                    
## -------------------------------------------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -------------------------
## G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)                                  3/16       0.0003335          1.0000000             0                      0    21.551724        172.54336  GRK2;GNA11;CHRM5         
## acetylcholine receptor signaling pathway (GO:0095500)                                                    3/19       0.0005660          1.0000000             0                      0    18.148820        135.69647  GRK2;GNA11;CHRM5         
## ventricular septum morphogenesis (GO:0060412)                                                            3/21       0.0007670          1.0000000             0                      0    16.420361        117.78305  NOTCH1;NOG;SOX4          
## limb development (GO:0060173)                                                                            3/24       0.0011451          1.0000000             0                      0    14.367816         97.30237  KDF1;NOG;KREMEN2         
## regulation of apoptotic signaling pathway (GO:2001233)                                                   3/25       0.0012930          1.0000000             0                      0    13.793103         91.73505  TMEM102;BCL2;TPD52L1     
## monovalent inorganic cation homeostasis (GO:0055067)                                                     3/26       0.0014524          1.0000000             0                      0    13.262600         86.66533  SLC12A6;CYP4F12;SLC9A1   
## regulation of neurogenesis (GO:0050767)                                                                  4/57       0.0015264          1.0000000             0                      0     8.066142         52.30754  IGSF10;NOTCH1;SORL1;WNT3 
## regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213)   2/7        0.0015357          0.9795651             0                      0    32.840722        212.76811  NOTCH1;NOG               
## ventricular septum development (GO:0003281)                                                              3/28       0.0018068          1.0000000             0                      0    12.315271         77.78571  NOTCH1;NOG;SOX4          
## negative regulation of glial cell differentiation (GO:0045686)                                           2/8        0.0020359          1.0000000             0                      0    28.735632        178.07000  NOTCH1;NOG               
## 
## 
## Term                                                                                                    Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes                                                     
## ------------------------------------------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ----------------------------------------------------------
## Wnt signaling pathway Homo sapiens P00057                                                               9/278      0.0007560          0.0846723             0                      0     3.721161        26.745718  TCF7L2;TLE2;CDH2;GNA11;NFATC2;KREMEN2;ARID1A;CSNK1G2;WNT3 
## Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Homo sapiens P00027   4/106      0.0138340          0.7747014             0                      0     4.337454        18.567032  GRM4;GNA11;CHRM5;RAP1GAP                                  
## Alpha adrenergic receptor signaling pathway Homo sapiens P00002                                         2/23       0.0168885          0.6305046             0                      0     9.995003        40.790819  GNA11;ADRA1B                                              
## Alzheimer disease-presenilin pathway Homo sapiens P00004                                                3/99       0.0554111          1.0000000             0                      0     3.483107        10.076543  TCF7L2;NOTCH1;WNT3                                        
## Apoptosis signaling pathway Homo sapiens P00006                                                         3/102      0.0595454          1.0000000             0                      0     3.380663         9.536903  ATF6B;TNFRSF10C;BCL2                                      
## Inflammation mediated by chemokine and cytokine signaling pathway Homo sapiens P00031                   4/188      0.0820274          1.0000000             0                      0     2.445586         6.115682  COL6A2;GNA11;NFATC2;MYLK                                  
## Cytoskeletal regulation by Rho GTPase Homo sapiens P00016                                               2/70       0.1240699          1.0000000             0                      0     3.284072         6.853564  ENAH;MYLK                                                 
## Cadherin signaling pathway Homo sapiens P00012                                                          3/150      0.1427209          1.0000000             0                      0     2.298851         4.475550  TCF7L2;CDH2;WNT3                                          
## Metabotropic glutamate receptor group I pathway Homo sapiens P00041                                     1/23       0.1821580          1.0000000             0                      0     4.997501         8.510149  GNA11                                                     
## Oxidative stress response Homo sapiens P00046                                                           1/24       0.1892814          1.0000000             0                      0     4.789272         7.971841  BCL2
filename.txt
## [1] "CD8_closed0open120enrichr.txt"

Extra: ``{r lm} newz<-consecount[, 6:37] transnew<-as.data.frame(t(newz)) names(transnew)<-consecount$SYMBOL as.factor(transnew[, 1796]) Ibrutreatment<-Treatmentdaygrouped>0 forlm<-as.data.frame(cbind(as.factor(transnew[, 1796]), patientID, TreatmentDay, Ibrutreatment)) names(forlm)<-c(“Open”, “PatientID”, “Treatmentday”, “Ibrutinib”) modelplus<-lm(OpenPatientID+factor(Treatmentdaygrouped),data=forlm) modelper<-lm(OpenPatientID+Ibrutinib,data=forlm)

summary(modelplus) summary(modelper) anova(modelplus,modelper) Ibrutreatment<-Treatmentdaygrouped>0

``

newz<-consecount[, 6:37]
transnew<-as.data.frame(t(newz))
names(transnew)<-consecount$SYMBOL
Ibrutreatment<-Treatmentdaygrouped>0
Ibrucoef<-c()
Ibrusignif<-c()
for (i in 1:length(consecount$consensusIDs)){
    forlm<-as.data.frame(cbind(as.factor(transnew[, i]), patientID, Ibrutreatment))
    names(forlm)<-c("Open", "PatientID", "Ibrutinib")
    modelibru<-lm(Open~PatientID+Ibrutinib,data=forlm)
    lmcoef<- modelibru$coefficients["IbrutinibTRUE"]
    prvalue<- coef(summary(modelibru))["IbrutinibTRUE","Pr(>|t|)"]
    Ibrucoef<-c(Ibrucoef, lmcoef)
    Ibrusignif<-c(Ibrusignif, prvalue)
}
## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable
scoresandlm<-as.data.frame(cbind(consecount.scores, Ibrucoef, Ibrusignif))

signif<-subset(scoresandlm, scoresandlm$"Ibrusignif"<0.05)
knitr::kable(signif[, 49:57])
SYMBOL GENENAME 0 3 8 30 120 Ibrucoef Ibrusignif
15 B3GALT6 beta-1,3-galactosyltransferase 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
22 MRPL20-AS1 MRPL20 antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
25 ATAD3B ATPase family AAA domain containing 3B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
32 MIB2 mindbomb E3 ubiquitin protein ligase 2 0.0000000 0.3333333 0.6666667 0.5000000 0.7142857 0.4476651 0.0234018
41 TMEM52 transmembrane protein 52 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
54 TPRG1L tumor protein p63 regulated 1 like 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
65 RNF207 ring finger protein 207 0.0000000 0.5555556 0.6666667 0.5000000 0.2857143 0.4798712 0.0307075
80 ZBTB48 zinc finger and BTB domain containing 48 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
90 PARK7 Parkinsonism associated deglycase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
106 NMNAT1 nicotinamide nucleotide adenylyltransferase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
108 UBE4B ubiquitination factor E4B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
116 SRM spermidine synthase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
131 MFN2 mitofusin 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
164 SDHB succinate dehydrogenase complex iron sulfur subunit B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
181 OTUD3 OTU deubiquitinase 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
206 CDC42 cell division cycle 42 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
208 ZBTB40 zinc finger and BTB domain containing 40 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
252 MTFR1L mitochondrial fission regulator 1 like 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
255 MIR3917 microRNA 3917 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
264 DHDDS dehydrodolichyl diphosphate synthase subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
271 ARID1A AT-rich interaction domain 1A 0.1428571 0.7777778 0.6666667 0.5000000 0.7142857 0.4396135 0.0310733
283 WDTC1 WD and tetratricopeptide repeats 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
284 TMEM222 transmembrane protein 222 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
306 SESN2 sestrin 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
311 TRNAU1AP tRNA selenocysteine 1 associated protein 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
317 YTHDF2 YTH N6-methyladenosine RNA binding protein 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
351 HDAC1 histone deacetylase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
366 AZIN2 antizyme inhibitor 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
387 TRAPPC3 trafficking protein particle complex 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
402 GNL2 G protein nucleolar 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
411 INPP5B inositol polyphosphate-5-phosphatase B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
413 SF3A3 splicing factor 3a subunit 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
417 RRAGC Ras related GTP binding C 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
418 MYCBP MYC binding protein 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
435 CAP1 cyclase associated actin cytoskeleton regulatory protein 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
449 CITED4 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
463 SLC2A1-AS1 SLC2A1 antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
470 KDM4A-AS1 KDM4A antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
485 ARMH1 armadillo like helical domain containing 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
488 PLK3 polo like kinase 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
492 EIF2B3 eukaryotic translation initiation factor 2B subunit gamma 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
502 AKR1A1 aldo-keto reductase family 1 member A1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
510 PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
556 SLC1A7 solute carrier family 1 member 7 0.7142857 0.4444444 0.3333333 0.5000000 0.5714286 -0.3220612 0.0262591
575 MYSM1 Myb like, SWIRM and MPN domains 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
583 TM2D1 TM2 domain containing 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
603 MIER1 MIER1 transcriptional regulator 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
612 LRRC40 leucine rich repeat containing 40 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
616 PTGER3 prostaglandin E receptor 3 0.2857143 1.0000000 0.6666667 0.6666667 0.7142857 0.4557166 0.0169499
627 PIGK phosphatidylinositol glycan anchor biosynthesis class K 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
642 PRKACB protein kinase cAMP-activated catalytic subunit beta 0.5714286 0.2222222 0.3333333 0.1666667 0.2857143 -0.3784219 0.0347546
645 RPF1 ribosome production factor 1 homolog 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
647 CTBS chitobiase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
648 SSX2IP SSX family member 2 interacting protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
656 LOC646626 uncharacterized LOC646626 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
658 ZNHIT6 zinc finger HIT-type containing 6 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
660 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
678 LRRC8B leucine rich repeat containing 8 VRAC subunit B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
710 ALG14 ALG14 UDP-N-acetylglucosaminyltransferase subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
713 TLCD4-RWDD3 TLCD4-RWDD3 readthrough 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
720 AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
722 MFSD14A major facilitator superfamily domain containing 14A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
724 DBT dihydrolipoamide branched chain transacylase E2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
733 PRMT6 protein arginine methyltransferase 6 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
743 CLCC1 chloride channel CLIC like 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
744 WDR47 WD repeat domain 47 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
746 TMEM167B transmembrane protein 167B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
786 DDX20 DEAD-box helicase 20 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
791 ST7L suppression of tumorigenicity 7 like 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
794 PPM1J protein phosphatase, Mg2+/Mn2+ dependent 1J 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
811 SIKE1 suppressor of IKBKE 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
830 EMBP1 embigin pseudogene 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
932 C1orf43 chromosome 1 open reading frame 43 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
938 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
966 GBA glucosylceramidase beta 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
978 MSTO2P misato family member 2, pseudogene 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
980 SYT11 synaptotagmin 11 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1002 IQGAP3 IQ motif containing GTPase activating protein 3 0.0000000 0.5555556 0.6666667 0.5000000 0.5714286 0.5201288 0.0073961
1031 PIGM phosphatidylinositol glycan anchor biosynthesis class M 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1033 IGSF8 immunoglobulin superfamily member 8 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1035 DCAF8 DDB1 and CUL4 associated factor 8 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1061 MIR5187 microRNA 5187 1.0000000 0.7777778 0.6666667 0.6666667 1.0000000 -0.2962963 0.0480495
1074 UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1076 NUF2 NUF2 component of NDC80 kinetochore complex 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1103 SLC19A2 solute carrier family 19 member 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1108 KIFAP3 kinesin associated protein 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1114 DNM3 dynamin 3 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
1120 LOC100506023 uncharacterized LOC100506023 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1128 MRPS14 mitochondrial ribosomal protein S14 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1139 TOR1AIP1 torsin 1A interacting protein 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1143 ACBD6 acyl-CoA binding domain containing 6 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1154 DHX9 DExH-box helicase 9 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1155 SMG7-AS1 SMG7 antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1157 ARPC5 actin related protein 2/3 complex subunit 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1194 TMEM9 transmembrane protein 9 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1219 RABIF RAB interacting factor 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1259 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
1272 CD46 CD46 molecule 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1286 SLC30A1 solute carrier family 30 member 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1297 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1306 RRP15 ribosomal RNA processing 15 homolog 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1308 LYPLAL1 lysophospholipase like 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1312 RAB3GAP2 RAB3 GTPase activating non-catalytic protein subunit 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1322 BROX BRO1 domain and CAAX motif containing 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1341 LEFTY1 left-right determination factor 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1365 GUK1 guanylate kinase 1 0.4285714 0.0000000 0.0000000 0.1666667 0.1428571 -0.3703704 0.0244875
1374 RNF187 ring finger protein 187 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1385 ARV1 ARV1 homolog, fatty acid homeostasis modulator 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1398 COA6 cytochrome c oxidase assembly factor 6 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1409 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1429 ZBTB18 zinc finger and BTB domain containing 18 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1435 EFCAB2 EF-hand calcium binding domain 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1442 ZNF669 zinc finger protein 669 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1450 ZNF672 zinc finger protein 672 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1452 PGBD2 piggyBac transposable element derived 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1456 GTPBP4 GTP binding protein 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1457 WDR37 WD repeat domain 37 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1470 GDI2 GDP dissociation inhibitor 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1474 RBM17 RNA binding motif protein 17 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1483 KIN Kin17 DNA and RNA binding protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1484 TAF3 TATA-box binding protein associated factor 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1495 UPF2 UPF2 regulator of nonsense mediated mRNA decay 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1497 SEC61A2 SEC61 translocon alpha 2 subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1510 DCLRE1C DNA cross-link repair 1C 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1511 MEIG1 meiosis/spermiogenesis associated 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1513 RPP38 ribonuclease P/MRP subunit p38 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1514 NMT2 N-myristoyltransferase 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1516 MINDY3 MINDY lysine 48 deubiquitinase 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1517 PTER phosphotriesterase related 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1524 STAM signal transducing adaptor molecule 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1531 DNAJC1 DnaJ heat shock protein family (Hsp40) member C1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1542 ARHGAP21 Rho GTPase activating protein 21 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1552 MASTL microtubule associated serine/threonine kinase like 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1560 WAC-AS1 WAC antisense RNA 1 (head to head) 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1576 EPC1 enhancer of polycomb homolog 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1582 NRP1 neuropilin 1 0.7142857 0.3333333 0.3333333 0.1666667 0.4285714 -0.4621578 0.0335728
1584 CUL2 cullin 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1585 CREM cAMP responsive element modulator 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1594 SEPTIN7P9 septin 7 pseudogene 9 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1597 ZNF33B zinc finger protein 33B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1615 ZFAND4 zinc finger AN1-type containing 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1619 MAPK8 mitogen-activated protein kinase 8 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1627 NCOA4 nuclear receptor coactivator 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1641 TFAM transcription factor A, mitochondrial 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1642 CCDC6 coiled-coil domain containing 6 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1655 NRBF2 nuclear receptor binding factor 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1668 TET1 tet methylcytosine dioxygenase 1 0.0000000 0.7777778 0.3333333 0.3333333 0.5714286 0.4959742 0.0200887
1702 PSAP prosaposin 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1706 DDIT4 DNA damage inducible transcript 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1709 MCU mitochondrial calcium uniporter 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1710 P4HA1 prolyl 4-hydroxylase subunit alpha 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1718 PPP3CB protein phosphatase 3 catalytic subunit beta 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1729 VCL vinculin 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1761 WAPL WAPL cohesin release factor 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1769 CFL1P1 cofilin 1 pseudogene 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1770 KLLN killin, p53 regulated DNA replication inhibitor 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1780 IFIT1 interferon induced protein with tetratricopeptide repeats 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1782 IFIT5 interferon induced protein with tetratricopeptide repeats 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1795 CPEB3 cytoplasmic polyadenylation element binding protein 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1804 CEP55 centrosomal protein 55 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1805 FRA10AC1 FRA10A associated CGG repeat 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1811 SORBS1 sorbin and SH3 domain containing 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1812 ALDH18A1 aldehyde dehydrogenase 18 family member A1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1821 LCOR ligand dependent nuclear receptor corepressor 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1830 MMS19 MMS19 homolog, cytosolic iron-sulfur assembly component 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1833 MORN4 MORN repeat containing 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1835 AVPI1 arginine vasopressin induced 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1839 R3HCC1L R3H domain and coiled-coil containing 1 like 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1854 BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1878 KCNIP2 potassium voltage-gated channel interacting protein 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1892 NFKB2 nuclear factor kappa B subunit 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1906 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1933 MXI1 MAX interactor 1, dimerization protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1935 DUSP5 dual specificity phosphatase 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1940 GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1955 TRUB1 TruB pseudouridine synthase family member 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1961 FAM204A family with sequence similarity 204 member A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
1968 GRK5 G protein-coupled receptor kinase 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1979 ATE1 arginyltransferase 1 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
1983 FAM24B-CUZD1 FAM24B-CUZD1 readthrough 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
1984 C10orf88 chromosome 10 open reading frame 88 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2001 MGMT O-6-methylguanine-DNA methyltransferase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2019 TUBGCP2 tubulin gamma complex associated protein 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2023 ECHS1 enoyl-CoA hydratase, short chain 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2046 LOC143666 uncharacterized LOC143666 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2089 NAP1L4 nucleosome assembly protein 1 like 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2090 CARS1 cysteinyl-tRNA synthetase 1 0.0000000 0.5555556 0.3333333 0.1666667 0.2857143 0.4074074 0.0455222
2110 SMPD1 sphingomyelin phosphodiesterase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2117 TPP1 tripeptidyl peptidase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2119 MRPL17 mitochondrial ribosomal protein L17 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2134 TMEM41B transmembrane protein 41B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2150 ZBED5 zinc finger BED-type containing 5 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2156 ARNTL aryl hydrocarbon receptor nuclear translocator like 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2159 FAR1 fatty acyl-CoA reductase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2162 COPB1 coatomer protein complex subunit beta 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2163 PSMA1 proteasome 20S subunit alpha 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2172 NUCB2 nucleobindin 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2193 PRMT3 protein arginine methyltransferase 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2196 CCDC34 coiled-coil domain containing 34 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2202 ARL14EP ADP ribosylation factor like GTPase 14 effector protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2203 DNAJC24 DnaJ heat shock protein family (Hsp40) member C24 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2211 TCP11L1 t-complex 11 like 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2212 CSTF3 cleavage stimulation factor subunit 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2214 C11orf91 chromosome 11 open reading frame 91 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2222 ABTB2 ankyrin repeat and BTB domain containing 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2225 APIP APAF1 interacting protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2239 ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2245 PRDM11 PR/SET domain 11 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2264 ARHGAP1 Rho GTPase activating protein 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2272 MADD MAP kinase activating death domain 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2274 SLC39A13 solute carrier family 39 member 13 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2287 SSRP1 structure specific recognition protein 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2312 CCDC86 coiled-coil domain containing 86 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2322 CYB561A3 cytochrome b561 family member A3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2343 EML3 EMAP like 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2344 B3GAT3 beta-1,3-glucuronyltransferase 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2345 GANAB glucosidase II alpha subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2365 RTN3 reticulon 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2400 EHD1 EH domain containing 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2428 LTBP3 latent transforming growth factor beta binding protein 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2431 ZNRD2 zinc ribbon domain containing 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2440 KAT5 lysine acetyltransferase 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2452 DRAP1 DR1 associated protein 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2459 RAB1B RAB1B, member RAS oncogene family 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2469 PELI3 pellino E3 ubiquitin protein ligase family member 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2484 KDM2A lysine demethylase 2A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2486 GRK2 G protein-coupled receptor kinase 2 0.2857143 0.8888889 0.6666667 0.5000000 0.8571429 0.3349436 0.0348889
2490 POLD4 DNA polymerase delta 4, accessory subunit 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2493 PPP1CA protein phosphatase 1 catalytic subunit alpha 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2505 CDK2AP2 cyclin dependent kinase 2 associated protein 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2510 NUDT8 nudix hydrolase 8 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2513 FAM86C2P family with sequence similarity 86, member A pseudogene 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2550 ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2564 UCP2 uncoupling protein 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2566 PGM2L1 phosphoglucomutase 2 like 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2567 LIPT2 lipoyl(octanoyl) transferase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2582 THAP12 THAP domain containing 12 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2597 KCTD21 potassium channel tetramerization domain containing 21 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2603 ANKRD42 ankyrin repeat domain 42 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2606 TMEM126A transmembrane protein 126A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2611 CCDC83 coiled-coil domain containing 83 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2612 PICALM phosphatidylinositol binding clathrin assembly protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2618 TMEM135 transmembrane protein 135 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2623 SLC36A4 solute carrier family 36 member 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2628 MED17 mediator complex subunit 17 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2634 ENDOD1 endonuclease domain containing 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2640 CCDC82 coiled-coil domain containing 82 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2646 BIRC2 baculoviral IAP repeat containing 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2685 DIXDC1 DIX domain containing 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2692 PTS 6-pyruvoyltetrahydropterin synthase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2699 RBM7 RNA binding motif protein 7 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2700 REXO2 RNA exonuclease 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2702 CADM1 cell adhesion molecule 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2730 ARCN1 archain 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2736 CCDC84 coiled-coil domain containing 84 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2739 HYOU1 hypoxia up-regulated 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2740 VPS11 VPS11 core subunit of CORVET and HOPS complexes 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2750 RNF26 ring finger protein 26 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2759 SC5D sterol-C5-desaturase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2761 SORL1 sortilin related receptor 1 0.1428571 0.6666667 0.6666667 0.5000000 0.7142857 0.4879227 0.0339216
2763 CRTAM cytotoxic and regulatory T cell molecule 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2772 SPA17 sperm autoantigenic protein 17 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2790 FAM118B family with sequence similarity 118 member B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2791 FOXRED1 FAD dependent oxidoreductase domain containing 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2809 APLP2 amyloid beta precursor like protein 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2810 ZBTB44 zinc finger and BTB domain containing 44 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2813 IGSF9B immunoglobulin superfamily member 9B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2814 IGSF9B immunoglobulin superfamily member 9B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2833 ADIPOR2 adiponectin receptor 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2846 TIGAR TP53 induced glycolysis regulatory phosphatase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2849 AKAP3 A-kinase anchoring protein 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2896 FAM86FP family with sequence similarity 86, member A pseudogene 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2922 MAGOHB mago homolog B, exon junction complex subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2925 PRR4 proline rich 4 0.8571429 0.5555556 0.3333333 0.0000000 0.2857143 -0.5008052 0.0158960
2932 BORCS5 BLOC-1 related complex subunit 5 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2934 CREBL2 cAMP responsive element binding protein like 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2938 DDX47 DEAD-box helicase 47 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2966 ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2980 MED21 mediator complex subunit 21 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2981 STK38L serine/threonine kinase 38 like 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
2991 CAPRIN2 caprin family member 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2993 DDX11-AS1 DDX11 antisense RNA 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
2995 SINHCAF SIN3-HDAC complex associated factor 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3015 YAF2 YY1 associated factor 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3025 ARID2 AT-rich interaction domain 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3027 SCAF11 SR-related CTD associated factor 11 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3047 ASB8 ankyrin repeat and SOCS box containing 8 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3058 FKBP11 FKBP prolyl isomerase 11 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3062 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3072 SPATS2 spermatogenesis associated serine rich 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3079 FMNL3 formin like 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3100 CSRNP2 cysteine and serine rich nuclear protein 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3103 DAZAP2 DAZ associated protein 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3158 MIR148B microRNA 148b 0.4285714 0.0000000 0.3333333 0.1666667 0.1428571 -0.3462158 0.0452981
3186 PA2G4 proliferation-associated 2G4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3213 PTGES3 prostaglandin E synthase 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3224 NXPH4 neurexophilin 4 0.0000000 0.5555556 0.6666667 0.3333333 0.5714286 0.4315620 0.0353835
3232 DDIT3 DNA damage inducible transcript 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3256 TAFA2 TAFA chemokine like family member 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3257 MON2 MON2 homolog, regulator of endosome-to-Golgi trafficking 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3265 XPOT exportin for tRNA 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3287 CPSF6 cleavage and polyadenylation specific factor 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3290 CCT2 chaperonin containing TCP1 subunit 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3296 RAB21 RAB21, member RAS oncogene family 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3297 TBC1D15 TBC1 domain family member 15 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3305 NAP1L1 nucleosome assembly protein 1 like 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3307 OSBPL8 oxysterol binding protein like 8 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3308 ZDHHC17 zinc finger DHHC-type containing 17 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3315 TMTC2 transmembrane O-mannosyltransferase targeting cadherins 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3321 POC1B-GALNT4 POC1B-GALNT4 readthrough 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3326 UBE2N ubiquitin conjugating enzyme E2 N 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3327 MRPL42 mitochondrial ribosomal protein L42 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3333 CEP83-DT CEP83 divergent transcript 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3335 NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3342 CCDC38 coiled-coil domain containing 38 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3347 NEDD1 NEDD1 gamma-tubulin ring complex targeting factor 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3350 TMPO-AS1 TMPO antisense RNA 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3352 IKBIP IKBKB interacting protein 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3353 UHRF1BP1L UHRF1 binding protein 1 like 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3355 DEPDC4 DEP domain containing 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3363 PARPBP PARP1 binding protein 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3401 CORO1C coronin 1C 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3419 ARPC3 actin related protein 2/3 complex subunit 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3433 MAPKAPK5-AS1 MAPKAPK5 antisense RNA 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3434 ERP29 endoplasmic reticulum protein 29 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3449 PLBD2 phospholipase B domain containing 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3450 RBM19 RNA binding motif protein 19 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3470 PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3482 NRAV negative regulator of antiviral response 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3498 CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3501 RNF34 ring finger protein 34 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3540 SBNO1 strawberry notch homolog 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3541 KMT5A lysine methyltransferase 5A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3548 EIF2B1 eukaryotic translation initiation factor 2B subunit alpha 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3563 RAN RAN, member RAS oncogene family 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3578 CHFR checkpoint with forkhead and ring finger domains 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3581 ZMYM5 zinc finger MYM-type containing 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3589 EEF1AKMT1 EEF1A lysine methyltransferase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3593 SKA3 spindle and kinetochore associated complex subunit 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3598 SACS sacsin molecular chaperone 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3611 CENPJ centromere protein J 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3617 USP12 ubiquitin specific peptidase 12 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3622 POMP proteasome maturation protein 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3623 SLC46A3 solute carrier family 46 member 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3624 SLC7A1 solute carrier family 7 member 1 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
3629 USPL1 ubiquitin specific peptidase like 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3637 BRCA2 BRCA2 DNA repair associated 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3647 ALG5 ALG5 dolichyl-phosphate beta-glucosyltransferase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3649 SUPT20H SPT20 homolog, SAGA complex component 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3656 TPTE2P5 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 5 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3668 DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3674 NUFIP1 nuclear FMR1 interacting protein 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3677 SLC25A30 solute carrier family 25 member 30 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3698 ARL11 ADP ribosylation factor like GTPase 11 0.0000000 0.4444444 0.3333333 0.3333333 0.5714286 0.4476651 0.0037328
3704 DLEU2 deleted in lymphocytic leukemia 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3717 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3725 KLF5 Kruppel like factor 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3728 COMMD6 COMM domain containing 6 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3737 MYCBP2 MYC binding protein 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3738 MIR3665 microRNA 3665 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3748 TGDS TDP-glucose 4,6-dehydratase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3749 GPR180 G protein-coupled receptor 180 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3753 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3759 UBAC2-AS1 UBAC2 antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3765 CLYBL citrate lyase beta like 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3769 TMTC4 transmembrane O-mannosyltransferase targeting cadherins 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3779 LIG4 DNA ligase 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3784 CARS2 cysteinyl-tRNA synthetase 2, mitochondrial 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3833 MRPL52 mitochondrial ribosomal protein L52 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3864 PSME1 proteasome activator subunit 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3867 IRF9 interferon regulatory factor 9 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3872 MDP1 magnesium dependent phosphatase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3874 TINF2 TERF1 interacting nuclear factor 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3888 SCFD1 sec1 family domain containing 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3893 HEATR5A HEAT repeat containing 5A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3894 DTD2 D-aminoacyl-tRNA deacylase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3906 NFKBIA NFKB inhibitor alpha 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3918 FBXO33 F-box protein 33 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3932 KLHDC2 kelch domain containing 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
3938 VCPKMT valosin containing protein lysine methyltransferase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3940 DMAC2L distal membrane arm assembly complex 2 like 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3946 NIN ninein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3947 PYGL glycogen phosphorylase L 0.1428571 0.6666667 0.6666667 0.3333333 0.7142857 0.4154589 0.0402135
3961 STYX serine/threonine/tyrosine interacting protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3981 TMEM260 transmembrane protein 260 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3983 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3994 L3HYPDH trans-L-3-hydroxyproline dehydratase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
3996 RTN1 reticulon 1 0.4285714 0.0000000 0.3333333 0.0000000 0.1428571 -0.3945250 0.0091218
4020 ZBTB1 zinc finger and BTB domain containing 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4026 CHURC1-FNTB CHURC1-FNTB readthrough 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4030 FUT8 fucosyltransferase 8 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4032 MPP5 membrane palmitoylated protein 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4054 LOC100289511 uncharacterized LOC100289511 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4060 PCNX1 pecanex 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4075 MIR4505 microRNA 4505 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4098 FOS Fos proto-oncogene, AP-1 transcription factor subunit 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4143 CALM1 calmodulin 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4160 TRIP11 thyroid hormone receptor interactor 11 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4168 GOLGA5 golgin A5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4187 AK7 adenylate kinase 7 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4193 CCDC85C coiled-coil domain containing 85C 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4211 HSP90AA1 heat shock protein 90 alpha family class A member 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4215 CINP cyclin dependent kinase 2 interacting protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4222 MARK3 microtubule affinity regulating kinase 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4248 PACS2 phosphofurin acidic cluster sorting protein 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4270 NSMCE3 NSE3 homolog, SMC5-SMC6 complex component 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4285 LPCAT4 lysophosphatidylcholine acyltransferase 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4287 ZNF770 zinc finger protein 770 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4298 FSIP1 fibrous sheath interacting protein 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4304 BMF Bcl2 modifying factor 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4315 IVD isovaleryl-CoA dehydrogenase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4330 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4348 EHD4 EH domain containing 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4357 UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4374 EIF3J-DT EIF3J divergent transcript 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4401 GALK2 galactokinase 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4407 USP8 ubiquitin specific peptidase 8 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4408 TRPM7 transient receptor potential cation channel subfamily M member 7 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4427 C15orf65 chromosome 15 open reading frame 65 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4433 MNS1 meiosis specific nuclear structural 1 0.1428571 0.5555556 0.3333333 0.5000000 0.5714286 0.4074074 0.0169845
4436 POLR2M RNA polymerase II subunit M 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4440 MINDY2 MINDY lysine 48 deubiquitinase 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4447 BNIP2 BCL2 interacting protein 2 0.5714286 0.3333333 0.0000000 0.3333333 0.1428571 -0.3800322 0.0322062
4448 BNIP2 BCL2 interacting protein 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4480 CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4488 RAB11A RAB11A, member RAS oncogene family 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4524 ADPGK-AS1 ADPGK antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4536 CLK3 CDC like kinase 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4547 SCAMP2 secretory carrier membrane protein 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4550 COX5A cytochrome c oxidase subunit 5A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4563 SNUPN snurportin 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4583 IDH3A isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4597 ST20-MTHFS ST20-MTHFS readthrough 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4630 PDE8A phosphodiesterase 8A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4634 KLHL25 kelch like family member 25 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4635 MRPL46 mitochondrial ribosomal protein L46 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4636 DET1 DET1 partner of COP1 E3 ubiquitin ligase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4655 MESP2 mesoderm posterior bHLH transcription factor 2 0.0000000 0.5555556 0.6666667 0.5000000 0.5714286 0.4879227 0.0209664
4700 CHSY1 chondroitin sulfate synthase 1 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
4746 C16orf91 chromosome 16 open reading frame 91 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4758 MSRB1 methionine sulfoxide reductase B1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4761 TBL3 transducin beta like 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4771 PGP phosphoglycolate phosphatase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4772 E4F1 E4F transcription factor 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4781 MIR3178 microRNA 3178 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4794 FLYWCH1 FLYWCH-type zinc finger 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4795 KREMEN2 kringle containing transmembrane protein 2 0.0000000 0.4444444 0.3333333 0.1666667 0.7142857 0.4090177 0.0305731
4800 HCFC1R1 host cell factor C1 regulator 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4809 ZNF263 zinc finger protein 263 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4823 LINC01569 long intergenic non-protein coding RNA 1569 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4828 CORO7-PAM16 CORO7-PAM16 readthrough 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4861 RMI2 RecQ mediated genome instability 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4868 GSPT1 G1 to S phase transition 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4899 CCP110 centriolar coiled-coil protein 110 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4926 EARS2 glutamyl-tRNA synthetase 2, mitochondrial 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4927 NDUFAB1 NADH:ubiquinone oxidoreductase subunit AB1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
4934 ARHGAP17 Rho GTPase activating protein 17 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4944 KIAA0556 KIAA0556 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
4972 MAZ MYC associated zinc finger protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5001 ZNF48 zinc finger protein 48 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5016 SRCAP Snf2 related CREBBP activator protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5042 ITGAM integrin subunit alpha M 0.7142857 0.4444444 0.3333333 0.5000000 0.2857143 -0.4025765 0.0412722
5053 C16orf87 chromosome 16 open reading frame 87 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5055 DNAJA2 DnaJ heat shock protein family (Hsp40) member A2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5077 RBL2 RB transcriptional corepressor like 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5082 CRNDE colorectal neoplasia differentially expressed 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5101 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5102 NLRC5 NLR family CARD domain containing 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5109 COQ9 coenzyme Q9 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5119 ZNF319 zinc finger protein 319 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5162 ATP6V0D1 ATPase H+ transporting V0 subunit d1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5177 PSKH1 protein serine kinase H1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5184 NFATC3 nuclear factor of activated T cells 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5187 PRMT7 protein arginine methyltransferase 7 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5198 NIP7 nucleolar pre-rRNA processing protein NIP7 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5210 DDX19B DEAD-box helicase 19B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5213 ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5218 CMTR2 cap methyltransferase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5229 IST1 IST1 factor associated with ESCRT-III 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5248 TMEM231 transmembrane protein 231 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5252 KARS1 lysyl-tRNA synthetase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5264 GAN gigaxonin 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5268 MPHOSPH6 M-phase phosphoprotein 6 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5269 HSBP1 heat shock factor binding protein 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5271 MBTPS1 membrane bound transcription factor peptidase, site 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5286 GINS2 GINS complex subunit 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5302 MIR5189 microRNA 5189 0.0000000 0.4444444 0.6666667 0.1666667 0.2857143 0.3268921 0.0468408
5329 SPATA2L spermatogenesis associated 2 like 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5365 SLC43A2 solute carrier family 43 member 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5401 ANKFY1 ankyrin repeat and FYVE domain containing 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5402 UBE2G1 ubiquitin conjugating enzyme E2 G1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5423 LOC100130950 uncharacterized LOC100130950 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5437 ALOX15P1 arachidonate 15-lipoxygenase pseudogene 1 0.1428571 0.5555556 0.6666667 0.5000000 0.5714286 0.4637681 0.0310063
5447 DLG4 discs large MAGUK scaffold protein 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5449 DLG4 discs large MAGUK scaffold protein 4 0.0000000 0.5555556 0.3333333 0.3333333 0.4285714 0.4025765 0.0200637
5474 MPDU1 mannose-P-dolichol utilization defect 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5479 WRAP53 WD repeat containing antisense to TP53 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5496 BORCS6 BLOC-1 related complex subunit 6 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5543 MPRIP myosin phosphatase Rho interacting protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5547 COPS3 COP9 signalosome subunit 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5558 GID4 GID complex subunit 4 homolog 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5577 B9D1 B9 domain containing 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5578 B9D1 B9 domain containing 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5589 DHRS7B dehydrogenase/reductase 7B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5590 TMEM11 transmembrane protein 11 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5592 MAP2K3 mitogen-activated protein kinase kinase 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5602 TMEM199 transmembrane protein 199 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5605 SLC46A1 solute carrier family 46 member 1 0.0000000 0.6666667 0.6666667 0.3333333 0.7142857 0.5442834 0.0053166
5607 PIGS phosphatidylinositol glycan anchor biosynthesis class S 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5608 ALDOC aldolase, fructose-bisphosphate C 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5618 FAM222B family with sequence similarity 222 member B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5635 ANKRD13B ankyrin repeat domain 13B 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
5642 CPD carboxypeptidase D 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5654 RAB11FIP4 RAB11 family interacting protein 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5657 UTP6 UTP6 small subunit processome component 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5665 PSMD11 proteasome 26S subunit, non-ATPase 11 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5694 GGNBP2 gametogenetin binding protein 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5742 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5770 ACLY ATP citrate lyase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5771 TTC25 tetratricopeptide repeat domain 25 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5859 PLEKHM1 pleckstrin homology and RUN domain containing M1 0.0000000 0.5555556 0.6666667 0.5000000 0.5714286 0.5523349 0.0122499
5862 KANSL1 KAT8 regulatory NSL complex subunit 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5887 CBX1 chromobox 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5888 SNX11 sorting nexin 11 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5910 SPOP speckle type BTB/POZ protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
5934 TOB1 transducer of ERBB2, 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5943 NOG noggin 0.2857143 0.7777778 0.6666667 0.5000000 0.7142857 0.3365539 0.0432522
5974 TRIM37 tripartite motif containing 37 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5980 CLTC clathrin heavy chain 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
5986 USP32 ubiquitin specific peptidase 32 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6030 GNA13 G protein subunit alpha 13 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6039 NOL11 nucleolar protein 11 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6051 WIPI1 WD repeat domain, phosphoinositide interacting 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6053 ABCA5 ATP binding cassette subfamily A member 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6069 RAB37 RAB37, member RAS oncogene family 0.0000000 0.4444444 0.6666667 0.1666667 0.7142857 0.5136876 0.0145615
6081 ATP5PD ATP synthase peripheral stalk subunit d 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6097 MYO15B myosin XVB 0.0000000 0.3333333 0.6666667 0.3333333 0.5714286 0.4315620 0.0353835
6123 AANAT aralkylamine N-acetyltransferase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6132 SRSF2 serine and arginine rich splicing factor 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6160 USP36 ubiquitin specific peptidase 36 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6206 DCXR dicarbonyl and L-xylulose reductase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6223 FOXK2 forkhead box K2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6233 USP14 ubiquitin specific peptidase 14 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6234 THOC1 THO complex 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6250 L3MBTL4 L3MBTL histone methyl-lysine binding protein 4 0.1428571 0.5555556 0.3333333 0.3333333 0.5714286 0.3832528 0.0128298
6257 ANKRD12 ankyrin repeat domain 12 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6268 IMPA2 inositol monophosphatase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6280 FAM210A family with sequence similarity 210 member A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6283 ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6287 MIB1 mindbomb E3 ubiquitin protein ligase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6294 NPC1 NPC intracellular cholesterol transporter 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6312 TRAPPC8 trafficking protein particle complex 8 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6314 RNF138 ring finger protein 138 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6320 ZNF397 zinc finger protein 397 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6326 C18orf21 chromosome 18 open reading frame 21 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6327 RPRD1A regulation of nuclear pre-mRNA domain containing 1A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6364 ME2 malic enzyme 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6370 POLI DNA polymerase iota 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6371 C18orf54 chromosome 18 open reading frame 54 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6372 RAB27B RAB27B, member RAS oncogene family 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6377 TXNL1 thioredoxin like 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6382 LOC100505549 uncharacterized LOC100505549 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6390 SEC11C SEC11 homolog C, signal peptidase complex subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6391 LMAN1 lectin, mannose binding 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6392 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6396 ZCCHC2 zinc finger CCHC-type containing 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6403 SERPINB8 serpin family B member 8 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6405 TMX3 thioredoxin related transmembrane protein 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6415 LINC00909 long intergenic non-protein coding RNA 909 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6423 ATP9B ATPase phospholipid transporting 9B (putative) 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6442 BSG basigin (Ok blood group) 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6445 FGF22 fibroblast growth factor 22 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6469 STK11 serine/threonine kinase 11 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6489 ATP8B3 ATPase phospholipid transporting 8B3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6490 REXO1 RNA exonuclease 1 homolog 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6495 SCAMP4 secretory carrier membrane protein 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6498 BTBD2 BTB domain containing 2 0.2857143 0.7777778 0.6666667 0.5000000 1.0000000 0.3349436 0.0348889
6500 MKNK2 MAPK interacting serine/threonine kinase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6512 TIMM13 translocase of inner mitochondrial membrane 13 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6519 THOP1 thimet oligopeptidase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6539 FZR1 fizzy and cell division cycle 20 related 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6556 PIAS4 protein inhibitor of activated STAT 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6565 FSD1 fibronectin type III and SPRY domain containing 1 0.2857143 0.8888889 0.6666667 0.5000000 0.7142857 0.3752013 0.0313950
6587 LOC100128568 uncharacterized LOC100128568 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6592 GTF2F1 general transcription factor IIF subunit 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6608 ZNF557 zinc finger protein 557 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6635 HNRNPM heterogeneous nuclear ribonucleoprotein M 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6638 ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif 10 0.2857143 0.8888889 0.6666667 0.5000000 0.8571429 0.3832528 0.0103448
6669 MIR1181 microRNA 1181 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6690 CARM1 coactivator associated arginine methyltransferase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6692 SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
6721 ZNF844 zinc finger protein 844 0.0000000 0.5555556 0.3333333 0.1666667 0.4285714 0.4074074 0.0196710
6729 ZNF442 zinc finger protein 442 0.2857143 0.6666667 1.0000000 0.5000000 0.7142857 0.4122383 0.0323027
6737 DHPS deoxyhypusine synthase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6763 CCDC130 coiled-coil domain containing 130 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6779 ADGRE5 adhesion G protein-coupled receptor E5 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6790 ILVBL ilvB acetolactate synthase like 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6816 MYO9B myosin IXB 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6837 COLGALT1 collagen beta(1-O)galactosyltransferase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6845 ARRDC2 arrestin domain containing 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6885 PBX4 PBX homeobox 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6902 ZNF85 zinc finger protein 85 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6919 ZNF91 zinc finger protein 91 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6920 ZNF675 zinc finger protein 675 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6929 POP4 POP4 homolog, ribonuclease P/MRP subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
6938 PDCD5 programmed cell death 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6981 KMT2B lysine methyltransferase 2B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
6983 U2AF1L4 U2 small nuclear RNA auxiliary factor 1 like 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7004 ZNF260 zinc finger protein 260 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7005 ZNF529 zinc finger protein 529 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7015 ZNF420 zinc finger protein 420 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7035 YIF1B Yip1 interacting factor homolog B, membrane trafficking protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7040 FAM98C family with sequence similarity 98 member C 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7059 SAMD4B sterile alpha motif domain containing 4B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7068 DLL3 delta like canonical Notch ligand 3 0.8571429 0.4444444 0.0000000 0.0000000 0.4285714 -0.6167472 0.0063073
7082 C19orf47 chromosome 19 open reading frame 47 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7125 ZNF526 zinc finger protein 526 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7134 CEACAM1 CEA cell adhesion molecule 1 0.0000000 0.5555556 0.6666667 0.3333333 0.4285714 0.4492754 0.0249265
7139 XRCC1 X-ray repair cross complementing 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7185 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 0.4285714 0.2222222 0.0000000 0.0000000 0.0000000 -0.3301127 0.0281008
7189 RTN2 reticulon 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7192 VASP vasodilator stimulated phosphoprotein 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7209 MYPOP Myb related transcription factor, partner of profilin 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7216 DACT3-AS1 DACT3 antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7231 CCDC9 coiled-coil domain containing 9 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7232 INAFM1 InaF motif containing 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7236 NAPA-AS1 NAPA antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7246 CARD8-AS1 CARD8 antisense RNA 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7251 SYNGR4 synaptogyrin 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7259 SPHK2 sphingosine kinase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7282 SNRNP70 small nuclear ribonucleoprotein U1 subunit 70 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7284 C19orf73 chromosome 19 open reading frame 73 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7285 PPFIA3 PTPRF interacting protein alpha 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7291 CCDC155 coiled-coil domain containing 155 0.0000000 0.5555556 0.6666667 0.3333333 0.7142857 0.6328502 0.0022437
7300 MIR150 microRNA 150 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7324 POLD1 DNA polymerase delta 1, catalytic subunit 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7328 C19orf48 chromosome 19 open reading frame 48 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7363 ZNF611 zinc finger protein 611 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7370 ZNF816-ZNF321P ZNF816-ZNF321P readthrough 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7373 ZNF347 zinc finger protein 347 0.0000000 0.6666667 0.6666667 0.1666667 0.2857143 0.4476651 0.0154662
7407 RDH13 retinol dehydrogenase 13 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7475 ZSCAN18 zinc finger and SCAN domain containing 18 0.2857143 1.0000000 0.6666667 0.3333333 0.8571429 0.4718196 0.0250422
7483 A1BG alpha-1-B glycoprotein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7495 MZF1-AS1 MZF1 antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7505 RNASEH1-AS1 RNASEH1 antisense RNA 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7518 ADAM17 ADAM metallopeptidase domain 17 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7530 ODC1 ornithine decarboxylase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7539 TRIB2 tribbles pseudokinase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7546 RDH14 retinol dehydrogenase 14 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7547 MIR4757 microRNA 4757 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7554 PUM2 pumilio RNA binding family member 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7555 RHOB ras homolog family member B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7556 HS1BP3 HCLS1 binding protein 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7570 PTRHD1 peptidyl-tRNA hydrolase domain containing 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7573 DNAJC27 DnaJ heat shock protein family (Hsp40) member C27 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7574 EFR3B EFR3 homolog B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7579 ASXL2 ASXL transcriptional regulator 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7581 RAB10 RAB10, member RAS oncogene family 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7611 BABAM2-AS1 BABAM2 antisense RNA 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7616 SPDYA speedy/RINGO cell cycle regulator family member A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7618 WDR43 WD repeat domain 43 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7623 LBH LBH regulator of WNT signaling pathway 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7628 MEMO1 mediator of cell motility 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7629 SPAST spastin 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7631 YIPF4 Yip1 domain family member 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7660 PKDCC protein kinase domain containing, cytoplasmic 0.0000000 0.5555556 0.3333333 0.5000000 0.2857143 0.4106280 0.0464990
7667 THADA THADA armadillo repeat containing 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7685 STPG4 sperm-tail PG-rich repeat containing 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7686 MSH2 mutS homolog 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7690 FOXN2 forkhead box N2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7713 VRK2 VRK serine/threonine kinase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7718 KIAA1841 KIAA1841 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7721 USP34 ubiquitin specific peptidase 34 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7735 PELI1 pellino E3 ubiquitin protein ligase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7744 ACTR2 actin related protein 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7772 PCBP1-AS1 PCBP1 antisense RNA 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7784 TEX261 testis expressed 261 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7785 NAGK N-acetylglucosamine kinase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7798 SMYD5 SMYD family member 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7802 ALMS1 ALMS1 centrosome and basal body associated protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7805 STAMBP STAM binding protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7811 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7858 IMMT inner membrane mitochondrial protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7884 SNRNP200 small nuclear ribonucleoprotein U5 subunit 200 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7893 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7899 ACTR1B actin related protein 1B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7909 C2orf15 chromosome 2 open reading frame 15 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7912 TXNDC9 thioredoxin domain containing 9 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7913 REV1 REV1 DNA directed polymerase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7918 RPL31 ribosomal protein L31 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7920 CNOT11 CCR4-NOT transcription complex subunit 11 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7930 MRPS9 mitochondrial ribosomal protein S9 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7938 GCC2 GRIP and coiled-coil domain containing 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7948 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7951 ANAPC1 anaphase promoting complex subunit 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7953 TMEM87B transmembrane protein 87B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7954 ZC3H8 zinc finger CCCH-type containing 8 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7955 ZC3H6 zinc finger CCCH-type containing 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7971 INSIG2 insulin induced gene 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
7974 C2orf76 chromosome 2 open reading frame 76 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7980 RALB RAS like proto-oncogene B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7984 TSN translin 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
7989 MIR4783 microRNA 4783 0.0000000 0.3333333 0.3333333 0.1666667 0.5714286 0.4154589 0.0452981
8037 EPC2 enhancer of polycomb homolog 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8040 RBM43 RNA binding motif protein 43 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8045 STAM2 signal transducing adaptor molecule 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8046 FMNL2 formin like 2 0.0000000 0.5555556 0.6666667 0.5000000 0.5714286 0.4975845 0.0118317
8057 WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8060 BAZ2B bromodomain adjacent to zinc finger domain 2B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8067 PSMD14 proteasome 26S subunit, non-ATPase 14 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8089 PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8091 SSB small RNA binding exonuclease protection factor La 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8094 UBR3 ubiquitin protein ligase E3 component n-recognin 3 0.5714286 0.0000000 0.3333333 0.3333333 0.2857143 -0.4041868 0.0336518
8104 METTL8 methyltransferase like 8 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8107 HAT1 histone acetyltransferase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8115 SP3 Sp3 transcription factor 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8116 OLA1 Obg like ATPase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8125 ATP5MC3 ATP synthase membrane subunit c locus 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8126 LNPK lunapark, ER junction formation factor 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8131 NFE2L2 nuclear factor, erythroid 2 like 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8147 ITGA4 integrin subunit alpha 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8177 SLC39A10 solute carrier family 39 member 10 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8178 DNAH7 dynein axonemal heavy chain 7 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8231 BMPR2 bone morphogenetic protein receptor type 2 0.5714286 1.0000000 0.6666667 1.0000000 0.8571429 0.3091787 0.0291497
8248 KLF7 Kruppel like factor 7 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8255 IDH1-AS1 IDH1 antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8256 PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8263 LANCL1 LanC like 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8266 BARD1 BRCA1 associated RING domain 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8272 XRCC5 X-ray repair cross complementing 5 0.4285714 0.1111111 0.0000000 0.0000000 0.1428571 -0.2979066 0.0497855
8299 NHEJ1 non-homologous end joining factor 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8309 DNPEP aspartyl aminopeptidase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8310 SPEG striated muscle enriched protein kinase 0.0000000 0.4444444 0.6666667 0.3333333 0.5714286 0.5217391 0.0086892
8323 MRPL44 mitochondrial ribosomal protein L44 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8325 CUL3 cullin 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8330 MFF mitochondrial fission factor 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8339 CAB39 calcium binding protein 39 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8342 PSMD1 proteasome 26S subunit, non-ATPase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8361 ATG16L1 autophagy related 16 like 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8371 LRRFIP1 LRR binding FLII interacting protein 1 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
8376 SCLY selenocysteine lyase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8392 CAPN10 calpain 10 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8401 STK25 serine/threonine kinase 25 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8404 DTYMK deoxythymidylate kinase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8405 ING5 inhibitor of growth family member 5 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8418 RBCK1 RANBP2-type and C3HC4-type zinc finger containing 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8419 TBC1D20 TBC1 domain family member 20 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8423 FAM110A family with sequence similarity 110 member A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8429 SDCBP2-AS1 SDCBP2 antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8453 C20orf27 chromosome 20 open reading frame 27 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8473 GPCPD1 glycerophosphocholine phosphodiesterase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8478 TMX4 thioredoxin related transmembrane protein 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8479 PLCB1 phospholipase C beta 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8493 RRBP1 ribosome binding protein 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8494 SNX5 sorting nexin 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8496 ZNF133 zinc finger protein 133 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8501 SMIM26 small integral membrane protein 26 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8506 RALGAPA2 Ral GTPase activating protein catalytic alpha subunit 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8507 KIZ kizuna centrosomal protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8508 XRN2 5’-3’ exoribonuclease 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8513 NAPB NSF attachment protein beta 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8521 ABHD12 abhydrolase domain containing 12 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8525 ZNF337 zinc finger protein 337 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8534 DUSP15 dual specificity phosphatase 15 0.0000000 0.5555556 0.6666667 0.1666667 0.5714286 0.4009662 0.0478727
8547 C20orf203 chromosome 20 open reading frame 203 0.1428571 0.7777778 0.6666667 0.3333333 0.7142857 0.3832528 0.0339567
8551 MAPRE1 microtubule associated protein RP/EB family member 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8559 E2F1 E2F transcription factor 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8565 AHCY adenosylhomocysteinase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8592 SCAND1 SCAN domain containing 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8603 DSN1 DSN1 component of MIS12 kinetochore complex 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8617 ACTR5 actin related protein 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8621 DHX35 DEAH-box helicase 35 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8632 IFT52 intraflagellar transport 52 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8635 OSER1-DT OSER1 divergent transcript 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8638 SERINC3 serine incorporator 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8646 STK4-AS1 STK4 antisense RNA 1 (head to head) 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
8677 SNORD12C small nucleolar RNA, C/D box 12C 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8715 VAPB VAMP associated protein B and C 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8729 SLMO2-ATP5E SLMO2-ATP5E readthrough 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8743 RPS21 ribosomal protein S21 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8752 DIDO1 death inducer-obliterator 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8764 PTK6 protein tyrosine kinase 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8800 C21orf91 chromosome 21 open reading frame 91 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8805 MRPL39 mitochondrial ribosomal protein L39 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8813 USP16 ubiquitin specific peptidase 16 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8814 CCT8 chaperonin containing TCP1 subunit 8 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8817 BACH1 BTB domain and CNC homolog 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8819 SOD1 superoxide dismutase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8822 URB1-AS1 URB1 antisense RNA 1 (head to head) 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8829 IFNAR1 interferon alpha and beta receptor subunit 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8831 TMEM50B transmembrane protein 50B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8832 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8834 DONSON downstream neighbor of SON 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8846 SETD4 SET domain containing 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8847 CBR1 carbonyl reductase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8857 PIGP phosphatidylinositol glycan anchor biosynthesis class P 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8864 HMGN1 high mobility group nucleosome binding domain 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8888 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8905 GATD3A glutamine amidotransferase like class 1 domain containing 3A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8933 PCNT pericentrin 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8950 PEX26 peroxisomal biogenesis factor 26 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
8981 KLHL22 kelch like family member 22 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8986 CRKL CRK like proto-oncogene, adaptor protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8988 THAP7-AS1 THAP7 antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
8995 SDF2L1 stromal cell derived factor 2 like 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9020 SLC2A11 solute carrier family 2 member 11 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9044 PITPNB phosphatidylinositol transfer protein beta 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9053 GAS2L1 growth arrest specific 2 like 1 0.0000000 0.4444444 0.6666667 0.3333333 0.5714286 0.4396135 0.0397280
9081 SELENOM selenoprotein M 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9088 DRG1 developmentally regulated GTP binding protein 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9095 DEPDC5 DEP domain containing 5, GATOR1 subcomplex subunit 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9106 MCM5 minichromosome maintenance complex component 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9117 MYH9 myosin heavy chain 9 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9162 DMC1 DNA meiotic recombinase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9211 POLR3H RNA polymerase III subunit H 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9226 NAGA alpha-N-acetylgalactosaminidase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9231 SERHL serine hydrolase like (pseudogene) 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9272 TBC1D22A TBC1 domain family member 22A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9295 SCO2 SCO cytochrome c oxidase assembly protein 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9299 SYCE3 synaptonemal complex central element protein 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9304 TRNT1 tRNA nucleotidyl transferase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9308 SETMAR SET domain and mariner transposase fusion gene 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9315 EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9322 MTMR14 myotubularin related protein 14 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9332 CRELD1 cysteine rich with EGF like domains 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9345 ATG7 autophagy related 7 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9349 TAMM41 TAM41 mitochondrial translocator assembly and maintenance homolog 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9352 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9359 HDAC11 histone deacetylase 11 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9365 SLC6A6 solute carrier family 6 member 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9368 MRPS25 mitochondrial ribosomal protein S25 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9376 DPH3 diphthamide biosynthesis 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9381 TBC1D5 TBC1 domain family member 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9385 EFHB EF-hand domain family member B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9386 KAT2B lysine acetyltransferase 2B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9394 MIR4442 microRNA 4442 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9395 NGLY1 N-glycanase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9396 OXSM 3-oxoacyl-ACP synthase, mitochondrial 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9397 NEK10 NIMA related kinase 10 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9398 SLC4A7 solute carrier family 4 member 7 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9429 ACAA1 acetyl-CoA acyltransferase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9443 EIF1B eukaryotic translation initiation factor 1B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9465 ABHD5 abhydrolase domain containing 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9466 TCAIM T cell activation inhibitor, mitochondrial 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9503 SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9506 MAP4 microtubule associated protein 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9508 ZNF589 zinc finger protein 589 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9512 TMA7 translation machinery associated 7 homolog 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9534 QRICH1 glutamine rich 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9569 TUSC2 tumor suppressor 2, mitochondrial calcium regulator 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9572 NPRL2 NPR2 like, GATOR1 complex subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9581 MANF mesencephalic astrocyte derived neurotrophic factor 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9610 RFT1 RFT1 homolog 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9613 DCP1A decapping mRNA 1A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9618 TASOR transcription activation suppressor 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9634 RPP14 ribonuclease P/MRP subunit p14 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9636 PDHB pyruvate dehydrogenase E1 beta subunit 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9639 FHIT fragile histidine triad diadenosine triphosphatase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9646 LRIG1 leucine rich repeats and immunoglobulin like domains 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9652 ARL6IP5 ADP ribosylation factor like GTPase 6 interacting protein 5 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9669 SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9672 FAM86DP family with sequence similarity 86 member D, pseudogene 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9680 DHFR2 dihydrofolate reductase 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9681 ARL6 ADP ribosylation factor like GTPase 6 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9683 RIOX2 ribosomal oxygenase 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9684 CLDND1 claudin domain containing 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9685 CPOX coproporphyrinogen oxidase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9686 DCBLD2 discoidin, CUB and LCCL domain containing 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9694 TFG trafficking from ER to golgi regulator 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9697 TRMT10C tRNA methyltransferase 10C, mitochondrial RNase P subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9703 NFKBIZ NFKB inhibitor zeta 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9707 CBLB Cbl proto-oncogene B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9711 IFT57 intraflagellar transport 57 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9717 NECTIN3 nectin cell adhesion molecule 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9719 PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9722 ABHD10 abhydrolase domain containing 10 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9733 NEPRO nucleolus and neural progenitor protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9734 CFAP44 cilia and flagella associated protein 44 0.0000000 0.2222222 0.0000000 0.1666667 0.4285714 0.2866345 0.0411643
9776 DTX3L deltex E3 ubiquitin ligase 3L 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9801 OSBPL11 oxysterol binding protein like 11 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9808 CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9819 RAB7A RAB7A, member RAS oncogene family 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9820 ACAD9 acyl-CoA dehydrogenase family member 9 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9826 CNBP CCHC-type zinc finger nucleic acid binding protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9828 HMCES 5-hydroxymethylcytosine binding, ES cell specific 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9837 FAM86HP family with sequence similarity 86, member A pseudogene 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9842 ASTE1 asteroid homolog 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9846 DNAJC13 DnaJ heat shock protein family (Hsp40) member C13 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9848 NPHP3 nephrocystin 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9856 MSL2 MSL complex subunit 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9862 DBR1 debranching RNA lariats 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9868 MRPS22 mitochondrial ribosomal protein S22 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9878 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9883 ATR ATR serine/threonine kinase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9885 TRPC1 transient receptor potential cation channel subfamily C member 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9888 LOC100289361 uncharacterized LOC100289361 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9894 PLSCR1 phospholipid scramblase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9899 COMMD2 COMM domain containing 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9900 RNF13 ring finger protein 13 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9905 ERICH6 glutamate rich 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9906 SIAH2 siah E3 ubiquitin protein ligase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9912 MBNL1-AS1 MBNL1 antisense RNA 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9917 DHX36 DEAH-box helicase 36 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9920 GMPS guanine monophosphate synthase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9927 CCNL1 cyclin L1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9931 GFM1 G elongation factor mitochondrial 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9932 LXN latexin 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9936 IL12A interleukin 12A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9941 KPNA4 karyopherin subunit alpha 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9944 NMD3 NMD3 ribosome export adaptor 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9954 LOC100128164 four and a half LIM domains 1 pseudogene 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9957 PRKCI protein kinase C iota 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9960 EIF5A2 eukaryotic translation initiation factor 5A2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9968 NCEH1 neutral cholesterol ester hydrolase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9982 FXR1 FMR1 autosomal homolog 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
9994 KLHL24 kelch like family member 24 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
9997 PARL presenilin associated rhomboid like 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10004 ALG3 ALG3 alpha-1,3- mannosyltransferase 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
10005 ALG3 ALG3 alpha-1,3- mannosyltransferase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10008 PSMD2 proteasome 26S subunit, non-ATPase 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10011 CLCN2 chloride voltage-gated channel 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10015 VPS8 VPS8 subunit of CORVET complex 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10025 TBCCD1 TBCC domain containing 1 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
10030 RPL39L ribosomal protein L39 like 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10059 TCTEX1D2 Tctex1 domain containing 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10061 UBXN7 UBX domain protein 7 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10073 BDH1 3-hydroxybutyrate dehydrogenase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10074 RUBCN rubicon autophagy regulator 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10085 LOC100129917 uncharacterized LOC100129917 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10094 MAEA macrophage erythroblast attacher 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10099 TACC3 transforming acidic coiled-coil containing protein 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10109 POLN DNA polymerase nu 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10113 RNF4 ring finger protein 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10125 GRK4 G protein-coupled receptor kinase 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10141 WFS1 wolframin ER transmembrane glycoprotein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10156 ABLIM2 actin binding LIM protein family member 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10186 ZCCHC4 zinc finger CCHC-type containing 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10187 ANAPC4 anaphase promoting complex subunit 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10190 SMIM20 small integral membrane protein 20 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10193 STIM2 stromal interaction molecule 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10215 UGDH-AS1 UGDH antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10224 SLC30A9 solute carrier family 30 member 9 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10227 ATP8A1 ATPase phospholipid transporting 8A1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10230 GNPDA2 glucosamine-6-phosphate deaminase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10233 ATP10D ATPase phospholipid transporting 10D (putative) 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10250 PDGFRA platelet derived growth factor receptor alpha 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10253 TMEM165 transmembrane protein 165 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10256 CEP135 centrosomal protein 135 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10270 CENPC centromere protein C 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10271 UBA6-AS1 UBA6 antisense RNA 1 (head to head) 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10278 GRSF1 G-rich RNA sequence binding factor 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10280 MOB1B MOB kinase activator 1B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10281 DCK deoxycytidine kinase 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
10284 COX18 cytochrome c oxidase assembly factor COX18 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10291 THAP6 THAP domain containing 6 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10293 CDKL2 cyclin dependent kinase like 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10297 NAAA N-acylethanolamine acid amidase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10311 LINC01094 long intergenic non-protein coding RNA 1094 0.8571429 0.2222222 0.3333333 0.5000000 0.5714286 -0.4605475 0.0325759
10333 ABRAXAS1 abraxas 1, BRCA1 A complex subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10352 FAM13A family with sequence similarity 13 member A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10358 PDLIM5 PDZ and LIM domain 5 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10360 STPG2 sperm tail PG-rich repeat containing 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10367 DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10372 PPP3CA protein phosphatase 3 catalytic subunit alpha 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10380 SLC9B1 solute carrier family 9 member B1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10389 PAPSS1 3’-phosphoadenosine 5’-phosphosulfate synthase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10391 HADH hydroxyacyl-CoA dehydrogenase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10397 OSTC oligosaccharyltransferase complex non-catalytic subunit 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10401 MCUB mitochondrial calcium uniporter dominant negative beta subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10408 FAM241A family with sequence similarity 241 member A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10409 AP1AR adaptor related protein complex 1 associated regulatory protein 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10421 USP53 ubiquitin specific peptidase 53 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10422 LOC645513 septin 7 pseudogene 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10431 QRFPR pyroglutamylated RFamide peptide receptor 0.0000000 0.5555556 0.3333333 0.1666667 0.4285714 0.3687601 0.0351560
10433 EXOSC9 exosome component 9 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10445 PLK4 polo like kinase 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10446 MFSD8 major facilitator superfamily domain containing 8 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10454 NOCT nocturnin 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10458 NDUFC1 NADH:ubiquinone oxidoreductase subunit C1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10466 ZNF330 zinc finger protein 330 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10477 MMAA metabolism of cobalamin associated A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10482 SLC10A7 solute carrier family 10 member 7 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10485 PRMT9 protein arginine methyltransferase 9 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10495 MIR4453HG MIR4453 host gene 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10496 TMEM154 transmembrane protein 154 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10497 TIGD4 tigger transposable element derived 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10512 NAF1 nuclear assembly factor 1 ribonucleoprotein 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10516 TMEM192 transmembrane protein 192 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10526 CLCN3 chloride voltage-gated channel 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10538 SPATA4 spermatogenesis associated 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10539 SPCS3 signal peptidase complex subunit 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10541 NEIL3 nei like DNA glycosylase 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10542 AGA aspartylglucosaminidase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10544 DCTD dCMP deaminase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10547 ING2 inhibitor of growth family member 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10555 CFAP97 cilia and flagella associated protein 97 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10582 MED10 mediator complex subunit 10 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10588 C5orf49 chromosome 5 open reading frame 49 0.1428571 0.7777778 0.6666667 0.5000000 0.7142857 0.4557166 0.0201865
10589 MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10597 DAP death associated protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10603 ZNF622 zinc finger protein 622 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10611 ZFR zinc finger RNA binding protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10615 AMACR alpha-methylacyl-CoA racemase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10618 BRIX1 biogenesis of ribosomes BRX1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10619 DNAJC21 DnaJ heat shock protein family (Hsp40) member C21 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10623 SKP2 S-phase kinase associated protein 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10624 NADK2 NAD kinase 2, mitochondrial 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10638 TTC33 tetratricopeptide repeat domain 33 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10642 OXCT1 3-oxoacid CoA-transferase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10652 ZNF131 zinc finger protein 131 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10657 C5orf34 chromosome 5 open reading frame 34 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10659 NNT-AS1 NNT antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10671 ARL15 ADP ribosylation factor like GTPase 15 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10680 MTREX Mtr4 exosome RNA helicase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10681 RNF138P1 ring finger protein 138 pseudogene 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10683 SLC38A9 solute carrier family 38 member 9 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10687 MIER3 MIER family member 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10696 KIF2A kinesin family member 2A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10707 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10710 MAST4 microtubule associated serine/threonine kinase family member 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10711 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10717 CDK7 cyclin dependent kinase 7 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10719 RAD17 RAD17 checkpoint clamp loader component 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10728 BTF3 basic transcription factor 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10743 AGGF1 angiogenic factor with G-patch and FHA domains 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10746 TBCA tubulin folding cofactor A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10748 SCAMP1 secretory carrier membrane protein 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10752 HOMER1 homer scaffold protein 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10753 TENT2 terminal nucleotidyltransferase 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10754 MTX3 metaxin 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10756 ZFYVE16 zinc finger FYVE-type containing 16 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10757 FAM151B family with sequence similarity 151 member B 0.0000000 0.5555556 0.6666667 0.3333333 0.5714286 0.4396135 0.0353280
10763 RPS23 ribosomal protein S23 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10777 POLR3G RNA polymerase III subunit G 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10786 FAM172A family with sequence similarity 172 member A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10792 RFESD Rieske Fe-S domain containing 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10798 CAST calpastatin 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10800 ERAP1 endoplasmic reticulum aminopeptidase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10802 LNPEP leucyl and cystinyl aminopeptidase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10811 ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10813 SLCO4C1 solute carrier organic anion transporter family member 4C1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10818 FBXL17 F-box and leucine rich repeat protein 17 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10828 WDR36 WD repeat domain 36 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10830 STARD4-AS1 STARD4 antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10832 EPB41L4A-AS1 EPB41L4A antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10836 APC APC regulator of WNT signaling pathway 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10839 REEP5 receptor accessory protein 5 0.5714286 1.0000000 1.0000000 0.8333333 0.8571429 0.3091787 0.0291497
10844 YTHDC2 YTH domain containing 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10849 FEM1C fem-1 homolog C 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10854 COMMD10 COMM domain containing 10 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10855 DTWD2 DTW domain containing 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10862 SNX2 sorting nexin 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10880 RAPGEF6 Rap guanine nucleotide exchange factor 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10888 IRF1 interferon regulatory factor 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10889 IRF1 interferon regulatory factor 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10890 RAD50 RAD50 double strand break repair protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10902 VDAC1 voltage dependent anion channel 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10912 JADE2 jade family PHD finger 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10916 CAMLG calcium modulating ligand 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10919 C5orf24 chromosome 5 open reading frame 24 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10921 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10923 MACROH2A1 macroH2A.1 histone 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
10928 KLHL3 kelch like family member 3 0.1428571 0.4444444 0.6666667 0.5000000 0.5714286 0.3671498 0.0325543
10936 FAM53C family with sequence similarity 53 member C 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10959 PURA purine rich element binding protein A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10969 TMCO6 transmembrane and coiled-coil domains 6 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10971 WDR55 WD repeat domain 55 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10984 DIAPH1 diaphanous related formin 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
10990 RNF14 ring finger protein 14 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10994 ARHGAP26 Rho GTPase activating protein 26 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
10995 NR3C1 nuclear receptor subfamily 3 group C member 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11004 PPP2R2B-IT1 PPP2R2B intronic transcript 1 0.7142857 0.2222222 0.3333333 0.1666667 0.2857143 -0.5152979 0.0059759
11006 JAKMIP2 janus kinase and microtubule interacting protein 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11022 RPS14 ribosomal protein S14 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11023 RBM22 RNA binding motif protein 22 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11038 FAM114A2 family with sequence similarity 114 member A2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11041 SAP30L-AS1 SAP30L antisense RNA 1 (head to head) 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11044 CNOT8 CCR4-NOT transcription complex subunit 8 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11063 RNF145 ring finger protein 145 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11064 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11076 MAT2B methionine adenosyltransferase 2B 0.5714286 0.3333333 0.0000000 0.1666667 0.2857143 -0.3784219 0.0347546
11077 MAT2B methionine adenosyltransferase 2B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11081 SPDL1 spindle apparatus coiled-coil protein 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11088 NPM1 nucleophosmin 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11105 BNIP1 BCL2 interacting protein 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11115 KIAA1191 KIAA1191 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11116 ARL10 ADP ribosylation factor like GTPase 10 0.0000000 0.6666667 0.0000000 0.3333333 0.7142857 0.4557166 0.0350399
11126 TSPAN17 tetraspanin 17 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11128 ZNF346 zinc finger protein 346 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11137 PRR7 proline rich 7, synaptic 0.4285714 0.0000000 0.0000000 0.0000000 0.2857143 -0.3478261 0.0261378
11140 PDLIM7 PDZ and LIM domain 7 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11150 CLK4 CDC like kinase 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11151 ZNF354A zinc finger protein 354A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11161 MGAT4B alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B 0.2857143 0.7777778 0.6666667 0.6666667 0.8571429 0.4380032 0.0474327
11169 MAPK9 mitogen-activated protein kinase 9 0.7142857 0.1111111 0.0000000 0.1666667 0.2857143 -0.5797101 0.0001285
11173 MGAT1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11175 HEIH hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA 0.5714286 0.0000000 0.0000000 0.1666667 0.1428571 -0.4283414 0.0084399
11181 MYLK4 myosin light chain kinase family member 4 1.0000000 0.4444444 1.0000000 0.6666667 0.8571429 -0.4025765 0.0276467
11206 FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11216 EEF1E1-BLOC1S5 EEF1E1-BLOC1S5 readthrough (NMD candidate) 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11225 SMIM13 small integral membrane protein 13 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11227 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11232 TBC1D7 TBC1 domain family member 7 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11234 SIRT5 sirtuin 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11235 NOL7 nucleolar protein 7 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11239 CD83 CD83 molecule 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
11248 NUP153 nucleoporin 153 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11268 TDP2 tyrosyl-DNA phosphodiesterase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11271 GMNN geminin DNA replication inhibitor 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11392 HCG27 HLA complex group 27 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11422 VWA7 von Willebrand factor A domain containing 7 0.1428571 0.8888889 0.6666667 0.5000000 0.7142857 0.5201288 0.0045242
11448 TAP2 transporter 2, ATP binding cassette subfamily B member 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11451 LOC100294145 uncharacterized LOC100294145 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11482 LEMD2 LEM domain containing 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11486 SMIM29 small integral membrane protein 29 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11498 PPARD peroxisome proliferator activated receptor delta 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11500 RPL10A ribosomal protein L10a 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11531 TMEM217 transmembrane protein 217 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11552 TOMM6 translocase of outer mitochondrial membrane 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11555 CCND3 cyclin D3 0.0000000 0.5555556 0.6666667 0.5000000 0.2857143 0.5040258 0.0239155
11570 PEX6 peroxisomal biogenesis factor 6 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11583 ZNF318 zinc finger protein 318 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11605 SUPT3H SPT3 homolog, SAGA and STAGA complex component 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11620 EFHC1 EF-hand domain containing 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11628 ELOVL5 ELOVL fatty acid elongase 5 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11634 BAG2 BCL2 associated athanogene 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11637 PHF3 PHD finger protein 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11641 SDHAF4 succinate dehydrogenase complex assembly factor 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11648 OOEP oocyte expressed protein 0.2857143 0.7777778 0.6666667 0.6666667 0.7142857 0.3977456 0.0247321
11660 PHIP pleckstrin homology domain interacting protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11667 TENT5A terminal nucleotidyltransferase 5A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11668 IBTK inhibitor of Bruton tyrosine kinase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11672 DOP1A DOP1 leucine zipper like protein A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11676 CYB5R4 cytochrome b5 reductase 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11680 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11687 SLC35A1 solute carrier family 35 member A1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11691 RNGTT RNA guanylyltransferase and 5’-phosphatase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11698 LYRM2 LYR motif containing 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11702 MANEA mannosidase endo-alpha 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11703 UFL1 UFM1 specific ligase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11705 NDUFAF4 NADH:ubiquinone oxidoreductase complex assembly factor 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11706 KLHL32 kelch like family member 32 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11716 ASCC3 activating signal cointegrator 1 complex subunit 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11717 HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11739 ARMC2 armadillo repeat containing 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11750 GTF3C6 general transcription factor IIIC subunit 6 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11751 RPF2 ribosome production factor 2 homolog 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11760 FYN FYN proto-oncogene, Src family tyrosine kinase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11779 CEP85L centrosomal protein 85 like 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11798 NCOA7 nuclear receptor coactivator 7 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11803 RNF146 ring finger protein 146 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11823 TBPL1 TATA-box binding protein like 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11830 HBS1L HBS1 like translational GTPase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11833 PDE7B phosphodiesterase 7B 0.0000000 0.4444444 0.6666667 0.3333333 0.1428571 0.4106280 0.0221890
11837 MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11850 REPS1 RALBP1 associated Eps domain containing 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11866 PLAGL1 PLAG1 like zinc finger 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11872 LOC100507557 uncharacterized LOC100507557 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11899 ZBTB2 zinc finger and BTB domain containing 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11907 MTRF1L mitochondrial translational release factor 1 like 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11912 MIR4466 microRNA 4466 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11914 TMEM242 transmembrane protein 242 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11918 GTF2H5 general transcription factor IIH subunit 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11932 MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11935 CAHM colon adenocarcinoma hypermethylated 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11938 MPC1 mitochondrial pyruvate carrier 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11945 FGFR1OP FGFR1 oncogene partner 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11961 SUN1 Sad1 and UNC84 domain containing 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11969 ZFAND2A zinc finger AN1-type containing 2A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11970 MICALL2 MICAL like 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
11986 GNA12 G protein subunit alpha 12 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11988 SDK1 sidekick cell adhesion molecule 1 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
11990 AP5Z1 adaptor related protein complex 5 subunit zeta 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
11999 ACTB actin beta 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12008 USP42 ubiquitin specific peptidase 42 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12036 BZW2 basic leucine zipper and W2 domains 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12039 SNX13 sorting nexin 13 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12055 KLHL7-DT KLHL7 divergent transcript 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12066 OSBPL3 oxysterol binding protein like 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12085 TAX1BP1 Tax1 binding protein 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12101 LSM5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12104 KBTBD2 kelch repeat and BTB domain containing 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12133 RALA RAS like proto-oncogene A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12137 C7orf25 chromosome 7 open reading frame 25 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12150 POLD2 DNA polymerase delta 2, accessory subunit 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12151 YKT6 YKT6 v-SNARE homolog 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12164 CCM2 CCM2 scaffold protein 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12171 HUS1 HUS1 checkpoint clamp component 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12178 SEC61G SEC61 translocon gamma subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12179 LANCL2 LanC like 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12183 MRPS17 mitochondrial ribosomal protein S17 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12197 LOC441242 uncharacterized LOC441242 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12207 RABGEF1 RAB guanine nucleotide exchange factor 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12209 TMEM248 transmembrane protein 248 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12229 BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12240 GTF2I general transcription factor IIi 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12241 GTF2IRD2 GTF2I repeat domain containing 2 0.5714286 1.0000000 1.0000000 0.8333333 0.8571429 0.2995169 0.0139971
12245 GTF2IRD2B GTF2I repeat domain containing 2B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12251 RHBDD2 rhomboid domain containing 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12253 TMEM120A transmembrane protein 120A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12276 DMTF1 cyclin D binding myb like transcription factor 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12279 ABCB1 ATP binding cassette subfamily B member 1 0.5714286 0.0000000 0.0000000 0.3333333 0.1428571 -0.4524960 0.0058702
12282 DBF4 DBF4 zinc finger 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12288 GTPBP10 GTP binding protein 10 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12289 CLDN12 claudin 12 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12291 MTERF1 mitochondrial transcription termination factor 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12298 FAM133B family with sequence similarity 133 member B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12312 PON1 paraoxonase 1 0.2857143 0.5555556 0.3333333 0.5000000 0.5714286 0.3027375 0.0218335
12320 SDHAF3 succinate dehydrogenase complex assembly factor 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12323 LMTK2 lemur tyrosine kinase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12339 FAM200A family with sequence similarity 200 member A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12349 MCM7 minichromosome maintenance complex component 7 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12387 FIS1 fission, mitochondrial 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12395 FBXL13 F-box and leucine rich repeat protein 13 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12402 ORC5 origin recognition complex subunit 5 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12403 KMT2E-AS1 KMT2E antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12422 DLD dihydrolipoamide dehydrogenase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12437 TES testin LIM domain protein 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12443 CAPZA2 capping actin protein of muscle Z-line subunit alpha 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12463 LRRC4 leucine rich repeat containing 4 0.1428571 0.7777778 0.3333333 0.5000000 0.7142857 0.4557166 0.0236367
12472 CALU calumenin 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12475 ATP6V1F ATPase H+ transporting V1 subunit F 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12482 STRIP2 striatin interacting protein 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12489 CEP41 centrosomal protein 41 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12502 AKR1B1 aldo-keto reductase family 1 member B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12504 AGBL3 ATP/GTP binding protein like 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12507 WDR91 WD repeat domain 91 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12509 NUP205 nucleoporin 205 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12511 LUZP6 leucine zipper protein 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12523 LUC7L2 LUC7 like 2, pre-mRNA splicing factor 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12534 NDUFB2-AS1 NDUFB2 antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12535 BRAF B-Raf proto-oncogene, serine/threonine kinase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12542 GSTK1 glutathione S-transferase kappa 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12543 CASP2 caspase 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12555 TPK1 thiamin pyrophosphokinase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12559 PDIA4 protein disulfide isomerase family A member 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12573 ZNF862 zinc finger protein 862 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12578 ZNF775 zinc finger protein 775 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12595 FASTK Fas activated serine/threonine kinase 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12625 LMBR1 limb development membrane protein 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12628 UBE3C ubiquitin protein ligase E3C 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12632 NCAPG2 non-SMC condensin II complex subunit G2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12638 ERICH1 glutamate rich 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12646 AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12651 ERI1 exoribonuclease 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12657 XKR6 XK related 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12673 VPS37A VPS37A subunit of ESCRT-I 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12678 ASAH1 N-acylsphingosine amidohydrolase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12686 ATP6V1B2 ATPase H+ transporting V1 subunit B2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12715 TNFRSF10C TNF receptor superfamily member 10c 0.0000000 0.6666667 0.6666667 0.3333333 0.7142857 0.5362319 0.0161788
12751 SARAF store-operated calcium entry associated regulatory factor 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12766 ERLIN2 ER lipid raft associated 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12770 BRF2 BRF2 RNA polymerase III transcription initiation factor subunit 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12790 KAT6A lysine acetyltransferase 6A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12796 VDAC3 voltage dependent anion channel 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12805 MCM4 minichromosome maintenance complex component 4 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12808 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12810 ATP6V1H ATPase H+ transporting V1 subunit H 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12813 MRPL15 mitochondrial ribosomal protein L15 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12816 SNORD54 small nucleolar RNA, C/D box 54 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12817 PLAG1 PLAG1 zinc finger 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12821 SDCBP syndecan binding protein 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12828 MIR4470 microRNA 4470 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12830 YTHDF3-AS1 YTHDF3 antisense RNA 1 (head to head) 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12831 LINC01299 long intergenic non-protein coding RNA 1299 0.5714286 0.1111111 0.3333333 0.0000000 0.2857143 -0.4347826 0.0236567
12841 SGK3 serum/glucocorticoid regulated kinase family member 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12843 SNHG6 small nucleolar RNA host gene 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12845 PPP1R42 protein phosphatase 1 regulatory subunit 42 0.1428571 0.5555556 0.3333333 0.3333333 0.5714286 0.3268921 0.0468408
12863 UBE2W ubiquitin conjugating enzyme E2 W 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12868 GDAP1 ganglioside induced differentiation associated protein 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12869 PEX2 peroxisomal biogenesis factor 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12870 PKIA cAMP-dependent protein kinase inhibitor alpha 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12871 ZC2HC1A zinc finger C2HC-type containing 1A 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12875 MRPS28 mitochondrial ribosomal protein S28 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12884 ZFAND1 zinc finger AN1-type containing 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12891 WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12904 RBM12B RNA binding motif protein 12B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12905 TMEM67 transmembrane protein 67 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12912 INTS8 integrator complex subunit 8 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12915 NDUFAF6 NADH:ubiquinone oxidoreductase complex assembly factor 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12918 UQCRB ubiquinol-cytochrome c reductase binding protein 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12946 UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12950 ATP6V1C1 ATPase H+ transporting V1 subunit C1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12973 MIR3610 microRNA 3610 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12976 EXT1 exostosin glycosyltransferase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12987 DERL1 derlin 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12991 ATAD2 ATPase family AAA domain containing 2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
12994 FAM91A1 family with sequence similarity 91 member A1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12995 TMEM65 transmembrane protein 65 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
12997 RNF139 ring finger protein 139 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13023 PHF20L1 PHD finger protein 20 like 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13027 NDRG1 N-myc downstream regulated 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13063 PUF60 poly(U) binding splicing factor 60 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13098 ZNF7 zinc finger protein 7 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13119 RFX3 regulatory factor X3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13135 RIC1 RIC1 homolog, RAB6A GEF complex partner 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13136 ERMP1 endoplasmic reticulum metallopeptidase 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13138 RANBP6 RAN binding protein 6 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13142 KDM4C lysine demethylase 4C 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13143 DMAC1 distal membrane arm assembly complex 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13145 NFIB nuclear factor I B 0.0000000 0.4444444 0.6666667 0.5000000 0.5714286 0.4589372 0.0119370
13149 SNAPC3 small nuclear RNA activating complex polypeptide 3 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13164 HACD4 3-hydroxyacyl-CoA dehydratase 4 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13167 KLHL9 kelch like family member 9 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13171 CDKN2B-AS1 CDKN2B antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13175 IFT74 intraflagellar transport 74 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13183 SMIM27 small integral membrane protein 27 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13187 SMU1 SMU1 DNA replication regulator and spliceosomal factor 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13199 UBE2R2 ubiquitin conjugating enzyme E2 R2 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13204 MYORG myogenesis regulating glycosidase (putative) 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13217 PIGO phosphatidylinositol glycan anchor biosynthesis class O 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13219 FAM214B family with sequence similarity 214 member B 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13221 FAM214B family with sequence similarity 214 member B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13236 TMEM8B transmembrane protein 8B 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13245 ZCCHC7 zinc finger CCHC-type containing 7 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13248 POLR1E RNA polymerase I subunit E 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13250 TOMM5 translocase of outer mitochondrial membrane 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13267 SMC5-AS1 SMC5 antisense RNA 1 (head to head) 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13268 KLF9 Kruppel like factor 9 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13272 ZFAND5 zinc finger AN1-type containing 5 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13286 VPS13A-AS1 VPS13A antisense RNA 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13295 KIF27 kinesin family member 27 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13316 ROR2 receptor tyrosine kinase like orphan receptor 2 0.0000000 0.5555556 0.6666667 0.5000000 0.4285714 0.4476651 0.0258894
13320 IARS1 isoleucyl-tRNA synthetase 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13323 BICD2 BICD cargo adaptor 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13325 ZNF484 zinc finger protein 484 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13369 TSTD2 thiosulfate sulfurtransferase like domain containing 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13372 TRMO tRNA methyltransferase O 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13375 NANS N-acetylneuraminate synthase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13383 TGFBR1 transforming growth factor beta receptor 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13385 NR4A3 nuclear receptor subfamily 4 group A member 3 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13395 NIPSNAP3A nipsnap homolog 3A 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13406 ABITRAM actin binding transcription modulator 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13428 SLC31A1 solute carrier family 31 member 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13429 FKBP15 FKBP prolyl isomerase 15 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13433 ALAD aminolevulinate dehydratase 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13434 C9orf43 chromosome 9 open reading frame 43 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13449 TRIM32 tripartite motif containing 32 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13451 MEGF9 multiple EGF like domains 9 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13461 GSN gelsolin 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13471 RABGAP1 RAB GTPase activating protein 1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13479 RPL35 ribosomal protein L35 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13481 GOLGA1 golgin A1 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13483 PPP6C protein phosphatase 6 catalytic subunit 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13496 RPL12 ribosomal protein L12 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13505 SH2D3C SH2 domain containing 3C 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13535 ODF2 outer dense fiber of sperm tails 2 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13556 IER5L immediate early response 5 like 0.8571429 1.0000000 1.0000000 1.0000000 1.0000000 0.1545894 0.0469135
13562 PRRX2 paired related homeobox 2 0.1428571 0.6666667 0.6666667 0.3333333 0.7142857 0.3913043 0.0457287
13642 TMEM141 transmembrane protein 141 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984
13664 ANAPC2 anaphase promoting complex subunit 2 0.5714286 1.0000000 0.6666667 0.8333333 1.0000000 0.3188406 0.0171174
13677 ARRDC1 arrestin domain containing 1 0.7142857 1.0000000 1.0000000 1.0000000 1.0000000 0.2512077 0.0090984