PEC3: ATAC-seq, CD8

Instalación y carga de packages

``{r installing} if (!requireNamespace(“BiocManager”, quietly = TRUE)) install.packages(“BiocManager”)

BiocManager::install(“limma”) BiocManager::install(“topGO”) BiocManager::install(“GO.db”) BiocManager::install(“org.Hs.eg.db”) BiocManager::install(“rtracklayer”) BiocManager::install(“GenomicRanges”) BiocManager::install(“ChIPQC”) BiocManager::install(“ChIPseeker”) BiocManager::install(“TxDb.Hsapiens.UCSC.hg19.knownGene”) install_github(“ColeWunderlich/soGGi”) BiocManager::install(“Rsubread”) BiocManager::install(“venn”)

library(devtools)

## Loading required package: usethis

library(rtracklayer)

## Loading required package: GenomicRanges

## Loading required package: stats4

## Loading required package: BiocGenerics

## Loading required package: parallel

## 
## Attaching package: 'BiocGenerics'

## The following objects are masked from 'package:parallel':
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##     clusterExport, clusterMap, parApply, parCapply, parLapply,
##     parLapplyLB, parRapply, parSapply, parSapplyLB

## The following objects are masked from 'package:stats':
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## The following objects are masked from 'package:base':
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##     dirname, do.call, duplicated, eval, evalq, Filter, Find, get, grep,
##     grepl, intersect, is.unsorted, lapply, Map, mapply, match, mget,
##     order, paste, pmax, pmax.int, pmin, pmin.int, Position, rank,
##     rbind, Reduce, rownames, sapply, setdiff, sort, table, tapply,
##     union, unique, unsplit, which, which.max, which.min

## Loading required package: S4Vectors

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## Attaching package: 'S4Vectors'

## The following object is masked from 'package:base':
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##     expand.grid

## Loading required package: IRanges

## Loading required package: GenomeInfoDb

library(GenomicRanges)
library(ChIPQC)

## Loading required package: ggplot2

## Loading required package: DiffBind

## Loading required package: SummarizedExperiment

## Loading required package: Biobase

## Welcome to Bioconductor
## 
##     Vignettes contain introductory material; view with
##     'browseVignettes()'. To cite Bioconductor, see
##     'citation("Biobase")', and for packages 'citation("pkgname")'.

## Loading required package: DelayedArray

## Loading required package: matrixStats

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## Attaching package: 'matrixStats'

## The following objects are masked from 'package:Biobase':
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##     anyMissing, rowMedians

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## Attaching package: 'DelayedArray'

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##     colMaxs, colMins, colRanges, rowMaxs, rowMins, rowRanges

## The following objects are masked from 'package:base':
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library(DT)
library(dplyr)

## 
## Attaching package: 'dplyr'

## The following object is masked from 'package:matrixStats':
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## The following objects are masked from 'package:stats':
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##     filter, lag

## The following objects are masked from 'package:base':
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##     intersect, setdiff, setequal, union

library(tidyr)

## 
## Attaching package: 'tidyr'

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##     expand

library(ChIPseeker)

## ChIPseeker v1.24.0  For help: https://guangchuangyu.github.io/software/ChIPseeker
## 
## If you use ChIPseeker in published research, please cite:
## Guangchuang Yu, Li-Gen Wang, Qing-Yu He. ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization. Bioinformatics 2015, 31(14):2382-2383

library(TxDb.Hsapiens.UCSC.hg19.knownGene)

## Loading required package: GenomicFeatures

## Loading required package: AnnotationDbi

## 
## Attaching package: 'AnnotationDbi'

## The following object is masked from 'package:dplyr':
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##     select

library(soGGi)

## Warning: replacing previous import 'ggplot2::Position' by
## 'BiocGenerics::Position' when loading 'soGGi'

library(limma)

## 
## Attaching package: 'limma'

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library(venn)
library(tidyr)
library(Rsubread)
library(csaw)
library(edgeR)
library(UpSetR)
library(enrichR)

## Welcome to enrichR
## Checking connection ...

## Connection is Live!

Lectura y carga de los datos de muestras ATAC-seq

setwd("/Users/javi/Documents/Master Bioinformática UOC/Proyecto fin de máster/Datos originales/ATAC-seq/GSE111013_RAW")
list.filenames<-list.files(pattern ="CD8.peaks.narrowPeak.gz$")
list.filenames

##  [1] "GSM3020245_ATAC-seq_CLL1_0d_CD8.peaks.narrowPeak.gz"  
##  [2] "GSM3020246_ATAC-seq_CLL1_3d_CD8.peaks.narrowPeak.gz"  
##  [3] "GSM3020247_ATAC-seq_CLL1_030d_CD8.peaks.narrowPeak.gz"
##  [4] "GSM3020248_ATAC-seq_CLL1_120d_CD8.peaks.narrowPeak.gz"
##  [5] "GSM3020266_ATAC-seq_CLL2_0d_CD8.peaks.narrowPeak.gz"  
##  [6] "GSM3020267_ATAC-seq_CLL2_3d_CD8.peaks.narrowPeak.gz"  
##  [7] "GSM3020268_ATAC-seq_CLL2_8d_CD8.peaks.narrowPeak.gz"  
##  [8] "GSM3020269_ATAC-seq_CLL2_30d_CD8.peaks.narrowPeak.gz" 
##  [9] "GSM3020270_ATAC-seq_CLL2_120d_CD8.peaks.narrowPeak.gz"
## [10] "GSM3020286_ATAC-seq_CLL4_0d_CD8.peaks.narrowPeak.gz"  
## [11] "GSM3020287_ATAC-seq_CLL4_3d_CD8.peaks.narrowPeak.gz"  
## [12] "GSM3020311_ATAC-seq_CLL5_0d_CD8.peaks.narrowPeak.gz"  
## [13] "GSM3020312_ATAC-seq_CLL5_1d_CD8.peaks.narrowPeak.gz"  
## [14] "GSM3020313_ATAC-seq_CLL5_2d_CD8.peaks.narrowPeak.gz"  
## [15] "GSM3020314_ATAC-seq_CLL5_3d_CD8.peaks.narrowPeak.gz"  
## [16] "GSM3020315_ATAC-seq_CLL5_8d_CD8.peaks.narrowPeak.gz"  
## [17] "GSM3020316_ATAC-seq_CLL5_30d_CD8.peaks.narrowPeak.gz" 
## [18] "GSM3020317_ATAC-seq_CLL5_150d_CD8.peaks.narrowPeak.gz"
## [19] "GSM3020318_ATAC-seq_CLL5_240d_CD8.peaks.narrowPeak.gz"
## [20] "GSM3020343_ATAC-seq_CLL6_0d_CD8.peaks.narrowPeak.gz"  
## [21] "GSM3020344_ATAC-seq_CLL6_030d_CD8.peaks.narrowPeak.gz"
## [22] "GSM3020345_ATAC-seq_CLL6_120d_CD8.peaks.narrowPeak.gz"
## [23] "GSM3020346_ATAC-seq_CLL6_280d_CD8.peaks.narrowPeak.gz"
## [24] "GSM3020366_ATAC-seq_CLL7_0d_CD8.peaks.narrowPeak.gz"  
## [25] "GSM3020367_ATAC-seq_CLL7_1d_CD8.peaks.narrowPeak.gz"  
## [26] "GSM3020368_ATAC-seq_CLL7_3d_CD8.peaks.narrowPeak.gz"  
## [27] "GSM3020369_ATAC-seq_CLL7_8d_CD8.peaks.narrowPeak.gz"  
## [28] "GSM3020370_ATAC-seq_CLL7_30d_CD8.peaks.narrowPeak.gz" 
## [29] "GSM3020371_ATAC-seq_CLL7_150d_CD8.peaks.narrowPeak.gz"
## [30] "GSM3020383_ATAC-seq_CLL8_0d_CD8.peaks.narrowPeak.gz"  
## [31] "GSM3020384_ATAC-seq_CLL8_3d_CD8.peaks.narrowPeak.gz"  
## [32] "GSM3020385_ATAC-seq_CLL8_030d_CD8.peaks.narrowPeak.gz"

list.data<-list()
for (i in 1:length(list.filenames)){
list.data[[i]]<-import(list.filenames[i], "narrowPeak")

}
names(list.data)<-list.filenames
CD8.data<-list.data

a<-CD8.data$`GSM3020245_ATAC-seq_CLL1_0d_CD8.peaks.narrowPeak.gz`

hist(a$score)

as.matrix(summary(as.factor(a@seqnames)))

##                       [,1]
## chr1                  5041
## chr10                 2444
## chr11                 2644
## chr12                 2763
## chr13                 1382
## chr14                 1822
## chr15                 1483
## chr16                 1653
## chr17                 2233
## chr17_gl000205_random    4
## chr18                 1064
## chr19                 2042
## chr19_gl000208_random    1
## chr1_gl000191_random     2
## chr1_gl000192_random     3
## chr2                  4354
## chr20                 1213
## chr21                  539
## chr22                  852
## chr3                  3481
## chr4                  2377
## chr5                  2827
## chr6                  3444
## chr7                  2698
## chr7_gl000195_random     7
## chr8                  2167
## chr9                  1980
## chr9_gl000199_random     1
## chrM                    10
## chrUn_gl000214           1
## chrUn_gl000219          10
## chrUn_gl000220          19
## chrUn_gl000224           3
## chrUn_gl000226           2
## chrX                  1711

short.names<-sapply(strsplit(list.filenames, "-seq_"), "[", 2)
short.names<-sapply(strsplit(short.names, ".peaks"), "[", 1)
short.names

##  [1] "CLL1_0d_CD8"   "CLL1_3d_CD8"   "CLL1_030d_CD8" "CLL1_120d_CD8"
##  [5] "CLL2_0d_CD8"   "CLL2_3d_CD8"   "CLL2_8d_CD8"   "CLL2_30d_CD8" 
##  [9] "CLL2_120d_CD8" "CLL4_0d_CD8"   "CLL4_3d_CD8"   "CLL5_0d_CD8"  
## [13] "CLL5_1d_CD8"   "CLL5_2d_CD8"   "CLL5_3d_CD8"   "CLL5_8d_CD8"  
## [17] "CLL5_30d_CD8"  "CLL5_150d_CD8" "CLL5_240d_CD8" "CLL6_0d_CD8"  
## [21] "CLL6_030d_CD8" "CLL6_120d_CD8" "CLL6_280d_CD8" "CLL7_0d_CD8"  
## [25] "CLL7_1d_CD8"   "CLL7_3d_CD8"   "CLL7_8d_CD8"   "CLL7_30d_CD8" 
## [29] "CLL7_150d_CD8" "CLL8_0d_CD8"   "CLL8_3d_CD8"   "CLL8_030d_CD8"

short.names[3]<-"CLL1_30d_CD8"
short.names[21]<-"CLL6_30d_CD8"
short.names[32]<-"CLL8_30d_CD8"

Filtrado de picos detectados

Filtramos los datos para mantener sólo aquellos pertenecientes a los cromosomas canónicos y no sexuales. Eliminamos también los picos artefactales asociados a “blacklists”

setwd("/Users/javi/Documents/Master Bioinformática UOC/Proyecto fin de máster/PEC3 ATAC-seq")
blkList <- import.bed("hg19-blacklist.v2.bed.gz")
Canonical_chrom<-c("chr1", "chr2", "chr3", "chr4","chr5", "chr6","chr7", "chr8","chr9", "chr10","chr11", "chr12","chr13", "chr14","chr15", "chr16","chr17", "chr18","chr19", "chr20", "chr21", "chr22")
CD8.filtered<-list()
CD8.data[[1]]

## GRanges object with 52277 ranges and 6 metadata columns:
##           seqnames              ranges strand |                          name
##              <Rle>           <IRanges>  <Rle> |                   <character>
##       [1]     chr1         10069-10311      * |     ATAC-seq_FE_0d_CD8_peak_1
##       [2]     chr1       569790-570064      * |     ATAC-seq_FE_0d_CD8_peak_2
##       [3]     chr1       713839-714391      * |     ATAC-seq_FE_0d_CD8_peak_3
##       [4]     chr1       839840-840211      * |     ATAC-seq_FE_0d_CD8_peak_4
##       [5]     chr1       894618-894764      * |     ATAC-seq_FE_0d_CD8_peak_5
##       ...      ...                 ...    ... .                           ...
##   [52273]     chrX 154807285-154807739      * | ATAC-seq_FE_0d_CD8_peak_52273
##   [52274]     chrX 154822263-154822422      * | ATAC-seq_FE_0d_CD8_peak_52274
##   [52275]     chrX 154841871-154842108      * | ATAC-seq_FE_0d_CD8_peak_52275
##   [52276]     chrX 154842537-154842743      * | ATAC-seq_FE_0d_CD8_peak_52276
##   [52277]     chrX 154862080-154862534      * | ATAC-seq_FE_0d_CD8_peak_52277
##               score signalValue    pValue    qValue      peak
##           <numeric>   <numeric> <numeric> <numeric> <integer>
##       [1]       111     8.11456  13.91620  11.12580       124
##       [2]       918    32.40973  97.05756  91.87830       136
##       [3]       254    12.97655  28.80828  25.49533       179
##       [4]       160    10.14320  19.03641  16.04733       232
##       [5]        36     4.56444   6.04979   3.66083        32
##       ...       ...         ...       ...       ...       ...
##   [52273]       342    14.33876  37.85284  34.27439       288
##   [52274]        56     5.57876   8.12360   5.60904        36
##   [52275]        40     4.56204   6.51479   4.09957        94
##   [52276]        88     6.67640  11.56942   8.88189        79
##   [52277]       439    17.00429  47.80342  43.95039       285
##   -------
##   seqinfo: 35 sequences from an unspecified genome; no seqlengths

length(list.filenames)

## [1] 32

for (i in 1:length(list.filenames)){
MacsCalls <- CD8.data[[i]]

data.frame(Blacklisted = sum(MacsCalls %over% blkList), Not_Blacklisted = sum(!MacsCalls %over% blkList))

MacsCalls.filtered <- MacsCalls[!MacsCalls %over% blkList]

Filtered.peaks<-MacsCalls.filtered[seqnames(MacsCalls.filtered) %in% Canonical_chrom]
summary(as.factor(seqnames(Filtered.peaks)))

CD8.filtered[[i]]<-Filtered.peaks
}

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr17_gl000206_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000212, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226, chrUn_gl000232, chrUn_gl000234, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr17_gl000206_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000212, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226, chrUn_gl000232, chrUn_gl000234, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr17_gl000206_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000212, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226, chrUn_gl000232, chrUn_gl000234, chrUn_gl000241
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000211, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000237
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000211, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000237
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr7_gl000195_random, chr9_gl000199_random, chrM, chrUn_gl000211, chrUn_gl000214, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000225, chrUn_gl000226, chrUn_gl000237
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr11_gl000202_random, chr17_gl000204_random, chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000198_random, chr9_gl000199_random, chrM, chrUn_gl000211, chrUn_gl000214, chrUn_gl000216, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr11_gl000202_random, chr17_gl000204_random, chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000198_random, chr9_gl000199_random, chrM, chrUn_gl000211, chrUn_gl000214, chrUn_gl000216, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

## Warning in .Seqinfo.mergexy(x, y): Each of the 2 combined objects has sequence levels not in the other:
##   - in 'x': chr11_gl000202_random, chr17_gl000204_random, chr17_gl000205_random, chr19_gl000208_random, chr1_gl000191_random, chr1_gl000192_random, chr4_gl000193_random, chr4_gl000194_random, chr7_gl000195_random, chr9_gl000198_random, chr9_gl000199_random, chrM, chrUn_gl000211, chrUn_gl000214, chrUn_gl000216, chrUn_gl000219, chrUn_gl000220, chrUn_gl000224, chrUn_gl000226
##   - in 'y': chrY
##   Make sure to always combine/compare objects based on the same reference
##   genome (use suppressWarnings() to suppress this warning).

summary(CD8.filtered)

##       Length Class   Mode
##  [1,] 49893  GRanges S4  
##  [2,] 21235  GRanges S4  
##  [3,]  8795  GRanges S4  
##  [4,] 37144  GRanges S4  
##  [5,]  4740  GRanges S4  
##  [6,] 45573  GRanges S4  
##  [7,] 17829  GRanges S4  
##  [8,] 24319  GRanges S4  
##  [9,] 43650  GRanges S4  
## [10,] 16994  GRanges S4  
## [11,] 30766  GRanges S4  
## [12,] 42540  GRanges S4  
## [13,] 41899  GRanges S4  
## [14,] 30640  GRanges S4  
## [15,] 47335  GRanges S4  
## [16,] 51973  GRanges S4  
## [17,] 50762  GRanges S4  
## [18,] 47344  GRanges S4  
## [19,] 23617  GRanges S4  
## [20,] 40023  GRanges S4  
## [21,] 40491  GRanges S4  
## [22,] 51247  GRanges S4  
## [23,] 42475  GRanges S4  
## [24,] 36669  GRanges S4  
## [25,] 38848  GRanges S4  
## [26,] 37340  GRanges S4  
## [27,] 44437  GRanges S4  
## [28,] 42586  GRanges S4  
## [29,] 37605  GRanges S4  
## [30,] 43580  GRanges S4  
## [31,] 48230  GRanges S4  
## [32,]  8183  GRanges S4

names(CD8.filtered)<-short.names 
names(CD8.filtered)

##  [1] "CLL1_0d_CD8"   "CLL1_3d_CD8"   "CLL1_30d_CD8"  "CLL1_120d_CD8"
##  [5] "CLL2_0d_CD8"   "CLL2_3d_CD8"   "CLL2_8d_CD8"   "CLL2_30d_CD8" 
##  [9] "CLL2_120d_CD8" "CLL4_0d_CD8"   "CLL4_3d_CD8"   "CLL5_0d_CD8"  
## [13] "CLL5_1d_CD8"   "CLL5_2d_CD8"   "CLL5_3d_CD8"   "CLL5_8d_CD8"  
## [17] "CLL5_30d_CD8"  "CLL5_150d_CD8" "CLL5_240d_CD8" "CLL6_0d_CD8"  
## [21] "CLL6_30d_CD8"  "CLL6_120d_CD8" "CLL6_280d_CD8" "CLL7_0d_CD8"  
## [25] "CLL7_1d_CD8"   "CLL7_3d_CD8"   "CLL7_8d_CD8"   "CLL7_30d_CD8" 
## [29] "CLL7_150d_CD8" "CLL8_0d_CD8"   "CLL8_3d_CD8"   "CLL8_30d_CD8"

Anotación de picos

A continuación pasamos a identificar, en cada muestra, la asociación de los picos detectados a los diferentes genes del genoma humano, así como su rol más probable.

CD8.anno<-list()
txdb <- TxDb.Hsapiens.UCSC.hg19.knownGene

for (i in 1:length(list.filenames)){
CD8.anno[[i]] <- annotatePeak(CD8.filtered[[i]], tssRegion=c(-3000, 3000),
 TxDb=txdb, annoDb="org.Hs.eg.db")
plotAnnoPie(CD8.anno[[i]], main = short.names[i]) #Opcional, sólo para comprobar la calidad de picos
}

## >> preparing features information...      2020-06-01 18:02:45 
## >> identifying nearest features...        2020-06-01 18:02:45 
## >> calculating distance from peak to TSS...   2020-06-01 18:02:47 
## >> assigning genomic annotation...        2020-06-01 18:02:47 
## >> adding gene annotation...          2020-06-01 19:50:36

## Loading required package: org.Hs.eg.db

## 

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:50:36 
## >> done...                    2020-06-01 19:50:36

## >> preparing features information...      2020-06-01 19:50:37 
## >> identifying nearest features...        2020-06-01 19:50:37 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:37 
## >> assigning genomic annotation...        2020-06-01 19:50:37 
## >> adding gene annotation...          2020-06-01 19:50:39

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:50:39 
## >> done...                    2020-06-01 19:50:39

## >> preparing features information...      2020-06-01 19:50:40 
## >> identifying nearest features...        2020-06-01 19:50:40 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:40 
## >> assigning genomic annotation...        2020-06-01 19:50:40 
## >> adding gene annotation...          2020-06-01 19:50:42

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:50:42 
## >> done...                    2020-06-01 19:50:42

## >> preparing features information...      2020-06-01 19:50:42 
## >> identifying nearest features...        2020-06-01 19:50:42 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:43 
## >> assigning genomic annotation...        2020-06-01 19:50:43 
## >> adding gene annotation...          2020-06-01 19:50:47

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:50:47 
## >> done...                    2020-06-01 19:50:47

## >> preparing features information...      2020-06-01 19:50:47 
## >> identifying nearest features...        2020-06-01 19:50:47 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:48 
## >> assigning genomic annotation...        2020-06-01 19:50:48 
## >> adding gene annotation...          2020-06-01 19:50:50

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:50:50 
## >> done...                    2020-06-01 19:50:50

## >> preparing features information...      2020-06-01 19:50:50 
## >> identifying nearest features...        2020-06-01 19:50:50 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:51 
## >> assigning genomic annotation...        2020-06-01 19:50:51 
## >> adding gene annotation...          2020-06-01 19:50:54

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:50:54 
## >> done...                    2020-06-01 19:50:54

## >> preparing features information...      2020-06-01 19:50:55 
## >> identifying nearest features...        2020-06-01 19:50:55 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:55 
## >> assigning genomic annotation...        2020-06-01 19:50:55 
## >> adding gene annotation...          2020-06-01 19:50:57

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:50:57 
## >> done...                    2020-06-01 19:50:57

## >> preparing features information...      2020-06-01 19:50:57 
## >> identifying nearest features...        2020-06-01 19:50:57 
## >> calculating distance from peak to TSS...   2020-06-01 19:50:58 
## >> assigning genomic annotation...        2020-06-01 19:50:58 
## >> adding gene annotation...          2020-06-01 19:51:00

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:00 
## >> done...                    2020-06-01 19:51:00

## >> preparing features information...      2020-06-01 19:51:00 
## >> identifying nearest features...        2020-06-01 19:51:00 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:01 
## >> assigning genomic annotation...        2020-06-01 19:51:01 
## >> adding gene annotation...          2020-06-01 19:51:03

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:03 
## >> done...                    2020-06-01 19:51:04

## >> preparing features information...      2020-06-01 19:51:04 
## >> identifying nearest features...        2020-06-01 19:51:04 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:04 
## >> assigning genomic annotation...        2020-06-01 19:51:04 
## >> adding gene annotation...          2020-06-01 19:51:07

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:07 
## >> done...                    2020-06-01 19:51:07

## >> preparing features information...      2020-06-01 19:51:07 
## >> identifying nearest features...        2020-06-01 19:51:07 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:08 
## >> assigning genomic annotation...        2020-06-01 19:51:08 
## >> adding gene annotation...          2020-06-01 19:51:10

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:10 
## >> done...                    2020-06-01 19:51:10

## >> preparing features information...      2020-06-01 19:51:10 
## >> identifying nearest features...        2020-06-01 19:51:10 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:11 
## >> assigning genomic annotation...        2020-06-01 19:51:11 
## >> adding gene annotation...          2020-06-01 19:51:13

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:13 
## >> done...                    2020-06-01 19:51:13

## >> preparing features information...      2020-06-01 19:51:13 
## >> identifying nearest features...        2020-06-01 19:51:13 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:14 
## >> assigning genomic annotation...        2020-06-01 19:51:14 
## >> adding gene annotation...          2020-06-01 19:51:17

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:17 
## >> done...                    2020-06-01 19:51:17

## >> preparing features information...      2020-06-01 19:51:18 
## >> identifying nearest features...        2020-06-01 19:51:18 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:18 
## >> assigning genomic annotation...        2020-06-01 19:51:18 
## >> adding gene annotation...          2020-06-01 19:51:20

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:20 
## >> done...                    2020-06-01 19:51:20

## >> preparing features information...      2020-06-01 19:51:20 
## >> identifying nearest features...        2020-06-01 19:51:20 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:21 
## >> assigning genomic annotation...        2020-06-01 19:51:21 
## >> adding gene annotation...          2020-06-01 19:51:23

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:24 
## >> done...                    2020-06-01 19:51:24

## >> preparing features information...      2020-06-01 19:51:24 
## >> identifying nearest features...        2020-06-01 19:51:24 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:25 
## >> assigning genomic annotation...        2020-06-01 19:51:25 
## >> adding gene annotation...          2020-06-01 19:51:27

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:27 
## >> done...                    2020-06-01 19:51:27

## >> preparing features information...      2020-06-01 19:51:27 
## >> identifying nearest features...        2020-06-01 19:51:27 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:29 
## >> assigning genomic annotation...        2020-06-01 19:51:29 
## >> adding gene annotation...          2020-06-01 19:51:31

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:31 
## >> done...                    2020-06-01 19:51:31

## >> preparing features information...      2020-06-01 19:51:31 
## >> identifying nearest features...        2020-06-01 19:51:31 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:32 
## >> assigning genomic annotation...        2020-06-01 19:51:32 
## >> adding gene annotation...          2020-06-01 19:51:34

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:35 
## >> done...                    2020-06-01 19:51:35

## >> preparing features information...      2020-06-01 19:51:35 
## >> identifying nearest features...        2020-06-01 19:51:35 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:35 
## >> assigning genomic annotation...        2020-06-01 19:51:35 
## >> adding gene annotation...          2020-06-01 19:51:38

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:38 
## >> done...                    2020-06-01 19:51:38

## >> preparing features information...      2020-06-01 19:51:38 
## >> identifying nearest features...        2020-06-01 19:51:38 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:39 
## >> assigning genomic annotation...        2020-06-01 19:51:39 
## >> adding gene annotation...          2020-06-01 19:51:41

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:41 
## >> done...                    2020-06-01 19:51:41

## >> preparing features information...      2020-06-01 19:51:41 
## >> identifying nearest features...        2020-06-01 19:51:41 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:44 
## >> assigning genomic annotation...        2020-06-01 19:51:44 
## >> adding gene annotation...          2020-06-01 19:51:45

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:46 
## >> done...                    2020-06-01 19:51:46

## >> preparing features information...      2020-06-01 19:51:46 
## >> identifying nearest features...        2020-06-01 19:51:46 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:47 
## >> assigning genomic annotation...        2020-06-01 19:51:47 
## >> adding gene annotation...          2020-06-01 19:51:49

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:49 
## >> done...                    2020-06-01 19:51:49

## >> preparing features information...      2020-06-01 19:51:49 
## >> identifying nearest features...        2020-06-01 19:51:49 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:50 
## >> assigning genomic annotation...        2020-06-01 19:51:50 
## >> adding gene annotation...          2020-06-01 19:51:52

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:53 
## >> done...                    2020-06-01 19:51:53

## >> preparing features information...      2020-06-01 19:51:53 
## >> identifying nearest features...        2020-06-01 19:51:53 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:54 
## >> assigning genomic annotation...        2020-06-01 19:51:54 
## >> adding gene annotation...          2020-06-01 19:51:56

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:56 
## >> done...                    2020-06-01 19:51:56

## >> preparing features information...      2020-06-01 19:51:56 
## >> identifying nearest features...        2020-06-01 19:51:56 
## >> calculating distance from peak to TSS...   2020-06-01 19:51:57 
## >> assigning genomic annotation...        2020-06-01 19:51:57 
## >> adding gene annotation...          2020-06-01 19:51:59

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:51:59 
## >> done...                    2020-06-01 19:51:59

## >> preparing features information...      2020-06-01 19:51:59 
## >> identifying nearest features...        2020-06-01 19:51:59 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:00 
## >> assigning genomic annotation...        2020-06-01 19:52:00 
## >> adding gene annotation...          2020-06-01 19:52:03

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:03 
## >> done...                    2020-06-01 19:52:03

## >> preparing features information...      2020-06-01 19:52:03 
## >> identifying nearest features...        2020-06-01 19:52:03 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:04 
## >> assigning genomic annotation...        2020-06-01 19:52:04 
## >> adding gene annotation...          2020-06-01 19:52:06

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:06 
## >> done...                    2020-06-01 19:52:06

## >> preparing features information...      2020-06-01 19:52:07 
## >> identifying nearest features...        2020-06-01 19:52:07 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:07 
## >> assigning genomic annotation...        2020-06-01 19:52:07 
## >> adding gene annotation...          2020-06-01 19:52:09

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:10 
## >> done...                    2020-06-01 19:52:10

## >> preparing features information...      2020-06-01 19:52:10 
## >> identifying nearest features...        2020-06-01 19:52:10 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:11 
## >> assigning genomic annotation...        2020-06-01 19:52:11 
## >> adding gene annotation...          2020-06-01 19:52:13

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:13 
## >> done...                    2020-06-01 19:52:13

## >> preparing features information...      2020-06-01 19:52:13 
## >> identifying nearest features...        2020-06-01 19:52:13 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:14 
## >> assigning genomic annotation...        2020-06-01 19:52:14 
## >> adding gene annotation...          2020-06-01 19:52:16

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:17 
## >> done...                    2020-06-01 19:52:17

## >> preparing features information...      2020-06-01 19:52:17 
## >> identifying nearest features...        2020-06-01 19:52:17 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:18 
## >> assigning genomic annotation...        2020-06-01 19:52:18 
## >> adding gene annotation...          2020-06-01 19:52:20

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:20 
## >> done...                    2020-06-01 19:52:20

## >> preparing features information...      2020-06-01 19:52:20 
## >> identifying nearest features...        2020-06-01 19:52:20 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:21 
## >> assigning genomic annotation...        2020-06-01 19:52:21 
## >> adding gene annotation...          2020-06-01 19:52:23

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:23 
## >> done...                    2020-06-01 19:52:23

names(CD8.anno)<-list.filenames
CD8.anno$`GSM3020245_ATAC-seq_CLL1_0d_CD8.peaks.narrowPeak.gz`

## Annotated peaks generated by ChIPseeker
## 49893/49893  peaks were annotated
## Genomic Annotation Summary:
##               Feature  Frequency
## 9    Promoter (<=1kb) 29.3688493
## 10   Promoter (1-2kb)  4.3473032
## 11   Promoter (2-3kb)  2.7278376
## 4              5' UTR  0.4128836
## 3              3' UTR  1.4571182
## 1            1st Exon  0.3928407
## 7          Other Exon  2.1465937
## 2          1st Intron 10.0094202
## 8        Other Intron 21.4198385
## 6  Downstream (<=300)  1.0662818
## 5   Distal Intergenic 26.6510332

#With this information we can then subset our peaks/nuc free regions to those only landing in TSS regions (+/- 500)
CD8.anno.TSS<-list()
for (i in 1:length(list.filenames)){
MacsGranges_Anno <- as.GRanges(CD8.anno[[i]])
CD8.anno.TSS[[i]] <- MacsGranges_Anno[abs(MacsGranges_Anno$distanceToTSS) < 
    1000]
}
summary(CD8.anno[[1]]@anno)

## [1] "GRanges object with 49893 ranges and 18 metadata columns"

summary(CD8.anno.TSS[[1]])

## [1] "GRanges object with 14650 ranges and 18 metadata columns"

names(CD8.anno.TSS)<-short.names

Observamos que el piechart de las muestras CLL1_30d_CLL y CLL8_30d_CLL son distintas al resto, lo que nos hace sospechar que los datos de las muestras pueden ser erróneos.

#Estudio diferencial del efecto del ibrutinib.

Búsqueda de piscos comunes.

Analizamos cuál es el grado de solapamiento de los picos entre muestras, y realizamos una primera observación del agrupamiento de picos en muestras del mismo tipo.

GRangesList(CD8.anno.TSS)

## GRangesList object of length 32:
## $CLL1_0d_CD8
## GRanges object with 14650 ranges and 18 metadata columns:
##           seqnames              ranges strand |                          name
##              <Rle>           <IRanges>  <Rle> |                   <character>
##       [1]     chr1       894618-894764      * |     ATAC-seq_FE_0d_CD8_peak_5
##       [2]     chr1       948355-949030      * |     ATAC-seq_FE_0d_CD8_peak_6
##       [3]     chr1       955086-955232      * |     ATAC-seq_FE_0d_CD8_peak_7
##       [4]     chr1     1051386-1051828      * |    ATAC-seq_FE_0d_CD8_peak_11
##       [5]     chr1     1167282-1167606      * |    ATAC-seq_FE_0d_CD8_peak_14
##       ...      ...                 ...    ... .                           ...
##   [14646]     chr9 140445958-140446104      * | ATAC-seq_FE_0d_CD8_peak_50511
##   [14647]     chr9 140473308-140473674      * | ATAC-seq_FE_0d_CD8_peak_50512
##   [14648]     chr9 140484923-140485144      * | ATAC-seq_FE_0d_CD8_peak_50513
##   [14649]     chr9 140499515-140500184      * | ATAC-seq_FE_0d_CD8_peak_50514
##   [14650]     chr9 140513053-140513298      * | ATAC-seq_FE_0d_CD8_peak_50515
##               score signalValue    pValue    qValue      peak       annotation
##           <numeric>   <numeric> <numeric> <numeric> <integer>      <character>
##       [1]        36     4.56444   6.04979   3.66083        32 Promoter (<=1kb)
##       [2]       281    11.00731  31.57639  28.17926       450 Promoter (<=1kb)
##       [3]        56     5.57876   8.12360   5.60904        40 Promoter (<=1kb)
##       [4]       476    17.82272  51.62801  47.66959       289 Promoter (<=1kb)
##       [5]       262    13.79990  29.56773  26.23165       143 Promoter (<=1kb)
##       ...       ...         ...       ...       ...       ...              ...
##   [14646]        36     4.56444   6.04979   3.66083        21 Promoter (<=1kb)
##   [14647]        56     5.57876   8.12360   5.60904       307 Promoter (<=1kb)
##   [14648]        77     6.59308  10.34694   7.71742        99 Promoter (<=1kb)
##   [14649]       287    11.98419  32.19537  28.78043       233 Promoter (<=1kb)
##   [14650]        94     6.54712  12.15277   9.44037        58 Promoter (<=1kb)
##             geneChr geneStart   geneEnd geneLength geneStrand      geneId
##           <integer> <integer> <integer>  <integer>  <integer> <character>
##       [1]         1    879583    894679      15097          2       26155
##       [2]         1    948847    949919       1073          1        9636
##       [3]         1    955503    991499      35997          1      375790
##       [4]         1   1017198   1051736      34539          2       54991
##       [5]         1   1152288   1167447      15160          2       51150
##       ...       ...       ...       ...        ...        ...         ...
##   [14646]         9 140446309 140447007        699          1       64975
##   [14647]         9 140449361 140473387      24027          2       92715
##   [14648]         9 140476531 140484937       8407          2      116225
##   [14649]         9 140500096 140509812       9717          1       92714
##   [14650]         9 140509784 140513308       3525          2       85026
##           transcriptId distanceToTSS         ENSEMBL      SYMBOL
##            <character>     <numeric>     <character> <character>
##       [1]   uc001abz.4             0 ENSG00000188976       NOC2L
##       [2]   uc001acj.4             0 ENSG00000187608       ISG15
##       [3]   uc001ack.2          -271 ENSG00000188157        AGRN
##       [4]   uc001acr.2             0 ENSG00000131591    C1orf159
##       [5]   uc001adh.4             0 ENSG00000078808        SDF4
##       ...          ...           ...             ...         ...
##   [14646]   uc004cnh.4          -205 ENSG00000182154      MRPL41
##   [14647]   uc004cnk.1             0 ENSG00000148399        DPH7
##   [14648]   uc004cno.1             0 ENSG00000165724     ZMYND19
##   [14649]   uc004cns.3             0 ENSG00000197070      ARRDC1
##   [14650]   uc004cnz.3            10 ENSG00000203993  ARRDC1-AS1
##                                                           GENENAME
##                                                        <character>
##       [1] NOC2 like nucleolar associated transcriptional repressor
##       [2]                            ISG15 ubiquitin like modifier
##       [3]                                                    agrin
##       [4]                      chromosome 1 open reading frame 159
##       [5]                            stromal cell derived factor 4
##       ...                                                      ...
##   [14646]                      mitochondrial ribosomal protein L41
##   [14647]                               diphthamide biosynthesis 7
##   [14648]                      zinc finger MYND-type containing 19
##   [14649]                             arrestin domain containing 1
##   [14650]                                   ARRDC1 antisense RNA 1
##   -------
##   seqinfo: 57 sequences (1 circular) from hg19 genome
## 
## ...
## <31 more elements>

consensusToCount <- soGGi:::runConsensusRegions(GRangesList(CD8.anno.TSS), "none")


as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains("_0d_")) %>% venn(main = "Overlap for untreated")

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains("3d_")) %>% venn(main = "Overlap for 3 days samples")

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains("30d_")) %>% venn(main = "Overlap for 30 days samples")

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains(c("120d_", "150d")) ) %>% venn(main = "Overlap for 120 and 150 days samples")

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains("_0d_")) %>% upset()

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains("3d_")) %>% upset()

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains("30d_")) %>% upset()

as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(contains(c("120d_", "150d")) ) %>% upset()

Observamos que, en el caso de células CD8, las muestras parecen solapar de manera coherente. En todos los casos existe un alto número de picos comunes a todas las muestras con respecto a los picos divergentes. En los casos en que existe un gran número de picos comunes a todas las muestras menos a una, es ésta la que tiene menor tamaño y el número de picos comunes faltantes se relaciona con el bajo número de picos totales de la muestra. Por ello, decidimos no eliminar, a priori, ninguna muestra del análisis.

short.names

##  [1] "CLL1_0d_CD8"   "CLL1_3d_CD8"   "CLL1_30d_CD8"  "CLL1_120d_CD8"
##  [5] "CLL2_0d_CD8"   "CLL2_3d_CD8"   "CLL2_8d_CD8"   "CLL2_30d_CD8" 
##  [9] "CLL2_120d_CD8" "CLL4_0d_CD8"   "CLL4_3d_CD8"   "CLL5_0d_CD8"  
## [13] "CLL5_1d_CD8"   "CLL5_2d_CD8"   "CLL5_3d_CD8"   "CLL5_8d_CD8"  
## [17] "CLL5_30d_CD8"  "CLL5_150d_CD8" "CLL5_240d_CD8" "CLL6_0d_CD8"  
## [21] "CLL6_30d_CD8"  "CLL6_120d_CD8" "CLL6_280d_CD8" "CLL7_0d_CD8"  
## [25] "CLL7_1d_CD8"   "CLL7_3d_CD8"   "CLL7_8d_CD8"   "CLL7_30d_CD8" 
## [29] "CLL7_150d_CD8" "CLL8_0d_CD8"   "CLL8_3d_CD8"   "CLL8_30d_CD8"

patientID<-sapply(strsplit(short.names, "CLL"), "[", 2)
patientID<-sapply(strsplit(patientID, "_"), "[", 1)
patientID

##  [1] "1" "1" "1" "1" "2" "2" "2" "2" "2" "4" "4" "5" "5" "5" "5" "5" "5" "5" "5"
## [20] "6" "6" "6" "6" "7" "7" "7" "7" "7" "7" "8" "8" "8"

TreatmentDay<-sapply(strsplit(short.names, "_"), "[", 2)
TreatmentDay

##  [1] "0d"   "3d"   "30d"  "120d" "0d"   "3d"   "8d"   "30d"  "120d" "0d"  
## [11] "3d"   "0d"   "1d"   "2d"   "3d"   "8d"   "30d"  "150d" "240d" "0d"  
## [21] "30d"  "120d" "280d" "0d"   "1d"   "3d"   "8d"   "30d"  "150d" "0d"  
## [31] "3d"   "30d"

TreatmentDay<-sapply(strsplit(TreatmentDay, "d"), "[", 1)
TreatmentDay<-as.numeric(TreatmentDay)

Treatmentdaygrouped <- TreatmentDay
for (i in 1:length(TreatmentDay)){
        if( TreatmentDay[i] > 0 & TreatmentDay[i] < 4){
            Treatmentdaygrouped[i] <- 3
        }
    else if( TreatmentDay[i] > 4 & TreatmentDay[i] < 9){
            Treatmentdaygrouped[i] <- 8
    }
    else if( TreatmentDay[i] > 30){
            Treatmentdaygrouped[i] <- 120
    }
}
length(Treatmentdaygrouped)

## [1] 32

PCA

Realizamos una reducción de la dimensionalidad por PCA

PCA_Plot <- as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(-consensusIDs) %>% as.matrix %>% t %>% prcomp %>% .$x %>% data.frame %>% mutate(Samples = rownames(.)) %>% mutate(Group = gsub("_\\d", "", Samples)) %>% ggplot(aes(x = PC1, y = PC2, shape=patientID,colour = TreatmentDay)) + geom_point(size = 5)+ scale_shape_manual(values=c(18:25))

PCA_Plot

A pesar de lo agrupado de un gran número de muestras, no detectamos claramente ningún outlier en el resto, por lo que mantenemos todas las muestras en nuestro análisis.

Opcional Conservamos sólo picos abiertos en más de la mitad de las muestras

``{r Identifying a set of non-redundant peaks. 2}

consensusToCount <- soGGi:::runConsensusRegions(GRangesList(CD8.anno.TSS), “none”) head(consensusToCount)

day0<-subset.Vector(CD8.anno.TSS, Treatmentdaygrouped == 0) day3<-subset.Vector(CD8.anno.TSS, Treatmentdaygrouped == 3) day8<-subset.Vector(CD8.anno.TSS, Treatmentdaygrouped == 8) day30<-subset.Vector(CD8.anno.TSS, Treatmentdaygrouped == 30) day120<-subset.Vector(CD8.anno.TSS, Treatmentdaygrouped == 120)

consensusday0 <- soGGi:::runConsensusRegions(GRangesList(day0), “none”) consensusday3 <- soGGi:::runConsensusRegions(GRangesList(day3), “none”) consensusday8 <- soGGi:::runConsensusRegions(GRangesList(day8), “none”) consensusday30 <- soGGi:::runConsensusRegions(GRangesList(day30), “none”) consensusday120 <- soGGi:::runConsensusRegions(GRangesList(day120), “none”)

``

A continuación probamos a ver cómo se distribuyen las muestras sin incluir la PC1 (el tratamiento de batch effect que realizaron los autores)

PCA_Plot <- as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(-consensusIDs) %>% as.matrix %>% t %>% prcomp %>% .$x %>% data.frame %>% mutate(Samples = rownames(.)) %>% mutate(Group = gsub("_\\d", "", Samples)) %>% ggplot(aes(x = PC2, y = PC3, shape=patientID,colour = TreatmentDay)) + geom_point(size = 5)+ scale_shape_manual(values=c(18:25))
PCA_Plot

library(tidyr)

PCA_plot_grouped <- as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(-consensusIDs) %>% 
    as.matrix %>% t %>% prcomp %>% .$x %>% data.frame %>% mutate(Samples = rownames(.)) %>% 
    mutate(Group = gsub("_\\d", "", Samples)) %>% ggplot(aes(x = PC1, y = PC2, 
    colour = as.character(Treatmentdaygrouped))) + geom_point(size = 3)

PCA_plot_grouped 

PCA2vs3_plot_grouped <- as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(-consensusIDs) %>% 
    as.matrix %>% t %>% prcomp %>% .$x %>% data.frame %>% mutate(Samples = rownames(.)) %>% 
    mutate(Group = gsub("_\\d", "", Samples)) %>% ggplot(aes(x = PC2, y = PC3, 
    colour = as.character(Treatmentdaygrouped))) + geom_point(size = 3)
PCA2vs3_plot_grouped

PCA2vs3_plot_grouped <- as.data.frame(elementMetadata(consensusToCount)) %>% dplyr::select(-consensusIDs) %>% 
    as.matrix %>% t %>% prcomp %>% .$x %>% data.frame %>% mutate(Samples = rownames(.)) %>% 
    mutate(Group = gsub("_\\d", "", Samples)) %>% ggplot(aes(x = PC2, y = PC3, 
    colour = patientID)) + geom_point(size = 3)
PCA2vs3_plot_grouped

First we will filter our peaks in a manner similar to Diffbind, where we keep only peaks which are present in at least two replicates (debería ser en todos?)

occurrences <- elementMetadata(consensusToCount) %>% as.data.frame %>% dplyr::select(-consensusIDs) %>% rowSums

table(occurrences) %>% rev %>% cumsum

##    32    31    30    29    28    27    26    25    24    23    22    21    20 
##  1755  3046  4428  5766  6989  8000  8843  9495 10157 10621 10927 11154 11332 
##    19    18    17    16    15    14    13    12    11    10     9     8     7 
## 11497 11662 11802 11933 12061 12195 12324 12464 12595 12748 12907 13079 13270 
##     6     5     4     3     2     1 
## 13438 13678 13980 14399 15081 17553

consensusToCount <- consensusToCount[occurrences >= 5, ] ### Podemos elegir otro número, El número de pacientes? etc

head(consensusToCount)

## GRanges object with 6 ranges and 33 metadata columns:
##       seqnames        ranges strand | CLL1_0d_CD8 CLL1_3d_CD8 CLL1_30d_CD8
##          <Rle>     <IRanges>  <Rle> |   <numeric>   <numeric>    <numeric>
##   [1]     chr1 762186-763239      * |           0           1            1
##   [2]     chr1 875592-876186      * |           0           0            0
##   [3]     chr1 894436-895579      * |           1           1            0
##   [4]     chr1 895780-896547      * |           0           0            0
##   [5]     chr1 901630-902639      * |           0           0            0
##   [6]     chr1 911398-912049      * |           0           0            0
##       CLL1_120d_CD8 CLL2_0d_CD8 CLL2_3d_CD8 CLL2_8d_CD8 CLL2_30d_CD8
##           <numeric>   <numeric>   <numeric>   <numeric>    <numeric>
##   [1]             0           0           1           0            0
##   [2]             0           0           1           0            0
##   [3]             1           0           1           0            0
##   [4]             0           0           1           0            0
##   [5]             0           0           1           0            0
##   [6]             0           0           1           0            0
##       CLL2_120d_CD8 CLL4_0d_CD8 CLL4_3d_CD8 CLL5_0d_CD8 CLL5_1d_CD8 CLL5_2d_CD8
##           <numeric>   <numeric>   <numeric>   <numeric>   <numeric>   <numeric>
##   [1]             1           0           1           1           1           1
##   [2]             1           0           0           1           0           0
##   [3]             1           0           1           1           1           1
##   [4]             1           0           0           1           1           1
##   [5]             1           0           1           1           1           1
##   [6]             1           0           1           1           1           1
##       CLL5_3d_CD8 CLL5_8d_CD8 CLL5_30d_CD8 CLL5_150d_CD8 CLL5_240d_CD8
##         <numeric>   <numeric>    <numeric>     <numeric>     <numeric>
##   [1]           1           1            1             1             1
##   [2]           1           1            0             1             0
##   [3]           1           1            1             1             1
##   [4]           1           1            1             1             1
##   [5]           1           1            1             1             1
##   [6]           1           1            1             1             1
##       CLL6_0d_CD8 CLL6_30d_CD8 CLL6_120d_CD8 CLL6_280d_CD8 CLL7_0d_CD8
##         <numeric>    <numeric>     <numeric>     <numeric>   <numeric>
##   [1]           1            1             1             1           1
##   [2]           0            0             0             0           0
##   [3]           1            1             1             1           1
##   [4]           1            1             1             1           1
##   [5]           1            1             1             1           1
##   [6]           1            1             1             1           1
##       CLL7_1d_CD8 CLL7_3d_CD8 CLL7_8d_CD8 CLL7_30d_CD8 CLL7_150d_CD8
##         <numeric>   <numeric>   <numeric>    <numeric>     <numeric>
##   [1]           1           1           1            1             1
##   [2]           0           1           1            1             1
##   [3]           1           1           1            1             1
##   [4]           1           1           1            1             1
##   [5]           1           1           1            1             1
##   [6]           1           1           1            1             1
##       CLL8_0d_CD8 CLL8_3d_CD8 CLL8_30d_CD8 consensusIDs
##         <numeric>   <numeric>    <numeric>  <character>
##   [1]           1           1            0  consensus_1
##   [2]           1           0            0  consensus_3
##   [3]           1           1            1  consensus_4
##   [4]           1           1            0  consensus_5
##   [5]           1           1            0  consensus_7
##   [6]           1           1            0  consensus_8
##   -------
##   seqinfo: 57 sequences (1 circular) from hg19 genome

# Aquí entiendo que el tutorial designa los 13606 picos comunes

#Conservamos sólo picos abiertos en más de la mitad de las muestras consensusday0 # 7 muestras consensusday120 # 7 muestras consensusday3# 10 muestras consensusday30 # 5 muestras consensusday8 # 3 muestras

consensus.anno <- annotatePeak(consensusToCount, tssRegion=c(-1000, 1000), TxDb=txdb, annoDb="org.Hs.eg.db")

## >> preparing features information...      2020-06-01 19:52:44 
## >> identifying nearest features...        2020-06-01 19:52:44 
## >> calculating distance from peak to TSS...   2020-06-01 19:52:44 
## >> assigning genomic annotation...        2020-06-01 19:52:44 
## >> adding gene annotation...          2020-06-01 19:52:46

## 'select()' returned 1:many mapping between keys and columns

## >> assigning chromosome lengths           2020-06-01 19:52:46 
## >> done...                    2020-06-01 19:52:46

consensus.anno.TSS<-as.GRanges(consensus.anno)

Establecimiento de un índice de apertura de la cromatina en promotores con respecto al tiempo de tratamiento.

Para ello seleccionamos los datos agrupados.

consecount<-as.data.frame(consensus.anno.TSS)

consensus.score.0<-integer(length(consensus.anno.TSS))
for (i in 1:length(Treatmentdaygrouped)){
    if (Treatmentdaygrouped[i] == 0){
        consensus.score.0 <-consensus.score.0 + consecount[, i+5]
    }
}
consensus.score.0<-consensus.score.0/max(consensus.score.0)
consensus.score.3<-as.vector(integer(length(consensus.anno.TSS)))
for (i in 1:length(Treatmentdaygrouped)){
    if (Treatmentdaygrouped[i] == 3){
        consensus.score.3 <-consensus.score.3 + consecount[, i+5]
    }
}
consensus.score.3<-consensus.score.3/max(consensus.score.3)
consensus.score.8<-as.vector(integer(length(consensus.anno.TSS)))
for (i in 1:length(Treatmentdaygrouped)){
    if (Treatmentdaygrouped[i] == 8){
        consensus.score.8 <-consensus.score.8 + consecount[, i+5]
    }
}
consensus.score.8<-consensus.score.8/max(consensus.score.8)


consensus.score.30<-as.vector(integer(length(consensus.anno.TSS)))
for (i in 1:length(Treatmentdaygrouped)){
    if (Treatmentdaygrouped[i] == 30){
        consensus.score.30 <-consensus.score.30 + consecount[, i+5]
    }
}
consensus.score.30<-consensus.score.30/max(consensus.score.30)

consensus.score.120<-as.vector(integer(length(consensus.anno.TSS)))
for (i in 1:length(Treatmentdaygrouped)){
    if (Treatmentdaygrouped[i] == 120){
        consensus.score.120 <-consensus.score.120 + consecount[, i+5]
    }
}
consensus.score.120<-consensus.score.120/max(consensus.score.120)



the.scores<-as.data.frame(cbind(consensus.score.0, consensus.score.3,consensus.score.8, consensus.score.30, consensus.score.120))

names(the.scores)<-c(0, 3, 8, 30, 120)
all.scores<-the.scores

consecount.scores<-cbind(consecount, all.scores)

Detección de promotores afectados por el tratamiento con ibrutinib y evolución temporal

openday0<-subset(consecount.scores, consecount.scores$"0">=0.7)

open0closed3<-subset(openday0, openday0$"3"<=0.3)
knitr::kable(open0closed3[, 49:55])

	SYMBOL	GENENAME	0	3	8	30	120
7972	INSIG2	insulin induced gene 2	0.7142857	0.2222222	0.3333333	0.5000000	0.4285714
10311	LINC01094	long intergenic non-protein coding RNA 1094	0.8571429	0.2222222	0.3333333	0.5000000	0.5714286
10820	FER	FER tyrosine kinase	0.7142857	0.2222222	0.6666667	0.5000000	0.4285714
11004	PPP2R2B-IT1	PPP2R2B intronic transcript 1	0.7142857	0.2222222	0.3333333	0.1666667	0.2857143
11169	MAPK9	mitogen-activated protein kinase 9	0.7142857	0.1111111	0.0000000	0.1666667	0.2857143

open0closed8<-subset(openday0, openday0$"8"<=0.3)
knitr::kable(open0closed8[, 49:55])

	SYMBOL	GENENAME	0	3	8	30	120
2844	CCND2	cyclin D2	0.7142857	0.8888889	0	0.3333333	0.7142857
4516	PKM	pyruvate kinase M1/2	0.8571429	0.5555556	0	0.3333333	0.7142857
7068	DLL3	delta like canonical Notch ligand 3	0.8571429	0.4444444	0	0.0000000	0.4285714
11169	MAPK9	mitogen-activated protein kinase 9	0.7142857	0.1111111	0	0.1666667	0.2857143

open0closed30<-subset(openday0, openday0$"30"<=0.3)
knitr::kable(open0closed30[, 49:55])

	SYMBOL	GENENAME	0	3	8	30	120
1582	NRP1	neuropilin 1	0.7142857	0.3333333	0.3333333	0.1666667	0.4285714
1622	TMEM273	transmembrane protein 273	0.7142857	0.7777778	0.3333333	0.1666667	0.5714286
2925	PRR4	proline rich 4	0.8571429	0.5555556	0.3333333	0.0000000	0.2857143
3208	BAZ2A	bromodomain adjacent to zinc finger domain 2A	0.7142857	0.7777778	0.6666667	0.0000000	0.7142857
7068	DLL3	delta like canonical Notch ligand 3	0.8571429	0.4444444	0.0000000	0.0000000	0.4285714
9840	ATP2C1	ATPase secretory pathway Ca2+ transporting 1	0.8571429	0.6666667	1.0000000	0.1666667	0.5714286
11004	PPP2R2B-IT1	PPP2R2B intronic transcript 1	0.7142857	0.2222222	0.3333333	0.1666667	0.2857143
11169	MAPK9	mitogen-activated protein kinase 9	0.7142857	0.1111111	0.0000000	0.1666667	0.2857143
11514	STK38	serine/threonine kinase 38	0.7142857	0.6666667	0.3333333	0.0000000	0.2857143
12957	RIMS2	regulating synaptic membrane exocytosis 2	0.7142857	0.5555556	0.3333333	0.1666667	0.4285714

open0closed120<-subset(openday0, openday0$"120"<=0.3)
knitr::kable(open0closed120[, 49:55])

	SYMBOL	GENENAME	0	3	8	30	120
779	DENND2D	DENN domain containing 2D	0.7142857	0.6666667	0.3333333	0.3333333	0.2857143
2925	PRR4	proline rich 4	0.8571429	0.5555556	0.3333333	0.0000000	0.2857143
5037	FUS	FUS RNA binding protein	0.7142857	0.4444444	0.6666667	0.5000000	0.2857143
5042	ITGAM	integrin subunit alpha M	0.7142857	0.4444444	0.3333333	0.5000000	0.2857143
5682	SLFN12L	schlafen family member 12 like	0.7142857	0.5555556	0.6666667	0.3333333	0.2857143
11004	PPP2R2B-IT1	PPP2R2B intronic transcript 1	0.7142857	0.2222222	0.3333333	0.1666667	0.2857143
11169	MAPK9	mitogen-activated protein kinase 9	0.7142857	0.1111111	0.0000000	0.1666667	0.2857143
11514	STK38	serine/threonine kinase 38	0.7142857	0.6666667	0.3333333	0.0000000	0.2857143
12300	CDK6	cyclin dependent kinase 6	0.7142857	0.4444444	0.3333333	0.6666667	0.2857143
12514	CREB3L2	cAMP responsive element binding protein 3 like 2	0.7142857	0.4444444	0.3333333	0.5000000	0.2857143

write.table(open0closed3, "CD8_open0closed3.txt", sep="\t")
write.table(open0closed8, "CD8_open0closed8.txt", sep="\t")
write.table(open0closed30, "CD8_open0closed30.txt", sep="\t")
write.table(open0closed120, "CD8_open0closed120.txt", sep="\t")

Opcional: agrupar las muestras de más de un mes y hacer una comparación Antes del tratamiento vs tratamiento estabilizado

open0closed_ibru<-subset(openday0, (openday0\("30"<=0.3) & (openday0\)“120”<=0.3)) open0closed_ibru

closedday0<-subset(consecount.scores, consecount.scores$"0"<=0.3)


closed0open3<-subset(closedday0, closedday0$"3">=0.7)
knitr::kable(closed0open3[, 49:55])

	SYMBOL	GENENAME	0	3	8	30	120
271	ARID1A	AT-rich interaction domain 1A	0.1428571	0.7777778	0.6666667	0.5000000	0.7142857
278	KDF1	keratinocyte differentiation factor 1	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
332	SERINC2	serine incorporator 2	0.2857143	0.7777778	0.3333333	0.3333333	0.4285714
616	PTGER3	prostaglandin E receptor 3	0.2857143	1.0000000	0.6666667	0.6666667	0.7142857
621	SLC44A5	solute carrier family 44 member 5	0.1428571	0.7777778	0.0000000	0.1666667	0.5714286
718	PLPPR5	phospholipid phosphatase related 5	0.1428571	0.7777778	0.6666667	0.1666667	0.4285714
1588	FZD8	frizzled class receptor 8	0.2857143	0.7777778	0.3333333	0.5000000	0.5714286
1668	TET1	tet methylcytosine dioxygenase 1	0.0000000	0.7777778	0.3333333	0.3333333	0.5714286
1840	LOXL4	lysyl oxidase like 4	0.2857143	0.7777778	0.6666667	0.3333333	0.5714286
1944	TCF7L2	transcription factor 7 like 2	0.2857143	0.8888889	0.6666667	0.3333333	0.7142857
2005	TCERG1L	transcription elongation regulator 1 like	0.2857143	0.7777778	0.6666667	0.5000000	0.2857143
2463	RIN1	Ras and Rab interactor 1	0.2857143	0.7777778	0.6666667	0.1666667	0.7142857
2486	GRK2	G protein-coupled receptor kinase 2	0.2857143	0.8888889	0.6666667	0.5000000	0.8571429
2713	DSCAML1	DS cell adhesion molecule like 1	0.2857143	0.7777778	0.6666667	0.3333333	0.7142857
3086	ASIC1	acid sensing ion channel subunit 1	0.2857143	0.7777778	0.6666667	0.3333333	0.5714286
3502	KDM2B	lysine demethylase 2B	0.2857143	0.8888889	0.6666667	0.3333333	0.7142857
4199	DEGS2	delta 4-desaturase, sphingolipid 2	0.2857143	0.7777778	0.6666667	0.1666667	0.7142857
4663	TTLL13P	tubulin tyrosine ligase like 13, pseudogene	0.2857143	0.7777778	0.3333333	0.5000000	0.5714286
5020	ZNF629	zinc finger protein 629	0.1428571	0.7777778	0.6666667	0.3333333	0.5714286
5027	HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.1428571	0.7777778	0.6666667	0.1666667	0.7142857
5158	KCTD19	potassium channel tetramerization domain containing 19	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
5360	MYO1C	myosin IC	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
5586	CCDC144CP	coiled-coil domain containing 144C, pseudogene	0.2857143	0.7777778	0.6666667	0.3333333	0.8571429
5596	KSR1	kinase suppressor of ras 1	0.2857143	0.7777778	0.6666667	0.5000000	0.5714286
5943	NOG	noggin	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
6211	CCDC57	coiled-coil domain containing 57	0.2857143	0.7777778	0.3333333	0.1666667	0.7142857
6379	ONECUT2	one cut homeobox 2	0.2857143	0.7777778	0.3333333	0.3333333	0.7142857
6497	CSNK1G2	casein kinase 1 gamma 2	0.2857143	0.7777778	0.3333333	0.3333333	0.7142857
6498	BTBD2	BTB domain containing 2	0.2857143	0.7777778	0.6666667	0.5000000	1.0000000
6525	TLE2	TLE family member 2, transcriptional corepressor	0.2857143	0.7777778	0.6666667	0.3333333	0.7142857
6565	FSD1	fibronectin type III and SPRY domain containing 1	0.2857143	0.8888889	0.6666667	0.5000000	0.7142857
6638	ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif 10	0.2857143	0.8888889	0.6666667	0.5000000	0.8571429
6969	LSR	lipolysis stimulated lipoprotein receptor	0.2857143	0.7777778	0.6666667	0.5000000	0.5714286
7034	SPINT2	serine peptidase inhibitor, Kunitz type 2	0.1428571	0.7777778	0.6666667	0.1666667	0.2857143
7475	ZSCAN18	zinc finger and SCAN domain containing 18	0.2857143	1.0000000	0.6666667	0.3333333	0.8571429
7881	DUSP2	dual specificity phosphatase 2	0.2857143	0.7777778	0.3333333	0.1666667	0.4285714
8148	CERKL	ceramide kinase like	0.1428571	0.8888889	0.6666667	0.1666667	0.4285714
8242	PARD3B	par-3 family cell polarity regulator beta	0.2857143	0.7777778	0.6666667	0.5000000	0.5714286
8363	DGKD	diacylglycerol kinase delta	0.2857143	0.7777778	0.3333333	0.3333333	0.5714286
8428	SDCBP2	syndecan binding protein 2	0.2857143	0.7777778	0.6666667	0.5000000	0.8571429
8484	JAG1	jagged canonical Notch ligand 1	0.2857143	0.8888889	0.3333333	0.3333333	0.4285714
8486	ISM1	isthmin 1	0.1428571	0.7777778	0.3333333	0.3333333	0.5714286
8518	LOC284798	uncharacterized LOC284798	0.2857143	0.7777778	0.3333333	0.5000000	0.7142857
8539	TSPY26P	testis specific protein Y-linked 26, pseudogene	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
8547	C20orf203	chromosome 20 open reading frame 203	0.1428571	0.7777778	0.6666667	0.3333333	0.7142857
8753	SLC17A9	solute carrier family 17 member 9	0.2857143	0.7777778	0.0000000	0.5000000	0.2857143
8928	COL6A2	collagen type VI alpha 2 chain	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
9043	MN1	MN1 proto-oncogene, transcriptional regulator	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
9070	SEC14L2	SEC14 like lipid binding 2	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
9262	LINC00899	long intergenic non-protein coding RNA 899	0.2857143	0.7777778	0.6666667	0.3333333	0.7142857
9596	WDR82	WD repeat domain 82	0.2857143	0.7777778	0.3333333	0.5000000	0.4285714
10588	C5orf49	chromosome 5 open reading frame 49	0.1428571	0.7777778	0.6666667	0.5000000	0.7142857
10742	F2RL1	F2R like trypsin receptor 1	0.2857143	0.8888889	0.3333333	0.5000000	0.5714286
11053	NIPAL4	NIPA like domain containing 4	0.2857143	0.7777778	0.6666667	0.3333333	0.5714286
11056	C5orf52	chromosome 5 open reading frame 52	0.2857143	0.7777778	0.6666667	0.3333333	0.2857143
11161	MGAT4B	alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B	0.2857143	0.7777778	0.6666667	0.6666667	0.8571429
11422	VWA7	von Willebrand factor A domain containing 7	0.1428571	0.8888889	0.6666667	0.5000000	0.7142857
11631	DST	dystonin	0.2857143	0.8888889	0.3333333	0.3333333	0.4285714
11648	OOEP	oocyte expressed protein	0.2857143	0.7777778	0.6666667	0.6666667	0.7142857
11674	ME1	malic enzyme 1	0.2857143	0.7777778	0.6666667	0.5000000	0.5714286
11927	FNDC1	fibronectin type III domain containing 1	0.2857143	0.7777778	0.6666667	0.3333333	0.5714286
12018	ZNF853	zinc finger protein 853	0.2857143	0.7777778	0.3333333	0.5000000	0.4285714
12463	LRRC4	leucine rich repeat containing 4	0.1428571	0.7777778	0.3333333	0.5000000	0.7142857
12642	MIR596	microRNA 596	0.2857143	0.7777778	0.3333333	0.1666667	0.7142857
13034	PTK2	protein tyrosine kinase 2	0.2857143	0.8888889	0.6666667	0.3333333	0.5714286
13116	VLDLR-AS1	VLDLR antisense RNA 1	0.2857143	0.7777778	0.3333333	0.3333333	0.5714286
13377	CORO2A	coronin 2A	0.1428571	0.7777778	0.3333333	0.1666667	0.2857143
13391	TMEFF1	transmembrane protein with EGF like and two follistatin like domains 1	0.2857143	0.8888889	0.6666667	0.3333333	0.7142857

closed0open8<-subset(closedday0, closedday0$"8">=0.7)
knitr::kable(closed0open8[, 49:55])

	SYMBOL	GENENAME	0	3	8	30	120
1719	USP54	ubiquitin specific peptidase 54	0.2857143	0.5555556	1	0.3333333	0.8571429
2310	MS4A6E	membrane spanning 4-domains A6E	0.1428571	0.1111111	1	0.1666667	0.2857143
5344	URAHP	urate (hydroxyiso-) hydrolase, pseudogene	0.1428571	0.5555556	1	0.1666667	0.4285714
6729	ZNF442	zinc finger protein 442	0.2857143	0.6666667	1	0.5000000	0.7142857
7693	NRXN1	neurexin 1	0.2857143	0.4444444	1	0.6666667	0.4285714
9343	GHRLOS	ghrelin opposite strand/antisense RNA	0.1428571	0.3333333	1	0.0000000	0.4285714
9735	SPICE1	spindle and centriole associated protein 1	0.1428571	0.1111111	1	0.1666667	0.4285714
10881	ACSL6	acyl-CoA synthetase long chain family member 6	0.2857143	0.4444444	1	0.5000000	0.2857143

closed0open30<-subset(closedday0, closedday0$"30">=0.7)
knitr::kable(closed0open30[, 49:55])

SYMBOL	GENENAME	0	3	8	30	120

closed0open120<-subset(closedday0, closedday0$"120">=0.7)
knitr::kable(closed0open120[, 49:55])

	SYMBOL	GENENAME	0	3	8	30	120
32	MIB2	mindbomb E3 ubiquitin protein ligase 2	0.0000000	0.3333333	0.6666667	0.5000000	0.7142857
86	CAMTA1	calmodulin binding transcription activator 1	0.2857143	0.5555556	0.6666667	0.0000000	0.7142857
168	MIR4695	microRNA 4695	0.1428571	0.5555556	0.6666667	0.5000000	0.8571429
202	RAP1GAP	RAP1 GTPase activating protein	0.2857143	0.4444444	0.3333333	0.5000000	0.7142857
234	STPG1	sperm tail PG-rich repeat containing 1	0.1428571	0.6666667	0.6666667	0.3333333	0.8571429
271	ARID1A	AT-rich interaction domain 1A	0.1428571	0.7777778	0.6666667	0.5000000	0.7142857
278	KDF1	keratinocyte differentiation factor 1	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
281	SLC9A1	solute carrier family 9 member A1	0.1428571	0.4444444	0.3333333	0.3333333	0.7142857
355	ZBTB8A	zinc finger and BTB domain containing 8A	0.2857143	0.5555556	0.6666667	0.1666667	0.7142857
361	FNDC5	fibronectin type III domain containing 5	0.2857143	0.5555556	0.6666667	0.5000000	0.8571429
399	ZC3H12A	zinc finger CCCH-type containing 12A	0.2857143	0.6666667	0.6666667	0.5000000	1.0000000
539	RAB3B	RAB3B, member RAS oncogene family	0.2857143	0.6666667	0.6666667	0.5000000	0.7142857
555	PODN	podocan	0.1428571	0.4444444	0.6666667	0.5000000	0.7142857
616	PTGER3	prostaglandin E receptor 3	0.2857143	1.0000000	0.6666667	0.6666667	0.7142857
773	KCNA2	potassium voltage-gated channel subfamily A member 2	0.2857143	0.6666667	0.6666667	0.3333333	0.7142857
818	IGSF3	immunoglobulin superfamily member 3	0.1428571	0.5555556	0.3333333	0.5000000	0.7142857
852	H2AC19	H2A clustered histone 19	0.2857143	0.5555556	0.3333333	0.5000000	0.8571429
941	ADAR	adenosine deaminase RNA specific	0.2857143	0.4444444	0.6666667	0.3333333	0.7142857
995	PAQR6	progestin and adipoQ receptor family member 6	0.1428571	0.6666667	0.6666667	0.3333333	0.7142857
1043	SLAMF7	SLAM family member 7	0.2857143	0.2222222	0.6666667	0.0000000	0.8571429
1077	PBX1	PBX homeobox 1	0.2857143	0.6666667	0.6666667	0.3333333	0.7142857
1099	XCL1	X-C motif chemokine ligand 1	0.2857143	0.5555556	0.6666667	0.5000000	0.8571429
1262	IL19	interleukin 19	0.1428571	0.4444444	0.6666667	0.0000000	0.7142857
1307	TGFB2-AS1	TGFB2 antisense RNA 1 (head to head)	0.2857143	0.5555556	0.3333333	0.5000000	0.7142857
1337	ENAH	ENAH actin regulator	0.2857143	0.6666667	0.6666667	0.3333333	0.7142857
1412	NID1	nidogen 1	0.1428571	0.4444444	0.6666667	0.3333333	0.7142857
1426	MAP1LC3C	microtubule associated protein 1 light chain 3 gamma	0.2857143	0.3333333	0.6666667	0.5000000	0.7142857
1558	ARMC4	armadillo repeat containing 4	0.2857143	0.6666667	0.6666667	0.3333333	0.7142857
1564	SVIL	supervillin	0.2857143	0.2222222	0.6666667	0.5000000	0.7142857
1719	USP54	ubiquitin specific peptidase 54	0.2857143	0.5555556	1.0000000	0.3333333	0.8571429
1870	KAZALD1	Kazal type serine peptidase inhibitor domain 1	0.2857143	0.4444444	0.6666667	0.3333333	0.7142857
1944	TCF7L2	transcription factor 7 like 2	0.2857143	0.8888889	0.6666667	0.3333333	0.7142857
2290	RTN4RL2	reticulon 4 receptor like 2	0.2857143	0.5555556	0.3333333	0.3333333	0.7142857
2325	LRRC10B	leucine rich repeat containing 10B	0.1428571	0.6666667	0.6666667	0.1666667	0.7142857
2426	MALAT1	metastasis associated lung adenocarcinoma transcript 1	0.2857143	0.6666667	0.6666667	0.5000000	0.8571429
2463	RIN1	Ras and Rab interactor 1	0.2857143	0.7777778	0.6666667	0.1666667	0.7142857
2486	GRK2	G protein-coupled receptor kinase 2	0.2857143	0.8888889	0.6666667	0.5000000	0.8571429
2584	LRRC32	leucine rich repeat containing 32	0.0000000	0.2222222	0.6666667	0.1666667	0.7142857
2713	DSCAML1	DS cell adhesion molecule like 1	0.2857143	0.7777778	0.6666667	0.3333333	0.7142857
2761	SORL1	sortilin related receptor 1	0.1428571	0.6666667	0.6666667	0.5000000	0.7142857
2888	PEX5	peroxisomal biogenesis factor 5	0.2857143	0.4444444	0.6666667	0.5000000	0.7142857
2906	LOC642846	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11-like	0.1428571	0.4444444	0.3333333	0.5000000	0.7142857
3384	NUAK1	NUAK family kinase 1	0.1428571	0.2222222	0.3333333	0.3333333	0.7142857
3502	KDM2B	lysine demethylase 2B	0.2857143	0.8888889	0.6666667	0.3333333	0.7142857
3791	PCID2	PCI domain containing 2	0.2857143	0.5555556	0.6666667	0.1666667	0.7142857
3947	PYGL	glycogen phosphorylase L	0.1428571	0.6666667	0.6666667	0.3333333	0.7142857
4047	ACTN1	actinin alpha 1	0.1428571	0.4444444	0.3333333	0.3333333	0.7142857
4199	DEGS2	delta 4-desaturase, sphingolipid 2	0.2857143	0.7777778	0.6666667	0.1666667	0.7142857
4239	CEP170B	centrosomal protein 170B	0.2857143	0.6666667	0.6666667	0.3333333	0.7142857
4277	CHRM5	cholinergic receptor muscarinic 5	0.2857143	0.3333333	0.0000000	0.1666667	0.8571429
4282	SLC12A6	solute carrier family 12 member 6	0.1428571	0.5555556	0.3333333	0.3333333	0.7142857
4561	SIN3A	SIN3 transcription regulator family member A	0.2857143	0.5555556	0.6666667	0.5000000	0.7142857
4618	TM6SF1	transmembrane 6 superfamily member 1	0.1428571	0.3333333	0.6666667	0.1666667	0.7142857
4643	HAPLN3	hyaluronan and proteoglycan link protein 3	0.2857143	0.5555556	0.6666667	0.5000000	0.7142857
4711	HBQ1	hemoglobin subunit theta 1	0.2857143	0.6666667	0.6666667	0.5000000	0.7142857
4749	TMEM204	transmembrane protein 204	0.2857143	0.6666667	0.6666667	0.3333333	0.7142857
4795	KREMEN2	kringle containing transmembrane protein 2	0.0000000	0.4444444	0.3333333	0.1666667	0.7142857
4798	TNFRSF12A	TNF receptor superfamily member 12A	0.1428571	0.5555556	0.6666667	0.3333333	0.7142857
4995	CORO1A	coronin 1A	0.2857143	0.1111111	0.6666667	0.1666667	0.8571429
5027	HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.1428571	0.7777778	0.6666667	0.1666667	0.7142857
5158	KCTD19	potassium channel tetramerization domain containing 19	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
5227	ZNF821	zinc finger protein 821	0.2857143	0.5555556	0.6666667	0.1666667	0.7142857
5325	CPNE7	copine 7	0.2857143	0.5555556	0.6666667	0.3333333	0.7142857
5360	MYO1C	myosin IC	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
5440	ALOX12-AS1	ALOX12 antisense RNA 1	0.2857143	0.4444444	0.6666667	0.3333333	0.8571429
5466	TMEM102	transmembrane protein 102	0.2857143	0.6666667	0.6666667	0.5000000	0.7142857
5586	CCDC144CP	coiled-coil domain containing 144C, pseudogene	0.2857143	0.7777778	0.6666667	0.3333333	0.8571429
5605	SLC46A1	solute carrier family 46 member 1	0.0000000	0.6666667	0.6666667	0.3333333	0.7142857
5627	MYO18A	myosin XVIIIA	0.2857143	0.4444444	0.6666667	0.3333333	0.7142857
5717	CWC25	CWC25 spliceosome associated protein homolog	0.2857143	0.6666667	0.3333333	0.1666667	0.8571429
5785	CAVIN1	caveolae associated protein 1	0.1428571	0.5555556	0.6666667	0.5000000	0.7142857
5853	FMNL1	formin like 1	0.1428571	0.4444444	0.6666667	0.3333333	0.7142857
5865	WNT3	Wnt family member 3	0.2857143	0.6666667	0.6666667	0.3333333	0.7142857
5943	NOG	noggin	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
6069	RAB37	RAB37, member RAS oncogene family	0.0000000	0.4444444	0.6666667	0.1666667	0.7142857
6076	USH1G	USH1 protein network component sans	0.2857143	0.6666667	0.6666667	0.5000000	0.7142857
6080	KCTD2	potassium channel tetramerization domain containing 2	0.2857143	0.3333333	0.0000000	0.3333333	0.7142857
6144	SEPTIN9	septin 9	0.2857143	0.3333333	0.3333333	0.3333333	0.7142857
6161	TIMP2	TIMP metallopeptidase inhibitor 2	0.2857143	0.6666667	0.6666667	0.3333333	0.7142857
6164	C1QTNF1	C1q and TNF related 1	0.2857143	0.5555556	0.6666667	0.3333333	0.7142857
6211	CCDC57	coiled-coil domain containing 57	0.2857143	0.7777778	0.3333333	0.1666667	0.7142857
6213	SLC16A3	solute carrier family 16 member 3	0.2857143	0.4444444	0.3333333	0.3333333	0.8571429
6246	TGIF1	TGFB induced factor homeobox 1	0.2857143	0.5555556	0.6666667	0.1666667	0.7142857
6308	CDH2	cadherin 2	0.2857143	0.3333333	0.0000000	0.1666667	0.7142857
6379	ONECUT2	one cut homeobox 2	0.2857143	0.7777778	0.3333333	0.3333333	0.7142857
6398	BCL2	BCL2 apoptosis regulator	0.2857143	0.5555556	0.3333333	0.5000000	0.7142857
6497	CSNK1G2	casein kinase 1 gamma 2	0.2857143	0.7777778	0.3333333	0.3333333	0.7142857
6498	BTBD2	BTB domain containing 2	0.2857143	0.7777778	0.6666667	0.5000000	1.0000000
6525	TLE2	TLE family member 2, transcriptional corepressor	0.2857143	0.7777778	0.6666667	0.3333333	0.7142857
6529	GNA11	G protein subunit alpha 11	0.2857143	0.3333333	0.6666667	0.5000000	0.7142857
6565	FSD1	fibronectin type III and SPRY domain containing 1	0.2857143	0.8888889	0.6666667	0.5000000	0.7142857
6604	TRIP10	thyroid hormone receptor interactor 10	0.2857143	0.5555556	0.6666667	0.3333333	0.7142857
6612	ZNF358	zinc finger protein 358	0.1428571	0.5555556	0.6666667	0.3333333	0.7142857
6638	ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif 10	0.2857143	0.8888889	0.6666667	0.5000000	0.8571429
6715	ZNF69	zinc finger protein 69	0.1428571	0.5555556	0.6666667	0.3333333	0.7142857
6717	ZNF763	zinc finger protein 763	0.1428571	0.5555556	0.6666667	0.5000000	0.7142857
6729	ZNF442	zinc finger protein 442	0.2857143	0.6666667	1.0000000	0.5000000	0.7142857
6747	RTBDN	retbindin	0.2857143	0.4444444	0.6666667	0.5000000	0.7142857
6758	NFIX	nuclear factor I X	0.1428571	0.5555556	0.3333333	0.3333333	0.7142857
6772	PALM3	paralemmin 3	0.2857143	0.5555556	0.6666667	0.5000000	0.7142857
6787	TECR	trans-2,3-enoyl-CoA reductase	0.2857143	0.5555556	0.6666667	0.1666667	0.7142857
6798	CYP4F12	cytochrome P450 family 4 subfamily F member 12	0.1428571	0.2222222	0.3333333	0.3333333	0.7142857
6909	LINC00664	long intergenic non-protein coding RNA 664	0.2857143	0.5555556	0.6666667	0.3333333	1.0000000
7158	ZNF234	zinc finger protein 234	0.2857143	0.5555556	0.6666667	0.5000000	0.7142857
7165	MIR4531	microRNA 4531	0.2857143	0.5555556	0.6666667	0.5000000	0.7142857
7175	ZNF296	zinc finger protein 296	0.2857143	0.5555556	0.0000000	0.1666667	0.7142857
7247	CCDC114	coiled-coil domain containing 114	0.1428571	0.4444444	0.3333333	0.1666667	0.7142857
7291	CCDC155	coiled-coil domain containing 155	0.0000000	0.5555556	0.6666667	0.3333333	0.7142857
7475	ZSCAN18	zinc finger and SCAN domain containing 18	0.2857143	1.0000000	0.6666667	0.3333333	0.8571429
7557	GDF7	growth differentiation factor 7	0.0000000	0.3333333	0.0000000	0.1666667	0.7142857
7606	FNDC4	fibronectin type III domain containing 4	0.2857143	0.6666667	0.6666667	0.3333333	0.7142857
7936	ECRG4	ECRG4 augurin precursor	0.1428571	0.1111111	0.3333333	0.1666667	0.7142857
7995	AMMECR1L	AMMECR1 like	0.0000000	0.1111111	0.0000000	0.0000000	0.7142857
8428	SDCBP2	syndecan binding protein 2	0.2857143	0.7777778	0.6666667	0.5000000	0.8571429
8518	LOC284798	uncharacterized LOC284798	0.2857143	0.7777778	0.3333333	0.5000000	0.7142857
8533	FOXS1	forkhead box S1	0.2857143	0.4444444	0.3333333	0.5000000	0.8571429
8539	TSPY26P	testis specific protein Y-linked 26, pseudogene	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
8547	C20orf203	chromosome 20 open reading frame 203	0.1428571	0.7777778	0.6666667	0.3333333	0.7142857
8548	C20orf203	chromosome 20 open reading frame 203	0.2857143	0.3333333	0.6666667	0.0000000	0.7142857
8552	BPIFB1	BPI fold containing family B member 1	0.2857143	0.6666667	0.6666667	0.5000000	0.7142857
8642	KCNK15	potassium two pore domain channel subfamily K member 15	0.2857143	0.6666667	0.6666667	0.1666667	0.7142857
8697	NFATC2	nuclear factor of activated T cells 2	0.2857143	0.6666667	0.6666667	0.0000000	0.7142857
8762	EEF1A2	eukaryotic translation elongation factor 1 alpha 2	0.2857143	0.6666667	0.6666667	0.5000000	0.7142857
8928	COL6A2	collagen type VI alpha 2 chain	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
8974	RANBP1	RAN binding protein 1	0.2857143	0.4444444	0.6666667	0.5000000	0.8571429
9043	MN1	MN1 proto-oncogene, transcriptional regulator	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
9070	SEC14L2	SEC14 like lipid binding 2	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857
9098	RFPL2	ret finger protein like 2	0.2857143	0.5555556	0.3333333	0.1666667	1.0000000
9262	LINC00899	long intergenic non-protein coding RNA 899	0.2857143	0.7777778	0.6666667	0.3333333	0.7142857
9279	MLC1	modulator of VRAC current 1	0.2857143	0.6666667	0.6666667	0.5000000	0.8571429
9428	DLEC1	DLEC1 cilia and flagella associated protein	0.2857143	0.4444444	0.6666667	0.3333333	0.7142857
9489	LRRC2-AS1	LRRC2 antisense RNA 1	0.2857143	0.6666667	0.6666667	0.6666667	0.8571429
9789	MYLK	myosin light chain kinase	0.2857143	0.6666667	0.3333333	0.5000000	0.8571429
9887	PAQR9	progestin and adipoQ receptor family member 9	0.1428571	0.3333333	0.6666667	0.3333333	0.7142857
9911	IGSF10	immunoglobulin superfamily member 10	0.2857143	0.0000000	0.6666667	0.3333333	0.7142857
10165	LINC01096	long intergenic non-protein coding RNA 1096	0.0000000	0.2222222	0.0000000	0.0000000	0.7142857
10296	PPEF2	protein phosphatase with EF-hand domain 2	0.2857143	0.3333333	0.6666667	0.3333333	0.7142857
10515	TRIM61	tripartite motif containing 61	0.2857143	0.5555556	0.6666667	0.5000000	0.7142857
10586	TENT4A	terminal nucleotidyltransferase 4A	0.2857143	0.2222222	0.6666667	0.3333333	0.7142857
10588	C5orf49	chromosome 5 open reading frame 49	0.1428571	0.7777778	0.6666667	0.5000000	0.7142857
10947	MATR3	matrin 3	0.0000000	0.4444444	0.3333333	0.1666667	0.7142857
11066	ADRA1B	adrenoceptor alpha 1B	0.2857143	0.2222222	0.6666667	0.3333333	0.8571429
11116	ARL10	ADP ribosylation factor like GTPase 10	0.0000000	0.6666667	0.0000000	0.3333333	0.7142857
11161	MGAT4B	alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B	0.2857143	0.7777778	0.6666667	0.6666667	0.8571429
11263	SOX4	SRY-box transcription factor 4	0.0000000	0.2222222	0.6666667	0.1666667	0.7142857
11270	C6orf62	chromosome 6 open reading frame 62	0.1428571	0.5555556	0.3333333	0.5000000	0.7142857
11422	VWA7	von Willebrand factor A domain containing 7	0.1428571	0.8888889	0.6666667	0.5000000	0.7142857
11432	ATF6B	activating transcription factor 6 beta	0.2857143	0.5555556	0.6666667	0.5000000	0.7142857
11483	GRM4	glutamate metabotropic receptor 4	0.2857143	0.5555556	0.6666667	0.5000000	0.8571429
11528	FGD2	FYVE, RhoGEF and PH domain containing 2	0.2857143	0.2222222	0.3333333	0.1666667	0.7142857
11602	TCTE1	t-complex-associated-testis-expressed 1	0.2857143	0.5555556	0.6666667	0.3333333	0.7142857
11607	CLIC5	chloride intracellular channel 5	0.1428571	0.5555556	0.6666667	0.5000000	0.7142857
11648	OOEP	oocyte expressed protein	0.2857143	0.7777778	0.6666667	0.6666667	0.7142857
11791	TPD52L1	TPD52 like 1	0.2857143	0.6666667	0.6666667	0.5000000	0.7142857
12125	TARP	TCR gamma alternate reading frame protein	0.2857143	0.5555556	0.3333333	0.3333333	0.8571429
12377	TRIP6	thyroid hormone receptor interactor 6	0.1428571	0.3333333	0.3333333	0.3333333	0.7142857
12431	GPR85	G protein-coupled receptor 85	0.1428571	0.4444444	0.0000000	0.1666667	0.7142857
12463	LRRC4	leucine rich repeat containing 4	0.1428571	0.7777778	0.3333333	0.5000000	0.7142857
12622	INSIG1	insulin induced gene 1	0.2857143	0.3333333	0.0000000	0.1666667	0.7142857
12642	MIR596	microRNA 596	0.2857143	0.7777778	0.3333333	0.1666667	0.7142857
12665	FAM66D	family with sequence similarity 66 member D	0.2857143	0.4444444	0.3333333	0.3333333	0.7142857
12715	TNFRSF10C	TNF receptor superfamily member 10c	0.0000000	0.6666667	0.6666667	0.3333333	0.7142857
12853	NCOA2	nuclear receptor coactivator 2	0.2857143	0.5555556	0.0000000	0.5000000	0.8571429
12866	LY96	lymphocyte antigen 96	0.2857143	0.6666667	0.6666667	0.5000000	0.7142857
12867	JPH1	junctophilin 1	0.2857143	0.5555556	0.3333333	0.5000000	0.7142857
12961	OXR1	oxidation resistance 1	0.2857143	0.3333333	0.3333333	0.5000000	0.7142857
12969	TRPS1	transcriptional repressor GATA binding 1	0.2857143	0.6666667	0.3333333	0.3333333	0.7142857
13038	DENND3	DENN domain containing 3	0.1428571	0.1111111	0.6666667	0.3333333	0.7142857
13106	CBWD1	COBW domain containing 1	0.2857143	0.4444444	0.3333333	0.5000000	0.7142857
13276	TRPM6	transient receptor potential cation channel subfamily M member 6	0.2857143	0.6666667	0.6666667	0.5000000	0.7142857
13391	TMEFF1	transmembrane protein with EGF like and two follistatin like domains 1	0.2857143	0.8888889	0.6666667	0.3333333	0.7142857
13518	PIP5KL1	phosphatidylinositol-4-phosphate 5-kinase like 1	0.2857143	0.6666667	0.3333333	0.1666667	0.7142857
13562	PRRX2	paired related homeobox 2	0.1428571	0.6666667	0.6666667	0.3333333	0.7142857
13570	NCS1	neuronal calcium sensor 1	0.2857143	0.6666667	0.6666667	0.3333333	0.8571429
13635	NOTCH1	notch receptor 1	0.2857143	0.3333333	0.6666667	0.3333333	0.7142857

write.table(closed0open3, "CD8_closed0open3.txt", sep="\t")
write.table(closed0open8, "CD8_closed0open8.txt", sep="\t")
write.table(closed0open30, "CD8_closed0open30.txt", sep="\t")
write.table(closed0open120, "CD8_closed0open120.txt", sep="\t")

Detección de promotores afectados por el tratamiento con ibrutinib y evolución temporal

Utilizamos la herramienta EnrichR:

dbs <- c( "GO_Molecular_Function_2018", "GO_Biological_Process_2018", "Panther_2016")

dfpeakcomp<-list(open0closed3$SYMBOL, open0closed8$SYMBOL, open0closed30$SYMBOL,open0closed120$SYMBOL, closed0open3$SYMBOL, closed0open8$SYMBOL, closed0open30$SYMBOL, closed0open120$SYMBOL)
enriched <- lapply(dfpeakcomp, enrichr, databases =dbs)

## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.
## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.
## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.
## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.
## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.
## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.

## No genes have been given

## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying Panther_2016... Done.
## Parsing results... Done.

setwd("/Users/javi/Documents/Master Bioinformática UOC/Proyecto fin de máster/PEC3 ATAC-seq/CD8")
summary(enriched[[1]])

##                            Length Class      Mode
## GO_Molecular_Function_2018 9      data.frame list
## GO_Biological_Process_2018 9      data.frame list
## Panther_2016               9      data.frame list

gofilesnames<-c("open0closed3" , "open0closed8", "open0closed30" ,"open0closed120" , "closed0open3" , "closed0open8","closed0open30", "closed0open120" )
names(enriched)<-gofilesnames

for (i in 1:length(names(enriched))){
    filename<-paste("CD8_", gofilesnames[i],"enrichr", sep ="")
    filename.txt<-paste("CD8_", gofilesnames[i],"enrichr.txt", sep ="")
   # printEnrich(enriched[[i]], file = filename.txt ,sep = "\t", columns = c(1:9))
   print("")
   print(filename)
   print(knitr::kable(enriched[[i]]$GO_Molecular_Function_2018[1:10,]))
   print(knitr::kable(enriched[[i]]$GO_Biological_Process_2018[1:10,]))
   print(knitr::kable(enriched[[i]]$Panther_2016[1:10,]))
}

## [1] ""
## [1] "CD8_open0closed3enrichr"
## 
## 
##        Term                                                                  Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## -----  --------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## 1      MAP kinase activity (GO:0004707)                                      1/14       0.0034954                  1             0                      0   285.714286       1616.08794  MAPK9 
## 2      epidermal growth factor receptor binding (GO:0005154)                 1/25       0.0062349                  1             0                      0   160.000000        812.41384  FER   
## 3      non-membrane spanning protein tyrosine kinase activity (GO:0004715)   1/43       0.0107048                  1             0                      0    93.023256        422.05209  FER   
## 4      growth factor receptor binding (GO:0070851)                           1/92       0.0227915                  1             0                      0    43.478261        164.40735  FER   
## 5      protein tyrosine kinase activity (GO:0004713)                         1/147      0.0362171                  1             0                      0    27.210884         90.29181  FER   
## 6      protein kinase activity (GO:0004672)                                  1/513      0.1218486                  1             0                      0     7.797271         16.41307  FER   
## NA     NA                                                                    NA                NA                 NA            NA                     NA           NA               NA  NA    
## NA.1   NA                                                                    NA                NA                 NA            NA                     NA           NA               NA  NA    
## NA.2   NA                                                                    NA                NA                 NA            NA                     NA           NA               NA  NA    
## NA.3   NA                                                                    NA                NA                 NA            NA                     NA           NA               NA  NA    
## 
## 
## Term                                                           Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes     
## -------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ----------
## response to reactive oxygen species (GO:0000302)               2/60       0.0000880          0.4490051             0                      0    133.33333        1245.1073  MAPK9;FER 
## cellular response to reactive oxygen species (GO:0034614)      2/65       0.0001033          0.2636905             0                      0    123.07692        1129.5281  MAPK9;FER 
## cellular response to oxidative stress (GO:0034599)             2/115      0.0003241          0.5512392             0                      0     69.56522         558.9258  MAPK9;FER 
## Fc-epsilon receptor signaling pathway (GO:0038095)             2/182      0.0008088          1.0000000             0                      0     43.95604         312.9628  MAPK9;FER 
## Fc receptor signaling pathway (GO:0038093)                     2/183      0.0008177          0.8345445             0                      0     43.71585         310.7766  MAPK9;FER 
## SREBP signaling pathway (GO:0032933)                           1/6        0.0014992          1.0000000             0                      0    666.66667        4335.2070  INSIG2    
## cellular response to sterol depletion (GO:0071501)             1/7        0.0017489          1.0000000             0                      0    571.42857        3627.8622  INSIG2    
## cellular response to oxygen-containing compound (GO:1901701)   2/274      0.0018198          1.0000000             0                      0     29.19708         184.2060  MAPK9;FER 
## tyrosine phosphorylation of STAT protein (GO:0007260)          1/8        0.0019986          1.0000000             0                      0    500.00000        3107.6633  FER       
## regulation of leukocyte degranulation (GO:0043300)             1/9        0.0022482          1.0000000             0                      0    444.44444        2710.0635  FER       
## 
## 
## Term                                                              Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## ----------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## Oxidative stress response Homo sapiens P00046                     1/24       0.0059861          0.6704476             0                      0    166.66667         853.0514  MAPK9 
## Interferon-gamma signaling pathway Homo sapiens P00035            1/28       0.0069810          0.3909383             0                      0    142.85714         709.2225  MAPK9 
## FAS signaling pathway Homo sapiens P00020                         1/31       0.0077267          0.2884633             0                      0    129.03226         627.4934  MAPK9 
## Toll receptor signaling pathway Homo sapiens P00054               1/49       0.0121912          0.3413542             0                      0     81.63265         359.7583  MAPK9 
## Alzheimer disease-amyloid secretase pathway Homo sapiens P00003   1/56       0.0139231          0.3118770             0                      0     71.42857         305.3005  MAPK9 
## B cell activation Homo sapiens P00010                             1/57       0.0141703          0.2645121             0                      0     70.17544         298.7093  MAPK9 
## Ras Pathway Homo sapiens P04393                                   1/69       0.0171329          0.2741272             0                      0     57.97101         235.7537  MAPK9 
## T cell activation Homo sapiens P00053                             1/73       0.0181189          0.2536648             0                      0     54.79452         219.7698  MAPK9 
## Parkinson disease Homo sapiens P00049                             1/81       0.0200885          0.2499900             0                      0     49.38272         192.9683  MAPK9 
## TGF-beta signaling pathway Homo sapiens P00052                    1/88       0.0218093          0.2442636             0                      0     45.45455         173.8828  MAPK9 
## [1] ""
## [1] "CD8_open0closed8enrichr"
## 
## 
##      Term                                                                  Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## ---  --------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## 1    MAP kinase activity (GO:0004707)                                      1/14       0.0027972                  1             0                      0   357.142857       2099.68841  MAPK9 
## 2    MHC class II protein complex binding (GO:0023026)                     1/16       0.0031964                  1             0                      0   312.500000       1795.54545  PKM   
## 3    Notch binding (GO:0005112)                                            1/17       0.0033959                  1             0                      0   294.117647       1672.11633  DLL3  
## 4    MHC protein complex binding (GO:0023023)                              1/19       0.0037948                  1             0                      0   263.157895       1466.87351  PKM   
## 5    phosphotransferase activity, alcohol group as acceptor (GO:0016773)   1/254      0.0498439                  1             0                      0    19.685039         59.03268  PKM   
## 6    cadherin binding (GO:0045296)                                         1/313      0.0611500                  1             0                      0    15.974441         44.63939  PKM   
## 7    kinase binding (GO:0019900)                                           1/418      0.0810211                  1             0                      0    11.961723         30.06036  CCND2 
## 8    protein kinase binding (GO:0019901)                                   1/495      0.0953915                  1             0                      0    10.101010         23.73501  CCND2 
## 9    RNA binding (GO:0003723)                                              1/1387     0.2498708                  1             0                      0     3.604903          4.99932  PKM   
## NA   NA                                                                    NA                NA                 NA            NA                     NA           NA               NA  NA    
## 
## 
## Term                                                                               Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## ---------------------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## positive regulation of macrophage derived foam cell differentiation (GO:0010744)   1/16       0.0031964                  1             0                      0     312.5000        1795.5455  MAPK9 
## positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)          1/16       0.0031964                  1             0                      0     312.5000        1795.5455  CCND2 
## glycolytic process (GO:0006096)                                                    1/23       0.0045924                  1             0                      0     217.3913        1170.2963  PKM   
## positive regulation of cell cycle G1/S phase transition (GO:1902808)               1/23       0.0045924                  1             0                      0     217.3913        1170.2963  CCND2 
## ATP generation from ADP (GO:0006757)                                               1/24       0.0047917                  1             0                      0     208.3333        1112.6830  PKM   
## glycolytic process through glucose-6-phosphate (GO:0061620)                        1/25       0.0049909                  1             0                      0     200.0000        1060.0262  PKM   
## canonical glycolysis (GO:0061621)                                                  1/25       0.0049909                  1             0                      0     200.0000        1060.0262  PKM   
## glucose catabolic process to pyruvate (GO:0061718)                                 1/25       0.0049909                  1             0                      0     200.0000        1060.0262  PKM   
## positive regulation of cyclin-dependent protein kinase activity (GO:1904031)       1/26       0.0051902                  1             0                      0     192.3077        1011.7279  CCND2 
## regulation of macrophage derived foam cell differentiation (GO:0010743)            1/29       0.0057878                  1             0                      0     172.4138         888.2777  MAPK9 
## 
## 
## Term                                                              Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## ----------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## Pyruvate metabolism Homo sapiens P02772                           1/8        0.0015991          0.1791024             0                      0    625.00000        4023.9353  PKM   
## Cell cycle Homo sapiens P00013                                    1/16       0.0031964          0.1789957             0                      0    312.50000        1795.5455  CCND2 
## Glycolysis Homo sapiens P00024                                    1/17       0.0033959          0.1267791             0                      0    294.11765        1672.1163  PKM   
## Oxidative stress response Homo sapiens P00046                     1/24       0.0047917          0.1341665             0                      0    208.33333        1112.6830  MAPK9 
## Interferon-gamma signaling pathway Homo sapiens P00035            1/28       0.0055886          0.1251846             0                      0    178.57143         926.2548  MAPK9 
## FAS signaling pathway Homo sapiens P00020                         1/31       0.0061860          0.1154717             0                      0    161.29032         820.2369  MAPK9 
## Notch signaling pathway Homo sapiens P00045                       1/38       0.0075788          0.1212616             0                      0    131.57895         642.4203  DLL3  
## PI3 kinase pathway Homo sapiens P00048                            1/42       0.0083741          0.1172375             0                      0    119.04762         569.3584  CCND2 
## Toll receptor signaling pathway Homo sapiens P00054               1/49       0.0097647          0.1215159             0                      0    102.04082         472.3453  MAPK9 
## Alzheimer disease-amyloid secretase pathway Homo sapiens P00003   1/56       0.0111538          0.1249222             0                      0     89.28571         401.4266  MAPK9 
## [1] ""
## [1] "CD8_open0closed30enrichr"
## 
## 
## Term                                                                            Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes  
## ------------------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -------
## manganese ion transmembrane transporter activity (GO:0005384)                   1/6        0.0029966          1.0000000             0                      0     333.3333        1936.7614  ATP2C1 
## vascular endothelial growth factor-activated receptor activity (GO:0005021)     1/7        0.0034952          1.0000000             0                      0     285.7143        1616.1022  NRP1   
## RNA polymerase I regulatory region sequence-specific DNA binding (GO:0001163)   1/8        0.0039936          1.0000000             0                      0     250.0000        1380.7627  BAZ2A  
## RNA polymerase I CORE element sequence-specific DNA binding (GO:0001164)        1/8        0.0039936          1.0000000             0                      0     250.0000        1380.7627  BAZ2A  
## hydrogen-exporting ATPase activity, phosphorylative mechanism (GO:0008553)      1/9        0.0044918          1.0000000             0                      0     222.2222        1201.2204  ATP2C1 
## mitogen-activated protein kinase kinase kinase binding (GO:0031435)             1/10       0.0049898          0.9572134             0                      0     200.0000        1060.0712  STK38  
## semaphorin receptor activity (GO:0017154)                                       1/11       0.0054876          0.9023129             0                      0     181.8182         946.4128  NRP1   
## MAP kinase activity (GO:0004707)                                                1/14       0.0069795          1.0000000             0                      0     142.8571         709.2545  MAPK9  
## calcium-transporting ATPase activity (GO:0005388)                               1/14       0.0069795          0.8925971             0                      0     142.8571         709.2545  ATP2C1 
## ligand-dependent nuclear receptor binding (GO:0016922)                          1/17       0.0084694          0.9748241             0                      0     117.6471         561.3294  BAZ2A  
## 
## 
## Term                                                                Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes       
## ------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------------
## actin cytoskeleton reorganization (GO:0031532)                      2/61       0.0004053                  1             0                      0     65.57377         512.1844  NRP1;ATP2C1 
## regulation of vesicle-mediated transport (GO:0060627)               2/138      0.0020512                  1             0                      0     28.98551         179.4009  RIMS2;NRP1  
## peptidyl-serine phosphorylation (GO:0018105)                        2/145      0.0022611                  1             0                      0     27.58621         168.0521  MAPK9;STK38 
## positive regulation of receptor binding (GO:1900122)                1/6        0.0029966                  1             0                      0    333.33333        1936.7614  NRP1        
## positive regulation of axon guidance (GO:1902669)                   1/6        0.0029966                  1             0                      0    333.33333        1936.7614  NRP1        
## retinal ganglion cell axon guidance (GO:0031290)                    1/6        0.0029966                  1             0                      0    333.33333        1936.7614  NRP1        
## peptidyl-serine modification (GO:0018209)                           2/170      0.0030905                  1             0                      0     23.52941         135.9861  MAPK9;STK38 
## substrate-dependent cell migration, cell extension (GO:0006930)     1/7        0.0034952                  1             0                      0    285.71429        1616.1022  NRP1        
## vascular endothelial growth factor signaling pathway (GO:0038084)   1/7        0.0034952                  1             0                      0    285.71429        1616.1022  NRP1        
## regulation of Cdc42 protein signal transduction (GO:0032489)        1/7        0.0034952                  1             0                      0    285.71429        1616.1022  NRP1        
## 
## 
## Term                                                              Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## ----------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## Axon guidance mediated by semaphorins Homo sapiens P00007         1/17       0.0084694          0.9485690             0                      0    117.64706        561.32936  NRP1  
## Oxidative stress response Homo sapiens P00046                     1/24       0.0119380          0.6685260             0                      0     83.33333        369.00264  MAPK9 
## Interferon-gamma signaling pathway Homo sapiens P00035            1/28       0.0139151          0.5194976             0                      0     71.42857        305.34140  MAPK9 
## FAS signaling pathway Homo sapiens P00020                         1/31       0.0153956          0.4310780             0                      0     64.51613        269.26908  MAPK9 
## Notch signaling pathway Homo sapiens P00045                       1/38       0.0188424          0.4220704             0                      0     52.63158        209.03390  DLL3  
## Toll receptor signaling pathway Homo sapiens P00054               1/49       0.0242369          0.4524216             0                      0     40.81633        151.83185  MAPK9 
## Alzheimer disease-amyloid secretase pathway Homo sapiens P00003   1/56       0.0276558          0.4424926             0                      0     35.71429        128.14001  MAPK9 
## B cell activation Homo sapiens P00010                             1/57       0.0281433          0.3940065             0                      0     35.08772        125.27878  MAPK9 
## Ras Pathway Homo sapiens P04393                                   1/69       0.0339766          0.4228201             0                      0     28.98551         98.03139  MAPK9 
## T cell activation Homo sapiens P00053                             1/73       0.0359140          0.4022371             0                      0     27.39726         91.14047  MAPK9 
## [1] ""
## [1] "CD8_open0closed120enrichr"
## 
## 
## Term                                                                     Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes      
## -----------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -----------
## cAMP response element binding (GO:0035497)                               1/7        0.0034952                  1             0                      0    285.71429       1616.10221  CREB3L2    
## mitogen-activated protein kinase kinase kinase binding (GO:0031435)      1/10       0.0049898                  1             0                      0    200.00000       1060.07117  STK38      
## ATP binding (GO:0005524)                                                 2/255      0.0068112                  1             0                      0     15.68627         78.26183  CDK6;STK38 
## MAP kinase activity (GO:0004707)                                         1/14       0.0069795                  1             0                      0    142.85714        709.25454  MAPK9      
## adenyl ribonucleotide binding (GO:0032559)                               2/279      0.0081043                  1             0                      0     14.33692         69.03747  CDK6;STK38 
## protein serine/threonine kinase activity (GO:0004674)                    2/368      0.0137803                  1             0                      0     10.86957         46.57080  CDK6;STK38 
## purine ribonucleoside triphosphate binding (GO:0035639)                  2/396      0.0158413                  1             0                      0     10.10101         41.87006  CDK6;STK38 
## cyclin-dependent protein serine/threonine kinase activity (GO:0004693)   1/33       0.0163815                  1             0                      0     60.60606        249.18786  CDK6       
## cyclin-dependent protein kinase activity (GO:0097472)                    1/34       0.0168742                  1             0                      0     58.82353        240.11596  CDK6       
## Rab guanyl-nucleotide exchange factor activity (GO:0017112)              1/51       0.0252148                  1             0                      0     39.21569        144.32643  DENND2D    
## 
## 
## Term                                                             Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes            
## ---------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -----------------
## phosphorylation (GO:0016310)                                     3/386      0.0007739                  1             0                      0     15.54404        111.35935  MAPK9;CDK6;STK38 
## protein phosphorylation (GO:0006468)                             3/470      0.0013681                  1             0                      0     12.76596         84.18253  MAPK9;CDK6;STK38 
## regulation of macromolecule metabolic process (GO:0060255)       2/129      0.0017958                  1             0                      0     31.00775        196.04101  MAPK9;CDK6       
## peptidyl-serine phosphorylation (GO:0018105)                     2/145      0.0022611                  1             0                      0     27.58621        168.05205  MAPK9;STK38      
## type B pancreatic cell development (GO:0003323)                  1/6        0.0029966                  1             0                      0    333.33333       1936.76142  CDK6             
## positive regulation of microglial cell activation (GO:1903980)   1/6        0.0029966                  1             0                      0    333.33333       1936.76142  ITGAM            
## astrocyte differentiation (GO:0048708)                           1/6        0.0029966                  1             0                      0    333.33333       1936.76142  CDK6             
## glandular epithelial cell development (GO:0002068)               1/6        0.0029966                  1             0                      0    333.33333       1936.76142  CDK6             
## regulation of dopamine metabolic process (GO:0042053)            1/6        0.0029966                  1             0                      0    333.33333       1936.76142  ITGAM            
## peptidyl-serine modification (GO:0018209)                        2/170      0.0030905                  1             0                      0     23.52941        135.98605  MAPK9;STK38      
## 
## 
## Term                                                                        Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes       
## --------------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------------
## Integrin signalling pathway Homo sapiens P00034                             2/156      0.0026108          0.2924128             0                      0     25.64103        152.51507  MAPK9;ITGAM 
## Oxidative stress response Homo sapiens P00046                               1/24       0.0119380          0.6685260             0                      0     83.33333        369.00264  MAPK9       
## Interferon-gamma signaling pathway Homo sapiens P00035                      1/28       0.0139151          0.5194976             0                      0     71.42857        305.34140  MAPK9       
## FAS signaling pathway Homo sapiens P00020                                   1/31       0.0153956          0.4310780             0                      0     64.51613        269.26908  MAPK9       
## Transcription regulation by bZIP transcription factor Homo sapiens P00055   1/42       0.0208071          0.4660799             0                      0     47.61905        184.40281  CREB3L2     
## Toll receptor signaling pathway Homo sapiens P00054                         1/49       0.0242369          0.4524216             0                      0     40.81633        151.83185  MAPK9       
## Alzheimer disease-amyloid secretase pathway Homo sapiens P00003             1/56       0.0276558          0.4424926             0                      0     35.71429        128.14001  MAPK9       
## B cell activation Homo sapiens P00010                                       1/57       0.0281433          0.3940065             0                      0     35.08772        125.27878  MAPK9       
## Ras Pathway Homo sapiens P04393                                             1/69       0.0339766          0.4228201             0                      0     28.98551         98.03139  MAPK9       
## T cell activation Homo sapiens P00053                                       1/73       0.0359140          0.4022371             0                      0     27.39726         91.14047  MAPK9       
## [1] ""
## [1] "CD8_closed0open3enrichr"
## 
## 
## Term                                                                     Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes               
## -----------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  --------------------
## RNA polymerase II repressing transcription factor binding (GO:0001103)   2/28       0.0040666                  1             0                      0    21.008403        115.65006  TCF7L2;TCERG1L      
## phosphotransferase activity, alcohol group as acceptor (GO:0016773)      4/254      0.0109648                  1             0                      0     4.631774         20.90349  DGKD;GRK2;KSR1;PTK2 
## repressing transcription factor binding (GO:0070491)                     2/53       0.0140378                  1             0                      0    11.098779         47.34743  TCF7L2;TCERG1L      
## kinase activity (GO:0016301)                                             4/280      0.0152016                  1             0                      0     4.201681         17.58973  DGKD;GRK2;KSR1;PTK2 
## JUN kinase binding (GO:0008432)                                          1/6        0.0202297                  1             0                      0    49.019608        191.20596  PTK2                
## prostaglandin E receptor activity (GO:0004957)                           1/6        0.0202297                  1             0                      0    49.019608        191.20596  PTGER3              
## malate dehydrogenase activity (GO:0016615)                               1/6        0.0202297                  1             0                      0    49.019608        191.20596  ME1                 
## protein-lysine 6-oxidase activity (GO:0004720)                           1/6        0.0202297                  1             0                      0    49.019608        191.20596  LOXL4               
## protein-glutamic acid ligase activity (GO:0070739)                       1/7        0.0235619                  1             0                      0    42.016807        157.48413  TTLL13P             
## MAP kinase tyrosine/serine/threonine phosphatase activity (GO:0017017)   1/7        0.0235619                  1             0                      0    42.016807        157.48413  DUSP2               
## 
## 
## Term                                                                                 Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes            
## -----------------------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -----------------
## negative regulation of cell-cell adhesion (GO:0022408)                               3/31       0.0001578          0.8053974             0                      0     28.46300        249.16518  JAG1;SPINT2;PTK2 
## regulation of cell-cell adhesion (GO:0022407)                                        3/32       0.0001737          0.4432780             0                      0     27.57353        238.73147  JAG1;SPINT2;PTK2 
## cell surface receptor signaling pathway involved in heart development (GO:0061311)   2/14       0.0010095          1.0000000             0                      0     42.01681        289.84393  JAG1;NOG         
## myoblast differentiation (GO:0045445)                                                2/16       0.0013254          1.0000000             0                      0     36.76471        243.60455  TCF7L2;JAG1      
## negative regulation of cell adhesion (GO:0007162)                                    3/65       0.0014122          1.0000000             0                      0     13.57466         89.08489  JAG1;SPINT2;PTK2 
## morphogenesis of an epithelium (GO:0002009)                                          2/19       0.0018763          1.0000000             0                      0     30.95975        194.37938  KDM2B;KDF1       
## dorsal/ventral pattern formation (GO:0009953)                                        2/20       0.0020802          1.0000000             0                      0     29.41176        181.62608  NOG;DSCAML1      
## embryonic skeletal system development (GO:0048706)                                   2/21       0.0022941          1.0000000             0                      0     28.01120        170.23517  NOG;DSCAML1      
## embryonic skeletal system morphogenesis (GO:0048704)                                 2/21       0.0022941          1.0000000             0                      0     28.01120        170.23517  NOG;DSCAML1      
## limb development (GO:0060173)                                                        2/24       0.0029954          1.0000000             0                      0     24.50980        142.41856  KDF1;NOG         
## 
## 
## Term                                                       Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes                           
## ---------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  --------------------------------
## Wnt signaling pathway Homo sapiens P00057                  5/278      0.0025556          0.2862237             0                      0     5.289886        31.577870  TCF7L2;TLE2;FZD8;ARID1A;CSNK1G2 
## Angiogenesis Homo sapiens P00005                           3/142      0.0125471          0.7026367             0                      0     6.213753        27.205470  TCF7L2;JAG1;PTK2                
## Pyruvate metabolism Homo sapiens P02772                    1/8        0.0268830          1.0000000             0                      0    36.764706       132.950800  ME1                             
## Alzheimer disease-presenilin pathway Homo sapiens P00004   2/99       0.0447373          1.0000000             0                      0     5.941771        18.460772  TCF7L2;FZD8                     
## Cadherin signaling pathway Homo sapiens P00012             2/150      0.0924229          1.0000000             0                      0     3.921569         9.338747  TCF7L2;FZD8                     
## Integrin signalling pathway Homo sapiens P00034            2/156      0.0987269          1.0000000             0                      0     3.770739         8.730762  COL6A2;PTK2                     
## Notch signaling pathway Homo sapiens P00045                1/38       0.1215004          1.0000000             0                      0     7.739938        16.314534  JAG1                            
## VEGF signaling pathway Homo sapiens P00056                 1/54       0.1681947          1.0000000             0                      0     5.446623         9.709330  PTK2                            
## Parkinson disease Homo sapiens P00049                      1/81       0.2415078          1.0000000             0                      0     3.631082         5.159235  CSNK1G2                         
## CCKR signaling map ST Homo sapiens P06959                  1/165      0.4312279          1.0000000             0                      0     1.782531         1.499320  PTK2                            
## [1] ""
## [1] "CD8_closed0open8enrichr"
## 
## 
##        Term                                                     Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes 
## -----  -------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## 1      acetylcholine receptor binding (GO:0033130)              1/7        0.0027970                  1             0                      0   357.142857      2099.715176  NRXN1 
## 2      long-chain fatty acid-CoA ligase activity (GO:0004467)   1/10       0.0039936                  1             0                      0   250.000000      1380.762654  ACSL6 
## 3      fatty acid ligase activity (GO:0015645)                  1/18       0.0071785                  1             0                      0   138.888889       685.647338  ACSL6 
## 4      calcium channel regulator activity (GO:0005246)          1/26       0.0103545                  1             0                      0    96.153846       439.455183  NRXN1 
## 5      calcium ion binding (GO:0005509)                         1/284      0.1081293                  1             0                      0     8.802817        19.581231  NRXN1 
## 6      metal ion binding (GO:0046872)                           1/442      0.1637387                  1             0                      0     5.656109        10.234636  NRXN1 
## 7      protein homodimerization activity (GO:0042803)           1/664      0.2367400                  1             0                      0     3.765060         5.424672  ACSL6 
## NA     NA                                                       NA                NA                 NA            NA                     NA           NA               NA  NA    
## NA.1   NA                                                       NA                NA                 NA            NA                     NA           NA               NA  NA    
## NA.2   NA                                                       NA                NA                 NA            NA                     NA           NA               NA  NA    
## 
## 
## Term                                                     Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes  
## -------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -------
## vocal learning (GO:0042297)                              1/6        0.0023979                  1             0                      0     416.6667         2513.825  NRXN1  
## imitative learning (GO:0098596)                          1/6        0.0023979                  1             0                      0     416.6667         2513.825  NRXN1  
## postsynaptic density assembly (GO:0097107)               1/7        0.0027970                  1             0                      0     357.1429         2099.715  NRXN1  
## postsynaptic density organization (GO:0097106)           1/9        0.0035949                  1             0                      0     277.7778         1563.399  NRXN1  
## positive regulation of synapse maturation (GO:0090129)   1/9        0.0035949                  1             0                      0     277.7778         1563.399  NRXN1  
## postsynaptic membrane assembly (GO:0097104)              1/9        0.0035949                  1             0                      0     277.7778         1563.399  NRXN1  
## protein localization to synapse (GO:0035418)             1/10       0.0039936                  1             0                      0     250.0000         1380.763  NRXN1  
## regulation of synapse maturation (GO:0090128)            1/10       0.0039936                  1             0                      0     250.0000         1380.763  NRXN1  
## postsynapse assembly (GO:0099068)                        1/11       0.0043922                  1             0                      0     227.2727         1233.617  NRXN1  
## establishment of chromosome localization (GO:0051303)    1/13       0.0051890                  1             0                      0     192.3077         1011.771  SPICE1 
## 
## 
##        Term   Overlap   P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score   Genes 
## -----  -----  --------  --------  -----------------  ------------  ---------------------  -----------  ---------------  ------
## NA     NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.1   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.2   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.3   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.4   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.5   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.6   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.7   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.8   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## NA.9   NA     NA        NA        NA                 NA            NA                     NA           NA               NA    
## [1] ""
## [1] "CD8_closed0open30enrichr"

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## [1] ""
## [1] "CD8_closed0open120enrichr"
## 
## 
## Term                                                            Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes                                                                    
## --------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -------------------------------------------------------------------------
## small GTPase binding (GO:0031267)                               4/63       0.0022108                  1             0                      0     7.297938        44.622659  PEX5;SORL1;RAP1GAP;FGD2                                                  
## potassium ion transmembrane transporter activity (GO:0015079)   3/38       0.0043661                  1             0                      0     9.074410        49.309335  KCNA2;KCNK15;SLC12A6                                                     
## actin filament binding (GO:0051015)                             5/127      0.0050968                  1             0                      0     4.525296        23.889698  SVIL;FMNL1;ACTN1;MYO18A;CORO1A                                           
## ligand-dependent nuclear receptor binding (GO:0016922)          2/17       0.0093932                  1             0                      0    13.522650        63.120683  NCOA2;ARID1A                                                             
## collagen binding (GO:0005518)                                   3/52       0.0104686                  1             0                      0     6.631300        30.234584  C1QTNF1;NID1;PODN                                                        
## nuclear hormone receptor binding (GO:0035257)                   3/56       0.0128039                  1             0                      0     6.157635        26.834992  NCOA2;TCF7L2;TRIP6                                                       
## protein homodimerization activity (GO:0042803)                  12/664     0.0135321                  1             0                      0     2.077275         8.937877  CDH2;ACTN1;NOG;BCL2;XCL1;PYGL;FSD1;TPD52L1;SDCBP2;CORO1A;DSCAML1;RAP1GAP 
## kinase inhibitor activity (GO:0019210)                          3/59       0.0147352                  1             0                      0     5.844535        24.649410  LRRC4;RTN4RL2;PODN                                                       
## miRNA binding (GO:0035198)                                      2/24       0.0183197                  1             0                      0     9.578544        38.312034  ZC3H12A;MATR3                                                            
## protein kinase inhibitor activity (GO:0004860)                  3/67       0.0206504                  1             0                      0     5.146680        19.969223  LRRC4;RTN4RL2;PODN                                                       
## 
## 
## Term                                                                                                     Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes                    
## -------------------------------------------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  -------------------------
## G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)                                  3/16       0.0003335          1.0000000             0                      0    21.551724        172.54336  GRK2;GNA11;CHRM5         
## acetylcholine receptor signaling pathway (GO:0095500)                                                    3/19       0.0005660          1.0000000             0                      0    18.148820        135.69647  GRK2;GNA11;CHRM5         
## ventricular septum morphogenesis (GO:0060412)                                                            3/21       0.0007670          1.0000000             0                      0    16.420361        117.78305  NOTCH1;NOG;SOX4          
## limb development (GO:0060173)                                                                            3/24       0.0011451          1.0000000             0                      0    14.367816         97.30237  KDF1;NOG;KREMEN2         
## regulation of apoptotic signaling pathway (GO:2001233)                                                   3/25       0.0012930          1.0000000             0                      0    13.793103         91.73505  TMEM102;BCL2;TPD52L1     
## monovalent inorganic cation homeostasis (GO:0055067)                                                     3/26       0.0014524          1.0000000             0                      0    13.262600         86.66533  SLC12A6;CYP4F12;SLC9A1   
## regulation of neurogenesis (GO:0050767)                                                                  4/57       0.0015264          1.0000000             0                      0     8.066142         52.30754  IGSF10;NOTCH1;SORL1;WNT3 
## regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213)   2/7        0.0015357          0.9795651             0                      0    32.840722        212.76811  NOTCH1;NOG               
## ventricular septum development (GO:0003281)                                                              3/28       0.0018068          1.0000000             0                      0    12.315271         77.78571  NOTCH1;NOG;SOX4          
## negative regulation of glial cell differentiation (GO:0045686)                                           2/8        0.0020359          1.0000000             0                      0    28.735632        178.07000  NOTCH1;NOG               
## 
## 
## Term                                                                                                    Overlap      P.value   Adjusted.P.value   Old.P.value   Old.Adjusted.P.value   Odds.Ratio   Combined.Score  Genes                                                     
## ------------------------------------------------------------------------------------------------------  --------  ----------  -----------------  ------------  ---------------------  -----------  ---------------  ----------------------------------------------------------
## Wnt signaling pathway Homo sapiens P00057                                                               9/278      0.0007560          0.0846723             0                      0     3.721161        26.745718  TCF7L2;TLE2;CDH2;GNA11;NFATC2;KREMEN2;ARID1A;CSNK1G2;WNT3 
## Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Homo sapiens P00027   4/106      0.0138340          0.7747014             0                      0     4.337454        18.567032  GRM4;GNA11;CHRM5;RAP1GAP                                  
## Alpha adrenergic receptor signaling pathway Homo sapiens P00002                                         2/23       0.0168885          0.6305046             0                      0     9.995003        40.790819  GNA11;ADRA1B                                              
## Alzheimer disease-presenilin pathway Homo sapiens P00004                                                3/99       0.0554111          1.0000000             0                      0     3.483107        10.076543  TCF7L2;NOTCH1;WNT3                                        
## Apoptosis signaling pathway Homo sapiens P00006                                                         3/102      0.0595454          1.0000000             0                      0     3.380663         9.536903  ATF6B;TNFRSF10C;BCL2                                      
## Inflammation mediated by chemokine and cytokine signaling pathway Homo sapiens P00031                   4/188      0.0820274          1.0000000             0                      0     2.445586         6.115682  COL6A2;GNA11;NFATC2;MYLK                                  
## Cytoskeletal regulation by Rho GTPase Homo sapiens P00016                                               2/70       0.1240699          1.0000000             0                      0     3.284072         6.853564  ENAH;MYLK                                                 
## Cadherin signaling pathway Homo sapiens P00012                                                          3/150      0.1427209          1.0000000             0                      0     2.298851         4.475550  TCF7L2;CDH2;WNT3                                          
## Metabotropic glutamate receptor group I pathway Homo sapiens P00041                                     1/23       0.1821580          1.0000000             0                      0     4.997501         8.510149  GNA11                                                     
## Oxidative stress response Homo sapiens P00046                                                           1/24       0.1892814          1.0000000             0                      0     4.789272         7.971841  BCL2

filename.txt

## [1] "CD8_closed0open120enrichr.txt"

Extra: ``{r lm} newz<-consecount[, 6:37] transnew<-as.data.frame(t(newz)) names(transnew)<-consecount$SYMBOL as.factor(transnew[, 1796]) Ibrutreatment<-Treatmentdaygrouped>0 forlm<-as.data.frame(cbind(as.factor(transnew[, 1796]), patientID, TreatmentDay, Ibrutreatment)) names(forlm)<-c(“Open”, “PatientID”, “Treatmentday”, “Ibrutinib”) modelplus<-lm(Open_{PatientID+factor(Treatmentdaygrouped),data=forlm) modelper<-lm(Open}PatientID+Ibrutinib,data=forlm)

summary(modelplus) summary(modelper) anova(modelplus,modelper) Ibrutreatment<-Treatmentdaygrouped>0

``

newz<-consecount[, 6:37]
transnew<-as.data.frame(t(newz))
names(transnew)<-consecount$SYMBOL
Ibrutreatment<-Treatmentdaygrouped>0
Ibrucoef<-c()
Ibrusignif<-c()
for (i in 1:length(consecount$consensusIDs)){
    forlm<-as.data.frame(cbind(as.factor(transnew[, i]), patientID, Ibrutreatment))
    names(forlm)<-c("Open", "PatientID", "Ibrutinib")
    modelibru<-lm(Open~PatientID+Ibrutinib,data=forlm)
    lmcoef<- modelibru$coefficients["IbrutinibTRUE"]
    prvalue<- coef(summary(modelibru))["IbrutinibTRUE","Pr(>|t|)"]
    Ibrucoef<-c(Ibrucoef, lmcoef)
    Ibrusignif<-c(Ibrusignif, prvalue)
}

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## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

## Warning in summary.lm(modelibru): essentially perfect fit: summary may be
## unreliable

scoresandlm<-as.data.frame(cbind(consecount.scores, Ibrucoef, Ibrusignif))

signif<-subset(scoresandlm, scoresandlm$"Ibrusignif"<0.05)
knitr::kable(signif[, 49:57])

	SYMBOL	GENENAME	0	3	8	30	120	Ibrucoef	Ibrusignif
15	B3GALT6	beta-1,3-galactosyltransferase 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
22	MRPL20-AS1	MRPL20 antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
25	ATAD3B	ATPase family AAA domain containing 3B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
32	MIB2	mindbomb E3 ubiquitin protein ligase 2	0.0000000	0.3333333	0.6666667	0.5000000	0.7142857	0.4476651	0.0234018
41	TMEM52	transmembrane protein 52	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
54	TPRG1L	tumor protein p63 regulated 1 like	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
65	RNF207	ring finger protein 207	0.0000000	0.5555556	0.6666667	0.5000000	0.2857143	0.4798712	0.0307075
80	ZBTB48	zinc finger and BTB domain containing 48	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
90	PARK7	Parkinsonism associated deglycase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
106	NMNAT1	nicotinamide nucleotide adenylyltransferase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
108	UBE4B	ubiquitination factor E4B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
116	SRM	spermidine synthase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
131	MFN2	mitofusin 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
164	SDHB	succinate dehydrogenase complex iron sulfur subunit B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
181	OTUD3	OTU deubiquitinase 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
206	CDC42	cell division cycle 42	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
208	ZBTB40	zinc finger and BTB domain containing 40	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
252	MTFR1L	mitochondrial fission regulator 1 like	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
255	MIR3917	microRNA 3917	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
264	DHDDS	dehydrodolichyl diphosphate synthase subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
271	ARID1A	AT-rich interaction domain 1A	0.1428571	0.7777778	0.6666667	0.5000000	0.7142857	0.4396135	0.0310733
283	WDTC1	WD and tetratricopeptide repeats 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
284	TMEM222	transmembrane protein 222	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
306	SESN2	sestrin 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
311	TRNAU1AP	tRNA selenocysteine 1 associated protein 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
317	YTHDF2	YTH N6-methyladenosine RNA binding protein 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
351	HDAC1	histone deacetylase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
366	AZIN2	antizyme inhibitor 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
387	TRAPPC3	trafficking protein particle complex 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
402	GNL2	G protein nucleolar 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
411	INPP5B	inositol polyphosphate-5-phosphatase B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
413	SF3A3	splicing factor 3a subunit 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
417	RRAGC	Ras related GTP binding C	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
418	MYCBP	MYC binding protein	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
435	CAP1	cyclase associated actin cytoskeleton regulatory protein 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
449	CITED4	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
463	SLC2A1-AS1	SLC2A1 antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
470	KDM4A-AS1	KDM4A antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
485	ARMH1	armadillo like helical domain containing 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
488	PLK3	polo like kinase 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
492	EIF2B3	eukaryotic translation initiation factor 2B subunit gamma	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
502	AKR1A1	aldo-keto reductase family 1 member A1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
510	PIK3R3	phosphoinositide-3-kinase regulatory subunit 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
556	SLC1A7	solute carrier family 1 member 7	0.7142857	0.4444444	0.3333333	0.5000000	0.5714286	-0.3220612	0.0262591
575	MYSM1	Myb like, SWIRM and MPN domains 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
583	TM2D1	TM2 domain containing 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
603	MIER1	MIER1 transcriptional regulator	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
612	LRRC40	leucine rich repeat containing 40	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
616	PTGER3	prostaglandin E receptor 3	0.2857143	1.0000000	0.6666667	0.6666667	0.7142857	0.4557166	0.0169499
627	PIGK	phosphatidylinositol glycan anchor biosynthesis class K	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
642	PRKACB	protein kinase cAMP-activated catalytic subunit beta	0.5714286	0.2222222	0.3333333	0.1666667	0.2857143	-0.3784219	0.0347546
645	RPF1	ribosome production factor 1 homolog	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
647	CTBS	chitobiase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
648	SSX2IP	SSX family member 2 interacting protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
656	LOC646626	uncharacterized LOC646626	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
658	ZNHIT6	zinc finger HIT-type containing 6	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
660	SH3GLB1	SH3 domain containing GRB2 like, endophilin B1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
678	LRRC8B	leucine rich repeat containing 8 VRAC subunit B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
710	ALG14	ALG14 UDP-N-acetylglucosaminyltransferase subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
713	TLCD4-RWDD3	TLCD4-RWDD3 readthrough	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
720	AGL	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
722	MFSD14A	major facilitator superfamily domain containing 14A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
724	DBT	dihydrolipoamide branched chain transacylase E2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
733	PRMT6	protein arginine methyltransferase 6	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
743	CLCC1	chloride channel CLIC like 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
744	WDR47	WD repeat domain 47	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
746	TMEM167B	transmembrane protein 167B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
786	DDX20	DEAD-box helicase 20	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
791	ST7L	suppression of tumorigenicity 7 like	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
794	PPM1J	protein phosphatase, Mg2+/Mn2+ dependent 1J	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
811	SIKE1	suppressor of IKBKE 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
830	EMBP1	embigin pseudogene 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
932	C1orf43	chromosome 1 open reading frame 43	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
938	UBE2Q1	ubiquitin conjugating enzyme E2 Q1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
966	GBA	glucosylceramidase beta	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
978	MSTO2P	misato family member 2, pseudogene	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
980	SYT11	synaptotagmin 11	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1002	IQGAP3	IQ motif containing GTPase activating protein 3	0.0000000	0.5555556	0.6666667	0.5000000	0.5714286	0.5201288	0.0073961
1031	PIGM	phosphatidylinositol glycan anchor biosynthesis class M	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1033	IGSF8	immunoglobulin superfamily member 8	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1035	DCAF8	DDB1 and CUL4 associated factor 8	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1061	MIR5187	microRNA 5187	1.0000000	0.7777778	0.6666667	0.6666667	1.0000000	-0.2962963	0.0480495
1074	UAP1	UDP-N-acetylglucosamine pyrophosphorylase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1076	NUF2	NUF2 component of NDC80 kinetochore complex	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1103	SLC19A2	solute carrier family 19 member 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1108	KIFAP3	kinesin associated protein 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1114	DNM3	dynamin 3	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
1120	LOC100506023	uncharacterized LOC100506023	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1128	MRPS14	mitochondrial ribosomal protein S14	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1139	TOR1AIP1	torsin 1A interacting protein 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1143	ACBD6	acyl-CoA binding domain containing 6	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1154	DHX9	DExH-box helicase 9	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1155	SMG7-AS1	SMG7 antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1157	ARPC5	actin related protein 2/3 complex subunit 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1194	TMEM9	transmembrane protein 9	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1219	RABIF	RAB interacting factor	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1259	DYRK3	dual specificity tyrosine phosphorylation regulated kinase 3	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
1272	CD46	CD46 molecule	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1286	SLC30A1	solute carrier family 30 member 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1297	FLVCR1	feline leukemia virus subgroup C cellular receptor 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1306	RRP15	ribosomal RNA processing 15 homolog	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1308	LYPLAL1	lysophospholipase like 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1312	RAB3GAP2	RAB3 GTPase activating non-catalytic protein subunit 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1322	BROX	BRO1 domain and CAAX motif containing	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1341	LEFTY1	left-right determination factor 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1365	GUK1	guanylate kinase 1	0.4285714	0.0000000	0.0000000	0.1666667	0.1428571	-0.3703704	0.0244875
1374	RNF187	ring finger protein 187	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1385	ARV1	ARV1 homolog, fatty acid homeostasis modulator	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1398	COA6	cytochrome c oxidase assembly factor 6	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1409	B3GALNT2	beta-1,3-N-acetylgalactosaminyltransferase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1429	ZBTB18	zinc finger and BTB domain containing 18	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1435	EFCAB2	EF-hand calcium binding domain 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1442	ZNF669	zinc finger protein 669	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1450	ZNF672	zinc finger protein 672	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1452	PGBD2	piggyBac transposable element derived 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1456	GTPBP4	GTP binding protein 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1457	WDR37	WD repeat domain 37	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1470	GDI2	GDP dissociation inhibitor 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1474	RBM17	RNA binding motif protein 17	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1483	KIN	Kin17 DNA and RNA binding protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1484	TAF3	TATA-box binding protein associated factor 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1495	UPF2	UPF2 regulator of nonsense mediated mRNA decay	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1497	SEC61A2	SEC61 translocon alpha 2 subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1510	DCLRE1C	DNA cross-link repair 1C	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1511	MEIG1	meiosis/spermiogenesis associated 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1513	RPP38	ribonuclease P/MRP subunit p38	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1514	NMT2	N-myristoyltransferase 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1516	MINDY3	MINDY lysine 48 deubiquitinase 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1517	PTER	phosphotriesterase related	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1524	STAM	signal transducing adaptor molecule	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1531	DNAJC1	DnaJ heat shock protein family (Hsp40) member C1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1542	ARHGAP21	Rho GTPase activating protein 21	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1552	MASTL	microtubule associated serine/threonine kinase like	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1560	WAC-AS1	WAC antisense RNA 1 (head to head)	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1576	EPC1	enhancer of polycomb homolog 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1582	NRP1	neuropilin 1	0.7142857	0.3333333	0.3333333	0.1666667	0.4285714	-0.4621578	0.0335728
1584	CUL2	cullin 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1585	CREM	cAMP responsive element modulator	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1594	SEPTIN7P9	septin 7 pseudogene 9	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1597	ZNF33B	zinc finger protein 33B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1615	ZFAND4	zinc finger AN1-type containing 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1619	MAPK8	mitogen-activated protein kinase 8	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1627	NCOA4	nuclear receptor coactivator 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1641	TFAM	transcription factor A, mitochondrial	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1642	CCDC6	coiled-coil domain containing 6	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1655	NRBF2	nuclear receptor binding factor 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1668	TET1	tet methylcytosine dioxygenase 1	0.0000000	0.7777778	0.3333333	0.3333333	0.5714286	0.4959742	0.0200887
1702	PSAP	prosaposin	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1706	DDIT4	DNA damage inducible transcript 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1709	MCU	mitochondrial calcium uniporter	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1710	P4HA1	prolyl 4-hydroxylase subunit alpha 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1718	PPP3CB	protein phosphatase 3 catalytic subunit beta	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1729	VCL	vinculin	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1761	WAPL	WAPL cohesin release factor	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1769	CFL1P1	cofilin 1 pseudogene 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1770	KLLN	killin, p53 regulated DNA replication inhibitor	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1780	IFIT1	interferon induced protein with tetratricopeptide repeats 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1782	IFIT5	interferon induced protein with tetratricopeptide repeats 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1795	CPEB3	cytoplasmic polyadenylation element binding protein 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1804	CEP55	centrosomal protein 55	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1805	FRA10AC1	FRA10A associated CGG repeat 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1811	SORBS1	sorbin and SH3 domain containing 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1812	ALDH18A1	aldehyde dehydrogenase 18 family member A1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1821	LCOR	ligand dependent nuclear receptor corepressor	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1830	MMS19	MMS19 homolog, cytosolic iron-sulfur assembly component	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1833	MORN4	MORN repeat containing 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1835	AVPI1	arginine vasopressin induced 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1839	R3HCC1L	R3H domain and coiled-coil containing 1 like	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1854	BLOC1S2	biogenesis of lysosomal organelles complex 1 subunit 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1878	KCNIP2	potassium voltage-gated channel interacting protein 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1892	NFKB2	nuclear factor kappa B subunit 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1906	CNNM2	cyclin and CBS domain divalent metal cation transport mediator 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1933	MXI1	MAX interactor 1, dimerization protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1935	DUSP5	dual specificity phosphatase 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1940	GPAM	glycerol-3-phosphate acyltransferase, mitochondrial	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1955	TRUB1	TruB pseudouridine synthase family member 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1961	FAM204A	family with sequence similarity 204 member A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
1968	GRK5	G protein-coupled receptor kinase 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1979	ATE1	arginyltransferase 1	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
1983	FAM24B-CUZD1	FAM24B-CUZD1 readthrough	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
1984	C10orf88	chromosome 10 open reading frame 88	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2001	MGMT	O-6-methylguanine-DNA methyltransferase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2019	TUBGCP2	tubulin gamma complex associated protein 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2023	ECHS1	enoyl-CoA hydratase, short chain 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2046	LOC143666	uncharacterized LOC143666	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2089	NAP1L4	nucleosome assembly protein 1 like 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2090	CARS1	cysteinyl-tRNA synthetase 1	0.0000000	0.5555556	0.3333333	0.1666667	0.2857143	0.4074074	0.0455222
2110	SMPD1	sphingomyelin phosphodiesterase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2117	TPP1	tripeptidyl peptidase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2119	MRPL17	mitochondrial ribosomal protein L17	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2134	TMEM41B	transmembrane protein 41B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2150	ZBED5	zinc finger BED-type containing 5	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2156	ARNTL	aryl hydrocarbon receptor nuclear translocator like	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2159	FAR1	fatty acyl-CoA reductase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2162	COPB1	coatomer protein complex subunit beta 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2163	PSMA1	proteasome 20S subunit alpha 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2172	NUCB2	nucleobindin 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2193	PRMT3	protein arginine methyltransferase 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2196	CCDC34	coiled-coil domain containing 34	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2202	ARL14EP	ADP ribosylation factor like GTPase 14 effector protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2203	DNAJC24	DnaJ heat shock protein family (Hsp40) member C24	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2211	TCP11L1	t-complex 11 like 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2212	CSTF3	cleavage stimulation factor subunit 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2214	C11orf91	chromosome 11 open reading frame 91	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2222	ABTB2	ankyrin repeat and BTB domain containing 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2225	APIP	APAF1 interacting protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2239	ACCS	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2245	PRDM11	PR/SET domain 11	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2264	ARHGAP1	Rho GTPase activating protein 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2272	MADD	MAP kinase activating death domain	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2274	SLC39A13	solute carrier family 39 member 13	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2287	SSRP1	structure specific recognition protein 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2312	CCDC86	coiled-coil domain containing 86	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2322	CYB561A3	cytochrome b561 family member A3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2343	EML3	EMAP like 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2344	B3GAT3	beta-1,3-glucuronyltransferase 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2345	GANAB	glucosidase II alpha subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2365	RTN3	reticulon 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2400	EHD1	EH domain containing 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2428	LTBP3	latent transforming growth factor beta binding protein 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2431	ZNRD2	zinc ribbon domain containing 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2440	KAT5	lysine acetyltransferase 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2452	DRAP1	DR1 associated protein 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2459	RAB1B	RAB1B, member RAS oncogene family	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2469	PELI3	pellino E3 ubiquitin protein ligase family member 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2484	KDM2A	lysine demethylase 2A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2486	GRK2	G protein-coupled receptor kinase 2	0.2857143	0.8888889	0.6666667	0.5000000	0.8571429	0.3349436	0.0348889
2490	POLD4	DNA polymerase delta 4, accessory subunit	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2493	PPP1CA	protein phosphatase 1 catalytic subunit alpha	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2505	CDK2AP2	cyclin dependent kinase 2 associated protein 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2510	NUDT8	nudix hydrolase 8	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2513	FAM86C2P	family with sequence similarity 86, member A pseudogene	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2550	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2564	UCP2	uncoupling protein 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2566	PGM2L1	phosphoglucomutase 2 like 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2567	LIPT2	lipoyl(octanoyl) transferase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2582	THAP12	THAP domain containing 12	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2597	KCTD21	potassium channel tetramerization domain containing 21	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2603	ANKRD42	ankyrin repeat domain 42	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2606	TMEM126A	transmembrane protein 126A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2611	CCDC83	coiled-coil domain containing 83	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2612	PICALM	phosphatidylinositol binding clathrin assembly protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2618	TMEM135	transmembrane protein 135	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2623	SLC36A4	solute carrier family 36 member 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2628	MED17	mediator complex subunit 17	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2634	ENDOD1	endonuclease domain containing 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2640	CCDC82	coiled-coil domain containing 82	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2646	BIRC2	baculoviral IAP repeat containing 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2685	DIXDC1	DIX domain containing 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2692	PTS	6-pyruvoyltetrahydropterin synthase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2699	RBM7	RNA binding motif protein 7	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2700	REXO2	RNA exonuclease 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2702	CADM1	cell adhesion molecule 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2730	ARCN1	archain 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2736	CCDC84	coiled-coil domain containing 84	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2739	HYOU1	hypoxia up-regulated 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2740	VPS11	VPS11 core subunit of CORVET and HOPS complexes	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2750	RNF26	ring finger protein 26	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2759	SC5D	sterol-C5-desaturase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2761	SORL1	sortilin related receptor 1	0.1428571	0.6666667	0.6666667	0.5000000	0.7142857	0.4879227	0.0339216
2763	CRTAM	cytotoxic and regulatory T cell molecule	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2772	SPA17	sperm autoantigenic protein 17	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2790	FAM118B	family with sequence similarity 118 member B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2791	FOXRED1	FAD dependent oxidoreductase domain containing 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2809	APLP2	amyloid beta precursor like protein 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2810	ZBTB44	zinc finger and BTB domain containing 44	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2813	IGSF9B	immunoglobulin superfamily member 9B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2814	IGSF9B	immunoglobulin superfamily member 9B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2833	ADIPOR2	adiponectin receptor 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2846	TIGAR	TP53 induced glycolysis regulatory phosphatase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2849	AKAP3	A-kinase anchoring protein 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2896	FAM86FP	family with sequence similarity 86, member A pseudogene	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2922	MAGOHB	mago homolog B, exon junction complex subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2925	PRR4	proline rich 4	0.8571429	0.5555556	0.3333333	0.0000000	0.2857143	-0.5008052	0.0158960
2932	BORCS5	BLOC-1 related complex subunit 5	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2934	CREBL2	cAMP responsive element binding protein like 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2938	DDX47	DEAD-box helicase 47	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2966	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2980	MED21	mediator complex subunit 21	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2981	STK38L	serine/threonine kinase 38 like	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
2991	CAPRIN2	caprin family member 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2993	DDX11-AS1	DDX11 antisense RNA 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
2995	SINHCAF	SIN3-HDAC complex associated factor	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3015	YAF2	YY1 associated factor 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3025	ARID2	AT-rich interaction domain 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3027	SCAF11	SR-related CTD associated factor 11	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3047	ASB8	ankyrin repeat and SOCS box containing 8	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3058	FKBP11	FKBP prolyl isomerase 11	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3062	PRKAG1	protein kinase AMP-activated non-catalytic subunit gamma 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3072	SPATS2	spermatogenesis associated serine rich 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3079	FMNL3	formin like 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3100	CSRNP2	cysteine and serine rich nuclear protein 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3103	DAZAP2	DAZ associated protein 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3158	MIR148B	microRNA 148b	0.4285714	0.0000000	0.3333333	0.1666667	0.1428571	-0.3462158	0.0452981
3186	PA2G4	proliferation-associated 2G4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3213	PTGES3	prostaglandin E synthase 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3224	NXPH4	neurexophilin 4	0.0000000	0.5555556	0.6666667	0.3333333	0.5714286	0.4315620	0.0353835
3232	DDIT3	DNA damage inducible transcript 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3256	TAFA2	TAFA chemokine like family member 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3257	MON2	MON2 homolog, regulator of endosome-to-Golgi trafficking	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3265	XPOT	exportin for tRNA	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3287	CPSF6	cleavage and polyadenylation specific factor 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3290	CCT2	chaperonin containing TCP1 subunit 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3296	RAB21	RAB21, member RAS oncogene family	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3297	TBC1D15	TBC1 domain family member 15	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3305	NAP1L1	nucleosome assembly protein 1 like 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3307	OSBPL8	oxysterol binding protein like 8	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3308	ZDHHC17	zinc finger DHHC-type containing 17	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3315	TMTC2	transmembrane O-mannosyltransferase targeting cadherins 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3321	POC1B-GALNT4	POC1B-GALNT4 readthrough	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3326	UBE2N	ubiquitin conjugating enzyme E2 N	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3327	MRPL42	mitochondrial ribosomal protein L42	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3333	CEP83-DT	CEP83 divergent transcript	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3335	NDUFA12	NADH:ubiquinone oxidoreductase subunit A12	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3342	CCDC38	coiled-coil domain containing 38	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3347	NEDD1	NEDD1 gamma-tubulin ring complex targeting factor	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3350	TMPO-AS1	TMPO antisense RNA 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3352	IKBIP	IKBKB interacting protein	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3353	UHRF1BP1L	UHRF1 binding protein 1 like	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3355	DEPDC4	DEP domain containing 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3363	PARPBP	PARP1 binding protein	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3401	CORO1C	coronin 1C	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3419	ARPC3	actin related protein 2/3 complex subunit 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3433	MAPKAPK5-AS1	MAPKAPK5 antisense RNA 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3434	ERP29	endoplasmic reticulum protein 29	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3449	PLBD2	phospholipase B domain containing 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3450	RBM19	RNA binding motif protein 19	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3470	PRKAB1	protein kinase AMP-activated non-catalytic subunit beta 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3482	NRAV	negative regulator of antiviral response	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3498	CAMKK2	calcium/calmodulin dependent protein kinase kinase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3501	RNF34	ring finger protein 34	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3540	SBNO1	strawberry notch homolog 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3541	KMT5A	lysine methyltransferase 5A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3548	EIF2B1	eukaryotic translation initiation factor 2B subunit alpha	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3563	RAN	RAN, member RAS oncogene family	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3578	CHFR	checkpoint with forkhead and ring finger domains	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3581	ZMYM5	zinc finger MYM-type containing 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3589	EEF1AKMT1	EEF1A lysine methyltransferase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3593	SKA3	spindle and kinetochore associated complex subunit 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3598	SACS	sacsin molecular chaperone	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3611	CENPJ	centromere protein J	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3617	USP12	ubiquitin specific peptidase 12	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3622	POMP	proteasome maturation protein	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3623	SLC46A3	solute carrier family 46 member 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3624	SLC7A1	solute carrier family 7 member 1	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
3629	USPL1	ubiquitin specific peptidase like 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3637	BRCA2	BRCA2 DNA repair associated	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3647	ALG5	ALG5 dolichyl-phosphate beta-glucosyltransferase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3649	SUPT20H	SPT20 homolog, SAGA complex component	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3656	TPTE2P5	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 5	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3668	DNAJC15	DnaJ heat shock protein family (Hsp40) member C15	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3674	NUFIP1	nuclear FMR1 interacting protein 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3677	SLC25A30	solute carrier family 25 member 30	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3698	ARL11	ADP ribosylation factor like GTPase 11	0.0000000	0.4444444	0.3333333	0.3333333	0.5714286	0.4476651	0.0037328
3704	DLEU2	deleted in lymphocytic leukemia 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3717	SUGT1	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3725	KLF5	Kruppel like factor 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3728	COMMD6	COMM domain containing 6	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3737	MYCBP2	MYC binding protein 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3738	MIR3665	microRNA 3665	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3748	TGDS	TDP-glucose 4,6-dehydratase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3749	GPR180	G protein-coupled receptor 180	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3753	DNAJC3	DnaJ heat shock protein family (Hsp40) member C3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3759	UBAC2-AS1	UBAC2 antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3765	CLYBL	citrate lyase beta like	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3769	TMTC4	transmembrane O-mannosyltransferase targeting cadherins 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3779	LIG4	DNA ligase 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3784	CARS2	cysteinyl-tRNA synthetase 2, mitochondrial	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3833	MRPL52	mitochondrial ribosomal protein L52	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3864	PSME1	proteasome activator subunit 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3867	IRF9	interferon regulatory factor 9	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3872	MDP1	magnesium dependent phosphatase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3874	TINF2	TERF1 interacting nuclear factor 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3888	SCFD1	sec1 family domain containing 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3893	HEATR5A	HEAT repeat containing 5A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3894	DTD2	D-aminoacyl-tRNA deacylase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3906	NFKBIA	NFKB inhibitor alpha	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3918	FBXO33	F-box protein 33	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3932	KLHDC2	kelch domain containing 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
3938	VCPKMT	valosin containing protein lysine methyltransferase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3940	DMAC2L	distal membrane arm assembly complex 2 like	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3946	NIN	ninein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3947	PYGL	glycogen phosphorylase L	0.1428571	0.6666667	0.6666667	0.3333333	0.7142857	0.4154589	0.0402135
3961	STYX	serine/threonine/tyrosine interacting protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3981	TMEM260	transmembrane protein 260	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3983	NAA30	N(alpha)-acetyltransferase 30, NatC catalytic subunit	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3994	L3HYPDH	trans-L-3-hydroxyproline dehydratase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
3996	RTN1	reticulon 1	0.4285714	0.0000000	0.3333333	0.0000000	0.1428571	-0.3945250	0.0091218
4020	ZBTB1	zinc finger and BTB domain containing 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4026	CHURC1-FNTB	CHURC1-FNTB readthrough	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4030	FUT8	fucosyltransferase 8	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4032	MPP5	membrane palmitoylated protein 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4054	LOC100289511	uncharacterized LOC100289511	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4060	PCNX1	pecanex 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4075	MIR4505	microRNA 4505	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4098	FOS	Fos proto-oncogene, AP-1 transcription factor subunit	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4143	CALM1	calmodulin 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4160	TRIP11	thyroid hormone receptor interactor 11	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4168	GOLGA5	golgin A5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4187	AK7	adenylate kinase 7	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4193	CCDC85C	coiled-coil domain containing 85C	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4211	HSP90AA1	heat shock protein 90 alpha family class A member 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4215	CINP	cyclin dependent kinase 2 interacting protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4222	MARK3	microtubule affinity regulating kinase 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4248	PACS2	phosphofurin acidic cluster sorting protein 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4270	NSMCE3	NSE3 homolog, SMC5-SMC6 complex component	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4285	LPCAT4	lysophosphatidylcholine acyltransferase 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4287	ZNF770	zinc finger protein 770	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4298	FSIP1	fibrous sheath interacting protein 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4304	BMF	Bcl2 modifying factor	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4315	IVD	isovaleryl-CoA dehydrogenase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4330	CHAC1	ChaC glutathione specific gamma-glutamylcyclotransferase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4348	EHD4	EH domain containing 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4357	UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4374	EIF3J-DT	EIF3J divergent transcript	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4401	GALK2	galactokinase 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4407	USP8	ubiquitin specific peptidase 8	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4408	TRPM7	transient receptor potential cation channel subfamily M member 7	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4427	C15orf65	chromosome 15 open reading frame 65	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4433	MNS1	meiosis specific nuclear structural 1	0.1428571	0.5555556	0.3333333	0.5000000	0.5714286	0.4074074	0.0169845
4436	POLR2M	RNA polymerase II subunit M	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4440	MINDY2	MINDY lysine 48 deubiquitinase 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4447	BNIP2	BCL2 interacting protein 2	0.5714286	0.3333333	0.0000000	0.3333333	0.1428571	-0.3800322	0.0322062
4448	BNIP2	BCL2 interacting protein 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4480	CLPX	caseinolytic mitochondrial matrix peptidase chaperone subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4488	RAB11A	RAB11A, member RAS oncogene family	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4524	ADPGK-AS1	ADPGK antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4536	CLK3	CDC like kinase 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4547	SCAMP2	secretory carrier membrane protein 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4550	COX5A	cytochrome c oxidase subunit 5A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4563	SNUPN	snurportin 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4583	IDH3A	isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4597	ST20-MTHFS	ST20-MTHFS readthrough	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4630	PDE8A	phosphodiesterase 8A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4634	KLHL25	kelch like family member 25	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4635	MRPL46	mitochondrial ribosomal protein L46	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4636	DET1	DET1 partner of COP1 E3 ubiquitin ligase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4655	MESP2	mesoderm posterior bHLH transcription factor 2	0.0000000	0.5555556	0.6666667	0.5000000	0.5714286	0.4879227	0.0209664
4700	CHSY1	chondroitin sulfate synthase 1	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
4746	C16orf91	chromosome 16 open reading frame 91	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4758	MSRB1	methionine sulfoxide reductase B1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4761	TBL3	transducin beta like 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4771	PGP	phosphoglycolate phosphatase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4772	E4F1	E4F transcription factor 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4781	MIR3178	microRNA 3178	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4794	FLYWCH1	FLYWCH-type zinc finger 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4795	KREMEN2	kringle containing transmembrane protein 2	0.0000000	0.4444444	0.3333333	0.1666667	0.7142857	0.4090177	0.0305731
4800	HCFC1R1	host cell factor C1 regulator 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4809	ZNF263	zinc finger protein 263	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4823	LINC01569	long intergenic non-protein coding RNA 1569	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4828	CORO7-PAM16	CORO7-PAM16 readthrough	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4861	RMI2	RecQ mediated genome instability 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4868	GSPT1	G1 to S phase transition 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4899	CCP110	centriolar coiled-coil protein 110	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4926	EARS2	glutamyl-tRNA synthetase 2, mitochondrial	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4927	NDUFAB1	NADH:ubiquinone oxidoreductase subunit AB1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
4934	ARHGAP17	Rho GTPase activating protein 17	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4944	KIAA0556	KIAA0556	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
4972	MAZ	MYC associated zinc finger protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5001	ZNF48	zinc finger protein 48	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5016	SRCAP	Snf2 related CREBBP activator protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5042	ITGAM	integrin subunit alpha M	0.7142857	0.4444444	0.3333333	0.5000000	0.2857143	-0.4025765	0.0412722
5053	C16orf87	chromosome 16 open reading frame 87	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5055	DNAJA2	DnaJ heat shock protein family (Hsp40) member A2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5077	RBL2	RB transcriptional corepressor like 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5082	CRNDE	colorectal neoplasia differentially expressed	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5101	HERPUD1	homocysteine inducible ER protein with ubiquitin like domain 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5102	NLRC5	NLR family CARD domain containing 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5109	COQ9	coenzyme Q9	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5119	ZNF319	zinc finger protein 319	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5162	ATP6V0D1	ATPase H+ transporting V0 subunit d1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5177	PSKH1	protein serine kinase H1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5184	NFATC3	nuclear factor of activated T cells 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5187	PRMT7	protein arginine methyltransferase 7	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5198	NIP7	nucleolar pre-rRNA processing protein NIP7	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5210	DDX19B	DEAD-box helicase 19B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5213	ST3GAL2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5218	CMTR2	cap methyltransferase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5229	IST1	IST1 factor associated with ESCRT-III	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5248	TMEM231	transmembrane protein 231	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5252	KARS1	lysyl-tRNA synthetase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5264	GAN	gigaxonin	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5268	MPHOSPH6	M-phase phosphoprotein 6	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5269	HSBP1	heat shock factor binding protein 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5271	MBTPS1	membrane bound transcription factor peptidase, site 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5286	GINS2	GINS complex subunit 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5302	MIR5189	microRNA 5189	0.0000000	0.4444444	0.6666667	0.1666667	0.2857143	0.3268921	0.0468408
5329	SPATA2L	spermatogenesis associated 2 like	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5365	SLC43A2	solute carrier family 43 member 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5401	ANKFY1	ankyrin repeat and FYVE domain containing 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5402	UBE2G1	ubiquitin conjugating enzyme E2 G1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5423	LOC100130950	uncharacterized LOC100130950	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5437	ALOX15P1	arachidonate 15-lipoxygenase pseudogene 1	0.1428571	0.5555556	0.6666667	0.5000000	0.5714286	0.4637681	0.0310063
5447	DLG4	discs large MAGUK scaffold protein 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5449	DLG4	discs large MAGUK scaffold protein 4	0.0000000	0.5555556	0.3333333	0.3333333	0.4285714	0.4025765	0.0200637
5474	MPDU1	mannose-P-dolichol utilization defect 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5479	WRAP53	WD repeat containing antisense to TP53	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5496	BORCS6	BLOC-1 related complex subunit 6	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5543	MPRIP	myosin phosphatase Rho interacting protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5547	COPS3	COP9 signalosome subunit 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5558	GID4	GID complex subunit 4 homolog	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5577	B9D1	B9 domain containing 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5578	B9D1	B9 domain containing 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5589	DHRS7B	dehydrogenase/reductase 7B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5590	TMEM11	transmembrane protein 11	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5592	MAP2K3	mitogen-activated protein kinase kinase 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5602	TMEM199	transmembrane protein 199	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5605	SLC46A1	solute carrier family 46 member 1	0.0000000	0.6666667	0.6666667	0.3333333	0.7142857	0.5442834	0.0053166
5607	PIGS	phosphatidylinositol glycan anchor biosynthesis class S	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5608	ALDOC	aldolase, fructose-bisphosphate C	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5618	FAM222B	family with sequence similarity 222 member B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5635	ANKRD13B	ankyrin repeat domain 13B	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
5642	CPD	carboxypeptidase D	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5654	RAB11FIP4	RAB11 family interacting protein 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5657	UTP6	UTP6 small subunit processome component	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5665	PSMD11	proteasome 26S subunit, non-ATPase 11	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5694	GGNBP2	gametogenetin binding protein 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5742	ORMDL3	ORMDL sphingolipid biosynthesis regulator 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5770	ACLY	ATP citrate lyase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5771	TTC25	tetratricopeptide repeat domain 25	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5859	PLEKHM1	pleckstrin homology and RUN domain containing M1	0.0000000	0.5555556	0.6666667	0.5000000	0.5714286	0.5523349	0.0122499
5862	KANSL1	KAT8 regulatory NSL complex subunit 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5887	CBX1	chromobox 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5888	SNX11	sorting nexin 11	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5910	SPOP	speckle type BTB/POZ protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
5934	TOB1	transducer of ERBB2, 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5943	NOG	noggin	0.2857143	0.7777778	0.6666667	0.5000000	0.7142857	0.3365539	0.0432522
5974	TRIM37	tripartite motif containing 37	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5980	CLTC	clathrin heavy chain	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
5986	USP32	ubiquitin specific peptidase 32	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6030	GNA13	G protein subunit alpha 13	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6039	NOL11	nucleolar protein 11	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6051	WIPI1	WD repeat domain, phosphoinositide interacting 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6053	ABCA5	ATP binding cassette subfamily A member 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6069	RAB37	RAB37, member RAS oncogene family	0.0000000	0.4444444	0.6666667	0.1666667	0.7142857	0.5136876	0.0145615
6081	ATP5PD	ATP synthase peripheral stalk subunit d	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6097	MYO15B	myosin XVB	0.0000000	0.3333333	0.6666667	0.3333333	0.5714286	0.4315620	0.0353835
6123	AANAT	aralkylamine N-acetyltransferase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6132	SRSF2	serine and arginine rich splicing factor 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6160	USP36	ubiquitin specific peptidase 36	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6206	DCXR	dicarbonyl and L-xylulose reductase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6223	FOXK2	forkhead box K2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6233	USP14	ubiquitin specific peptidase 14	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6234	THOC1	THO complex 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6250	L3MBTL4	L3MBTL histone methyl-lysine binding protein 4	0.1428571	0.5555556	0.3333333	0.3333333	0.5714286	0.3832528	0.0128298
6257	ANKRD12	ankyrin repeat domain 12	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6268	IMPA2	inositol monophosphatase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6280	FAM210A	family with sequence similarity 210 member A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6283	ESCO1	establishment of sister chromatid cohesion N-acetyltransferase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6287	MIB1	mindbomb E3 ubiquitin protein ligase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6294	NPC1	NPC intracellular cholesterol transporter 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6312	TRAPPC8	trafficking protein particle complex 8	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6314	RNF138	ring finger protein 138	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6320	ZNF397	zinc finger protein 397	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6326	C18orf21	chromosome 18 open reading frame 21	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6327	RPRD1A	regulation of nuclear pre-mRNA domain containing 1A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6364	ME2	malic enzyme 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6370	POLI	DNA polymerase iota	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6371	C18orf54	chromosome 18 open reading frame 54	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6372	RAB27B	RAB27B, member RAS oncogene family	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6377	TXNL1	thioredoxin like 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6382	LOC100505549	uncharacterized LOC100505549	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6390	SEC11C	SEC11 homolog C, signal peptidase complex subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6391	LMAN1	lectin, mannose binding 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6392	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6396	ZCCHC2	zinc finger CCHC-type containing 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6403	SERPINB8	serpin family B member 8	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6405	TMX3	thioredoxin related transmembrane protein 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6415	LINC00909	long intergenic non-protein coding RNA 909	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6423	ATP9B	ATPase phospholipid transporting 9B (putative)	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6442	BSG	basigin (Ok blood group)	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6445	FGF22	fibroblast growth factor 22	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6469	STK11	serine/threonine kinase 11	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6489	ATP8B3	ATPase phospholipid transporting 8B3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6490	REXO1	RNA exonuclease 1 homolog	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6495	SCAMP4	secretory carrier membrane protein 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6498	BTBD2	BTB domain containing 2	0.2857143	0.7777778	0.6666667	0.5000000	1.0000000	0.3349436	0.0348889
6500	MKNK2	MAPK interacting serine/threonine kinase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6512	TIMM13	translocase of inner mitochondrial membrane 13	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6519	THOP1	thimet oligopeptidase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6539	FZR1	fizzy and cell division cycle 20 related 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6556	PIAS4	protein inhibitor of activated STAT 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6565	FSD1	fibronectin type III and SPRY domain containing 1	0.2857143	0.8888889	0.6666667	0.5000000	0.7142857	0.3752013	0.0313950
6587	LOC100128568	uncharacterized LOC100128568	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6592	GTF2F1	general transcription factor IIF subunit 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6608	ZNF557	zinc finger protein 557	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6635	HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6638	ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif 10	0.2857143	0.8888889	0.6666667	0.5000000	0.8571429	0.3832528	0.0103448
6669	MIR1181	microRNA 1181	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6690	CARM1	coactivator associated arginine methyltransferase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6692	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
6721	ZNF844	zinc finger protein 844	0.0000000	0.5555556	0.3333333	0.1666667	0.4285714	0.4074074	0.0196710
6729	ZNF442	zinc finger protein 442	0.2857143	0.6666667	1.0000000	0.5000000	0.7142857	0.4122383	0.0323027
6737	DHPS	deoxyhypusine synthase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6763	CCDC130	coiled-coil domain containing 130	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6779	ADGRE5	adhesion G protein-coupled receptor E5	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6790	ILVBL	ilvB acetolactate synthase like	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6816	MYO9B	myosin IXB	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6837	COLGALT1	collagen beta(1-O)galactosyltransferase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6845	ARRDC2	arrestin domain containing 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6885	PBX4	PBX homeobox 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6902	ZNF85	zinc finger protein 85	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6919	ZNF91	zinc finger protein 91	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6920	ZNF675	zinc finger protein 675	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6929	POP4	POP4 homolog, ribonuclease P/MRP subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
6938	PDCD5	programmed cell death 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6981	KMT2B	lysine methyltransferase 2B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
6983	U2AF1L4	U2 small nuclear RNA auxiliary factor 1 like 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7004	ZNF260	zinc finger protein 260	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7005	ZNF529	zinc finger protein 529	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7015	ZNF420	zinc finger protein 420	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7035	YIF1B	Yip1 interacting factor homolog B, membrane trafficking protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7040	FAM98C	family with sequence similarity 98 member C	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7059	SAMD4B	sterile alpha motif domain containing 4B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7068	DLL3	delta like canonical Notch ligand 3	0.8571429	0.4444444	0.0000000	0.0000000	0.4285714	-0.6167472	0.0063073
7082	C19orf47	chromosome 19 open reading frame 47	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7125	ZNF526	zinc finger protein 526	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7134	CEACAM1	CEA cell adhesion molecule 1	0.0000000	0.5555556	0.6666667	0.3333333	0.4285714	0.4492754	0.0249265
7139	XRCC1	X-ray repair cross complementing 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7185	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit	0.4285714	0.2222222	0.0000000	0.0000000	0.0000000	-0.3301127	0.0281008
7189	RTN2	reticulon 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7192	VASP	vasodilator stimulated phosphoprotein	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7209	MYPOP	Myb related transcription factor, partner of profilin	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7216	DACT3-AS1	DACT3 antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7231	CCDC9	coiled-coil domain containing 9	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7232	INAFM1	InaF motif containing 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7236	NAPA-AS1	NAPA antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7246	CARD8-AS1	CARD8 antisense RNA 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7251	SYNGR4	synaptogyrin 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7259	SPHK2	sphingosine kinase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7282	SNRNP70	small nuclear ribonucleoprotein U1 subunit 70	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7284	C19orf73	chromosome 19 open reading frame 73	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7285	PPFIA3	PTPRF interacting protein alpha 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7291	CCDC155	coiled-coil domain containing 155	0.0000000	0.5555556	0.6666667	0.3333333	0.7142857	0.6328502	0.0022437
7300	MIR150	microRNA 150	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7324	POLD1	DNA polymerase delta 1, catalytic subunit	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7328	C19orf48	chromosome 19 open reading frame 48	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7363	ZNF611	zinc finger protein 611	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7370	ZNF816-ZNF321P	ZNF816-ZNF321P readthrough	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7373	ZNF347	zinc finger protein 347	0.0000000	0.6666667	0.6666667	0.1666667	0.2857143	0.4476651	0.0154662
7407	RDH13	retinol dehydrogenase 13	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7475	ZSCAN18	zinc finger and SCAN domain containing 18	0.2857143	1.0000000	0.6666667	0.3333333	0.8571429	0.4718196	0.0250422
7483	A1BG	alpha-1-B glycoprotein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7495	MZF1-AS1	MZF1 antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7505	RNASEH1-AS1	RNASEH1 antisense RNA 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7518	ADAM17	ADAM metallopeptidase domain 17	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7530	ODC1	ornithine decarboxylase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7539	TRIB2	tribbles pseudokinase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7546	RDH14	retinol dehydrogenase 14	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7547	MIR4757	microRNA 4757	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7554	PUM2	pumilio RNA binding family member 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7555	RHOB	ras homolog family member B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7556	HS1BP3	HCLS1 binding protein 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7570	PTRHD1	peptidyl-tRNA hydrolase domain containing 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7573	DNAJC27	DnaJ heat shock protein family (Hsp40) member C27	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7574	EFR3B	EFR3 homolog B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7579	ASXL2	ASXL transcriptional regulator 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7581	RAB10	RAB10, member RAS oncogene family	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7611	BABAM2-AS1	BABAM2 antisense RNA 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7616	SPDYA	speedy/RINGO cell cycle regulator family member A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7618	WDR43	WD repeat domain 43	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7623	LBH	LBH regulator of WNT signaling pathway	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7628	MEMO1	mediator of cell motility 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7629	SPAST	spastin	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7631	YIPF4	Yip1 domain family member 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7660	PKDCC	protein kinase domain containing, cytoplasmic	0.0000000	0.5555556	0.3333333	0.5000000	0.2857143	0.4106280	0.0464990
7667	THADA	THADA armadillo repeat containing	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7685	STPG4	sperm-tail PG-rich repeat containing 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7686	MSH2	mutS homolog 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7690	FOXN2	forkhead box N2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7713	VRK2	VRK serine/threonine kinase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7718	KIAA1841	KIAA1841	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7721	USP34	ubiquitin specific peptidase 34	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7735	PELI1	pellino E3 ubiquitin protein ligase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7744	ACTR2	actin related protein 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7772	PCBP1-AS1	PCBP1 antisense RNA 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7784	TEX261	testis expressed 261	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7785	NAGK	N-acetylglucosamine kinase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7798	SMYD5	SMYD family member 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7802	ALMS1	ALMS1 centrosome and basal body associated protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7805	STAMBP	STAM binding protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7811	MTHFD2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7858	IMMT	inner membrane mitochondrial protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7884	SNRNP200	small nuclear ribonucleoprotein U5 subunit 200	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7893	CNNM3	cyclin and CBS domain divalent metal cation transport mediator 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7899	ACTR1B	actin related protein 1B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7909	C2orf15	chromosome 2 open reading frame 15	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7912	TXNDC9	thioredoxin domain containing 9	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7913	REV1	REV1 DNA directed polymerase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7918	RPL31	ribosomal protein L31	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7920	CNOT11	CCR4-NOT transcription complex subunit 11	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7930	MRPS9	mitochondrial ribosomal protein S9	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7938	GCC2	GRIP and coiled-coil domain containing 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7948	BUB1	BUB1 mitotic checkpoint serine/threonine kinase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7951	ANAPC1	anaphase promoting complex subunit 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7953	TMEM87B	transmembrane protein 87B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7954	ZC3H8	zinc finger CCCH-type containing 8	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7955	ZC3H6	zinc finger CCCH-type containing 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7971	INSIG2	insulin induced gene 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
7974	C2orf76	chromosome 2 open reading frame 76	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7980	RALB	RAS like proto-oncogene B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7984	TSN	translin	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
7989	MIR4783	microRNA 4783	0.0000000	0.3333333	0.3333333	0.1666667	0.5714286	0.4154589	0.0452981
8037	EPC2	enhancer of polycomb homolog 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8040	RBM43	RNA binding motif protein 43	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8045	STAM2	signal transducing adaptor molecule 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8046	FMNL2	formin like 2	0.0000000	0.5555556	0.6666667	0.5000000	0.5714286	0.4975845	0.0118317
8057	WDSUB1	WD repeat, sterile alpha motif and U-box domain containing 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8060	BAZ2B	bromodomain adjacent to zinc finger domain 2B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8067	PSMD14	proteasome 26S subunit, non-ATPase 14	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8089	PHOSPHO2-KLHL23	PHOSPHO2-KLHL23 readthrough	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8091	SSB	small RNA binding exonuclease protection factor La	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8094	UBR3	ubiquitin protein ligase E3 component n-recognin 3	0.5714286	0.0000000	0.3333333	0.3333333	0.2857143	-0.4041868	0.0336518
8104	METTL8	methyltransferase like 8	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8107	HAT1	histone acetyltransferase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8115	SP3	Sp3 transcription factor	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8116	OLA1	Obg like ATPase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8125	ATP5MC3	ATP synthase membrane subunit c locus 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8126	LNPK	lunapark, ER junction formation factor	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8131	NFE2L2	nuclear factor, erythroid 2 like 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8147	ITGA4	integrin subunit alpha 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8177	SLC39A10	solute carrier family 39 member 10	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8178	DNAH7	dynein axonemal heavy chain 7	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8231	BMPR2	bone morphogenetic protein receptor type 2	0.5714286	1.0000000	0.6666667	1.0000000	0.8571429	0.3091787	0.0291497
8248	KLF7	Kruppel like factor 7	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8255	IDH1-AS1	IDH1 antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8256	PIKFYVE	phosphoinositide kinase, FYVE-type zinc finger containing	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8263	LANCL1	LanC like 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8266	BARD1	BRCA1 associated RING domain 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8272	XRCC5	X-ray repair cross complementing 5	0.4285714	0.1111111	0.0000000	0.0000000	0.1428571	-0.2979066	0.0497855
8299	NHEJ1	non-homologous end joining factor 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8309	DNPEP	aspartyl aminopeptidase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8310	SPEG	striated muscle enriched protein kinase	0.0000000	0.4444444	0.6666667	0.3333333	0.5714286	0.5217391	0.0086892
8323	MRPL44	mitochondrial ribosomal protein L44	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8325	CUL3	cullin 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8330	MFF	mitochondrial fission factor	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8339	CAB39	calcium binding protein 39	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8342	PSMD1	proteasome 26S subunit, non-ATPase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8361	ATG16L1	autophagy related 16 like 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8371	LRRFIP1	LRR binding FLII interacting protein 1	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
8376	SCLY	selenocysteine lyase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8392	CAPN10	calpain 10	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8401	STK25	serine/threonine kinase 25	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8404	DTYMK	deoxythymidylate kinase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8405	ING5	inhibitor of growth family member 5	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8418	RBCK1	RANBP2-type and C3HC4-type zinc finger containing 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8419	TBC1D20	TBC1 domain family member 20	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8423	FAM110A	family with sequence similarity 110 member A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8429	SDCBP2-AS1	SDCBP2 antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8453	C20orf27	chromosome 20 open reading frame 27	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8473	GPCPD1	glycerophosphocholine phosphodiesterase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8478	TMX4	thioredoxin related transmembrane protein 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8479	PLCB1	phospholipase C beta 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8493	RRBP1	ribosome binding protein 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8494	SNX5	sorting nexin 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8496	ZNF133	zinc finger protein 133	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8501	SMIM26	small integral membrane protein 26	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8506	RALGAPA2	Ral GTPase activating protein catalytic alpha subunit 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8507	KIZ	kizuna centrosomal protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8508	XRN2	5’-3’ exoribonuclease 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8513	NAPB	NSF attachment protein beta	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8521	ABHD12	abhydrolase domain containing 12	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8525	ZNF337	zinc finger protein 337	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8534	DUSP15	dual specificity phosphatase 15	0.0000000	0.5555556	0.6666667	0.1666667	0.5714286	0.4009662	0.0478727
8547	C20orf203	chromosome 20 open reading frame 203	0.1428571	0.7777778	0.6666667	0.3333333	0.7142857	0.3832528	0.0339567
8551	MAPRE1	microtubule associated protein RP/EB family member 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8559	E2F1	E2F transcription factor 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8565	AHCY	adenosylhomocysteinase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8592	SCAND1	SCAN domain containing 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8603	DSN1	DSN1 component of MIS12 kinetochore complex	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8617	ACTR5	actin related protein 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8621	DHX35	DEAH-box helicase 35	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8632	IFT52	intraflagellar transport 52	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8635	OSER1-DT	OSER1 divergent transcript	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8638	SERINC3	serine incorporator 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8646	STK4-AS1	STK4 antisense RNA 1 (head to head)	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
8677	SNORD12C	small nucleolar RNA, C/D box 12C	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8715	VAPB	VAMP associated protein B and C	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8729	SLMO2-ATP5E	SLMO2-ATP5E readthrough	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8743	RPS21	ribosomal protein S21	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8752	DIDO1	death inducer-obliterator 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8764	PTK6	protein tyrosine kinase 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8800	C21orf91	chromosome 21 open reading frame 91	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8805	MRPL39	mitochondrial ribosomal protein L39	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8813	USP16	ubiquitin specific peptidase 16	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8814	CCT8	chaperonin containing TCP1 subunit 8	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8817	BACH1	BTB domain and CNC homolog 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8819	SOD1	superoxide dismutase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8822	URB1-AS1	URB1 antisense RNA 1 (head to head)	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8829	IFNAR1	interferon alpha and beta receptor subunit 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8831	TMEM50B	transmembrane protein 50B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8832	DNAJC28	DnaJ heat shock protein family (Hsp40) member C28	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8834	DONSON	downstream neighbor of SON	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8846	SETD4	SET domain containing 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8847	CBR1	carbonyl reductase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8857	PIGP	phosphatidylinositol glycan anchor biosynthesis class P	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8864	HMGN1	high mobility group nucleosome binding domain 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8888	NDUFV3	NADH:ubiquinone oxidoreductase subunit V3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8905	GATD3A	glutamine amidotransferase like class 1 domain containing 3A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8933	PCNT	pericentrin	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8950	PEX26	peroxisomal biogenesis factor 26	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
8981	KLHL22	kelch like family member 22	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8986	CRKL	CRK like proto-oncogene, adaptor protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8988	THAP7-AS1	THAP7 antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
8995	SDF2L1	stromal cell derived factor 2 like 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9020	SLC2A11	solute carrier family 2 member 11	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9044	PITPNB	phosphatidylinositol transfer protein beta	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9053	GAS2L1	growth arrest specific 2 like 1	0.0000000	0.4444444	0.6666667	0.3333333	0.5714286	0.4396135	0.0397280
9081	SELENOM	selenoprotein M	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9088	DRG1	developmentally regulated GTP binding protein 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9095	DEPDC5	DEP domain containing 5, GATOR1 subcomplex subunit	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9106	MCM5	minichromosome maintenance complex component 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9117	MYH9	myosin heavy chain 9	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9162	DMC1	DNA meiotic recombinase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9211	POLR3H	RNA polymerase III subunit H	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9226	NAGA	alpha-N-acetylgalactosaminidase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9231	SERHL	serine hydrolase like (pseudogene)	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9272	TBC1D22A	TBC1 domain family member 22A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9295	SCO2	SCO cytochrome c oxidase assembly protein 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9299	SYCE3	synaptonemal complex central element protein 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9304	TRNT1	tRNA nucleotidyl transferase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9308	SETMAR	SET domain and mariner transposase fusion gene	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9315	EDEM1	ER degradation enhancing alpha-mannosidase like protein 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9322	MTMR14	myotubularin related protein 14	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9332	CRELD1	cysteine rich with EGF like domains 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9345	ATG7	autophagy related 7	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9349	TAMM41	TAM41 mitochondrial translocator assembly and maintenance homolog	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9352	RAF1	Raf-1 proto-oncogene, serine/threonine kinase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9359	HDAC11	histone deacetylase 11	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9365	SLC6A6	solute carrier family 6 member 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9368	MRPS25	mitochondrial ribosomal protein S25	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9376	DPH3	diphthamide biosynthesis 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9381	TBC1D5	TBC1 domain family member 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9385	EFHB	EF-hand domain family member B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9386	KAT2B	lysine acetyltransferase 2B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9394	MIR4442	microRNA 4442	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9395	NGLY1	N-glycanase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9396	OXSM	3-oxoacyl-ACP synthase, mitochondrial	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9397	NEK10	NIMA related kinase 10	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9398	SLC4A7	solute carrier family 4 member 7	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9429	ACAA1	acetyl-CoA acyltransferase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9443	EIF1B	eukaryotic translation initiation factor 1B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9465	ABHD5	abhydrolase domain containing 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9466	TCAIM	T cell activation inhibitor, mitochondrial	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9503	SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9506	MAP4	microtubule associated protein 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9508	ZNF589	zinc finger protein 589	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9512	TMA7	translation machinery associated 7 homolog	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9534	QRICH1	glutamine rich 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9569	TUSC2	tumor suppressor 2, mitochondrial calcium regulator	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9572	NPRL2	NPR2 like, GATOR1 complex subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9581	MANF	mesencephalic astrocyte derived neurotrophic factor	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9610	RFT1	RFT1 homolog	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9613	DCP1A	decapping mRNA 1A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9618	TASOR	transcription activation suppressor	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9634	RPP14	ribonuclease P/MRP subunit p14	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9636	PDHB	pyruvate dehydrogenase E1 beta subunit	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9639	FHIT	fragile histidine triad diadenosine triphosphatase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9646	LRIG1	leucine rich repeats and immunoglobulin like domains 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9652	ARL6IP5	ADP ribosylation factor like GTPase 6 interacting protein 5	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9669	SHQ1	SHQ1, H/ACA ribonucleoprotein assembly factor	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9672	FAM86DP	family with sequence similarity 86 member D, pseudogene	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9680	DHFR2	dihydrofolate reductase 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9681	ARL6	ADP ribosylation factor like GTPase 6	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9683	RIOX2	ribosomal oxygenase 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9684	CLDND1	claudin domain containing 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9685	CPOX	coproporphyrinogen oxidase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9686	DCBLD2	discoidin, CUB and LCCL domain containing 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9694	TFG	trafficking from ER to golgi regulator	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9697	TRMT10C	tRNA methyltransferase 10C, mitochondrial RNase P subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9703	NFKBIZ	NFKB inhibitor zeta	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9707	CBLB	Cbl proto-oncogene B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9711	IFT57	intraflagellar transport 57	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9717	NECTIN3	nectin cell adhesion molecule 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9719	PLCXD2	phosphatidylinositol specific phospholipase C X domain containing 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9722	ABHD10	abhydrolase domain containing 10	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9733	NEPRO	nucleolus and neural progenitor protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9734	CFAP44	cilia and flagella associated protein 44	0.0000000	0.2222222	0.0000000	0.1666667	0.4285714	0.2866345	0.0411643
9776	DTX3L	deltex E3 ubiquitin ligase 3L	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9801	OSBPL11	oxysterol binding protein like 11	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9808	CHCHD6	coiled-coil-helix-coiled-coil-helix domain containing 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9819	RAB7A	RAB7A, member RAS oncogene family	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9820	ACAD9	acyl-CoA dehydrogenase family member 9	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9826	CNBP	CCHC-type zinc finger nucleic acid binding protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9828	HMCES	5-hydroxymethylcytosine binding, ES cell specific	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9837	FAM86HP	family with sequence similarity 86, member A pseudogene	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9842	ASTE1	asteroid homolog 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9846	DNAJC13	DnaJ heat shock protein family (Hsp40) member C13	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9848	NPHP3	nephrocystin 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9856	MSL2	MSL complex subunit 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9862	DBR1	debranching RNA lariats 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9868	MRPS22	mitochondrial ribosomal protein S22	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9878	ATP1B3	ATPase Na+/K+ transporting subunit beta 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9883	ATR	ATR serine/threonine kinase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9885	TRPC1	transient receptor potential cation channel subfamily C member 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9888	LOC100289361	uncharacterized LOC100289361	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9894	PLSCR1	phospholipid scramblase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9899	COMMD2	COMM domain containing 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9900	RNF13	ring finger protein 13	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9905	ERICH6	glutamate rich 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9906	SIAH2	siah E3 ubiquitin protein ligase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9912	MBNL1-AS1	MBNL1 antisense RNA 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9917	DHX36	DEAH-box helicase 36	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9920	GMPS	guanine monophosphate synthase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9927	CCNL1	cyclin L1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9931	GFM1	G elongation factor mitochondrial 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9932	LXN	latexin	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9936	IL12A	interleukin 12A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9941	KPNA4	karyopherin subunit alpha 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9944	NMD3	NMD3 ribosome export adaptor	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9954	LOC100128164	four and a half LIM domains 1 pseudogene	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9957	PRKCI	protein kinase C iota	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9960	EIF5A2	eukaryotic translation initiation factor 5A2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9968	NCEH1	neutral cholesterol ester hydrolase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9982	FXR1	FMR1 autosomal homolog 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
9994	KLHL24	kelch like family member 24	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
9997	PARL	presenilin associated rhomboid like	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10004	ALG3	ALG3 alpha-1,3- mannosyltransferase	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
10005	ALG3	ALG3 alpha-1,3- mannosyltransferase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10008	PSMD2	proteasome 26S subunit, non-ATPase 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10011	CLCN2	chloride voltage-gated channel 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10015	VPS8	VPS8 subunit of CORVET complex	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10025	TBCCD1	TBCC domain containing 1	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
10030	RPL39L	ribosomal protein L39 like	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10059	TCTEX1D2	Tctex1 domain containing 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10061	UBXN7	UBX domain protein 7	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10073	BDH1	3-hydroxybutyrate dehydrogenase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10074	RUBCN	rubicon autophagy regulator	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10085	LOC100129917	uncharacterized LOC100129917	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10094	MAEA	macrophage erythroblast attacher	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10099	TACC3	transforming acidic coiled-coil containing protein 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10109	POLN	DNA polymerase nu	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10113	RNF4	ring finger protein 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10125	GRK4	G protein-coupled receptor kinase 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10141	WFS1	wolframin ER transmembrane glycoprotein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10156	ABLIM2	actin binding LIM protein family member 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10186	ZCCHC4	zinc finger CCHC-type containing 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10187	ANAPC4	anaphase promoting complex subunit 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10190	SMIM20	small integral membrane protein 20	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10193	STIM2	stromal interaction molecule 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10215	UGDH-AS1	UGDH antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10224	SLC30A9	solute carrier family 30 member 9	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10227	ATP8A1	ATPase phospholipid transporting 8A1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10230	GNPDA2	glucosamine-6-phosphate deaminase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10233	ATP10D	ATPase phospholipid transporting 10D (putative)	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10250	PDGFRA	platelet derived growth factor receptor alpha	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10253	TMEM165	transmembrane protein 165	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10256	CEP135	centrosomal protein 135	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10270	CENPC	centromere protein C	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10271	UBA6-AS1	UBA6 antisense RNA 1 (head to head)	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10278	GRSF1	G-rich RNA sequence binding factor 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10280	MOB1B	MOB kinase activator 1B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10281	DCK	deoxycytidine kinase	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
10284	COX18	cytochrome c oxidase assembly factor COX18	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10291	THAP6	THAP domain containing 6	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10293	CDKL2	cyclin dependent kinase like 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10297	NAAA	N-acylethanolamine acid amidase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10311	LINC01094	long intergenic non-protein coding RNA 1094	0.8571429	0.2222222	0.3333333	0.5000000	0.5714286	-0.4605475	0.0325759
10333	ABRAXAS1	abraxas 1, BRCA1 A complex subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10352	FAM13A	family with sequence similarity 13 member A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10358	PDLIM5	PDZ and LIM domain 5	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10360	STPG2	sperm tail PG-rich repeat containing 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10367	DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10372	PPP3CA	protein phosphatase 3 catalytic subunit alpha	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10380	SLC9B1	solute carrier family 9 member B1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10389	PAPSS1	3’-phosphoadenosine 5’-phosphosulfate synthase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10391	HADH	hydroxyacyl-CoA dehydrogenase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10397	OSTC	oligosaccharyltransferase complex non-catalytic subunit	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10401	MCUB	mitochondrial calcium uniporter dominant negative beta subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10408	FAM241A	family with sequence similarity 241 member A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10409	AP1AR	adaptor related protein complex 1 associated regulatory protein	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10421	USP53	ubiquitin specific peptidase 53	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10422	LOC645513	septin 7 pseudogene	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10431	QRFPR	pyroglutamylated RFamide peptide receptor	0.0000000	0.5555556	0.3333333	0.1666667	0.4285714	0.3687601	0.0351560
10433	EXOSC9	exosome component 9	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10445	PLK4	polo like kinase 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10446	MFSD8	major facilitator superfamily domain containing 8	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10454	NOCT	nocturnin	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10458	NDUFC1	NADH:ubiquinone oxidoreductase subunit C1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10466	ZNF330	zinc finger protein 330	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10477	MMAA	metabolism of cobalamin associated A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10482	SLC10A7	solute carrier family 10 member 7	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10485	PRMT9	protein arginine methyltransferase 9	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10495	MIR4453HG	MIR4453 host gene	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10496	TMEM154	transmembrane protein 154	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10497	TIGD4	tigger transposable element derived 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10512	NAF1	nuclear assembly factor 1 ribonucleoprotein	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10516	TMEM192	transmembrane protein 192	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10526	CLCN3	chloride voltage-gated channel 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10538	SPATA4	spermatogenesis associated 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10539	SPCS3	signal peptidase complex subunit 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10541	NEIL3	nei like DNA glycosylase 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10542	AGA	aspartylglucosaminidase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10544	DCTD	dCMP deaminase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10547	ING2	inhibitor of growth family member 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10555	CFAP97	cilia and flagella associated protein 97	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10582	MED10	mediator complex subunit 10	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10588	C5orf49	chromosome 5 open reading frame 49	0.1428571	0.7777778	0.6666667	0.5000000	0.7142857	0.4557166	0.0201865
10589	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10597	DAP	death associated protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10603	ZNF622	zinc finger protein 622	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10611	ZFR	zinc finger RNA binding protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10615	AMACR	alpha-methylacyl-CoA racemase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10618	BRIX1	biogenesis of ribosomes BRX1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10619	DNAJC21	DnaJ heat shock protein family (Hsp40) member C21	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10623	SKP2	S-phase kinase associated protein 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10624	NADK2	NAD kinase 2, mitochondrial	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10638	TTC33	tetratricopeptide repeat domain 33	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10642	OXCT1	3-oxoacid CoA-transferase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10652	ZNF131	zinc finger protein 131	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10657	C5orf34	chromosome 5 open reading frame 34	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10659	NNT-AS1	NNT antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10671	ARL15	ADP ribosylation factor like GTPase 15	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10680	MTREX	Mtr4 exosome RNA helicase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10681	RNF138P1	ring finger protein 138 pseudogene 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10683	SLC38A9	solute carrier family 38 member 9	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10687	MIER3	MIER family member 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10696	KIF2A	kinesin family member 2A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10707	SREK1	splicing regulatory glutamic acid and lysine rich protein 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10710	MAST4	microtubule associated serine/threonine kinase family member 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10711	PIK3R1	phosphoinositide-3-kinase regulatory subunit 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10717	CDK7	cyclin dependent kinase 7	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10719	RAD17	RAD17 checkpoint clamp loader component	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10728	BTF3	basic transcription factor 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10743	AGGF1	angiogenic factor with G-patch and FHA domains 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10746	TBCA	tubulin folding cofactor A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10748	SCAMP1	secretory carrier membrane protein 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10752	HOMER1	homer scaffold protein 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10753	TENT2	terminal nucleotidyltransferase 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10754	MTX3	metaxin 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10756	ZFYVE16	zinc finger FYVE-type containing 16	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10757	FAM151B	family with sequence similarity 151 member B	0.0000000	0.5555556	0.6666667	0.3333333	0.5714286	0.4396135	0.0353280
10763	RPS23	ribosomal protein S23	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10777	POLR3G	RNA polymerase III subunit G	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10786	FAM172A	family with sequence similarity 172 member A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10792	RFESD	Rieske Fe-S domain containing	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10798	CAST	calpastatin	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10800	ERAP1	endoplasmic reticulum aminopeptidase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10802	LNPEP	leucyl and cystinyl aminopeptidase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10811	ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10813	SLCO4C1	solute carrier organic anion transporter family member 4C1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10818	FBXL17	F-box and leucine rich repeat protein 17	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10828	WDR36	WD repeat domain 36	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10830	STARD4-AS1	STARD4 antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10832	EPB41L4A-AS1	EPB41L4A antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10836	APC	APC regulator of WNT signaling pathway	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10839	REEP5	receptor accessory protein 5	0.5714286	1.0000000	1.0000000	0.8333333	0.8571429	0.3091787	0.0291497
10844	YTHDC2	YTH domain containing 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10849	FEM1C	fem-1 homolog C	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10854	COMMD10	COMM domain containing 10	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10855	DTWD2	DTW domain containing 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10862	SNX2	sorting nexin 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10880	RAPGEF6	Rap guanine nucleotide exchange factor 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10888	IRF1	interferon regulatory factor 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10889	IRF1	interferon regulatory factor 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10890	RAD50	RAD50 double strand break repair protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10902	VDAC1	voltage dependent anion channel 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10912	JADE2	jade family PHD finger 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10916	CAMLG	calcium modulating ligand	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10919	C5orf24	chromosome 5 open reading frame 24	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10921	PCBD2	pterin-4 alpha-carbinolamine dehydratase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10923	MACROH2A1	macroH2A.1 histone	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
10928	KLHL3	kelch like family member 3	0.1428571	0.4444444	0.6666667	0.5000000	0.5714286	0.3671498	0.0325543
10936	FAM53C	family with sequence similarity 53 member C	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10959	PURA	purine rich element binding protein A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10969	TMCO6	transmembrane and coiled-coil domains 6	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10971	WDR55	WD repeat domain 55	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10984	DIAPH1	diaphanous related formin 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
10990	RNF14	ring finger protein 14	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10994	ARHGAP26	Rho GTPase activating protein 26	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
10995	NR3C1	nuclear receptor subfamily 3 group C member 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11004	PPP2R2B-IT1	PPP2R2B intronic transcript 1	0.7142857	0.2222222	0.3333333	0.1666667	0.2857143	-0.5152979	0.0059759
11006	JAKMIP2	janus kinase and microtubule interacting protein 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11022	RPS14	ribosomal protein S14	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11023	RBM22	RNA binding motif protein 22	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11038	FAM114A2	family with sequence similarity 114 member A2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11041	SAP30L-AS1	SAP30L antisense RNA 1 (head to head)	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11044	CNOT8	CCR4-NOT transcription complex subunit 8	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11063	RNF145	ring finger protein 145	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11064	UBLCP1	ubiquitin like domain containing CTD phosphatase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11076	MAT2B	methionine adenosyltransferase 2B	0.5714286	0.3333333	0.0000000	0.1666667	0.2857143	-0.3784219	0.0347546
11077	MAT2B	methionine adenosyltransferase 2B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11081	SPDL1	spindle apparatus coiled-coil protein 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11088	NPM1	nucleophosmin 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11105	BNIP1	BCL2 interacting protein 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11115	KIAA1191	KIAA1191	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11116	ARL10	ADP ribosylation factor like GTPase 10	0.0000000	0.6666667	0.0000000	0.3333333	0.7142857	0.4557166	0.0350399
11126	TSPAN17	tetraspanin 17	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11128	ZNF346	zinc finger protein 346	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11137	PRR7	proline rich 7, synaptic	0.4285714	0.0000000	0.0000000	0.0000000	0.2857143	-0.3478261	0.0261378
11140	PDLIM7	PDZ and LIM domain 7	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11150	CLK4	CDC like kinase 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11151	ZNF354A	zinc finger protein 354A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11161	MGAT4B	alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B	0.2857143	0.7777778	0.6666667	0.6666667	0.8571429	0.4380032	0.0474327
11169	MAPK9	mitogen-activated protein kinase 9	0.7142857	0.1111111	0.0000000	0.1666667	0.2857143	-0.5797101	0.0001285
11173	MGAT1	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11175	HEIH	hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA	0.5714286	0.0000000	0.0000000	0.1666667	0.1428571	-0.4283414	0.0084399
11181	MYLK4	myosin light chain kinase family member 4	1.0000000	0.4444444	1.0000000	0.6666667	0.8571429	-0.4025765	0.0276467
11206	FARS2	phenylalanyl-tRNA synthetase 2, mitochondrial	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11216	EEF1E1-BLOC1S5	EEF1E1-BLOC1S5 readthrough (NMD candidate)	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11225	SMIM13	small integral membrane protein 13	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11227	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11232	TBC1D7	TBC1 domain family member 7	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11234	SIRT5	sirtuin 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11235	NOL7	nucleolar protein 7	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11239	CD83	CD83 molecule	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
11248	NUP153	nucleoporin 153	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11268	TDP2	tyrosyl-DNA phosphodiesterase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11271	GMNN	geminin DNA replication inhibitor	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11392	HCG27	HLA complex group 27	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11422	VWA7	von Willebrand factor A domain containing 7	0.1428571	0.8888889	0.6666667	0.5000000	0.7142857	0.5201288	0.0045242
11448	TAP2	transporter 2, ATP binding cassette subfamily B member	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11451	LOC100294145	uncharacterized LOC100294145	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11482	LEMD2	LEM domain containing 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11486	SMIM29	small integral membrane protein 29	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11498	PPARD	peroxisome proliferator activated receptor delta	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11500	RPL10A	ribosomal protein L10a	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11531	TMEM217	transmembrane protein 217	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11552	TOMM6	translocase of outer mitochondrial membrane 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11555	CCND3	cyclin D3	0.0000000	0.5555556	0.6666667	0.5000000	0.2857143	0.5040258	0.0239155
11570	PEX6	peroxisomal biogenesis factor 6	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11583	ZNF318	zinc finger protein 318	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11605	SUPT3H	SPT3 homolog, SAGA and STAGA complex component	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11620	EFHC1	EF-hand domain containing 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11628	ELOVL5	ELOVL fatty acid elongase 5	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11634	BAG2	BCL2 associated athanogene 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11637	PHF3	PHD finger protein 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11641	SDHAF4	succinate dehydrogenase complex assembly factor 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11648	OOEP	oocyte expressed protein	0.2857143	0.7777778	0.6666667	0.6666667	0.7142857	0.3977456	0.0247321
11660	PHIP	pleckstrin homology domain interacting protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11667	TENT5A	terminal nucleotidyltransferase 5A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11668	IBTK	inhibitor of Bruton tyrosine kinase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11672	DOP1A	DOP1 leucine zipper like protein A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11676	CYB5R4	cytochrome b5 reductase 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11680	SYNCRIP	synaptotagmin binding cytoplasmic RNA interacting protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11687	SLC35A1	solute carrier family 35 member A1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11691	RNGTT	RNA guanylyltransferase and 5’-phosphatase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11698	LYRM2	LYR motif containing 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11702	MANEA	mannosidase endo-alpha	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11703	UFL1	UFM1 specific ligase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11705	NDUFAF4	NADH:ubiquinone oxidoreductase complex assembly factor 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11706	KLHL32	kelch like family member 32	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11716	ASCC3	activating signal cointegrator 1 complex subunit 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11717	HACE1	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11739	ARMC2	armadillo repeat containing 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11750	GTF3C6	general transcription factor IIIC subunit 6	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11751	RPF2	ribosome production factor 2 homolog	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11760	FYN	FYN proto-oncogene, Src family tyrosine kinase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11779	CEP85L	centrosomal protein 85 like	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11798	NCOA7	nuclear receptor coactivator 7	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11803	RNF146	ring finger protein 146	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11823	TBPL1	TATA-box binding protein like 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11830	HBS1L	HBS1 like translational GTPase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11833	PDE7B	phosphodiesterase 7B	0.0000000	0.4444444	0.6666667	0.3333333	0.1428571	0.4106280	0.0221890
11837	MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11850	REPS1	RALBP1 associated Eps domain containing 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11866	PLAGL1	PLAG1 like zinc finger 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11872	LOC100507557	uncharacterized LOC100507557	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11899	ZBTB2	zinc finger and BTB domain containing 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11907	MTRF1L	mitochondrial translational release factor 1 like	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11912	MIR4466	microRNA 4466	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11914	TMEM242	transmembrane protein 242	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11918	GTF2H5	general transcription factor IIH subunit 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11932	MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11935	CAHM	colon adenocarcinoma hypermethylated	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11938	MPC1	mitochondrial pyruvate carrier 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11945	FGFR1OP	FGFR1 oncogene partner	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11961	SUN1	Sad1 and UNC84 domain containing 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11969	ZFAND2A	zinc finger AN1-type containing 2A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11970	MICALL2	MICAL like 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
11986	GNA12	G protein subunit alpha 12	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11988	SDK1	sidekick cell adhesion molecule 1	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
11990	AP5Z1	adaptor related protein complex 5 subunit zeta 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
11999	ACTB	actin beta	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12008	USP42	ubiquitin specific peptidase 42	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12036	BZW2	basic leucine zipper and W2 domains 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12039	SNX13	sorting nexin 13	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12055	KLHL7-DT	KLHL7 divergent transcript	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12066	OSBPL3	oxysterol binding protein like 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12085	TAX1BP1	Tax1 binding protein 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12101	LSM5	LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12104	KBTBD2	kelch repeat and BTB domain containing 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12133	RALA	RAS like proto-oncogene A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12137	C7orf25	chromosome 7 open reading frame 25	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12150	POLD2	DNA polymerase delta 2, accessory subunit	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12151	YKT6	YKT6 v-SNARE homolog	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12164	CCM2	CCM2 scaffold protein	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12171	HUS1	HUS1 checkpoint clamp component	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12178	SEC61G	SEC61 translocon gamma subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12179	LANCL2	LanC like 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12183	MRPS17	mitochondrial ribosomal protein S17	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12197	LOC441242	uncharacterized LOC441242	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12207	RABGEF1	RAB guanine nucleotide exchange factor 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12209	TMEM248	transmembrane protein 248	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12229	BUD23	BUD23 rRNA methyltransferase and ribosome maturation factor	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12240	GTF2I	general transcription factor IIi	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12241	GTF2IRD2	GTF2I repeat domain containing 2	0.5714286	1.0000000	1.0000000	0.8333333	0.8571429	0.2995169	0.0139971
12245	GTF2IRD2B	GTF2I repeat domain containing 2B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12251	RHBDD2	rhomboid domain containing 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12253	TMEM120A	transmembrane protein 120A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12276	DMTF1	cyclin D binding myb like transcription factor 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12279	ABCB1	ATP binding cassette subfamily B member 1	0.5714286	0.0000000	0.0000000	0.3333333	0.1428571	-0.4524960	0.0058702
12282	DBF4	DBF4 zinc finger	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12288	GTPBP10	GTP binding protein 10	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12289	CLDN12	claudin 12	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12291	MTERF1	mitochondrial transcription termination factor 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12298	FAM133B	family with sequence similarity 133 member B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12312	PON1	paraoxonase 1	0.2857143	0.5555556	0.3333333	0.5000000	0.5714286	0.3027375	0.0218335
12320	SDHAF3	succinate dehydrogenase complex assembly factor 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12323	LMTK2	lemur tyrosine kinase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12339	FAM200A	family with sequence similarity 200 member A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12349	MCM7	minichromosome maintenance complex component 7	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12387	FIS1	fission, mitochondrial 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12395	FBXL13	F-box and leucine rich repeat protein 13	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12402	ORC5	origin recognition complex subunit 5	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12403	KMT2E-AS1	KMT2E antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12422	DLD	dihydrolipoamide dehydrogenase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12437	TES	testin LIM domain protein	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12443	CAPZA2	capping actin protein of muscle Z-line subunit alpha 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12463	LRRC4	leucine rich repeat containing 4	0.1428571	0.7777778	0.3333333	0.5000000	0.7142857	0.4557166	0.0236367
12472	CALU	calumenin	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12475	ATP6V1F	ATPase H+ transporting V1 subunit F	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12482	STRIP2	striatin interacting protein 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12489	CEP41	centrosomal protein 41	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12502	AKR1B1	aldo-keto reductase family 1 member B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12504	AGBL3	ATP/GTP binding protein like 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12507	WDR91	WD repeat domain 91	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12509	NUP205	nucleoporin 205	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12511	LUZP6	leucine zipper protein 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12523	LUC7L2	LUC7 like 2, pre-mRNA splicing factor	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12534	NDUFB2-AS1	NDUFB2 antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12535	BRAF	B-Raf proto-oncogene, serine/threonine kinase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12542	GSTK1	glutathione S-transferase kappa 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12543	CASP2	caspase 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12555	TPK1	thiamin pyrophosphokinase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12559	PDIA4	protein disulfide isomerase family A member 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12573	ZNF862	zinc finger protein 862	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12578	ZNF775	zinc finger protein 775	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12595	FASTK	Fas activated serine/threonine kinase	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12625	LMBR1	limb development membrane protein 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12628	UBE3C	ubiquitin protein ligase E3C	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12632	NCAPG2	non-SMC condensin II complex subunit G2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12638	ERICH1	glutamate rich 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12646	AGPAT5	1-acylglycerol-3-phosphate O-acyltransferase 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12651	ERI1	exoribonuclease 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12657	XKR6	XK related 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12673	VPS37A	VPS37A subunit of ESCRT-I	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12678	ASAH1	N-acylsphingosine amidohydrolase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12686	ATP6V1B2	ATPase H+ transporting V1 subunit B2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12715	TNFRSF10C	TNF receptor superfamily member 10c	0.0000000	0.6666667	0.6666667	0.3333333	0.7142857	0.5362319	0.0161788
12751	SARAF	store-operated calcium entry associated regulatory factor	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12766	ERLIN2	ER lipid raft associated 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12770	BRF2	BRF2 RNA polymerase III transcription initiation factor subunit	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12790	KAT6A	lysine acetyltransferase 6A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12796	VDAC3	voltage dependent anion channel 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12805	MCM4	minichromosome maintenance complex component 4	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12808	PCMTD1	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12810	ATP6V1H	ATPase H+ transporting V1 subunit H	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12813	MRPL15	mitochondrial ribosomal protein L15	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12816	SNORD54	small nucleolar RNA, C/D box 54	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12817	PLAG1	PLAG1 zinc finger	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12821	SDCBP	syndecan binding protein	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12828	MIR4470	microRNA 4470	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12830	YTHDF3-AS1	YTHDF3 antisense RNA 1 (head to head)	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12831	LINC01299	long intergenic non-protein coding RNA 1299	0.5714286	0.1111111	0.3333333	0.0000000	0.2857143	-0.4347826	0.0236567
12841	SGK3	serum/glucocorticoid regulated kinase family member 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12843	SNHG6	small nucleolar RNA host gene 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12845	PPP1R42	protein phosphatase 1 regulatory subunit 42	0.1428571	0.5555556	0.3333333	0.3333333	0.5714286	0.3268921	0.0468408
12863	UBE2W	ubiquitin conjugating enzyme E2 W	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12868	GDAP1	ganglioside induced differentiation associated protein 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12869	PEX2	peroxisomal biogenesis factor 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12870	PKIA	cAMP-dependent protein kinase inhibitor alpha	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12871	ZC2HC1A	zinc finger C2HC-type containing 1A	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12875	MRPS28	mitochondrial ribosomal protein S28	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12884	ZFAND1	zinc finger AN1-type containing 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12891	WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12904	RBM12B	RNA binding motif protein 12B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12905	TMEM67	transmembrane protein 67	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12912	INTS8	integrator complex subunit 8	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12915	NDUFAF6	NADH:ubiquinone oxidoreductase complex assembly factor 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12918	UQCRB	ubiquinol-cytochrome c reductase binding protein	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12946	UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12950	ATP6V1C1	ATPase H+ transporting V1 subunit C1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12973	MIR3610	microRNA 3610	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12976	EXT1	exostosin glycosyltransferase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12987	DERL1	derlin 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12991	ATAD2	ATPase family AAA domain containing 2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
12994	FAM91A1	family with sequence similarity 91 member A1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12995	TMEM65	transmembrane protein 65	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
12997	RNF139	ring finger protein 139	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13023	PHF20L1	PHD finger protein 20 like 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13027	NDRG1	N-myc downstream regulated 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13063	PUF60	poly(U) binding splicing factor 60	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13098	ZNF7	zinc finger protein 7	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13119	RFX3	regulatory factor X3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13135	RIC1	RIC1 homolog, RAB6A GEF complex partner 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13136	ERMP1	endoplasmic reticulum metallopeptidase 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13138	RANBP6	RAN binding protein 6	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13142	KDM4C	lysine demethylase 4C	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13143	DMAC1	distal membrane arm assembly complex 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13145	NFIB	nuclear factor I B	0.0000000	0.4444444	0.6666667	0.5000000	0.5714286	0.4589372	0.0119370
13149	SNAPC3	small nuclear RNA activating complex polypeptide 3	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13164	HACD4	3-hydroxyacyl-CoA dehydratase 4	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13167	KLHL9	kelch like family member 9	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13171	CDKN2B-AS1	CDKN2B antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13175	IFT74	intraflagellar transport 74	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13183	SMIM27	small integral membrane protein 27	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13187	SMU1	SMU1 DNA replication regulator and spliceosomal factor	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13199	UBE2R2	ubiquitin conjugating enzyme E2 R2	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13204	MYORG	myogenesis regulating glycosidase (putative)	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13217	PIGO	phosphatidylinositol glycan anchor biosynthesis class O	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13219	FAM214B	family with sequence similarity 214 member B	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13221	FAM214B	family with sequence similarity 214 member B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13236	TMEM8B	transmembrane protein 8B	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13245	ZCCHC7	zinc finger CCHC-type containing 7	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13248	POLR1E	RNA polymerase I subunit E	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13250	TOMM5	translocase of outer mitochondrial membrane 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13267	SMC5-AS1	SMC5 antisense RNA 1 (head to head)	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13268	KLF9	Kruppel like factor 9	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13272	ZFAND5	zinc finger AN1-type containing 5	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13286	VPS13A-AS1	VPS13A antisense RNA 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13295	KIF27	kinesin family member 27	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13316	ROR2	receptor tyrosine kinase like orphan receptor 2	0.0000000	0.5555556	0.6666667	0.5000000	0.4285714	0.4476651	0.0258894
13320	IARS1	isoleucyl-tRNA synthetase 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13323	BICD2	BICD cargo adaptor 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13325	ZNF484	zinc finger protein 484	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13369	TSTD2	thiosulfate sulfurtransferase like domain containing 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13372	TRMO	tRNA methyltransferase O	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13375	NANS	N-acetylneuraminate synthase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13383	TGFBR1	transforming growth factor beta receptor 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13385	NR4A3	nuclear receptor subfamily 4 group A member 3	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13395	NIPSNAP3A	nipsnap homolog 3A	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13406	ABITRAM	actin binding transcription modulator	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13428	SLC31A1	solute carrier family 31 member 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13429	FKBP15	FKBP prolyl isomerase 15	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13433	ALAD	aminolevulinate dehydratase	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13434	C9orf43	chromosome 9 open reading frame 43	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13449	TRIM32	tripartite motif containing 32	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13451	MEGF9	multiple EGF like domains 9	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13461	GSN	gelsolin	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13471	RABGAP1	RAB GTPase activating protein 1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13479	RPL35	ribosomal protein L35	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13481	GOLGA1	golgin A1	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13483	PPP6C	protein phosphatase 6 catalytic subunit	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13496	RPL12	ribosomal protein L12	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13505	SH2D3C	SH2 domain containing 3C	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13535	ODF2	outer dense fiber of sperm tails 2	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13556	IER5L	immediate early response 5 like	0.8571429	1.0000000	1.0000000	1.0000000	1.0000000	0.1545894	0.0469135
13562	PRRX2	paired related homeobox 2	0.1428571	0.6666667	0.6666667	0.3333333	0.7142857	0.3913043	0.0457287
13642	TMEM141	transmembrane protein 141	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984
13664	ANAPC2	anaphase promoting complex subunit 2	0.5714286	1.0000000	0.6666667	0.8333333	1.0000000	0.3188406	0.0171174
13677	ARRDC1	arrestin domain containing 1	0.7142857	1.0000000	1.0000000	1.0000000	1.0000000	0.2512077	0.0090984